LOCUS       NM_001303273            5985 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus TNF receptor-associated factor 6 (Traf6), transcript
            variant 2, mRNA.
ACCESSION   NM_001303273 XM_006499156
VERSION     NM_001303273.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5985)
  AUTHORS   Cheng,M., Xu,B., Sun,Y., Wang,J., Lu,Y., Shi,C., Pan,T., Zhao,W.,
            Li,X., Song,X., Wang,J., Wang,N., Yang,W., Jiang,Y., Huang,H.,
            Yang,G., Zeng,Y., Yang,D., Wang,C. and Cao,X.
  TITLE     ASB3 expression aggravates inflammatory bowel disease by targeting
            TRAF6 protein stability and affecting the intestinal microbiota
  JOURNAL   mBio 15 (9), e0204324 (2024)
   PUBMED   39162488
  REMARK    GeneRIF: ASB3 expression aggravates inflammatory bowel disease by
            targeting TRAF6 protein stability and affecting the intestinal
            microbiota.
REFERENCE   2  (bases 1 to 5985)
  AUTHORS   Lim,Y.J., Park,S.A., Wang,D., Jin,W., Ku,W.L., Zhang,D., Xu,J.,
            Patino,L.C., Liu,N., Chen,W., Kazmi,R., Zhao,K., Zhang,Y.E., Sun,L.
            and Chen,W.
  TITLE     MicroRNA-19b exacerbates systemic sclerosis through promoting Th9
            cells
  JOURNAL   Cell Rep 43 (8), 114565 (2024)
   PUBMED   39083380
REFERENCE   3  (bases 1 to 5985)
  AUTHORS   Zhao,Y., Li,T., Zhang,L., Yang,J., Zhao,F., Wang,Y., Ouyang,Y. and
            Liu,J.
  TITLE     TRAF6 promotes spinal microglial M1 polarization to aggravate
            neuropathic pain by activating the c-JUN/NF-kB signaling pathway
  JOURNAL   Cell Biol Toxicol 40 (1), 54 (2024)
   PUBMED   38995476
  REMARK    GeneRIF: TRAF6 promotes spinal microglial M1 polarization to
            aggravate neuropathic pain by activating the c-JUN/NF-kB signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5985)
  AUTHORS   Ayyasamy,R., Fan,S., Czernik,P., Lecka-Czernik,B., Chattopadhyay,S.
            and Chakravarti,R.
  TITLE     14-3-3zeta suppresses RANKL signaling by destabilizing TRAF6
  JOURNAL   J Biol Chem 300 (7), 107487 (2024)
   PUBMED   38908751
  REMARK    GeneRIF: 14-3-3zeta suppresses RANKL signaling by destabilizing
            TRAF6.
REFERENCE   5  (bases 1 to 5985)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5985)
  AUTHORS   Naito,A., Azuma,S., Tanaka,S., Miyazaki,T., Takaki,S., Takatsu,K.,
            Nakao,K., Nakamura,K., Katsuki,M., Yamamoto,T. and Inoue,J.
  TITLE     Severe osteopetrosis, defective interleukin-1 signalling and lymph
            node organogenesis in TRAF6-deficient mice
  JOURNAL   Genes Cells 4 (6), 353-362 (1999)
   PUBMED   10421844
REFERENCE   7  (bases 1 to 5985)
  AUTHORS   Lomaga,M.A., Yeh,W.C., Sarosi,I., Duncan,G.S., Furlonger,C., Ho,A.,
            Morony,S., Capparelli,C., Van,G., Kaufman,S., van der Heiden,A.,
            Itie,A., Wakeham,A., Khoo,W., Sasaki,T., Cao,Z., Penninger,J.M.,
            Paige,C.J., Lacey,D.L., Dunstan,C.R., Boyle,W.J., Goeddel,D.V. and
            Mak,T.W.
  TITLE     TRAF6 deficiency results in osteopetrosis and defective
            interleukin-1, CD40, and LPS signaling
  JOURNAL   Genes Dev 13 (8), 1015-1024 (1999)
   PUBMED   10215628
REFERENCE   8  (bases 1 to 5985)
  AUTHORS   Hsu,H., Lacey,D.L., Dunstan,C.R., Solovyev,I., Colombero,A.,
            Timms,E., Tan,H.L., Elliott,G., Kelley,M.J., Sarosi,I., Wang,L.,
            Xia,X.Z., Elliott,R., Chiu,L., Black,T., Scully,S., Capparelli,C.,
            Morony,S., Shimamoto,G., Bass,M.B. and Boyle,W.J.
  TITLE     Tumor necrosis factor receptor family member RANK mediates
            osteoclast differentiation and activation induced by
            osteoprotegerin ligand
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3540-3545 (1999)
   PUBMED   10097072
REFERENCE   9  (bases 1 to 5985)
  AUTHORS   Schito,M.L., Chobotar,B. and Barta,J.R.
  TITLE     Major histocompatibility complex class I- and II-deficient
            knock-out mice are resistant to primary but susceptible to
            secondary Eimeria papillata infections
  JOURNAL   Parasitol Res 84 (5), 394-398 (1998)
   PUBMED   9610637
REFERENCE   10 (bases 1 to 5985)
  AUTHORS   Ishida,T., Mizushima,Si., Azuma,S., Kobayashi,N., Tojo,T.,
            Suzuki,K., Aizawa,S., Watanabe,T., Mosialos,G., Kieff,E.,
            Yamamoto,T. and Inoue,J.
  TITLE     Identification of TRAF6, a novel tumor necrosis factor
            receptor-associated factor protein that mediates signaling from an
            amino-terminal domain of the CD40 cytoplasmic region
  JOURNAL   J Biol Chem 271 (46), 28745-28748 (1996)
   PUBMED   8910514
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL929571.10.
            
            On Dec 30, 2014 this sequence version replaced XM_006499156.1.
            
            Summary: This gene encodes a member of the TNF receptor associated
            factor (TRAF) family of adaptor proteins that mediate signaling
            events from members of the TNF receptor and Toll/IL-1 receptor
            families to activate transcription factors such as NF-kappa-B and
            AP-1. The product of this gene is essential for perinatal and
            postnatal survival. Mice deficient in this protein exhibit
            osteopetrosis and defective in development of epidermal appendixes,
            normal B cell differentiation, lymph node organogenesis,
            interleukin-1 signaling, lipopolysaccharide signaling and neural
            tube closure. This protein possesses ubiquitin ligase activity.
            Alternate splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155434.1, SRR10223970.3954.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL929571.10        12159-12197
            40-201              AL929571.10        12198-12359
            202-519             AL929571.10        18218-18535
            520-670             AL929571.10        22203-22353
            671-829             AL929571.10        23795-23953
            830-901             AL929571.10        25167-25238
            902-979             AL929571.10        27994-28071
            980-2230            AL929571.10        30402-31652
            2231-5985           AL929571.10        31653-35407
FEATURES             Location/Qualifiers
     source          1..5985
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 53.9 cM"
     gene            1..5985
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /note="TNF receptor-associated factor 6"
                     /db_xref="GeneID:22034"
                     /db_xref="MGI:MGI:108072"
     exon            1..201
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            202..519
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..670
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            671..829
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            830..901
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..979
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            980..5985
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5263..5268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5280
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /note="major polyA site"
     regulatory      5816..5821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5841
                     /gene="Traf6"
                     /gene_synonym="2310003F17Rik; C630032O20Rik"
                     /note="major polyA site"
ORIGIN      
        1 tagcgagctg agaaggcgga agcagcggcg gccgcggctg gggctgaggc tccggccgtc
       61 ggcggacgca gcagccgcgg cccacgagcc gggagtttgg cgtcggagcc acttggtctc
      121 ggagtgccgt gtatgtaggc gacgcggcgc agcccgggga agccttccca gttggttgtg
      181 aagtctcagc gtgtacgatc gatcgactga caacagagct actatgagtc tcttaaactg
      241 tgagaacagc tgcgggtcca gccagtcgtc cagtgactgc tgcgctgcca tggccgcctc
      301 ctgcagcgct gcagtgaaag atgacagcgt gagtggctct gccagcaccg ggaacctctc
      361 cagctccttc atggaggaga tccagggcta cgatgtggag tttgacccac ctctggagag
      421 caagtatgag tgtcccatct gcttgatggc tttacgggaa gcagtgcaaa caccatgtgg
      481 ccacaggttc tgcaaagcct gcatcatcaa atccataagg gatgcagggc acaagtgccc
      541 agttgacaat gaaatactgc tggaaaatca actgtttccc gacaattttg caaagcgaga
      601 gattctttcc ctgacggtaa agtgcccaaa taaaggctgt ttgcaaaaga tggaactgag
      661 acatctcgag gatcatcaag tacattgtga atttgctcta gtgaattgtc cccagtgcca
      721 acgtcctttc cagaagtgcc aggttaatac acacattatt gaggattgtc ccaggaggca
      781 ggtttcttgt gtaaactgtg ctgtgtccat ggcatatgaa gagaaagaga tccatgatca
      841 aagctgtcct ctggcaaata tcatctgtga atactgtggt acaatcctca tcagagaaca
      901 gatgcctaat cattatgatc tggactgccc aacagctcca atcccttgca cattcagtgt
      961 ttttggctgt catgaaaaga tgcagaggaa tcacttggca cgacacttgc aagagaatac
     1021 ccagttgcac atgagactgt tggcccaggc tgttcataat gttaaccttg ctttgcgtcc
     1081 gtgcgatgcc gcctctccat cccggggatg tcgtccagag gacccaaatt atgaggaaac
     1141 tatcaaacag ttggagagtc gcctagtaag acaggaccat cagatccggg agctgactgc
     1201 caaaatggaa actcagagta tgtacgtggg cgagctcaaa cggaccattc ggaccctgga
     1261 ggacaaggtt gccgaaatgg aagcacagca gtgtaacggg atctacattt ggaagattgg
     1321 caactttggg atgcacttga aatcccaaga agaggaaaga cctgttgtca tccatagccc
     1381 tggattctac acaggcagac ctgggtacaa gctgtgcatg cgcctgcatc ttcagttacc
     1441 gacagctcag cgctgtgcaa actatatatc cctttttgtc cacacaatgc aaggagaata
     1501 tgacagccac ctcccctggc ccttccaggg tacaatacgc cttacaattc tcgaccagtc
     1561 tgaagcactt ataaggcaaa accacgaaga ggtcatggac gccaaaccag aactgcttgc
     1621 ctttcagcga cccacaatcc cacggaaccc caaaggtttt ggctatgtaa catttatgca
     1681 cctggaagcc ttaagacagg gaaccttcat taaggatgat acattactag tgcgctgtga
     1741 agtctctacc cgctttgaca tgggtggcct tcggaaggag ggtttccagc cacgaagtac
     1801 tgatgcgggg gtgtagcgtc catgtacttg tgttcaaaaa ctaggaacca tatgggaaaa
     1861 ccgtgccttc catgcctggc cccagtaaac aatgttcaaa caagcagtgg gagaggtgta
     1921 aggcctagca gcagatgtca tcagtgaggt cacgagccac ttcttactgt taacaaatac
     1981 ctgaggcagt tcccatggga acctacatgt cccctgtatc ttcaaaacgt caacatttga
     2041 agggcctgtg gctcatctgt ctgtcagggt accccttcac tgtgcttcca tgggctattt
     2101 tgtccgtgta ctttactgta aaaaaggcca gacttagcgt gctgcagctc aatcgtttaa
     2161 taagaccggt gccttaaaaa cttgaggggt ttttaggaca ctgattacta tattaaacat
     2221 gaaaatcacc actgcctgtg ctggtgccag tagagaagtt accgctctgg tgttgagttc
     2281 tcatttagtt gactcctgtg aatttcagag gctttgaacc atgatccctg gaaggcttaa
     2341 gttctcaagt actccctcct ctatagttca ctaaggatcc agggactggt ttaaccctta
     2401 cttagtgtga atgtattgtc cactgaacac caagcatccc ccactacttt cctgttttga
     2461 aatatgctcc aggcggcctc ttcccagtct gtaagaccgc ggtcatgtgc ttgccaactg
     2521 ctgagtgtta ctgccatgga acctttcttg tctgtcccgt gcagcttggt ttccacagcc
     2581 ggttgcatat cttctgttgc ttgcaaacac aaaatcacca gcccaaacga gtgatttagc
     2641 tcactagcca ttaaatggca tctcgtggat gatgacagca actcttacag ccaggaaact
     2701 tcagcccctc ttaactagct tttgatttag cttataaggt taattgaaat aaaattgatt
     2761 tttctcaagg ggttggagaa ttggctcagt ggttaagagc cttggctgct cttccagagg
     2821 atccccagtc tgtaactcca gttccagggc atctgacacc ctcatacaga cactcatgca
     2881 ggcaaaacac cagtgcacat aaaattaaac aaacaaataa ataaataaat tgatttcctc
     2941 aaaacagaat ttattggaac ttgggaaatt gtaggtacct gagagatgcc taaaccaagg
     3001 ttggctatca cggttgtgtg gacactcagc ttgagtggtg gctttgtcca gctcagtaga
     3061 ggttctgatc tgtgacccta atgtggagag gtgactgtcg tgctgctgtg tatttgttaa
     3121 tgtcctgtac atatacagta ctttggagtc tagttctcag ggagccctac gactagttag
     3181 agcctttgta aggaagcaga ggggatcctc tcctgctgtt tacacaagat cagctatgtg
     3241 ttctggtggt aagaaaggca tccgtgcctt cagctgaatc agagacccga gcagtgctct
     3301 gacctgccct gttcccagag aacgctcaga gcctccacca aggagtctgt ttctcagctg
     3361 tagccagcca gggccacttt gacctcttca ttttcccctg cttccatcct tcccctataa
     3421 aggtgagggg aagaccttgt cccctaccat tatcacaagc tcatcacagg tctcttctgt
     3481 tggatccagg aaatgtgtgt cccttagctg tgcctccagc agccctgagc tgcttgtagc
     3541 aacttctgcc taaggagcac tgcatggtct tatactgtag ttgtttccca gtggagtaat
     3601 aaatgtgggc ttgtttgttg tttctttaaa gcaagcagta gctgtgtcta tatttattta
     3661 gaaattgcct gaagaagatt actcaactat ttgaagactt attttctata tgcctttctt
     3721 aattttttta tgttatatgt caccacaaaa atatgaactc cccaaccccc tctccgtttt
     3781 ttgaaaaagg aaatgacatt taagaacttc ctcatcagat ttctcttttt aaaatatctg
     3841 tattaggaag agcagtcgtt tcctgccgtg gttttgactt tttttaaaaa aaactctaac
     3901 atcttttaaa gtttttttgc ataagttaaa ctgttcccag ctttaaattg tcctccctat
     3961 agggcaagtt ggactaggtg tttctagtat ccgcattgag aagcccagtg ctgagccaca
     4021 atactcacta aaaggctttc cccgtagagg tgtgactgcc cctaactgct aacacggatg
     4081 gttcactgca gtgtaatgtc catccgctag aatacacctc aggtagtttt agaacttgca
     4141 gcatttggtg tttgtaataa gccaaccagt tactttatgt tactcaattg ccacgaatgc
     4201 agagtaaaac taatcaagct gacattcaag gtcaacactt agtaaggtca actcaggatc
     4261 aagtcttagc ctagaaagcc gctttcttta cttcaccact ttctgaacat tctctttgta
     4321 ccaatgggcc tataagaatc cgtatagtcc agagtgcatt ggccatcttt ccttaccaat
     4381 ctagaacact gctgaattta aagttgtttc ttcttagaaa aatgcctacc ttactattga
     4441 agatttttcc ccaagtcata tatttccctc ttagaaatca ggccagacgg cagttctagt
     4501 ttggaagttg gttacagtcc tttggctgtt accatctcta gccattctgc tttcttctgg
     4561 agaatgaaga ggagaaaagt gcattaaagt acaaaaggtg tcctctcacc ctcggaagat
     4621 caactgacag gtgttggatg atctccaaca agtaaatttt gtgaccagta taaagttgaa
     4681 tttgtaccaa tatcaaacaa agtctgacca atgtaaatta tgtgcacaat tagaatatct
     4741 tctccttaag gagaggttgc ttgtttctgc tttacctgga gtttccttct ttcgcatgtg
     4801 actggaaaac gttttaactt taactatcga ggtgattctt acttaagact ttgaagtgct
     4861 tttctctctt tttctgtcgt taacacacat cttttcttga cttgactcaa attctcgcca
     4921 ttgttacagt tttttatggg gtgtttggtg attagtttgc tggctgcctt gagggagtga
     4981 acagggcacg gtcaagcgtc gtttgattgt ctgttgaaat actctttaaa tgtcggcatt
     5041 ctcagggtaa ctgtcatttg tttcaaagtt gatgtgattg tctgggaaat ggatggatgc
     5101 ttcccaattc ccagaatcca gaaaaatgaa accagatgtg atcaacctga acttgggaca
     5161 ctctcggtca caagcgttga agtcactcaa aaaggactaa gctagttatt tctctgtggg
     5221 tcctctgtgt ctttgatgtt ttaaattgct cagccccgcc ccaataaata aataaataaa
     5281 taagaaaaga aaagagttgt agtttttcac attgtggaat gtggagagga actccttttc
     5341 ctgtcctgtg tctcctcagc ggagcccagc cctgcctgac acaggagaaa agggtggcct
     5401 gttggtcacc tgcccttcag aatgtagccc catctgactc ctaaaacccc agtttccttc
     5461 agtgcaggct ccaggagagg gcagagaccc cattctggtc actgctgaac ccctgttttt
     5521 agcatactgt gcatgggcct ggccaatagt cacaagcttt aatgggagcc agggcagaag
     5581 ctgactggct gctgggtagc ctacttgtca tgtaagtcag ttggtaaagt gagagtgttc
     5641 ttttttctgc ttttctcccg ggactttgct actgcagttc tcaaacatgg aagtgagttt
     5701 aagacctagt gaacacctcc cacctaggat ctgcagtgac attgggtgtg ctctgattta
     5761 atgcttctat catgtaaatt ctaatttctc cttaaggctg ttcaatcctg aaataattaa
     5821 acaacttgaa gttgtataaa attctccttg gaaacttgtg atattttatt gtaatttatc
     5881 ttgtagcttc tgctttatgc caacttaaaa tttgtggaaa tgttgtgagg aactttactc
     5941 ttatgtcttt gtctacagga gtatttttat aaaggattta tttgc
//
