LOCUS       NM_011633               2249 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus TNF receptor-associated factor 5 (Traf5), mRNA.
ACCESSION   NM_011633 XM_195779
VERSION     NM_011633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2249)
  AUTHORS   Cheng,W.L., Chao,S.P., Zhao,F., Cai,H.H., Zeng,Z., Cao,J.L.,
            Jin,Z., Deng,K.Q., Hu,X., Wang,H. and Lu,Z.
  TITLE     Tumor necrosis factor receptor-associated factor 5 protects against
            intimal hyperplasia by regulation of macrophage polarization via
            directly targeting PPARgamma
  JOURNAL   Inflamm Res 73 (6), 929-943 (2024)
   PUBMED   38642079
  REMARK    GeneRIF: Tumor necrosis factor receptor-associated factor 5
            protects against intimal hyperplasia by regulation of macrophage
            polarization via directly targeting PPARgamma.
REFERENCE   2  (bases 1 to 2249)
  AUTHORS   Li,M., Gan,C., Zhang,R., Wang,J., Wang,Y., Zhu,W., Liu,L., Shang,J.
            and Zhao,Q.
  TITLE     TRAF5 regulates intestinal mucosal Th1/Th17 cell immune responses
            via Runx1 in colitis mice
  JOURNAL   Immunology 170 (4), 495-509 (2023)
   PUBMED   37575027
  REMARK    GeneRIF: TRAF5 regulates intestinal mucosal Th1/Th17 cell immune
            responses via Runx1 in colitis mice.
REFERENCE   3  (bases 1 to 2249)
  AUTHORS   Kawahara,E., Azuma,M., Nagashima,H., Omori,K., Akiyama,S.,
            Fujimori,Y., Oishi,M., Shibui,N., Kawaguchi,K., Morita,M.,
            Okuyama,Y., Ishii,N. and So,T.
  TITLE     TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in
            CD4+ T Lymphocytes
  JOURNAL   J Immunol 208 (3), 642-650 (2022)
   PUBMED   34996840
  REMARK    GeneRIF: TNF Receptor-Associated Factor 5 Limits IL-27 Receptor
            Signaling in CD4(+) T Lymphocytes.
REFERENCE   4  (bases 1 to 2249)
  AUTHORS   Gissler,M.C., Anto-Michel,N., Pennig,J., Scherrer,P., Li,X.,
            Marchini,T., Pfeiffer,K., Hardtner,C., Abogunloko,T., Mwinyella,T.,
            Sol Mitre,L., Spiga,L., Koentges,C., Smolka,C., von Elverfeldt,D.,
            Hoppe,N., Stachon,P., Dufner,B., Heidt,T., Piepenburg,S.,
            Hilgendorf,I., Bjune,J.I., Dankel,S.N., Mellgren,G., Seifert,G.,
            Eisenhardt,S.U., Bugger,H., von Zur Muhlen,C., Bode,C., Zirlik,A.,
            Wolf,D. and Willecke,F.
  TITLE     Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation
            and Aggravates Diet-Induced Obesity in Mice
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (10), 2563-2574 (2021)
   PUBMED   34348490
  REMARK    GeneRIF: Genetic Deficiency of TRAF5 Promotes Adipose Tissue
            Inflammation and Aggravates Diet-Induced Obesity in Mice.
REFERENCE   5  (bases 1 to 2249)
  AUTHORS   Phung,H.T., Nagashima,H., Kobayashi,S., Asano,N., Machiyama,T.,
            Sakurai,T., Tayama,S., Asao,A., Imatani,A., Kawabe,T., Okuyama,Y.,
            Ishii,N. and So,T.
  TITLE     TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium
            Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells
  JOURNAL   Immunohorizons 4 (3), 129-139 (2020)
   PUBMED   32156688
  REMARK    GeneRIF: TRAF5 Deficiency Ameliorates the Severity of Dextran
            Sulfate Sodium Colitis by Decreasing TRAF2 Expression in
            Nonhematopoietic Cells.
            Erratum:[Immunohorizons. 2020 Apr 23;4(4):216. doi:
            10.4049/immunohorizons.2000022.. PMID: 32327454]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2249)
  AUTHORS   Nakano,H., Sakon,S., Koseki,H., Takemori,T., Tada,K., Matsumoto,M.,
            Munechika,E., Sakai,T., Shirasawa,T., Akiba,H., Kobata,T.,
            Santee,S.M., Ware,C.F., Rennert,P.D., Taniguchi,M., Yagita,H. and
            Okumura,K.
  TITLE     Targeted disruption of Traf5 gene causes defects in CD40- and
            CD27-mediated lymphocyte activation
  JOURNAL   Proc Natl Acad Sci U S A 96 (17), 9803-9808 (1999)
   PUBMED   10449775
REFERENCE   7  (bases 1 to 2249)
  AUTHORS   Kawamata,S., Hori,T., Imura,A., Takaori-Kondo,A. and Uchiyama,T.
  TITLE     Activation of OX40 signal transduction pathways leads to tumor
            necrosis factor receptor-associated factor (TRAF) 2- and
            TRAF5-mediated NF-kappaB activation
  JOURNAL   J Biol Chem 273 (10), 5808-5814 (1998)
   PUBMED   9488716
REFERENCE   8  (bases 1 to 2249)
  AUTHORS   Nakano,H., Shindo,M., Yamada,K., Yoshida,M.C., Santee,S.M.,
            Ware,C.F., Jenkins,N.A., Gilbert,D.J., Yagita,H., Copeland,N.C. and
            Okumura,K.
  TITLE     Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning,
            expression and assignment of the TRAF5 gene to chromosome 1q32
  JOURNAL   Genomics 42 (1), 26-32 (1997)
   PUBMED   9177772
REFERENCE   9  (bases 1 to 2249)
  AUTHORS   Ishida,T.K., Tojo,T., Aoki,T., Kobayashi,N., Ohishi,T.,
            Watanabe,T., Yamamoto,T. and Inoue,J.
  TITLE     TRAF5, a novel tumor necrosis factor receptor-associated factor
            family protein, mediates CD40 signaling
  JOURNAL   Proc Natl Acad Sci U S A 93 (18), 9437-9442 (1996)
   PUBMED   8790348
REFERENCE   10 (bases 1 to 2249)
  AUTHORS   Nakano,H., Oshima,H., Chung,W., Williams-Abbott,L., Ware,C.F.,
            Yagita,H. and Okumura,K.
  TITLE     TRAF5, an activator of NF-kappaB and putative signal transducer for
            the lymphotoxin-beta receptor
  JOURNAL   J Biol Chem 271 (25), 14661-14664 (1996)
   PUBMED   8663299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY290436.1, AK144694.1 and BE691772.1.
            
            On May 2, 2013 this sequence version replaced NM_011633.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144694.1, D78141.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY290436.1         2-51
            51-2242             AK144694.1         2-2193
            2243-2249           BE691772.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..2249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.11 cM"
     gene            1..2249
                     /gene="Traf5"
                     /note="TNF receptor-associated factor 5"
                     /db_xref="GeneID:22033"
                     /db_xref="MGI:MGI:107548"
     exon            1..344
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            345..563
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2022
                     /gene="Traf5"
                     /codon_start=1
                     /product="TNF receptor-associated factor 5"
                     /protein_id="NP_035763.2"
                     /db_xref="GeneID:22033"
                     /db_xref="MGI:MGI:107548"
                     /translation="MAHSEEQAAVPCAFIRQNSGNSISLDFEPDTEYQFVEQLEERYK
                     CAFCHSVLHNPHQTGCGHRFCQQCIRSLRELNSVPICPVDKEVIKPQEVFKDNCCKRE
                     VLNLHVYCKNAPGCNARIILGRFQDHLQHCSFQAVPCPNESCREAMLRKDVKEHLSAY
                     CRFREEKCLYCKRDIVVTNLQDHEENSCPAYPVSCPNRCVQTIPRARVNEHLTVCPEA
                     EQDCPFKHYGCTVKGKRGNLLEHERAALQDHMLLVLEKNYQLEQRISDLYQSLEQKES
                     KIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALTSHTDKSAWLEAQVRQLLQIVN
                     QQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGETSKHDAHINIHKAQLNKNEE
                     RFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNG
                     DGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFKADPNSSS
                     FKRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLFLKVAVDLTDLEDL"
     exon            564..621
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            622..723
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            724..888
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            889..966
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1041
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1134
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1275
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1444
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..2249
                     /gene="Traf5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf5"
                     /note="hexamer: AATAAT"
     polyA_site      2247
                     /gene="Traf5"
                     /note="major polyA site"
ORIGIN      
        1 ggagcccgcc gctggagctg gcctaacccg ctgctgaggc gaagcagcct agtgcccgcc
       61 gccgtagggc gccagcggag ctccgcgagc cccgcaagtg gcgaagtccg ggtgagctaa
      121 ccgtcccggc tcctcagaaa ccgaaagcaa ctcagggtgg tgagccggag gcgtgtgtgg
      181 tagcgggcga actgaggcga cgcgggacac ccgcgcccgg ccgagggcac ttttgcaaga
      241 cttgtgagca cagcccgtta acgtgagctt aatgccaggg tctcgagcct gcgccggtgc
      301 tatagcgcgt gctcgattgg aaacagaacc cgactctgca gaagaatggc tcattcggag
      361 gagcaagcgg ctgtcccctg cgccttcatc cgccagaact ctggcaactc aatttccttg
      421 gactttgagc ccgacaccga gtaccagttt gtggagcagc tggaagaacg ctacaaatgt
      481 gccttctgcc actccgtgct tcacaacccc caccagaccg gctgcgggca ccgcttctgc
      541 cagcagtgca tccggtctct gagagaattg aactcggtgc cgatctgccc ggtagacaag
      601 gaggtcatca agcctcagga ggtgttcaaa gacaactgct gcaaaagaga agttctcaat
      661 ttacacgtct actgcaaaaa cgcccccggg tgcaatgcca ggattattct gggacgattc
      721 caggaccacc ttcagcactg ttccttccaa gccgtgccct gccctaacga gagctgccgg
      781 gaagccatgc tccggaaaga cgtgaaagag cacctgagcg catactgccg gttccgagag
      841 gagaagtgcc tttactgcaa aagggacata gtggtgacca acctgcagga tcatgaggaa
      901 aactcgtgtc ctgcgtaccc agtgtcttgt cccaacaggt gtgtgcagac tattccaaga
      961 gctagggtga atgaacacct tactgtatgt cctgaggctg agcaagactg tccctttaag
     1021 cactatggct gcactgtcaa gggtaagcgg gggaacttgc tggagcatga gcgggcagcc
     1081 ctgcaggacc acatgcttct ggttttagag aagaactacc aactagaaca gcggatctct
     1141 gatttatatc agagtctcga acagaaggaa agcaagatcc agcagctggc agaaaccgtg
     1201 aagaagttcg aaaaggagct taagcagttc acacagatgt ttggcagaaa tggaactttc
     1261 ctctcaaatg tccaggctct caccagtcac acggacaagt cagcttggct ggaagcgcag
     1321 gtgcggcagc tgctacaaat agttaaccag cagccaagtc gacttgatct gaggtctttg
     1381 gtggatgcgg ttgacagcgt gaaacagagg atcacccagc tggaagccag tgaccagaga
     1441 ttagttcttt tagaggggga gaccagcaag cacgacgcac acattaatat ccacaaagca
     1501 cagctgaata agaacgaaga gcggtttaag cagctggagg gcgcctgcta cagtggcaag
     1561 ctcatctgga aggtgacaga ttacagggtg aagaagaggg aggccgtgga ggggcacaca
     1621 gtgtccgtct tcagccagcc tttctacacc agccgctgcg gctaccggct ctgtgccagg
     1681 gcgtacctga acggggacgg gtcggggaag ggaacgcacc tgtccctgta ctttgtggtg
     1741 atgcgcggtg agtttgactc gctgctgcag tggccgttca ggcagagggt gaccctgatg
     1801 cttttggacc agagcggcaa gaagaaccat attgtggaga ccttcaaagc tgaccccaac
     1861 agcagcagct tcaaaaggcc agatggcgag atgaacattg cctctggctg tccccgcttt
     1921 gtgtcgcact ctactctgga gaactccaag aacacctaca ttaaagacga cacactgttc
     1981 ttgaaagtgg ccgtggattt aactgacttg gaggatctgt agtgttacct gataaggaaa
     2041 cttctcagca caggaaaagg tgtggctgtc ccttgggcgc agccctctgg actgagcagg
     2101 ctcttgttct tgtcttcctg cctccgatgt ctgatgtgtc atctttttat cttggatcct
     2161 tccctggttt gaaactttaa actcttgaaa tattgctgtt atttatattt ttgtatcttc
     2221 caaaaaatta taataatttg acaacaagg
//
