LOCUS       NM_009423               3016 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus TNF receptor associated factor 4 (Traf4), mRNA.
ACCESSION   NM_009423
VERSION     NM_009423.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3016)
  AUTHORS   Nelson,H.A., Mullins,N.A. and Abell,A.N.
  TITLE     MAP3K4 signaling regulates HDAC6 and TRAF4 coexpression and
            stabilization in trophoblast stem cells
  JOURNAL   J Biol Chem 301 (2), 108116 (2024)
   PUBMED   39710325
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3016)
  AUTHORS   Xiao,J., Chen,X., Liu,W., Qian,W., Bulek,K., Hong,L.,
            Miller-Little,W., Li,X. and Liu,C.
  TITLE     TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven
            airway inflammation
  JOURNAL   JCI Insight 8 (18), e169736 (2023)
   PUBMED   37607012
  REMARK    GeneRIF: TRAF4 is crucial for ST2+ memory Th2 cell expansion in
            IL-33-driven airway inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3016)
  AUTHORS   Li,J., Wang,C.Q., Xiao,W.C., Chen,Y., Tu,J., Wan,F., Deng,K.Q. and
            Li,H.P.
  TITLE     TRAF Family Member 4 Promotes Cardiac Hypertrophy Through the
            Activation of the AKT Pathway
  JOURNAL   J Am Heart Assoc 12 (17), e028185 (2023)
   PUBMED   37642020
  REMARK    GeneRIF: TRAF Family Member 4 Promotes Cardiac Hypertrophy Through
            the Activation of the AKT Pathway.
REFERENCE   4  (bases 1 to 3016)
  AUTHORS   Xie,C., Zhou,H., Athanasopoulos,V., Shen,Q., Zhang,Y., Meng,X.,
            Burgio,G., Arsov,T., Lungu,A.C., Zhang,P., Qin,Y., Ma,J., Wu,X.,
            Jiang,X., Ding,H., Meng,Y., Shen,N., He,Y. and Vinuesa,C.G.
  TITLE     De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role
            for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation
  JOURNAL   Arthritis Rheumatol 75 (6), 1058-1071 (2023)
   PUBMED   36622335
  REMARK    GeneRIF: De Novo PACSIN1 Gene Variant Found in Childhood Lupus and
            a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7
            Activation.
REFERENCE   5  (bases 1 to 3016)
  AUTHORS   Xin,Y., He,Q., Liang,H., Zhang,K., Guo,J., Zhong,Q., Chen,D.,
            Li,J., Liu,Y. and Chen,S.
  TITLE     m6A epitranscriptomic modification regulates neural
            progenitor-to-glial cell transition in the retina
  JOURNAL   Elife 11, e79994 (2022)
   PUBMED   36459087
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3016)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3016)
  AUTHORS   Regnier,C.H., Masson,R., Kedinger,V., Textoris,J., Stoll,I.,
            Chenard,M.P., Dierich,A., Tomasetto,C. and Rio,M.C.
  TITLE     Impaired neural tube closure, axial skeleton malformations, and
            tracheal ring disruption in TRAF4-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5585-5590 (2002)
   PUBMED   11943846
  REMARK    GeneRIF: Impaired neural tube closure, axial skeleton
            malformations, and tracheal ring disruption in TRAF4-deficient
            mice.
            Erratum:[Proc Natl Acad Sci U S A 2002 Jun11;99(12):8457]
REFERENCE   8  (bases 1 to 3016)
  AUTHORS   Grech,A., Quinn,R., Srinivasan,D., Badoux,X. and Brink,R.
  TITLE     Complete structural characterisation of the mammalian and
            Drosophila TRAF genes: implications for TRAF evolution and the role
            of RING finger splice variants
  JOURNAL   Mol Immunol 37 (12-13), 721-734 (2000)
   PUBMED   11275257
REFERENCE   9  (bases 1 to 3016)
  AUTHORS   Shiels,H., Li,X., Schumacker,P.T., Maltepe,E., Padrid,P.A.,
            Sperling,A., Thompson,C.B. and Lindsten,T.
  TITLE     TRAF4 deficiency leads to tracheal malformation with resulting
            alterations in air flow to the lungs
  JOURNAL   Am J Pathol 157 (2), 679-688 (2000)
   PUBMED   10934170
REFERENCE   10 (bases 1 to 3016)
  AUTHORS   Masson,R., Regnier,C.H., Chenard,M.P., Wendling,C., Mattei,M.G.,
            Tomasetto,C. and Rio,M.C.
  TITLE     Tumor necrosis factor receptor associated factor 4 (TRAF4)
            expression pattern during mouse development
  JOURNAL   Mech Dev 71 (1-2), 187-191 (1998)
   PUBMED   9507120
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046015.1 and AK040877.1.
            
            On Jul 16, 2009 this sequence version replaced NM_009423.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053900.1, AK040877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AK046015.1         41-63
            24-3016             AK040877.1         2-2994
FEATURES             Location/Qualifiers
     source          1..3016
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..3016
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /note="TNF receptor associated factor 4"
                     /db_xref="GeneID:22032"
                     /db_xref="MGI:MGI:1202880"
     exon            1..253
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1523
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /EC_number="2.3.2.27"
                     /note="cysteine-rich motif associated to RING and Traf
                     domains protein 1"
                     /codon_start=1
                     /product="TNF receptor-associated factor 4"
                     /protein_id="NP_033449.2"
                     /db_xref="CCDS:CCDS25090.1"
                     /db_xref="GeneID:22032"
                     /db_xref="MGI:MGI:1202880"
                     /translation="MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQ
                     EFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGH
                     LNTCSFNVVPCPNRCPAKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGVC
                     PQESVYCENKCGARMMRRLLAQHATSECPKRTQPCAYCTKEFVYDTIQSHQYQCPRLP
                     VPCPNQCGVGTVAREDLPTHLKDSCSTAFVLCPFKESGCKHRCPKLAMGRHVEESVKP
                     HLAMMCALVSRQRQELQELRRELEELSIGSDGVLIWKIGSYGRRLQEAKAKPNLECFS
                     PAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVTFSLLD
                     QSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNY
                     VRDDAVFIRASVELPRKILS"
     exon            254..305
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..410
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /inference="alignment:Splign:2.1.0"
     exon            411..572
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /inference="alignment:Splign:2.1.0"
     exon            573..734
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..890
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /inference="alignment:Splign:2.1.0"
     exon            891..3016
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2009..2014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /note="hexamer: AATAAA"
     polyA_site      2039
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /note="major polyA site"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
                     /note="hexamer: AATAAA"
     polyA_site      2941
                     /gene="Traf4"
                     /gene_synonym="A530032M13Rik; CART1; msp2"
ORIGIN      
        1 ggccgccagt cggcgccgcc cgcagccggg aaacgcggcc cgagcgaggc gcgggctgtg
       61 gggccgccgc gtgcccggcc ccgctcgccc gtgcccgctg ccagcccgcc atgcccggct
      121 tcgactacaa gttcctggag aagcccaagc ggcggctgct gtgcccactg tgcgggaagc
      181 ccatgcgcga gcctgtgcag gtgtctactt gtggccaccg cttctgcgac acctgcctgc
      241 aggagtttct cagtgaagga gtcttcaaat gccctgagga ccaacttcct ctggactatg
      301 ccaagatcta cccagaccca gagctggagg tccaggtgtt aggcttggct atccgctgca
      361 tccacagtga ggagggctgc cgctggagcg ggccacttcg tcatctacag ggccacttga
      421 acacttgcag cttcaatgta gtcccctgcc ctaatcgctg cccagccaag ctgagccggc
      481 gtgacctgcc tgcccacctg cagcacgact gccctaagcg ccgcctcaag tgtgaattct
      541 gtggctgtga cttcagtggg gaggcctacg agagtcacga gggcgtgtgc ccccaagaga
      601 gtgtgtactg tgagaacaag tgtggggccc gcatgatgag gcgactgttg gcccagcatg
      661 ccacgtctga gtgccccaag cgcacccagc cctgtgccta ctgtaccaag gaatttgttt
      721 atgacaccat ccagagccac cagtaccagt gcccacgcct gcctgttccc tgccccaacc
      781 aatgtggagt gggcactgtg gcccgggaag acctgcccac ccatctgaag gatagctgca
      841 gcactgcctt tgttctctgc cctttcaaag agtctggctg caagcacagg tgccctaagc
      901 tggcaatggg acgtcacgtg gaggagagcg taaagccaca tctggctatg atgtgtgccc
      961 tggtgagccg acagcggcaa gagctgcagg agctgcgaag agagctggaa gaactatcca
     1021 taggcagcga tggagtgctc atctggaaga ttggcagcta tgggcgtcgt ctacaagagg
     1081 ccaaggccaa gcctaacctg gagtgcttca gcccagcctt ctatacgcat aagtacggct
     1141 acaagctgca ggtgtctgca ttcctcaacg gcaacggcag tggtgagggc acacacctct
     1201 ccatctacat ccgtgtcttg ccgggcgcct ttgacaatct ccttgagtgg ccctttgccc
     1261 gccgggtcac cttctccctg ctggatcaga gtgacccagg tttggctaag ccacagcatg
     1321 tcactgagac cttccaccct gatccaaact ggaagaactt ccagaagccc ggcacgtggc
     1381 gaggctccct ggatgagagt tctctgggct tcggctaccc caagttcatt tcccaccagg
     1441 acatccgaaa gcggaactac gtgcgggatg atgcggtttt catccgtgcc tctgtcgaac
     1501 tgccccggaa gatcctcagc tgagtagagc cttttggctt caagtgggaa gggaggcggg
     1561 actggatctg aaactggatt gggggccgga cctcctttca gcttcttttg cctaggctgt
     1621 tagcccactc tccctaccac caccaccacc accaccacca tccctacccc tcaggtgcct
     1681 ccaattggtg cttcagccct ggcccctggg gggagcaggt ctcggggtta tcaagggctg
     1741 gaaacacgat cccagggcct gtctcccctc ctgggcaggg cagacatgcc ttgatgccag
     1801 ccacattcta cctggactga ggtgcctgct caggtgctat gtcccaagag ccatagtggg
     1861 ggtgggaggt attggcaaag ggaggggtaa gggtagttag aagaatctgc cttgagatta
     1921 acttctcttt ccattcaccc agtggtgccc tctctggtta tttatttctc tagtgctagg
     1981 tgggcacagc aggggaactc tgatttttaa taaatcctga attgtattta ttaacctgat
     2041 tccagcctgt ctcctcccag taggttaggg ttctgggagg ctgggcccag ccagaggaga
     2101 ggggtgaact gctctgcttg cagccatacc tctctagtgg acgatatggg gattgcagga
     2161 aacttggagt gggagcatca cctgccctct ggtggttcaa tagataggtg cagttaccac
     2221 ttaagctggc atctccagtc catacctcac caaagacaag tgctgcttag cggggctgtc
     2281 tatatcagta ataaccatgt gtgtgtatgt gtgcaggcca aagatcaaca tcaggggtct
     2341 tcctcagtta cactccacct ttttgagaca gatcaaaaat cctggagttt gctgattcca
     2401 caagactcta tcttccctcg gctgatccag cagcctgggt ggtaccggtg tgcattgccg
     2461 tatccagtct tgtactccaa ggccatcttt acagcctgaa gtcttgtggc caggagtcaa
     2521 gggaagtagc ttttcccctt agagtcactg ttagagttaa tgaggctgca tgtgcctgac
     2581 agatgaagga ctgagtgagt gagtgagtgt cagtctgtac tccaggagta aagaggcctt
     2641 tgagatgtag aaagcactta agattttctc acctgtaatt tcatttgctt tttgtgcagt
     2701 tctgaatggc tgcctctgtg accagaggca gtgcatttca ccagtcaact aagaatagaa
     2761 gcaaactgac tccttcagtt agtttggggc aaagtctgga tttctgtggg gtcccctcac
     2821 ccccaccgtg catgccagac tcaactacat acatgctcaa accctaaatt ctttatcagt
     2881 aggcgtatag ttcccactaa ttttggcaat aaatttgggc ttgctttcag caagttactt
     2941 agctttgtgg ggttaactcc acttattaat ggtaaaatga attctgttca actactggta
     3001 ttggaatata atcatg
//
