LOCUS       NM_153137               2142 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TRAF3 interacting protein 3 (Traf3ip3), mRNA.
ACCESSION   NM_153137
VERSION     NM_153137.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Deng,M., Tam,J.W., Wang,L., Liang,K., Li,S., Zhang,L., Guo,H.,
            Luo,X., Zhang,Y., Petrucelli,A., Davis,B.K., Conti,B.J., June
            Brickey,W., Ko,C.C., Lei,Y.L., Sun,S. and Ting,J.P.
  TITLE     TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral
            signaling by promoting TBK1 K48 ubiquitination
  JOURNAL   Nat Commun 11 (1), 2193 (2020)
   PUBMED   32366851
  REMARK    GeneRIF: Mice with myeloid-specific gene deletion of Traf3ip3 have
            increased RNA virus-triggered IFN-I production and reduced
            susceptibility to virus.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Zhang,X., Wang,K., Zhao,W., Cao,L., Zhang,S., Jin,R., Sun,X.,
            Hao,J., Huang,X., Zhu,M., Wu,H., Zhao,H. and Ge,Q.
  TITLE     TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via
            the MEK/ERK signaling pathway
  JOURNAL   Cell Mol Immunol 17 (4), 395-406 (2020)
   PUBMED   31076725
  REMARK    GeneRIF: TRAF3IP3 at the trans-Golgi network regulates NKT2
            maturation via the MEK/ERK signaling pathway.
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Zhu,W., Li,J., Zhang,R., Cai,Y., Wang,C., Qi,S., Chen,S., Liang,X.,
            Qi,N. and Hou,F.
  TITLE     TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral
            innate immunity
  JOURNAL   EMBO J 38 (18), e102075 (2019)
   PUBMED   31390091
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Peng,S., Wang,K., Gu,Y., Chen,Y., Nan,X., Xing,J., Cui,Q., Chen,Y.,
            Ge,Q. and Zhao,H.
  TITLE     TRAF3IP3, a novel autophagy up-regulated gene, is involved in
            marginal zone B lymphocyte development and survival
  JOURNAL   Clin Exp Immunol 182 (1), 57-68 (2015)
   PUBMED   26011558
  REMARK    GeneRIF: TRAF3IP3 contributes to marginal zone B cell survival by
            up-regulating autophagy, thereby promoting the T cell-independent
            type II immune response.
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Gardam,S., Sierro,F., Basten,A., Mackay,F. and Brink,R.
  TITLE     TRAF2 and TRAF3 signal adapters act cooperatively to control the
            maturation and survival signals delivered to B cells by the BAFF
            receptor
  JOURNAL   Immunity 28 (3), 391-401 (2008)
   PUBMED   18313334
  REMARK    GeneRIF: TRAF2 and TRAF3 were shown to function in a cooperative
            and nonredundant manner to suppress nuclear factor-kappaB2
            (NF-kappaB2) activation, gene expression, and survival in mature B
            cells.
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Dadgostar,H., Doyle,S.E., Shahangian,A., Garcia,D.E. and Cheng,G.
  TITLE     T3JAM, a novel protein that specifically interacts with TRAF3 and
            promotes the activation of JNK(1)
  JOURNAL   FEBS Lett 553 (3), 403-407 (2003)
   PUBMED   14572659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041994.1, AK031400.1, BC137605.1 and BC036561.1.
            
            On Apr 25, 2009 this sequence version replaced NM_153137.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036561.1, AK031400.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1051              AK041994.1         2-1052
            1052-1479           AK031400.1         992-1419
            1480-2063           BC137605.1         1091-1674
            2064-2142           BC036561.1         1871-1949
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.62 cM"
     gene            1..2142
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /note="TRAF3 interacting protein 3"
                     /db_xref="GeneID:215243"
                     /db_xref="MGI:MGI:2441706"
     exon            1..252
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            253..358
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            359..758
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            759..906
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            907..970
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            971..995
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1025
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1121
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1193
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1334
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1472
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1608
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1671
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1728
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1865
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2121
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /note="hexamer: AATAAA"
     polyA_site      2118
                     /gene="Traf3ip3"
                     /gene_synonym="6030423D04Rik; T3jam"
                     /note="major polyA site"
ORIGIN      
        1 gcaggggccc tctcaaattg ctaagggcaa ggagaggaac tgaggtttgt gaacactgtg
       61 gcttgtgttt cctgtttcag catgctgctg tgcgaaaata acgtcagtat aagaagaaaa
      121 tggtgagggg gtttagaaac ttcttcagaa actcggcttg acagcttccc cagccttctg
      181 agaccagaga gacctagaaa gaaagggctg aaggctctcc tgagacactt gagacagaac
      241 ctgggacttg agggatccct gtaacaggct cttcagctcc cgctgagaac tctgaactaa
      301 gaaggccaga ttcgtgtagg aagccaccca tcatctcctc tgcatacaca gccaggagat
      361 ccaagcagct gttcaaggaa agtaagccaa acacaacagg tgctcgggag gccaccatga
      421 tcagctcaga ctcgaggtcc tcccctggct tggctcggtg ggctgagagc tatgaggcca
      481 agtgtgagcg acgtcaggag acccgagaaa accgtcgccg ccgccgcaat gagaccactt
      541 gccgccagcc agggaaggtg ctgaggaccc aacacaagga acggcttcag ggagctcggc
      601 agctacagtt cctcaaaagg agaaacctgg aagaagagaa gaaaggccaa gccagggaac
      661 aagggccctc cagcaagaca gatggaggaa caggccaagt gtctatcctc aaggagtcct
      721 tgcctggtgc caacaaggcc tctttccctg gacagcagga aacagggata agctctgagg
      781 ttttcccggc cttacatcat tcctcctcag gcatccagag ggatctgggt ggccaccatg
      841 cctcccatgg gagagccttt ccaccacagg actctgacat caagaagcca cacagacagc
      901 accggggcac tcagacaaag gcagaagagg cattgccaac aataaagaat gatgccagtc
      961 agcaaaccaa atgtggagtt gctgtcctag acaaggacat cattcaactc tcggaatacc
     1021 tcaaagaagc cttacatagg gagctgatcc taaaaaagaa aatggtgatt ctccaggacc
     1081 tcctgcctgc cctgatccgg gcctctgaca gctcctggaa gggacagctt aatgaagaca
     1141 agctgaaggg caaactaaga tccctagaaa accagctcta cacctgcctg cagaaacact
     1201 ccccctgggg aatgaaaaag gtgctgctgg agatggaaga ccagagaagc agctatgagc
     1261 agaaggctaa ggcgtcactg cagaaagtgc tggaggagaa aatgtgtgca gagcagcagc
     1321 tacagagggc acagctgtcc ctggctttgg cagagcagaa gtgtcaggag tggaagagtc
     1381 agtacgaggc tctgaaggag gactggagga ccctagggga ccagcacaga gagctggaga
     1441 gccaactgca tgtgcttcag tccaaactac agggagcaga cagcagagac tcacagatga
     1501 gccaggccct gcagctttta gaaaatgagc accaggagct gcagaccaaa ctcgagagcc
     1561 tgcagggaga cggagagcag cagagctctg agacccagga cctacaagat caactaaaga
     1621 agtcagagga agagaaacag gccctggtga gcaaagtaca acagctacag agtctgcttc
     1681 agaatcaatc cttacaactt caagaacagg agaagctctt aaagaaagat cagggtctgc
     1741 ctgtgtggaa tccaaagctc tcccttgatg aagtgaagcc tgagggcaca agaaaggaga
     1801 aagaggagga gctcagagac caactacaaa aggagacatt tcagctccaa gtcaaggaaa
     1861 aggagctgca gtgtggtcaa tggctcccag tgctgatggt ggtgattgct acagcactgg
     1921 cagtgttcct ggcaaacaaa ggcaacctgg tcatctgaag aacttctggc atctatctga
     1981 agtaaaactc agatgcaaac aactccatga aaaccttgag ttctggtact ttataacttg
     2041 ggtttccctc caaatgaatc cggactctta gttttatttt tttttcacca ggttgtaaat
     2101 aaactttatc tcacaagact aaaaaaaaaa aaaaaaaaaa aa
//
