LOCUS       NM_134000               2867 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus TRAF3 interacting protein 2 (Traf3ip2), mRNA.
ACCESSION   NM_134000
VERSION     NM_134000.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Taylor,T.C., Coleman,B.M., Arunkumar,S.P., Dey,I., Dillon,J.T.,
            Ponde,N.O., Poholek,A.C., Schwartz,D.M., McGeachy,M.J., Conti,H.R.
            and Gaffen,S.L.
  TITLE     IkappaBzeta is an essential mediator of immunity to oropharyngeal
            candidiasis
  JOURNAL   Cell Host Microbe 31 (10), 1700-1713 (2023)
   PUBMED   37725983
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Wang,S., Kuai,Y., Lin,S., Li,L., Gu,Q., Zhang,X., Li,X., He,Y.,
            Chen,S., Xia,X., Ruan,Z., Lin,C., Ding,Y., Zhang,Q., Qi,C., Li,J.,
            He,X., Pathak,J.L., Zhou,W., Liu,S., Wang,L. and Zheng,L.
  TITLE     NF-kappaB Activator 1 downregulation in macrophages activates STAT3
            to promote adenoma-adenocarcinoma transition and immunosuppression
            in colorectal cancer
  JOURNAL   BMC Med 21 (1), 115 (2023)
   PUBMED   36978108
  REMARK    GeneRIF: NF-kappaB Activator 1 downregulation in macrophages
            activates STAT3 to promote adenoma-adenocarcinoma transition and
            immunosuppression in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Bechara,R., Amatya,N., Bailey,R.D., Li,Y., Aggor,F.E.Y., Li,D.D.,
            Jawale,C.V., Coleman,B.M., Dai,N., Gokhale,N.S., Taylor,T.C.,
            Horner,S.M., Poholek,A.C., Bansal,A., Biswas,P.S. and Gaffen,S.L.
  TITLE     The m6A reader IMP2 directs autoimmune inflammation through an
            IL-17- and TNFalpha-dependent C/EBP transcription factor axis
  JOURNAL   Sci Immunol 6 (61) (2021)
   PUBMED   34215679
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   He,R., Wu,S., Gao,R., Chen,J., Peng,Q., Hu,H., Zhu,L., Du,Y.,
            Sun,W., Ma,X., Zhang,H., Cui,Z., Wang,H., Martin,B.N., Wang,Y.,
            Zhang,C.J. and Wang,C.
  TITLE     Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key
            Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in
            Autoimmune Diseases
  JOURNAL   J Immunol 206 (10), 2353-2365 (2021)
   PUBMED   33941656
  REMARK    GeneRIF: Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key
            Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in
            Autoimmune Diseases.
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Lin,X., Fu,B., Yin,S., Li,Z., Liu,H., Zhang,H., Xing,N., Wang,Y.,
            Xue,W., Xiong,Y., Zhang,S., Zhao,Q., Xu,S., Zhang,J., Wang,P.,
            Nian,W., Wang,X. and Wu,H.
  TITLE     ORF8 contributes to cytokine storm during SARS-CoV-2 infection by
            activating IL-17 pathway
  JOURNAL   iScience 24 (4), 102293 (2021)
   PUBMED   33723527
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Qian,Y., Liu,C., Hartupee,J., Altuntas,C.Z., Gulen,M.F.,
            Jane-Wit,D., Xiao,J., Lu,Y., Giltiay,N., Liu,J., Kordula,T.,
            Zhang,Q.W., Vallance,B., Swaidani,S., Aronica,M., Tuohy,V.K.,
            Hamilton,T. and Li,X.
  TITLE     The adaptor Act1 is required for interleukin 17-dependent signaling
            associated with autoimmune and inflammatory disease
  JOURNAL   Nat Immunol 8 (3), 247-256 (2007)
   PUBMED   17277779
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Chang,S.H., Park,H. and Dong,C.
  TITLE     Act1 adaptor protein is an immediate and essential signaling
            component of interleukin-17 receptor
  JOURNAL   J Biol Chem 281 (47), 35603-35607 (2006)
   PUBMED   17035243
  REMARK    GeneRIF: Act1 adaptor protein is an immediate and essential
            signaling component of interleukin-17 receptor
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Qian,Y., Qin,J., Cui,G., Naramura,M., Snow,E.C., Ware,C.F.,
            Fairchild,R.L., Omori,S.A., Rickert,R.C., Scott,M., Kotzin,B.L. and
            Li,X.
  TITLE     Act1, a negative regulator in CD40- and BAFF-mediated B cell
            survival
  JOURNAL   Immunity 21 (4), 575-587 (2004)
   PUBMED   15485634
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Kanamori,M., Kai,C., Hayashizaki,Y. and Suzuki,H.
  TITLE     NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor
            molecule TRAF6
  JOURNAL   FEBS Lett 532 (1-2), 241-246 (2002)
   PUBMED   12459498
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160403.5.
            
            On Nov 17, 2006 this sequence version replaced NM_134000.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052190.1, JX869941.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-413               AC160403.5         67252-67664
            414-1223            AC160403.5         80168-80977
            1224-1413           AC160403.5         88853-89042
            1414-1592           AC160403.5         93538-93716
            1593-1681           AC160403.5         95624-95712
            1682-1750           AC160403.5         100026-100094
            1751-1867           AC160403.5         101167-101283
            1868-1942           AC160403.5         105224-105298
            1943-2867           AC160403.5         108701-109625
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 20.86 cM"
     gene            1..2867
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /note="TRAF3 interacting protein 2"
                     /db_xref="GeneID:103213"
                     /db_xref="MGI:MGI:2143599"
     exon            1..413
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     exon            414..1223
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..2089
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /EC_number="2.3.2.27"
                     /note="adapter protein CIKS; connection to IKK and
                     SAPK/JNK; E3 ubiquitin-protein ligase CIKS; nuclear factor
                     NF-kappa-B activator 1"
                     /codon_start=1
                     /product="E3 ubiquitin ligase TRAF3IP2"
                     /protein_id="NP_598761.2"
                     /db_xref="CCDS:CCDS23789.1"
                     /db_xref="GeneID:103213"
                     /db_xref="MGI:MGI:2143599"
                     /translation="MNRSIPVEVDESEPFPSQLLKPIPEYSPEEELEPPAPNTRNMAP
                     SSLSVLQCPPLKLANHQPVSQQVTCLRAKVLEEGEASFFRRHPELGKDISSCSSGASE
                     PESELGALPPEHRFTLTEKRNRWLGSQLSAASPDTGHESDKSDPSLPNALADSFSGGQ
                     EMMPRPRPRPGPHRHRAAPDVPTIDTGYDSQPQDVLGIRQLERPLPLTSSCYLQDLPG
                     PLRSRELPPQFELERYPMNAQLLPPHPSPQAPWNCQYYCPGGPYHHQVPHGHGYPPAA
                     AYQQVLQPALPGQVLPGARARGPRPVQKVILNDSSPQDQEERPAQRDFSFPRLPRDQL
                     YRPPSNGVEAPEESLDLPAELRPHGPQAPSLAAVPRPPSNPLARGTLRTSNLPEELRK
                     VFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIV
                     AISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFISQGSMNFRFIPVLFPNAKKE
                     HVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL"
     exon            1224..1413
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1592
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1681
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1750
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1867
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1942
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2867
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /note="hexamer: AATAAA"
     polyA_site      2385
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /note="major polyA site"
     regulatory      2510..2515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
                     /note="hexamer: ATTAAA"
     polyA_site      2534
                     /gene="Traf3ip2"
                     /gene_synonym="Act1; CIKS"
ORIGIN      
        1 aagctgctca agaataagca gtgtgaagac cgcaagttct gtctccggga gacaccttct
       61 caggcgctgc agtaacccag aagcccgggg cattcctcac agtttcttat ctgggtggta
      121 aaagcaggat gcagcctaat tggttgctgg ttctctctgg tgaacgcaag aggtttctgt
      181 tttaagaaat aaagtgactt cttggcggtt gattcactgc cccacgggga gaggctgagc
      241 agaggcttcc tctccgtaga gatttgcata cagcatccac ttcctgctcg agagcctgct
      301 ccaccactta cctgggactg gagagggcga gggaggtctg agcggcccaa ggtggatccc
      361 cgtgagcaga gccagcgacc accccctggg ccgtctgtcg gtggcgatct tagaaactag
      421 aatgaaccga agcattcccg tggaggttga tgaatcagaa ccattcccga gtcaattgct
      481 gaaaccgatc ccagaatact ctccagaaga ggaattggaa ccacctgccc ccaatacaag
      541 gaacatggca cccagcagct tgtctgtgct ccagtgccct cccctgaaac tggcaaacca
      601 ccagcctgtg tcacaacagg tcacctgcct gcgagctaaa gtcctggagg aaggtgaagc
      661 cagtttcttt agaaggcacc ctgaacttgg caaagatatt tcctcatgtt cctctggagc
      721 cagcgagcct gagtctgagc tcggagccct ccctccagag catcggttca cacttacgga
      781 aaaacgcaat agatggctgg gatctcagct ttcagcagct tctcctgaca ctggccatga
      841 atcagacaaa tcagacccaa gtttacctaa tgctttggca gactccttca gtggtggcca
      901 agagatgatg ccccggcccc ggccccggcc tgggccccac aggcacaggg cagccccaga
      961 tgtgcccacg atagacactg gctatgattc ccagccccaa gatgtcctgg gcatcaggca
     1021 gttggagagg ccattgcccc tcacctcctc gtgttacctg caggacctcc ctgggcctct
     1081 gaggtccagg gaattgccac ctcagtttga acttgagagg tatccaatga acgcccagct
     1141 gctgccgccc catccttccc cacaggcccc atggaactgt cagtactact gccccggagg
     1201 gccctaccac caccaggtgc cacacggcca tggctaccct ccagcagcag cctaccagca
     1261 agtactccag cctgctctgc ctgggcaggt ccttcctggg gcaagggcaa gaggcccacg
     1321 ccctgtgcag aaggtcatcc tgaatgactc cagcccccaa gaccaagaag agagacctgc
     1381 acagagagac ttctctttcc cgaggctccc gagggaccag ctctaccgcc caccatctaa
     1441 tggagtggaa gcccctgagg agtccttgga ccttcctgca gagctgagac cacatggtcc
     1501 ccaggctcca tccctagctg ccgtgcctag accccctagc aaccccttag cccgaggaac
     1561 tctaagaacc agcaatttgc cagaagaatt acggaaagtc tttatcactt attctatgga
     1621 cacagccatg gaggtggtga aatttgtgaa ctttctgttg gtgaacggct tccaaactgc
     1681 gattgacata tttgaggata gaatccgggg tattgatatc attaaatgga tggagcgcta
     1741 tcttcgagat aagacagtga tgataatcgt agcaatcagc cccaaataca aacaggatgt
     1801 ggaaggcgct gagtcgcagc tggacgagga cgagcatggc ttacatacta agtacattca
     1861 tcggatgatg cagattgagt tcataagtca gggaagcatg aacttcagat tcatccctgt
     1921 gctcttccca aatgccaaga aggagcatgt gccgacctgg cttcagaaca ctcatgttta
     1981 cagctggccc aagaataaga aaaacatcct gctgcggctg ctcagggagg aagagtatgt
     2041 ggctcctccc cgaggccctc tgcccaccct tcaggtggta cccttgtgac gatggccact
     2101 ccagctcagt gccagcctgt tctcacagca ttcttctagc ggagctggct ggtggcaccc
     2161 aggccctgga acacctcttc tacagagtcc tctgtctcct gagtctgagt tgtcctcgct
     2221 gggcttccag agcttcagtg cctggatgct gcaggtgaca gaaacaaaca tctatgacca
     2281 caaaaactct catcacttca gctactttta tgagtcggtc agatgctctg tgtccttaga
     2341 ccagtctaaa tcatgctcaa ataataaaat gattattctt tgtaagaatg tgtttatctc
     2401 agtggaggtg ggcatattaa tttatactga aaagggcagc tctgggatat caacaaaact
     2461 gctcagatat agtagtagat aaatgtgaca aagttctctg tataaaagga ttaaaaccag
     2521 aaagttatac atccttttaa cgtgaaaggc tttctcttgc agttgaggct tttaatgaag
     2581 caatcctaat tgtaaacaga gtaattgggt ggggagtgta gctcggtggt ggaacacttg
     2641 cttagcatgt aggagtccag gattcaaccc ccatcccttc acgaagagaa aaaggtctgg
     2701 ccatttatgt aaaactatct gagaatatgc ataaaggaac aggggctgtg taaccagagt
     2761 tatggtctag ttttctatct ctgtcccact cctgagtgta cctctgacta agcaagtcat
     2821 tttgcttttc tgggatttgg gagacttata aaatcatatg gaaaggt
//
