LOCUS       NM_028718               3521 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TRAF3 interacting protein 1 (Traf3ip1), mRNA.
ACCESSION   NM_028718 XM_129927
VERSION     NM_028718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3521)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3521)
  AUTHORS   Li-Villarreal,N., Rasmussen,T.L., Christiansen,A.E., Dickinson,M.E.
            and Hsu,C.W.
  TITLE     Three-dimensional microCT imaging of mouse heart development from
            early post-implantation to late fetal stages
  JOURNAL   Mamm Genome 34 (2), 156-165 (2023)
   PUBMED   36595063
  REMARK    Review article
REFERENCE   3  (bases 1 to 3521)
  AUTHORS   Katoh,Y., Terada,M., Nishijima,Y., Takei,R., Nozaki,S., Hamada,H.
            and Nakayama,K.
  TITLE     Overall Architecture of the Intraflagellar Transport (IFT)-B
            Complex Containing Cluap1/IFT38 as an Essential Component of the
            IFT-B Peripheral Subcomplex
  JOURNAL   J Biol Chem 291 (21), 10962-10975 (2016)
   PUBMED   26980730
REFERENCE   4  (bases 1 to 3521)
  AUTHORS   Bizet,A.A., Becker-Heck,A., Ryan,R., Weber,K., Filhol,E., Krug,P.,
            Halbritter,J., Delous,M., Lasbennes,M.C., Linghu,B., Oakeley,E.J.,
            Zarhrate,M., Nitschke,P., Garfa-Traore,M., Serluca,F., Yang,F.,
            Bouwmeester,T., Pinson,L., Cassuto,E., Dubot,P., Elshakhs,N.A.S.,
            Sahel,J.A., Salomon,R., Drummond,I.A., Gubler,M.C., Antignac,C.,
            Chibout,S., Szustakowski,J.D., Hildebrandt,F., Lorentzen,E.,
            Sailer,A.W., Benmerah,A., Saint-Mezard,P. and Saunier,S.
  TITLE     Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in
            microtubule stabilization
  JOURNAL   Nat Commun 6, 8666 (2015)
   PUBMED   26487268
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3521)
  AUTHORS   Liew,G.M., Ye,F., Nager,A.R., Murphy,J.P., Lee,J.S., Aguiar,M.,
            Breslow,D.K., Gygi,S.P. and Nachury,M.V.
  TITLE     The intraflagellar transport protein IFT27 promotes BBSome exit
            from cilia through the GTPase ARL6/BBS3
  JOURNAL   Dev Cell 31 (3), 265-278 (2014)
   PUBMED   25443296
REFERENCE   6  (bases 1 to 3521)
  AUTHORS   Ng,M.H., Ho,T.H., Kok,K.H., Siu,K.L., Li,J. and Jin,D.Y.
  TITLE     MIP-T3 is a negative regulator of innate type I IFN response
  JOURNAL   J Immunol 187 (12), 6473-6482 (2011)
   PUBMED   22079989
REFERENCE   7  (bases 1 to 3521)
  AUTHORS   Berbari,N.F., Kin,N.W., Sharma,N., Michaud,E.J., Kesterson,R.A. and
            Yoder,B.K.
  TITLE     Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic
            development, and altered cell size regulation
  JOURNAL   Dev Biol 360 (1), 66-76 (2011)
   PUBMED   21945076
  REMARK    GeneRIF: Homozygous Traf3ip1 mutants are not viable and have both
            neural developmental defects and polydactyly, phenotypes typical of
            mutants with ciliary assembly defects.
REFERENCE   8  (bases 1 to 3521)
  AUTHORS   Keady,B.T., Le,Y.Z. and Pazour,G.J.
  TITLE     IFT20 is required for opsin trafficking and photoreceptor outer
            segment development
  JOURNAL   Mol Biol Cell 22 (7), 921-930 (2011)
   PUBMED   21307337
REFERENCE   9  (bases 1 to 3521)
  AUTHORS   Follit,J.A., Xu,F., Keady,B.T. and Pazour,G.J.
  TITLE     Characterization of mouse IFT complex B
  JOURNAL   Cell Motil Cytoskeleton 66 (8), 457-468 (2009)
   PUBMED   19253336
  REMARK    GeneRIF: Data show that overexpression of IFT54/Traf3ip1 displaces
            IFT20 from the Golgi apparatus. IFT54s effect on IFT20 is a
            dominant negative phenotype caused by its overexpression.
REFERENCE   10 (bases 1 to 3521)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY739359.1, AY613437.1, BC051115.1 and CK794620.1.
            
            On Feb 2, 2010 this sequence version replaced NM_028718.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC117868.2, AY613437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY739359.1         1-9
            10-2457             AY613437.1         13-2460
            2458-3497           BC051115.1         1332-2371
            3498-3521           CK794620.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..3521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 46.16 cM"
     gene            1..3521
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="TRAF3 interacting protein 1"
                     /db_xref="GeneID:74019"
                     /db_xref="MGI:MGI:1921269"
     exon            1..221
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1976
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="TNF receptor-associated factor 3 interacting
                     protein 1; microtubule-interacting protein associated with
                     TRAF3; microtubule-interacting protein that associates
                     with TRAF3; intraflagellar transport protein 54 homolog"
                     /codon_start=1
                     /product="TRAF3-interacting protein 1"
                     /protein_id="NP_082994.1"
                     /db_xref="CCDS:CCDS35664.1"
                     /db_xref="GeneID:74019"
                     /db_xref="MGI:MGI:1921269"
                     /translation="MNAAVVRRTQEALGKVIRRPPLTEKLLNKPPFRYLHDIITEVIR
                     ITGFMKGLYTDAEMKSENVKDKDAKISFLQKAIDVVMMVSGEPLAAKPARIVAGHEPE
                     RTNELLQLIGKCCLSKLSSDEAVKRVLAGDKGDSRGRAQRTSKAQEPNNKSGKEEESR
                     IHKEDKRSSEAKERSASAEHKQKEELKEDSKPREKERDKEKAKEADRDRHRDPDRDRN
                     RDGEREKARARAKDRDRNNRDRDREAERDRERDRRSEGGKEKERVKDRDRDRDKGRDR
                     ERRKSKNGEHTRDPDREKSRDADKPEKKSSSSGEISRKLSDGSFKDVKAEMEADISVG
                     ASRSSTLKPSKRRSKHSLEGDSPSDAEVEAGPAGQDKPEVMENAEVPSELPSSLRRIP
                     RPGSARPAPPRVKRQESTETLVVDRSGSGKTVSSVIIDSQNSDNEDDEQFVVEAAPQL
                     SEIADIDMVPSGELEDEEKHGGLVKKILETKKDYEKLQQSLKPGEKERSLIFESAWKK
                     EKDIVSKEIEKLRVSIQTLCKSALPLGKIMDYIQEDVDAMQNELQLWHSENRQHAEAL
                     SQEQSITDSAVEPLKAELSELEQQIRDQQDKICAVKANILKNEEKIQKMVHSINLSSR
                     R"
     exon            222..290
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            291..452
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            453..590
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1010
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1082
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1158
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1179
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1264
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1348
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1472
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1509
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1586
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1810
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..3500
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="hexamer: ATTAAA"
     polyA_site      2149
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="major polyA site"
     regulatory      3472..3477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="hexamer: ATTAAA"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="hexamer: AATAAT"
     polyA_site      3497
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="major polyA site"
     polyA_site      3500
                     /gene="Traf3ip1"
                     /gene_synonym="3930402D05Rik; MIP-T3"
                     /note="major polyA site"
ORIGIN      
        1 gatgggagac cggcgcgccg ggacggcggg catctcgggg caccgggcag aggcgcggcg
       61 cgcgaggagg ggcgcgagcg gtcgcgggcg gcagcgccat gaacgccgca gtggtgcggc
      121 ggacgcagga ggctctgggc aaggtgatcc ggaggccgcc gctcaccgag aagctgctca
      181 acaagccacc gttccgctac ctgcacgaca tcatcaccga ggtgattagg ataactggct
      241 tcatgaaggg cctctacaca gatgctgaga tgaagtcaga aaatgtcaag gataaagatg
      301 caaaaattag cttcttacag aaggccatag atgtggtcat gatggtgtca ggtgaaccct
      361 tggcagcaaa accagctaga attgtggccg ggcacgaacc tgaaagaacc aatgagctgc
      421 ttcaattgat tggcaagtgc tgcctcagca agctctccag tgatgaggca gtgaagagag
      481 tcttagctgg ggacaagggg gactcgagag ggcgggccca gcggacgtcg aaagcacaag
      541 agcccaacaa caagagtggg aaggaggaag agtccagaat acacaaagag gataaacgaa
      601 gctctgaggc caaggagaga agcgcaagtg cagagcacaa acagaaggag gaactgaagg
      661 aagacagcaa gcctcgggag aaggagaggg acaaggagaa ggccaaggag gccgacagag
      721 accggcacag agaccccgac agggacagaa acagagacgg agagcgagag aaagcccgag
      781 cacgggccaa ggacagggac agaaacaaca gagaccggga cagagaggca gaaagggaca
      841 gggagaggga caggaggagc gagggcggga aagaaaaaga gagggtgaag gaccgagacc
      901 gagaccgtga caagggaaga gaccgggaac ggcggaaatc gaagaatgga gaacataccc
      961 gggatcctga cagggagaaa agcagagatg cagacaagcc agagaaaaag tcctcaagct
     1021 caggggagat atctagaaag ctgtcagatg gatctttcaa agatgtcaaa gcagagatgg
     1081 aggctgacat ttctgtggga gcatctaggt cctcgacgtt aaaaccatca aaacggcgat
     1141 cgaagcattc actggaaggt gactccccca gcgatgcaga agtagaagct ggacctgctg
     1201 gccaagataa gccggaggtg atggagaatg cggaagttcc cagtgagctt ccctccagcc
     1261 tcagaagaat acctcggcct gggagtgcac ggccagcacc tcccagggtc aaacgacaag
     1321 agagcacaga gacactggtg gtagacaggt cgggaagtgg taaaaccgtc tccagtgtga
     1381 tcatcgactc ccagaactct gacaatgagg atgacgagca gtttgtggtg gaggctgccc
     1441 ctcagctgtc agaaatcgca gacattgaca tggtgccgtc aggggagctg gaggatgagg
     1501 agaagcacgg tgggctcgtg aagaagatct tggagacgaa gaaggattat gagaaattgc
     1561 agcagtctct caagcctggt gagaaggaga gatcactcat ctttgagtca gcatggaaga
     1621 aggagaaaga catcgtttcc aaggagatag agaagctccg cgtgtccatc cagaccctgt
     1681 gtaagagtgc gcttcccctg ggaaagatca tggactacat ccaggaggac gtggacgcca
     1741 tgcagaatga gctgcagctg tggcacagtg agaacaggca gcatgccgaa gccctgagcc
     1801 aggagcagag tatcacagac agtgcggtgg agcccctgaa ggccgagctt tctgagctgg
     1861 agcaacagat cagagaccag caggacaaga tctgtgctgt gaaggccaac atcctgaaga
     1921 atgaggagaa gatccagaaa atggtgcaca gtatcaacct gtcgtcacga aggtgaatgg
     1981 ccagtcctgc agagatggag ccatcttcct catgacggac aaggggcagg aaccgcccct
     2041 ctgagcccca gtctgctgag aaatggcctg ctgtgccctg agccagctaa ggtcagatct
     2101 ttcggtttag gcactacaat tattaaaagg ctgtgttttc ttccttccag ctacagtgct
     2161 tactacttag agcctccagc tcgcctttgt gggagggctt atttctttgt ttgttttttt
     2221 ttttttggca aatacatttc ctgctgcagc ctggctgact ctgtaccctg gtgttctgga
     2281 ggtaagttgt ctcatcctac taggtaaaca gcaggcccag agttctgctt ttgagtctcc
     2341 caggactcca tactagcact gagcaaagga caactatgaa ttttttggtg ggtattttat
     2401 aaatagaatg aggcctaaaa tggttaaatt gccattttca tttctacctg agggtgtcat
     2461 gttagcccgt gtccttgtaa ggtgcctgtc acctgggcgg ggttgctgct ctcttattgt
     2521 ataggcttct ttctgcagcc tccccatgac cctgctgtct gcatttctag ccctgaaagc
     2581 tcataggttg agaaggagaa tttagcccag cctttatggg cattgtgtga tgggaacctg
     2641 ccttggccac cggcttactc cggatggata agcagtcccc caggcctctt taagaggaca
     2701 ttgtcgcatg aagggctgac atggcccttc tctttggtga aggtgtgctc tacaagttgg
     2761 gagtgaggag agactgagag gaagagagta ctccaattta catgttgtgt ttgttttcct
     2821 ttttaaaaga cccttttcaa aagcaaagtt gttttttttt taatggttta tattcagttt
     2881 ttcacctact gtaaatactc attaaggtct tgaattactg tatgaaggat ctcactgtgt
     2941 ctggagatgt tcttactggc gtaaggtctg aagtagtctt ccatttctgg gtatttcttt
     3001 tgtgcactgc atcacaccct gggatgtgtg aagactgcct tagcacacga ggcacagcca
     3061 gggtttctca gtcagtgaag gcagagccca gctctcgcct gggggcctgg acagtgtgag
     3121 aagcccttca gccccttagt ctttcctgtc tgaagcacac cgcaccaccc tgccaaacag
     3181 atgcttccag ataggttagg ggagggaagg attgcttgtc agccagcctt ttgtgtgttc
     3241 atgagctctt ttctactgaa ttaaatgact tagccataac cctaagtgga ccccatatat
     3301 accaacgtaa tatatataca tatatgtata tatacatcct tttatgaatt tgtatatatg
     3361 aatagaattt ttatgttgag aaaattacat acattgtatg tgagtaaatt tttatatgct
     3421 gtagtcatca gattgtatca taaagtttta tttttctttt atatgtaaat cattaaaata
     3481 atcacctatt tttcctataa aaaaaaaaaa aaaaaaaaaa a
//
