LOCUS       NM_009422               3044 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus TNF receptor-associated factor 2 (Traf2), transcript
            variant 2, mRNA.
ACCESSION   NM_009422
VERSION     NM_009422.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3044)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3044)
  AUTHORS   Li,Z., Zhao,J., Wu,Y., Fan,S., Yuan,H., Xia,J., Hu,L., Yang,J.,
            Liu,J., Wu,X., Lin,R. and Yang,L.
  TITLE     TRAF2 decrease promotes the TGF-beta-mTORC1 signal in MAFLD-HCC
            through enhancing AXIN1-mediated Smad7 degradation
  JOURNAL   FASEB J 38 (4), e23491 (2024)
   PUBMED   38363556
  REMARK    GeneRIF: TRAF2 decrease promotes the TGF-beta-mTORC1 signal in
            MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
REFERENCE   3  (bases 1 to 3044)
  AUTHORS   Yao,J., Liang,X., Xu,S., Liu,Y., Shui,L., Li,S., Guo,H., Xiao,Z.,
            Zhao,Y. and Zheng,M.
  TITLE     TRAF2 inhibits senescence in hepatocellular carcinoma cells via
            regulating the ROMO1/ NAD+/SIRT3/SOD2 axis
  JOURNAL   Free Radic Biol Med 211, 47-62 (2024)
   PUBMED   38043870
  REMARK    GeneRIF: TRAF2 inhibits senescence in hepatocellular carcinoma
            cells via regulating the ROMO1/ NAD[+]/SIRT3/SOD2 axis.
REFERENCE   4  (bases 1 to 3044)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (bases 1 to 3044)
  AUTHORS   Song,Y., Song,B., Yu,Z., Li,A., Xia,L., Zhao,Y., Lu,Z. and Li,Z.
  TITLE     Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 316 (2023)
   PUBMED   38062811
  REMARK    GeneRIF: Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer.
REFERENCE   6  (bases 1 to 3044)
  AUTHORS   Song,H.Y., Rothe,M. and Goeddel,D.V.
  TITLE     The tumor necrosis factor-inducible zinc finger protein A20
            interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6721-6725 (1996)
   PUBMED   8692885
REFERENCE   7  (bases 1 to 3044)
  AUTHORS   Lee,S.Y., Park,C.G. and Choi,Y.
  TITLE     T cell receptor-dependent cell death of T cell hybridomas mediated
            by the CD30 cytoplasmic domain in association with tumor necrosis
            factor receptor-associated factors
  JOURNAL   J Exp Med 183 (2), 669-674 (1996)
   PUBMED   8627180
REFERENCE   8  (bases 1 to 3044)
  AUTHORS   Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
  TITLE     TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
            receptor 1 signal transduction pathways
  JOURNAL   Cell 84 (2), 299-308 (1996)
   PUBMED   8565075
REFERENCE   9  (bases 1 to 3044)
  AUTHORS   Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
  TITLE     The TNFR2-TRAF signaling complex contains two novel proteins
            related to baculoviral inhibitor of apoptosis proteins
  JOURNAL   Cell 83 (7), 1243-1252 (1995)
   PUBMED   8548810
REFERENCE   10 (bases 1 to 3044)
  AUTHORS   Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB841262.1, AK152174.1 and AK052934.1.
            
            On Mar 13, 2014 this sequence version replaced NM_009422.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052934.1, AK159581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BB841262.1         1-32
            33-2158             AK152174.1         1-2126
            2159-3044           AK052934.1         2108-2993
FEATURES             Location/Qualifiers
     source          1..3044
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.32 cM"
     gene            1..3044
                     /gene="Traf2"
                     /note="TNF receptor-associated factor 2"
                     /db_xref="GeneID:22030"
                     /db_xref="MGI:MGI:101835"
     exon            1..79
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            80..298
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1616
                     /gene="Traf2"
                     /EC_number="2.3.2.27"
                     /note="isoform b is encoded by transcript variant 2; E3
                     ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin
                     transferase TRAF2"
                     /codon_start=1
                     /product="TNF receptor-associated factor 2 isoform b"
                     /protein_id="NP_033448.2"
                     /db_xref="CCDS:CCDS15779.1"
                     /db_xref="GeneID:22030"
                     /db_xref="MGI:MGI:101835"
                     /translation="MAAASVTSPGSLELLQPGFSKTLLGTRLEAKYLCSACKNILRRP
                     FQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVES
                     LPAVCPNDGCTWKGTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTEQECPKRS
                     LSCQHCRAPCSHVDLEVHYEVCPKFPLTCDGCGKKKIPRETFQDHVRACSKCRVLCRF
                     HTVGCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPELLQRCQILE
                     QKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLA
                     MADLEQKVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCL
                     RVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNREHVIDAFRPD
                     VTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL"
     exon            299..377
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..476
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..638
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            639..713
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            714..788
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1070
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1248
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1397
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..3044
                     /gene="Traf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf2"
                     /note="hexamer: ATTAAA"
     polyA_site      2160
                     /gene="Traf2"
                     /note="major polyA site"
ORIGIN      
        1 gtccgtcaga cggggcgggc cgcggcagcg ggggtgtttc ccggcgagcg ctgagttccg
       61 ggcgcgcgaa gaccgttggg gctttgtggt gtgtgggggt tgtaactcac atggctgcag
      121 ccagtgtgac ttcccctggc tccctagaac tgctacagcc tggcttctcc aagaccctcc
      181 tggggaccag gttagaagcc aagtacctct gttcagcctg caaaaacatc ctgcggaggc
      241 ctttccaggc ccagtgtggg caccgctact gctccttctg cctgaccagc atcctcagct
      301 ctgggcccca gaactgtgct gcctgtgtct atgaaggcct gtatgaagaa ggcatttcta
      361 ttttagagag tagttcggcc tttccagata acgctgcccg cagagaggtg gagagcctgc
      421 cagctgtctg tcccaatgat ggatgcactt ggaaggggac cttgaaagaa tacgagagct
      481 gccacgaagg actttgccca ttcctgctga cggagtgtcc tgcatgtaaa ggcctggtcc
      541 gcctcagcga gaaggagcac cacactgagc aggaatgccc caaaaggagc ctgagctgcc
      601 agcactgcag agcaccctgt agccacgtgg acctggaggt acactatgag gtctgcccca
      661 agtttccctt aacctgtgat ggctgtggca agaagaagat ccctcgggag acgtttcagg
      721 accatgttag agcatgcagc aaatgccggg ttctctgcag attccacacc gttggctgtt
      781 cagagatggt ggagactgag aacctgcagg atcatgagct gcagcggcta cgggaacacc
      841 tagccctact gctgagctca ttcttggagg cccaagcctc tccaggaacc ttgaaccagg
      901 tggggccaga gctactccag cggtgccaga ttttggagca gaagatagca acctttgaga
      961 acattgtctg cgtcttgaac cgtgaagtag agagggtagc agtgactgca gaggcttgta
     1021 gccggcagca ccggctagac caggacaaga ttgaggccct gagtaacaag gtgcaacagc
     1081 tggagaggag catcggcctc aaggacctgg ccatggctga cctggagcag aaggtctccg
     1141 agttggaagt atccacctat gatggggtct tcatctggaa gatctctgac ttcaccagaa
     1201 agcgtcagga agccgtagct ggccggacac cagctatctt ctccccagcc ttctacacaa
     1261 gcagatatgg ctacaagatg tgtctacgag tctacttgaa tggcgacggc actgggcggg
     1321 gaactcatct gtctctcttc ttcgtggtga tgaaaggccc caatgatgct ctgttgcagt
     1381 ggccttttaa tcagaaggta acattgatgt tgctggacca taacaaccgg gagcatgtga
     1441 tcgacgcatt caggcccgat gtaacctcgt cctccttcca gaggcctgtc agtgacatga
     1501 acatcgccag tggctgcccc ctcttctgcc ctgtgtccaa gatggaggcc aagaattcct
     1561 atgtgcggga tgatgcgatc ttcatcaaag ctattgtgga cctaacagga ctctagccac
     1621 ccctgctaag aatagcagct cagtgaggag ctgtcacatt aggccagcca ggccctgcca
     1681 cacacgggtg ggcaggcttg gtgtaaatgc tggggagggc ctcagcctag agccaatcac
     1741 catcacacag aaaggcagga agaagcctcc agttggcctt cagctggcaa actgagttgg
     1801 acggtccact gagctcaagg gcctggtgga gcccgctggg gagcttctca gctttccaat
     1861 aggaaagctc ctgctgtctc ctctgtctgg ggaagggaga gacctgtagg tgggtgctca
     1921 gaaagggcct ctccagagag agtctcaaga gctgcagcag gagcaaagtg actggccttc
     1981 cccaccccat cctttggaaa agaggtagcg gctacacagg agaaggcatg cgcctgcagg
     2041 gtgtagccca agagagaagc tctctgagac ataggccctc actggagaag ggcctgcctg
     2101 ggctgcacag ccttgccagg tggcctgtat gggggagaag tgattaaatg ttgagatgtc
     2161 tgtgctgagt ggtgttcatc tggctcctgc tgtgtctagg tagtgatgac cctctggcta
     2221 tcacttctgc cttactcatt ctggacacct ctattcctta tatccttcaa gcccagtgac
     2281 cactccattg tgagtctgcc tgggtagaga tgaaggtctg accttgacct ggccaatgta
     2341 caggcctttg tctcaggatc cttgcctggt ttgcacaata ggaaatgtgg tgggcagcat
     2401 ggtgtgagct gtgagcatgc tgtgatggag gtggaccctg ccgggcccag ctgcaaacat
     2461 gcccagctgt gagcatgctg tgatggaggt ggaccctgcc ggggcccagc tgcaaacatg
     2521 cccagctgcg agcatgctgt gatggaggag gaggagacac tgccctctag accccttcat
     2581 gtcccctgtg gactgttgtg ctcatggctt ctctgacttt tcacactgga tttactggtt
     2641 ttaaaaggta cagaaacagc acagctgtca tcgtggcggc aaactgacct cactctggct
     2701 gggccccgta acttgctgga gaagggtgca tcttgtttct ttctctctgt cctgtgagtt
     2761 cttacgctgg aagctaggcc tacctgtcac ctagtggacc cagaagagct ggttatctct
     2821 tacacatgtt gtgcttgctc tgcagagatc taggacctca cagcatgtgg gcaggaccta
     2881 agcattttac atgggctctg gagtaagttg tacttctctg aggactctag tggacatttt
     2941 aaccaggatt attgctctag gatttctcca tagacattgc ccatttctgt ccgttttttc
     3001 tacttagttt cttcctgctt tgtaaacatt tttgatctaa gact
//
