LOCUS       NP_033448                501 aa            linear   ROD 24-DEC-2024
DEFINITION  TNF receptor-associated factor 2 isoform b [Mus musculus].
ACCESSION   NP_033448
VERSION     NP_033448.2
DBSOURCE    REFSEQ: accession NM_009422.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Li,Z., Zhao,J., Wu,Y., Fan,S., Yuan,H., Xia,J., Hu,L., Yang,J.,
            Liu,J., Wu,X., Lin,R. and Yang,L.
  TITLE     TRAF2 decrease promotes the TGF-beta-mTORC1 signal in MAFLD-HCC
            through enhancing AXIN1-mediated Smad7 degradation
  JOURNAL   FASEB J 38 (4), e23491 (2024)
   PUBMED   38363556
  REMARK    GeneRIF: TRAF2 decrease promotes the TGF-beta-mTORC1 signal in
            MAFLD-HCC through enhancing AXIN1-mediated Smad7 degradation.
REFERENCE   3  (residues 1 to 501)
  AUTHORS   Yao,J., Liang,X., Xu,S., Liu,Y., Shui,L., Li,S., Guo,H., Xiao,Z.,
            Zhao,Y. and Zheng,M.
  TITLE     TRAF2 inhibits senescence in hepatocellular carcinoma cells via
            regulating the ROMO1/ NAD+/SIRT3/SOD2 axis
  JOURNAL   Free Radic Biol Med 211, 47-62 (2024)
   PUBMED   38043870
  REMARK    GeneRIF: TRAF2 inhibits senescence in hepatocellular carcinoma
            cells via regulating the ROMO1/ NAD[+]/SIRT3/SOD2 axis.
REFERENCE   4  (residues 1 to 501)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (residues 1 to 501)
  AUTHORS   Song,Y., Song,B., Yu,Z., Li,A., Xia,L., Zhao,Y., Lu,Z. and Li,Z.
  TITLE     Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer
  JOURNAL   Front Biosci (Landmark Ed) 28 (11), 316 (2023)
   PUBMED   38062811
  REMARK    GeneRIF: Silencing of CPNE1-TRAF2 Axis Restrains the Development of
            Pancreatic Cancer.
REFERENCE   6  (residues 1 to 501)
  AUTHORS   Song,H.Y., Rothe,M. and Goeddel,D.V.
  TITLE     The tumor necrosis factor-inducible zinc finger protein A20
            interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
  JOURNAL   Proc Natl Acad Sci U S A 93 (13), 6721-6725 (1996)
   PUBMED   8692885
REFERENCE   7  (residues 1 to 501)
  AUTHORS   Lee,S.Y., Park,C.G. and Choi,Y.
  TITLE     T cell receptor-dependent cell death of T cell hybridomas mediated
            by the CD30 cytoplasmic domain in association with tumor necrosis
            factor receptor-associated factors
  JOURNAL   J Exp Med 183 (2), 669-674 (1996)
   PUBMED   8627180
REFERENCE   8  (residues 1 to 501)
  AUTHORS   Hsu,H., Shu,H.B., Pan,M.G. and Goeddel,D.V.
  TITLE     TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF
            receptor 1 signal transduction pathways
  JOURNAL   Cell 84 (2), 299-308 (1996)
   PUBMED   8565075
REFERENCE   9  (residues 1 to 501)
  AUTHORS   Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
  TITLE     The TNFR2-TRAF signaling complex contains two novel proteins
            related to baculoviral inhibitor of apoptosis proteins
  JOURNAL   Cell 83 (7), 1243-1252 (1995)
   PUBMED   8548810
REFERENCE   10 (residues 1 to 501)
  AUTHORS   Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB841262.1, AK152174.1 and AK052934.1.
            
            On Dec 23, 2005 this sequence version replaced NP_033448.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (b) that is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052934.1, AK159581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.32 cM"
     Protein         1..501
                     /product="TNF receptor-associated factor 2 isoform b"
                     /EC_number="2.3.2.27"
                     /note="E3 ubiquitin-protein ligase TRAF2; RING-type E3
                     ubiquitin transferase TRAF2"
                     /calculated_mol_wt=55895
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q12933; propagated from
                     UniProtKB/Swiss-Prot (P39429.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12933; propagated from
                     UniProtKB/Swiss-Prot (P39429.1)"
     Site            7
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12933; propagated from
                     UniProtKB/Swiss-Prot (P39429.1)"
     Site            11
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12933; propagated from
                     UniProtKB/Swiss-Prot (P39429.1)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12933; propagated from
                     UniProtKB/Swiss-Prot (P39429.1)"
     Region          31..73
                     /region_name="RING-HC_TRAF2"
                     /note="RING finger, HC subclass, found in tumor necrosis
                     factor (TNF) receptor-associated factor 2 (TRAF2) and
                     similar proteins; cd16639"
                     /db_xref="CDD:438301"
     Site            117
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKC.
                     /evidence=ECO:0000269|PubMed:19150425; propagated from
                     UniProtKB/Swiss-Prot (P39429.1)"
     Region          178..235
                     /region_name="zf-TRAF"
                     /note="TRAF-type zinc finger; pfam02176"
                     /db_xref="CDD:280357"
     Region          267..330
                     /region_name="TRAF_BIRC3_bd"
                     /note="TNF receptor-associated factor BIRC3 binding
                     domain; pfam16673"
                     /db_xref="CDD:465226"
     Region          283..293
                     /region_name="Important for interaction with BIRC2 and
                     BIRC3"
                     /note="propagated from UniProtKB/Swiss-Prot (P39429.1)"
     Region          334..497
                     /region_name="MATH_TRAF2"
                     /note="Tumor Necrosis Factor Receptor (TNFR) Associated
                     Factor (TRAF) family, TRAF2 subfamily, TRAF domain; TRAF
                     molecules serve as adapter proteins that link TNFRs and
                     downstream kinase cascades resulting in the activation of
                     transcription factors and the...; cd03778"
                     /db_xref="CDD:239747"
     Site            order(335,338,346,348,355,357,385..386,417,420,437)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239747"
     Site            order(393,395,399,410,447..448,453,455..456,466..468)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239747"
     Site            order(401,406,445,448..450,453..454,456,467..468,474)
                     /site_type="active"
                     /note="TRADD binding site [active]"
                     /db_xref="CDD:239747"
     CDS             1..501
                     /gene="Traf2"
                     /coded_by="NM_009422.3:111..1616"
                     /note="isoform b is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS15779.1"
                     /db_xref="GeneID:22030"
                     /db_xref="MGI:MGI:101835"
ORIGIN      
        1 maaasvtspg slellqpgfs ktllgtrlea kylcsackni lrrpfqaqcg hrycsfclts
       61 ilssgpqnca acvyeglyee gisilesssa fpdnaarrev eslpavcpnd gctwkgtlke
      121 yescheglcp flltecpack glvrlsekeh hteqecpkrs lscqhcrapc shvdlevhye
      181 vcpkfpltcd gcgkkkipre tfqdhvracs kcrvlcrfht vgcsemvete nlqdhelqrl
      241 rehlalllss fleaqaspgt lnqvgpellq rcqileqkia tfenivcvln revervavta
      301 eacsrqhrld qdkiealsnk vqqlersigl kdlamadleq kvselevsty dgvfiwkisd
      361 ftrkrqeava grtpaifspa fytsrygykm clrvylngdg tgrgthlslf fvvmkgpnda
      421 llqwpfnqkv tlmlldhnnr ehvidafrpd vtsssfqrpv sdmniasgcp lfcpvskmea
      481 knsyvrddai fikaivdltg l
//
