LOCUS       NM_001326601            3766 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus TNF receptor-associated factor 1 (Traf1), transcript
            variant 2, mRNA.
ACCESSION   NM_001326601 XM_006497845
VERSION     NM_001326601.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3766)
  AUTHORS   Zhang,X., Xu,Y., Zhang,W., Yang,B., Zhang,Y., Jia,Z., Huang,S.,
            Zhang,A. and Li,S.
  TITLE     TRAF1 improves cisplatin-induced acute kidney injury via inhibition
            of inflammation and metabolic disorders
  JOURNAL   Biochim Biophys Acta Gen Subj 1867 (9), 130423 (2023)
   PUBMED   37419425
  REMARK    GeneRIF: TRAF1 improves cisplatin-induced acute kidney injury via
            inhibition of inflammation and metabolic disorders.
REFERENCE   2  (bases 1 to 3766)
  AUTHORS   Mirzaesmaeili,A., Zangiabadi,S., Raspanti,J., Akram,A., Inman,R.D.
            and Abdul-Sater,A.A.
  TITLE     Cutting Edge: Negative Regulation of Inflammasome Activation by
            TRAF1 Can Limit Gout
  JOURNAL   J Immunol 210 (5), 531-535 (2023)
   PUBMED   36637223
  REMARK    GeneRIF: Cutting Edge: Negative Regulation of Inflammasome
            Activation by TRAF1 Can Limit Gout.
REFERENCE   3  (bases 1 to 3766)
  AUTHORS   Li,H., Wang,Q. and Gong,D.
  TITLE     LINC00313 alleviates osteoarthritis progression in mice through
            promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK
            signaling pathway
  JOURNAL   Immunopharmacol Immunotoxicol 44 (5), 732-745 (2022)
   PUBMED   35815528
  REMARK    GeneRIF: LINC00313 alleviates osteoarthritis progression in mice
            through promoting TRAF1 promoter methylation and inhibiting the
            ASK1/JNK signaling pathway.
REFERENCE   4  (bases 1 to 3766)
  AUTHORS   Bai,W., Wang,Q., Deng,Z., Li,T., Xiao,H. and Wu,Z.
  TITLE     TRAF1 suppresses antifungal immunity through CXCL1-mediated
            neutrophil recruitment during Candida albicans intradermal
            infection
  JOURNAL   Cell Commun Signal 18 (1), 30 (2020)
   PUBMED   32093731
  REMARK    GeneRIF: TRAF1 suppresses antifungal immunity through
            CXCL1-mediated neutrophil recruitment during Candida albicans
            intradermal infection.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3766)
  AUTHORS   Zhou,A.C., Batista,N.V. and Watts,T.H.
  TITLE     4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue
            through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance
            Tissue-Resident Memory T Cell Formation during Respiratory
            Influenza Infection
  JOURNAL   J Immunol 202 (8), 2482-2492 (2019)
   PUBMED   30867239
  REMARK    GeneRIF: these data point to an important role for 4-1BB, TRAF1,
            and mTOR in the persistence of CD8 effector T cells in the lung
            parenchyma, thereby allowing the transition to Trm.
REFERENCE   6  (bases 1 to 3766)
  AUTHORS   Speiser,D.E., Lee,S.Y., Wong,B., Arron,J., Santana,A., Kong,Y.Y.,
            Ohashi,P.S. and Choi,Y.
  TITLE     A regulatory role for TRAF1 in antigen-induced apoptosis of T cells
  JOURNAL   J Exp Med 185 (10), 1777-1783 (1997)
   PUBMED   9151703
REFERENCE   7  (bases 1 to 3766)
  AUTHORS   Lee,S.Y., Lee,S.Y. and Choi,Y.
  TITLE     TRAF-interacting protein (TRIP): a novel component of the tumor
            necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes
            that inhibits TRAF2-mediated NF-kappaB activation
  JOURNAL   J Exp Med 185 (7), 1275-1285 (1997)
   PUBMED   9104814
REFERENCE   8  (bases 1 to 3766)
  AUTHORS   Lee,S.Y., Park,C.G. and Choi,Y.
  TITLE     T cell receptor-dependent cell death of T cell hybridomas mediated
            by the CD30 cytoplasmic domain in association with tumor necrosis
            factor receptor-associated factors
  JOURNAL   J Exp Med 183 (2), 669-674 (1996)
   PUBMED   8627180
REFERENCE   9  (bases 1 to 3766)
  AUTHORS   Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
  TITLE     The TNFR2-TRAF signaling complex contains two novel proteins
            related to baculoviral inhibitor of apoptosis proteins
  JOURNAL   Cell 83 (7), 1243-1252 (1995)
   PUBMED   8548810
REFERENCE   10 (bases 1 to 3766)
  AUTHORS   Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029135.1, BY209774.1 and AL929068.20.
            
            On May 21, 2016 this sequence version replaced XM_006497845.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L35302.1, SRR7345562.2028889.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AK029135.1         3-192
            191-557             BY209774.1         2-368
            558-2258            AK029135.1         627-2327
            2259-3766           AL929068.20        104358-105865       c
FEATURES             Location/Qualifiers
     source          1..3766
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 23.13 cM"
     gene            1..3766
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /note="TNF receptor-associated factor 1"
                     /db_xref="GeneID:22029"
                     /db_xref="MGI:MGI:101836"
     exon            1..249
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            250..288
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..387
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            388..535
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             414..1643
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="TNF receptor-associated factor 1"
                     /protein_id="NP_001313530.1"
                     /db_xref="CCDS:CCDS15956.1"
                     /db_xref="GeneID:22029"
                     /db_xref="MGI:MGI:101836"
                     /translation="MASSSAPDENEFQFGCPPAPCQDPSEPRVLCCTACLSENLRDDE
                     DRICPKCRADNLHPVSPGSPLTQEKVHSDVAEAEIMCPFAGVGCSFKGSPQSMQEHEA
                     TSQSSHLYLLLAVLKEWKSSPGSNLGSAPMALERNLSELQLQAAVEATGDLEVDCYRA
                     PCCESQEELALQHLVKEKLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLD
                     REHILSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHES
                     VCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPF
                     RNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHA
                     YVKDDTMFLKCIVDTSA"
     exon            536..620
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            621..686
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            687..1097
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1275
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1424
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..3766
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2192
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /note="major polyA site"
     regulatory      2240..2245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /note="hexamer: AACAAA"
     polyA_site      2260
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagtatctca ggagtgcagc cactgatgga atgctaggag tcagctagca ccaggacccc
       61 aacagaagca ctccagttct gtttccttga gggaggagcg atcagcccgc cccccggcca
      121 gcctccgaag ccagcccagc tcagtcccac ccgcctgccc agcccagctt cccttggctt
      181 ccgccagccc agcccggttc tctgccccaa ggacgctacc gcccggtgcg agcagaaggc
      241 ggcgcacaga tacagaaagt gaggctcaga catattgaag accgtgtgac atagggtagc
      301 caaatgacag tgtgagaaag tgacatttac tcaaggccac ccagatatcc tggaggaccc
      361 agaaccctgg agattcccat cagaaagacc ttctggccac ctgaaacccc aagatggcct
      421 ccagctcagc ccctgatgaa aacgagtttc aatttggttg cccccctgct ccctgccagg
      481 acccatcgga gcccagagtt ctctgctgca cagcctgtct ctctgagaac ctgagagatg
      541 atgaggatcg gatctgtcct aaatgcagag cagacaacct ccatcctgtg agcccaggaa
      601 gccctctgac tcaggagaag gttcactctg atgtagctga ggctgaaatc atgtgcccct
      661 ttgcaggtgt tggctgttcc ttcaagggga gcccacaatc catgcaggag catgaggcta
      721 cctcccagtc ctcccacctg tacctgctgc tggcggtctt aaaggagtgg aaatcctcac
      781 caggctccaa cctagggtct gcacccatgg cactggagcg gaacctgtca gagctgcagc
      841 ttcaggcagc tgtggaagcg acaggggacc tggaggtaga ctgctaccgg gcaccttgct
      901 gtgagagcca ggaagaactg gccctgcagc acttggtgaa ggagaagctg ctggctcagc
      961 tggaggagaa gctgcgtgtg tttgcaaaca ttgttgctgt cctcaacaag gaagtggagg
     1021 cttcccacct ggcactggcc gcctccatcc accagagcca gttggaccga gagcacatcc
     1081 tgagcttgga gcagagggtg gtggaattac agcaaaccct ggctcaaaaa gaccaggtcc
     1141 tgggcaagct tgagcacagt ctgcgactca tggaggaggc atcctttgat ggtactttcc
     1201 tgtggaagat caccaatgtc accaagcggt gccacgagtc agtgtgtggc cggactgtca
     1261 gcctcttctc tccagctttc tacactgcca agtatggtta caagttgtgc ctgcgcttgt
     1321 acctgaacgg ggatggctca ggcaagaaga cccacctgtc cctcttcatc gtgatcatga
     1381 gaggagaata cgatgctctc ctgccctggc ctttcaggaa caaggtcacc tttatgctac
     1441 ttgaccagaa caaccgagag catgctattg atgccttccg gcctgacctg agctcagcct
     1501 ccttccagcg gccacagagt gagaccaacg tggccagcgg ctgcccgctc ttcttccccc
     1561 tcagcaagct gcagtcaccc aagcacgcct acgtcaaaga tgacacaatg ttcctcaaat
     1621 gcattgtgga cactagtgct tagggatggg gggagggggt gtctcctgac agaaccagct
     1681 tagactgggg gacttagcta gacagccagg ccctgcctgc ccttggagcc cacagcccac
     1741 gacaaggagg agccaaggct ggcatgactt cagcgccaca gcatgctggt tatggctgat
     1801 gtgaggctgg agaaacgtgt gcgtacagag acagagtgga ggagaagaca gaagtgctct
     1861 tttcacacag actacacgac accaggaggc cagcatgcca gcagcttctg aatgttgaga
     1921 ccagcctaga tcaggatgaa aagagccagg cctgaggctt ggacattgag ccaaggctat
     1981 ggggcctaag tggaggggca ctcctaccag gacattctct cgaggtcagg gcataactgg
     2041 aaaaatgccc ccatctctct gttcagactc aaaactagaa ccacagggca gaagggtcag
     2101 acattaatgt gaatttaacc tgccctggac tgagttccta tgttaacaga cacgcaaaca
     2161 ggtaaaccca gaaactgccc tgggaaatgc tttctggctg catctggaga tctttgatgt
     2221 ttttaccgac aaaacaaata acaaaagcct tgaattgcaa gcttcaggtg tgagaccaca
     2281 cccacagagg attctggagc aatacccagg gtccccctcc ccttcagctt cccattcacc
     2341 taaacctcta aacctagcag cccagttacc caacagacag acagaagcac acccaagaaa
     2401 gagctcacca tgcaagtctg aagctggtgt ccaacacaca gcaccttcac gactgctcac
     2461 agagtgccca gccaaaggga gactacactg ctagggtctg ccattcctcc attcatgcac
     2521 ctaccttcct tccttccttc cttccttcct tccttccttc cttccttcct tccttccctt
     2581 ccttccttcc ttccttcctt ccttcattta ttccttcctt cctccctttc ttcccctctc
     2641 ctcttcctac cctttctctt ccccctttct ctcccttccc cctcacccca tctccttcta
     2701 aaactaagtc tcatgtagcc cagactggtt tcaaactcag tatatagtca agaatgacac
     2761 tgaatccctg attctcctgc tcctagctcc caagtgctag gatcacaggt gtgtgtcact
     2821 ctgtctgtta cccaaggtgc tggggattga gcccagggct tcctccgtgg tggacaagta
     2881 ccctgcttag ctgcatcccc acacctttaa tggcgcactt ctgaggggag gagaaccttg
     2941 tcttcacaca gtgtgagagg cactgtgctt tcagcgaagc acggacagcc ctgagtgtcg
     3001 tctgtgcctg gacactgcag ctgcagggga aatagtgaga tctgcaaccc actctcctga
     3061 atcttctagt tcatcgggaa gcctgcatga taataattat cactaaaagc agaatggcgg
     3121 ggaaagcaga cggacagatg agggaaggct tcatggaaga agtgagcctc aaaccagcct
     3181 gaaatatgtg gaggatgtgg gtgtggagga gaggacagcc ttggggggat gggacgtgtc
     3241 ttggctgcaa gcaggggctg ggtgatgaaa ggaaggctgg accagccaaa acatagatag
     3301 gccaactggc cagaacacag aaatcaacat ctatgagctc ttgcacacct gcagggcctg
     3361 ggcctgttaa caggagggca cgacagtggt ttaaacagac agatcattta tcttccagag
     3421 aagctctgtg ctgttctctt ccaggtgact gagggatcgg ggaggcaagc tgctggcaaa
     3481 tctcatttca ctgtgtcctc acagccgccc actgaggtgc acaggcttgc acccatttgc
     3541 agatgggaaa gccgaggcca gagcaatcat ggcagggaca ctaacattgc aagccctatc
     3601 ttcggtgtcc ggtcttcctc ccttcctcca ggtttccctc cagccatgaa atggttggaa
     3661 ggtctttcac ccagcccgag ggccagctct gcaggatatt gccaaccttg catttgctca
     3721 gagaccacag tgagccacag acaatgataa aaagtgggaa gaactg
//
