LOCUS       NP_001313530             409 aa            linear   ROD 05-JUN-2024
DEFINITION  TNF receptor-associated factor 1 [Mus musculus].
ACCESSION   NP_001313530 XP_006497908
VERSION     NP_001313530.1
DBSOURCE    REFSEQ: accession NM_001326601.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 409)
  AUTHORS   Zhang,X., Xu,Y., Zhang,W., Yang,B., Zhang,Y., Jia,Z., Huang,S.,
            Zhang,A. and Li,S.
  TITLE     TRAF1 improves cisplatin-induced acute kidney injury via inhibition
            of inflammation and metabolic disorders
  JOURNAL   Biochim Biophys Acta Gen Subj 1867 (9), 130423 (2023)
   PUBMED   37419425
  REMARK    GeneRIF: TRAF1 improves cisplatin-induced acute kidney injury via
            inhibition of inflammation and metabolic disorders.
REFERENCE   2  (residues 1 to 409)
  AUTHORS   Mirzaesmaeili,A., Zangiabadi,S., Raspanti,J., Akram,A., Inman,R.D.
            and Abdul-Sater,A.A.
  TITLE     Cutting Edge: Negative Regulation of Inflammasome Activation by
            TRAF1 Can Limit Gout
  JOURNAL   J Immunol 210 (5), 531-535 (2023)
   PUBMED   36637223
  REMARK    GeneRIF: Cutting Edge: Negative Regulation of Inflammasome
            Activation by TRAF1 Can Limit Gout.
REFERENCE   3  (residues 1 to 409)
  AUTHORS   Li,H., Wang,Q. and Gong,D.
  TITLE     LINC00313 alleviates osteoarthritis progression in mice through
            promoting TRAF1 promoter methylation and inhibiting the ASK1/JNK
            signaling pathway
  JOURNAL   Immunopharmacol Immunotoxicol 44 (5), 732-745 (2022)
   PUBMED   35815528
  REMARK    GeneRIF: LINC00313 alleviates osteoarthritis progression in mice
            through promoting TRAF1 promoter methylation and inhibiting the
            ASK1/JNK signaling pathway.
REFERENCE   4  (residues 1 to 409)
  AUTHORS   Bai,W., Wang,Q., Deng,Z., Li,T., Xiao,H. and Wu,Z.
  TITLE     TRAF1 suppresses antifungal immunity through CXCL1-mediated
            neutrophil recruitment during Candida albicans intradermal
            infection
  JOURNAL   Cell Commun Signal 18 (1), 30 (2020)
   PUBMED   32093731
  REMARK    GeneRIF: TRAF1 suppresses antifungal immunity through
            CXCL1-mediated neutrophil recruitment during Candida albicans
            intradermal infection.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 409)
  AUTHORS   Zhou,A.C., Batista,N.V. and Watts,T.H.
  TITLE     4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue
            through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance
            Tissue-Resident Memory T Cell Formation during Respiratory
            Influenza Infection
  JOURNAL   J Immunol 202 (8), 2482-2492 (2019)
   PUBMED   30867239
  REMARK    GeneRIF: these data point to an important role for 4-1BB, TRAF1,
            and mTOR in the persistence of CD8 effector T cells in the lung
            parenchyma, thereby allowing the transition to Trm.
REFERENCE   6  (residues 1 to 409)
  AUTHORS   Speiser,D.E., Lee,S.Y., Wong,B., Arron,J., Santana,A., Kong,Y.Y.,
            Ohashi,P.S. and Choi,Y.
  TITLE     A regulatory role for TRAF1 in antigen-induced apoptosis of T cells
  JOURNAL   J Exp Med 185 (10), 1777-1783 (1997)
   PUBMED   9151703
REFERENCE   7  (residues 1 to 409)
  AUTHORS   Lee,S.Y., Lee,S.Y. and Choi,Y.
  TITLE     TRAF-interacting protein (TRIP): a novel component of the tumor
            necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes
            that inhibits TRAF2-mediated NF-kappaB activation
  JOURNAL   J Exp Med 185 (7), 1275-1285 (1997)
   PUBMED   9104814
REFERENCE   8  (residues 1 to 409)
  AUTHORS   Lee,S.Y., Park,C.G. and Choi,Y.
  TITLE     T cell receptor-dependent cell death of T cell hybridomas mediated
            by the CD30 cytoplasmic domain in association with tumor necrosis
            factor receptor-associated factors
  JOURNAL   J Exp Med 183 (2), 669-674 (1996)
   PUBMED   8627180
REFERENCE   9  (residues 1 to 409)
  AUTHORS   Rothe,M., Pan,M.G., Henzel,W.J., Ayres,T.M. and Goeddel,D.V.
  TITLE     The TNFR2-TRAF signaling complex contains two novel proteins
            related to baculoviral inhibitor of apoptosis proteins
  JOURNAL   Cell 83 (7), 1243-1252 (1995)
   PUBMED   8548810
REFERENCE   10 (residues 1 to 409)
  AUTHORS   Rothe,M., Wong,S.C., Henzel,W.J. and Goeddel,D.V.
  TITLE     A novel family of putative signal transducers associated with the
            cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
  JOURNAL   Cell 78 (4), 681-692 (1994)
   PUBMED   8069916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029135.1, BY209774.1 and AL929068.20.
            
            On May 21, 2016 this sequence version replaced XP_006497908.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L35302.1, SRR7345562.2028889.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..409
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 23.13 cM"
     Protein         1..409
                     /product="TNF receptor-associated factor 1"
                     /EC_number="2.3.2.27"
                     /calculated_mol_wt=45334
     Site            139
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:18429822; propagated from
                     UniProtKB/Swiss-Prot (P39428.2)"
     Site            156..157
                     /site_type="cleavage"
                     /note="Cleavage, by CASP8. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P39428.2)"
     Region          175..238
                     /region_name="TRAF_BIRC3_bd"
                     /note="TNF receptor-associated factor BIRC3 binding
                     domain; pfam16673"
                     /db_xref="CDD:465226"
     Region          260..406
                     /region_name="MATH_TRAF1"
                     /note="Tumor Necrosis Factor Receptor (TNFR) Associated
                     Factor (TRAF) family, TRAF1 subfamily, TRAF domain,
                     C-terminal MATH subdomain; TRAF molecules serve as adapter
                     proteins that link TNFRs and downstream kinase cascades
                     resulting in the activation of...; cd03779"
                     /db_xref="CDD:239748"
     Site            order(263,265,293..294,325,328,345)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:239748"
     Site            order(301,303,307,318,355..356,373..376)
                     /site_type="active"
                     /note="TNFR binding site [active]"
                     /db_xref="CDD:239748"
     Site            order(309,314,353,356..358,361..362,364,375..376,382)
                     /site_type="other"
                     /note="putative TRADD binding site [polypeptide binding]"
                     /db_xref="CDD:239748"
     CDS             1..409
                     /gene="Traf1"
                     /gene_synonym="4732496E14Rik"
                     /coded_by="NM_001326601.1:414..1643"
                     /db_xref="CCDS:CCDS15956.1"
                     /db_xref="GeneID:22029"
                     /db_xref="MGI:MGI:101836"
ORIGIN      
        1 masssapden efqfgcppap cqdpseprvl cctaclsenl rddedricpk cradnlhpvs
       61 pgspltqekv hsdvaeaeim cpfagvgcsf kgspqsmqeh eatsqsshly lllavlkewk
      121 sspgsnlgsa pmalernlse lqlqaaveat gdlevdcyra pccesqeela lqhlvkekll
      181 aqleeklrvf anivavlnke veashlalaa sihqsqldre hilsleqrvv elqqtlaqkd
      241 qvlgklehsl rlmeeasfdg tflwkitnvt krchesvcgr tvslfspafy takygyklcl
      301 rlylngdgsg kkthlslfiv imrgeydall pwpfrnkvtf mlldqnnreh aidafrpdls
      361 sasfqrpqse tnvasgcplf fplsklqspk hayvkddtmf lkcivdtsa
//
