LOCUS       NM_001085549            6617 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TraB domain containing 2B (Trabd2b), mRNA.
ACCESSION   NM_001085549 XM_981216
VERSION     NM_001085549.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6617)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6617)
  AUTHORS   George,M.R., Duan,Q., Nagle,A., Kathiriya,I.S., Huang,Y., Rao,K.,
            Haldar,S.M. and Bruneau,B.G.
  TITLE     Minimal in vivo requirements for developmentally regulated cardiac
            long intergenic non-coding RNAs
  JOURNAL   Development 146 (23) (2019)
   PUBMED   31784461
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6617)
  AUTHORS   Gerhardt,B., Leesman,L., Burra,K., Snowball,J., Rosenzweig,R.,
            Guzman,N., Ambalavanan,M. and Sinner,D.
  TITLE     Notum attenuates Wnt/beta-catenin signaling to promote tracheal
            cartilage patterning
  JOURNAL   Dev Biol 436 (1), 14-27 (2018)
   PUBMED   29428562
REFERENCE   4  (bases 1 to 6617)
  AUTHORS   Reis,A.H., Macdonald,B., Feistel,K., Brito,J.M., Amado,N.G., Xu,C.,
            Abreu,J.G. and He,X.I.
  TITLE     Expression and evolution of the Tiki1 and Tiki2 genes in
            vertebrates
  JOURNAL   Int J Dev Biol 58 (5), 355-362 (2014)
   PUBMED   25354456
REFERENCE   5  (bases 1 to 6617)
  AUTHORS   Zhang,R.
  TITLE     Hkat, a novel nutritionally regulated transmembrane protein in
            adipose tissues
  JOURNAL   Sci Rep 2, 825 (2012)
   PUBMED   23152936
  REMARK    GeneRIF: Hkat (Gm12824) is a novel nutritionally regulated gene
            that is potentially involved in metabolism.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL670175.12
            and AL646006.17.
            
            On Jul 25, 2007 this sequence version replaced XM_981216.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AL670175.12        93114-93309
            197-757             AL670175.12        95283-95843
            758-904             AL646006.17        100523-100669
            905-1079            AL646006.17        106690-106864
            1080-1170           AL646006.17        120105-120195
            1171-1443           AL646006.17        122975-123247
            1444-6617           AL646006.17        130157-135330
FEATURES             Location/Qualifiers
     source          1..6617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.84 cM"
     gene            1..6617
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /note="TraB domain containing 2B"
                     /db_xref="GeneID:666048"
                     /db_xref="MGI:MGI:3650152"
     exon            1..196
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1648
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /note="UPF0632 protein A; TRAB domain-containing protein
                     2B; metalloprotease TIKI2; heart, kidney and
                     adipose-enriched transmembrane protein"
                     /codon_start=1
                     /product="metalloprotease TIKI2 precursor"
                     /protein_id="NP_001079018.1"
                     /db_xref="CCDS:CCDS38843.1"
                     /db_xref="GeneID:666048"
                     /db_xref="MGI:MGI:3650152"
                     /translation="MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWT
                     IRRHPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTHVYFELDLTDPYTISALASCQL
                     LPHGENLQDVLPRELYWRLKRHLDYVKLMIPSWMTPAQRGKGLYADYLFNAIAGNWER
                     KRPVWVMLMVNSLTETDVRSRGVPVLDLYLAQQAEKMKKSTGAVERVEEQCHPLNGLN
                     FSQVLFALNQTLLQHESVRAGSLQAPYTTEDLIKHYNCGDLNAVIFNHDTSQLPNFIN
                     TTLPPHEQVTAQEIDSYFRQELIYKRNERMGKRVMALLQENQDKICFFAFGAGHFLGN
                     NTVIDVLRQAGLEVDHTPAGQAIHGPAAVGSPAPPPEITSPASPAPATPAAAVPEATS
                     ATPTTPPEEEDPVLSPHLLLPDSLSQLEEFGRQKWRKRLNKHQRPRQFNDLWVRIEDS
                     TTISPPPLPLQPTPSSETTKPFVKSSHQLQQQDAVGPTSSSAPTLGLLHAITASIVAP
                     FLLHSLGPS"
     exon            197..757
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /inference="alignment:Splign:2.1.0"
     exon            758..904
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1079
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1170
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1443
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..6617
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6596..6601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /note="hexamer: ATTAAA"
     polyA_site      6617
                     /gene="Trabd2b"
                     /gene_synonym="Gm12824; Hkat"
                     /note="major polyA site"
ORIGIN      
        1 tccagaagat cctcggtgcc cagctggggg ctccccgccc tgctgagggg gcgctgccca
       61 agagggaccc ccgcgtcccg cgggccccgg caggatgcac gccgccctgg cggggccgct
      121 gctagccgcc ctccttgcca ccgcccgcgc ccgtccgcaa ccccccgacg gaggacagtg
      181 ccggccgcct ggatcgcaga gggacctgaa ctccttcctg tggactattc ggcgccatcc
      241 tccagcctac ttgtttggca ccatccacgt tccctatacc cgagtctggg acttcatccc
      301 tgataattcc aaagcagcct tccaggccag cactcacgtc tactttgagt tggatctgac
      361 agatccctat accatctcag ccctggccag ttgccagctg ctgccccatg gggagaacct
      421 gcaggacgtg ctgccaaggg agctctactg gcgcctgaag cgccacctgg actatgtgaa
      481 gctgatgatc ccctcctgga tgacgccagc acagcgcggc aaggggctgt atgctgacta
      541 cctgttcaat gccattgctg gtaactggga gcgcaagagg cccgtgtggg tgatgctcat
      601 ggtgaactcc ctcacggaga cagatgtgcg ctcccgaggt gtgcctgtgc tggacctcta
      661 cctggcccag caggctgaga agatgaagaa gagcacaggg gctgtggagc gggttgagga
      721 gcagtgccat cctctcaatg ggctcaactt ctcccaggtg ttgtttgccc tgaaccagac
      781 tctgctgcag cacgaaagtg tgcgggctgg gagcctgcag gcaccctaca ccacagagga
      841 cctcatcaaa cactacaact gcggggacct caatgctgtc atcttcaacc atgacacatc
      901 ccagctaccc aacttcatca acaccaccct cccacctcat gagcaggtga cagcccagga
      961 aatcgacagc tacttccggc aggagctcat ctacaagagg aatgagcgca tgggaaagag
     1021 ggtcatggcg ctgctgcagg aaaaccagga caagatctgc ttctttgcct tcggagcagg
     1081 tcactttctg gggaacaaca ctgtcatcga tgtcctaaga caggcagggc tggaggtgga
     1141 ccacacacct gctgggcaag ccatccacgg tcctgctgct gttggaagcc cagctccccc
     1201 tcctgagatc acctctcctg ccagcccagc tccagcaacc ccagccgctg cagtcccaga
     1261 agcaacctca gcgaccccca ccacccctcc tgaggaggaa gacccagtcc tgtccccaca
     1321 cctcttgctc cccgacagcc taagccagct agaggagttc ggaaggcaga agtggcgaaa
     1381 gagactaaat aaacatcagc ggccaaggca gttcaatgac ctctgggtcc gaatcgagga
     1441 cagcactacg atctcgccac ctccgctgcc cctgcagcct acccccagct ccgaaaccac
     1501 caagcccttt gtcaagtcct cacaccaact ccagcagcag gacgctgtgg ggcctaccag
     1561 cagctcagcg cctacactgg gcctcctcca tgccatcact gcctccattg tagccccctt
     1621 cctactacac agccttgggc cttcctgacc tcgaccaccc ttgcagagaa gccagagaaa
     1681 ccacaggagt ctgtggccgt gtccaccatc tgacaccacc tcagatggtg ctaacaccct
     1741 caaggcagtt cacacaggac agggacctta gagcactaga gctttattct actccagtta
     1801 catcttcttt tttgtagaag gtcttaattt cccatagtgc tatggggctc ttttgtaaaa
     1861 tatgtgtcca tattaaaaga gaaaatgtat ttattctatt gataaaacta tttttatgta
     1921 gcttatgtta tagtccctga attagtccca aacaccaacc cagggaagga acccaggttc
     1981 ccatgacctc tgtgacctgt gtagacagtg gctttgaatt ggccccaagc ctcctactca
     2041 ggcttgactt ctcccactgt aggcacctct gagggcaggc agaaaggcag ccccagcttt
     2101 tgtgaggcta aatttcagag ccaggggcat agtggccagc catcctccct aaccctgtcc
     2161 aggccccaga agggcaattt aaggagaaat gaagaaagaa agaaagaaag aaagaaagaa
     2221 agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa gaatgctgct attttgaagt
     2281 cccacgtgtc tgtggactgg cccgccaggg ttcctggtgg gtttttccat taaagtagga
     2341 gactggtgct gtgggagatg agcccagtcc tgtggtcaga tggctacact gagatccaaa
     2401 aagtgaatgg ggttacccaa ggtcacaaag caagtgggtg attgatgttc cagtgtcact
     2461 gatccagctt ccattcaaga ggggctggta aacctggtta gggctgggaa gtgagctggg
     2521 cagaggacag gaatgggcag gggtggacac agaacagtct taggggcgat ggagtgcagg
     2581 agcctccagt tgtggtgatg accgtggtag agacaaccac ctgccaaaag cctgctgtgc
     2641 gatgtgatga cctccaattc aatgataagg ctgaaccccc aaaagaggga aaagatccac
     2701 ccaagatgta tgccctgccc agccctggat tagggtgata caaaaaatac ccttgctcct
     2761 caaactgtgt tctactcctg ctctttcggt caggagaaga accaggggag gcagatttcc
     2821 caaactggaa ccctcccaat cttcccatgg cagacaagga ggccatttct ccagctcccc
     2881 ctgctggctt ctgtagccag gagcctctag cagccagcat ggacaggcag ggagttgagg
     2941 cacagaagcc ttctgtcctc cggggtctga ctgagaacac agtgggccaa agctggactt
     3001 gtggctcatt atttaaggag tcctagatcc tgagagcaga aaagagccct cacctggcaa
     3061 caagagtaag aatgacgcta aggtccagaa agaggaaagg cctctccaaa gtggcacagc
     3121 tgagacaggc atgttgactc cggtcccgtt ctctcacctc actgcacatg ggtttccctg
     3181 gcaggcttga tggcgcctgg ttggctacag caccgccatg cttaggttgg cagacatctc
     3241 ccttctgaga tggcaggact ctgggcaact cattgcatag tcaggggtcc cacaggcatc
     3301 ctggcaggca gcagaattct ttccagctct gccccagtgg acaggtttaa gcctgagacc
     3361 tggcaagatt ctggaactct gcttcacagg gtcccgccag tcccatggac accacactgt
     3421 aaactgaact tgacctcaac caggactgga gtcagtttat ccttggcaaa aaaatgtgac
     3481 ttcctattgc tgagcgggaa ggggcttagc tgacttttaa agcaggctca gaagttagac
     3541 atcaaacgga tcgtgcagag cgctattggg atgagataag tgtaaaggaa ttggaaacac
     3601 acaggccaga ttcccctgtt tggggcagag tatggcatga gatgtatgga gatcaagctc
     3661 gaggttaatt aaagatgaag catttgggga aagagtccaa gcacctgacc gtgtgcccag
     3721 acctgtgcca ggcgtggggc caagatggtg aattaataca gcatgtaatc actgtgcaag
     3781 cacagtgcca gggttacaca catgggctga attgtaccca cccttctggg cccagaagag
     3841 ttcaccatca acatgggata agtggagcta tcctgggcta ctttcccagc cccaacatca
     3901 ggccacttgt ctttccagac cccttcttaa ggaagactga aagggaagga agtgtttcaa
     3961 attctcttcc ccaccacatt ttaaggtttt taaagatgac gtgccctgct tagtagcaca
     4021 tgtctgtaag gactgtactt gggagtctga ggcaagagca tcaacaagca tcataagagg
     4081 tccagactgg gatgcacagt gagttctaaa acagcttgaa gtacatgacc agaccctata
     4141 tgaaaaatga agggaaggga agggaggagg ggaggtaagg aaggaagaag aaagggaggg
     4201 agggagggag ggagggatgg ggcaggaggg agggaggcag gagggaggga aggagggcag
     4261 agtagtccaa cagatcaaca aaattcaagg taggtgtgga cttagaaaga aagaaccatt
     4321 gttcagacac ctagggccaa agtttcctgg cccctggaga gctctaccaa gccagggttt
     4381 aagcaagtag caaactcaac ttgctggcct acatcctagg agaccttgca cacaaaacag
     4441 aatgtatggc taggccactt aaacttccct tcctgctctg gaaacagacc agtagtccat
     4501 cagcagtttc tcagacttca tgttcttgct ggctagactc ataaacacag agcccagttc
     4561 ccttgagatt ccaatgagta tttttaggac tttcgtttta actttgagtc aaacagaaag
     4621 atggaaggcc tgtggcctag cagattaagt gaccagcact tagcggggaa tcaaagaggt
     4681 gtccatgcca atctcggagg tcaaagacac ggtctgcaat gtctggactg agggtgactc
     4741 acaacgttca ccttatactg aaagacccaa gcacatcctt ctcacatgga gtgtggtcac
     4801 cggcaatgtc ctagtcttgt ccagtccaga cttgggcaag cctggaagct caggtacttt
     4861 gtcccaccag tgcccctatc acaacagatc ccagagaaaa gaactgctgg ttgtagtttt
     4921 aatgacaccc taagtggcaa aaaaaaaaaa aaaaaaaaaa gaccaccaga cttgtggtag
     4981 taataaccat gagataaaca ccaggccctc tacttggtat ttaagaccct ccatgacccc
     5041 actcagctga ccttgctggt catgtctcat ccctcctacc ccagcctgac agatggaatc
     5101 atatctgtta tttctagaat agacatggtg ctttatacat gttactcccc aggggaagct
     5161 ctcttctctc cccccagcta tttatcccat gaggataacc ctagcggctt gctccaggat
     5221 gtcccccacg gaaccctttg tacattacta gtcccacaca cacattccag agttagggct
     5281 ctttagatat gaatttgctc cctgttggaa atacaagcaa atcaatgagg tgggtcctgt
     5341 gtctgttttt ttttttatga cctttgacac aaaagtgata gatgaagatg tgctgagagg
     5401 gacaagggag gaaaggaagc aggacagagg aagaagaggt tggagctagg aaaggcaaaa
     5461 gacagccttg gctttctatt tgagacaact tccacatccc tagctgctaa aggatagcat
     5521 ctgagagtag agttctccag gtggaggtag acgcatagta tgcaaggccc cagggtccac
     5581 tggctgaaga tgtggcaacc agctggaaat cttggcaaag gattggtgta aatgccatga
     5641 aagtgcccct ggctttgtaa ggtttgggtt ctttacacat tgttagtttt ccaaaaattc
     5701 atctaagcag ccaaaaatat caccctggct ggccatctaa gcctgtagat tcagtactca
     5761 gctaaagcct ctctacaccc ctcccccatt cttacacagc ccagccaggc ttgccaagaa
     5821 ctggcagaaa ctcttgctgc ccttgggcag gggacctctt ggggaggaga tgcctggatt
     5881 gaaaccctgc ccatgactcc agctcagagc cacttcttag tcagtgcccg accttgagga
     5941 agggaaatca gagcttataa gggctcttgg accctatctg gccctttcca ggcaatgtca
     6001 gctcctcacc actgtctcca aaggcagact ttgcctatag agaggccttt gcttgctgct
     6061 tgggaagcca cagaagctct ttcagcttct gtttcttcat ggaccatagg gagagtttcc
     6121 tggggccagg aggataattc tgtgtatcat attgacacca caggccacca tgatgggagc
     6181 atgtgacaga taagaaaaca taacttaaag gccccctcca tcctaaaacc tgccttgggg
     6241 aatgtgattt ttaataggat ccaagtctaa gatgcctgga gtgagaaacc aaggactctt
     6301 agactggagt ctctctggtt gcaaggctga ggtgggtgtg gctctcagct aaagaagggg
     6361 gaagttgacc ttagcttttg cccagttctg tctcagattt gttggctacc ccactgtgcc
     6421 tcactgtacc aaactggcct cagctctcac catgtttgtg gtgttcttta tcacctcttc
     6481 cttcacccct gccccatgaa ttgtcatgaa gagttcttta agagtataat agaagacaaa
     6541 gaaagatgct attaatgtta ttttgccaaa aatatttttg tagcataata tattaattaa
     6601 agatgttatg aacttga
//
