LOCUS       NM_009186               3416 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transformer 2 beta (Tra2b), transcript variant 1,
            mRNA.
ACCESSION   NM_009186 NM_177199
VERSION     NM_009186.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3416)
  AUTHORS   Karginov,T.A., Menoret,A., Leclair,N.K., Harrison,A.G.,
            Chandiran,K., Suarez-Ramirez,J.E., Yurieva,M., Karlinsey,K.,
            Wang,P., O'Neill,R.J., Murphy,P.A., Adler,A.J., Cauley,L.S.,
            Anczukow,O., Zhou,B. and Vella,A.T.
  TITLE     Autoregulated splicing of TRA2beta programs T cell fate in response
            to antigen-receptor stimulation
  JOURNAL   Science 385 (6714), eadj1979 (2024)
   PUBMED   39265028
  REMARK    GeneRIF: Autoregulated splicing of TRA2beta programs T cell fate in
            response to antigen-receptor stimulation.
REFERENCE   2  (bases 1 to 3416)
  AUTHORS   Lin,L., Zhao,J., Kubota,N., Li,Z., Lam,Y.L., Nguyen,L.P., Yang,L.,
            Pokharel,S.P., Blue,S.M., Yee,B.A., Chen,R., Yeo,G.W., Chen,C.W.,
            Chen,L. and Zheng,S.
  TITLE     Epistatic interactions between NMD and TRP53 control progenitor
            cell maintenance and brain size
  JOURNAL   Neuron 112 (13), 2157-2176 (2024)
   PUBMED   38697111
REFERENCE   3  (bases 1 to 3416)
  AUTHORS   Li,M.J., Xiong,D., Wang,S. and Huang,H.
  TITLE     Tra2beta Enhances Cell Proliferation by Inducing the Expression of
            Transcription Factor SP1 in Cervical Cancer
  JOURNAL   Biomed Environ Sci 36 (2), 146-159 (2023)
   PUBMED   36861193
  REMARK    GeneRIF: Tra2beta Enhances Cell Proliferation by Inducing the
            Expression of Transcription Factor SP1 in Cervical Cancer.
REFERENCE   4  (bases 1 to 3416)
  AUTHORS   Gao,F., Ma,J., Yu,Y.Q., Gao,X.F., Bai,Y., Sun,Y., Liu,J., Liu,X.,
            Barry,D.M., Wilhelm,S., Piccinni-Ash,T., Wang,N., Liu,D.,
            Ross,R.A., Hao,Y., Huang,X., Jia,J.J., Yang,Q., Zheng,H., van
            Nispen,J., Chen,J., Li,H., Zhang,J., Li,Y.Q. and Chen,Z.F.
  TITLE     A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating
            contagious itch behavior
  JOURNAL   Cell Rep 41 (1), 111444 (2022)
   PUBMED   36198265
REFERENCE   5  (bases 1 to 3416)
  AUTHORS   Elliott,D.J., Best,A., Dalgliesh,C., Ehrmann,I. and Grellscheid,S.
  TITLE     How does Tra2beta protein regulate tissue-specific RNA splicing?
  JOURNAL   Biochem Soc Trans 40 (4), 784-788 (2012)
   PUBMED   22817734
  REMARK    Review article
REFERENCE   6  (bases 1 to 3416)
  AUTHORS   Mende,Y., Jakubik,M., Riessland,M., Schoenen,F., Rossbach,K.,
            Kleinridders,A., Kohler,C., Buch,T. and Wirth,B.
  TITLE     Deficiency of the splicing factor Sfrs10 results in early embryonic
            lethality in mice and has no impact on full-length SMN/Smn splicing
  JOURNAL   Hum Mol Genet 19 (11), 2154-2167 (2010)
   PUBMED   20190275
REFERENCE   7  (bases 1 to 3416)
  AUTHORS   Shukla,S. and Fisher,S.A.
  TITLE     Tra2beta as a novel mediator of vascular smooth muscle
            diversification
  JOURNAL   Circ Res 103 (5), 485-492 (2008)
   PUBMED   18669920
REFERENCE   8  (bases 1 to 3416)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   9  (bases 1 to 3416)
  AUTHORS   Segade,F., Hurle,B., Claudio,E., Ramos,S. and Lazo,P.S.
  TITLE     Molecular cloning of a mouse homologue for the Drosophila splicing
            regulator Tra2
  JOURNAL   FEBS Lett 387 (2-3), 152-156 (1996)
   PUBMED   8674539
REFERENCE   10 (bases 1 to 3416)
  AUTHORS   Segade,F., Claudio,E., Wrobel,K., Ramos,S. and Lazo,P.S.
  TITLE     Isolation of nine gene sequences induced by silica in murine
            macrophages
  JOURNAL   J Immunol 154 (5), 2384-2392 (1995)
   PUBMED   7868905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154605.2, AK049573.1, CT009567.9 and AI847347.1.
            
            On Aug 27, 2016 this sequence version replaced NM_009186.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049573.1, BC061177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC154605.2         56222-56297         c
            77-1710             AK049573.1         2-1635
            1711-3399           CT009567.9         198294-199982       c
            3400-3416           AI847347.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..3416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.18 cM"
     gene            1..3416
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /note="transformer 2 beta"
                     /db_xref="GeneID:20462"
                     /db_xref="MGI:MGI:106016"
     exon            1..265
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1096
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     splicing factor, arginine/serine-rich 10 (transformer 2
                     homolog, Drosophila); transformer-2 protein homolog beta;
                     silica-induced gene 41 protein; transformer-2 protein
                     homolog B; transformer 2 beta homolog"
                     /codon_start=1
                     /product="transformer-2 protein homolog beta isoform 1"
                     /protein_id="NP_033212.1"
                     /db_xref="CCDS:CCDS37297.1"
                     /db_xref="GeneID:20462"
                     /db_xref="MGI:MGI:106016"
                     /translation="MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSR
                     RSRSKSRSRSESRSRSRRSSRRHYTRSRSRSRSHRRSRSRSYSRDYRRRHSHSHSPMS
                     TRRRHVGNRANPDPNCCLGVFGLSLYTTERDLREVFSKYGPIADVSIVYDQQSRRSRG
                     FAFVYFENVDDAKEAKERANGMELDGRRIRVDFSITKRPHTPTPGIYMGRPTYGSSRR
                     RDYYDRGYDRGYDDRDYYSRSYRGGGGGGGGWRAAQDRDQIYRRRSPSPYYSRGGYRS
                     RSRSRSYSPRRY"
     exon            266..399
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            400..562
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            563..751
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            752..867
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            868..951
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1011
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1085
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..3400
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /note="hexamer: AAGAAA"
     polyA_site      2089
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /note="major polyA site"
     regulatory      2179..2184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /note="hexamer: ATTAAA"
     regulatory      2196..2201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /note="hexamer: AATATA"
     polyA_site      2201
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
                     /note="major polyA site"
     polyA_site      2221
                     /gene="Tra2b"
                     /gene_synonym="5730405G21Rik; D16Ertd266e; Sfrs10; SIG-41;
                     Silg41; TRA2beta"
ORIGIN      
        1 gggaggggcc aggaaagcgc gccttcgggg gagtgggtgg gaccaggtta aagagcgtgg
       61 cgtcacatcc ggcagtgtta gaccggtgcg gaggtggtgc ggagcgtgtc ggcttcgagc
      121 tcctcgcaaa agtgtggcgt cgcgctaggc tgcggcggag cctctgtaag gaaggcggga
      181 gcttgacagc ttcaggaaag gcccgtagcg gtgacagcga cccggagtca tgagcgacag
      241 cggcgagcag aactacggcg agcgggaatc ccgttctgct tcccgaagtg gaagtgctca
      301 cggatcgggg aaatctgcac ggcatacacc tgcaaggtct cgctccaagg aagactcaag
      361 gcgttctaga tcaaagtcca ggtccaggtc tgaatctagg tctagatcca gaagaagttc
      421 tagaaggcat tatacaaggt cacgatcacg atctcgctcg catagacgat cccggagcag
      481 gtcttacagc cgagattatc gcaggcgcca cagccacagc cattctccca tgtctactcg
      541 aaggcgtcat gttgggaacc gggcaaatcc tgaccccaac tgttgtcttg gcgtgtttgg
      601 gttgagctta tacaccacag aaagagacct aagagaagtg ttctctaaat atggccccat
      661 tgctgatgtg tctattgtat atgaccagca atctagacgt tcaagaggat ttgcctttgt
      721 atattttgaa aatgtagacg atgccaagga agctaaagaa cgtgccaatg gaatggagct
      781 tgatgggcgt cgaattagag tcgatttctc tataacaaaa aggccccata ccccaacacc
      841 aggaatttat atggggagac ccacttatgg cagttctcgc cgccgagact attatgacag
      901 agggtacgat cggggttatg atgaccggga ctattacagc agatcataca gaggaggagg
      961 tggtggagga ggtggatgga gagcagctca agacagggat cagatttaca gaagacggtc
     1021 accttctcct tactacagtc gtggaggata caggtcacgt tctcgatcac gatcctactc
     1081 acctcgtcgc tactaaagca tgaagttgaa gactttctga aacctgccat agagctggga
     1141 tattgtttgt ggacaatatt ttctattgtc tcctgtttaa aaagtgaaca gtgcctagtg
     1201 aagttaggtg acttttacac cttttatgat gactactttt ggtggagttg aaatgctgtt
     1261 ttcattctgc atttgtgtag ttcggtgctt tgttcaaagt taagtgtttt cagaaaagta
     1321 tgttttgcat gtattttttt acagtccaaa ttttgactgc tgagaagttt ctattgtaaa
     1381 aaacttcatt taaaaggttt ttctactgaa tccagggtat tctgaagatc gaagcctgtg
     1441 tgtaaaatgc taccagatgg caaaaagcaa caataaacaa gtttgatttt tacttttctt
     1501 tctaaatatc aatgcttaac cagaaccatt cttaagttat cagtaaaaaa gtaaaaagtt
     1561 aaataaatgt ctttcaggag tccatgaaac ttgccatatt caatatacct gcgattaagt
     1621 gttaaaaaat acgctgtaac tctgtactgc tagtattaga acaaaactct tcccatacag
     1681 caaatgctta atgcttacat taatgtggat gtgtcggcct ttatgtaatc tgtattatat
     1741 atagcaggga ataagagcta cagatacatg cctttaaagg gctgtttctt aaggctgtta
     1801 caaggagata atggtatttc aactaattat cagcaagtga caatacattc caccacagat
     1861 ggactcttgt tcttctagcg tttagactat atgaaaatac tgggtgcttc aaagtatgga
     1921 aggagcgaag ggatcatcaa accttgtcat ggatgaagac tgcctgttca ttttttaaat
     1981 atgattttca ggtcctttgc ttaccaaagg aggcccaatt cactcaaatg ttttgagaac
     2041 tgtttaaata aaggcaagaa aaattgctga tgcaacttgt ttttacaaag aagtgttggt
     2101 tttcttttta actgttgtaa ttaaagtcct gtagtttatt tagtgactga tgcaatattg
     2161 ttcttgcttc aagataacat taaatctatt tctcaaatat attggccaag tagaactgga
     2221 atgaatgttt ctctttggtg cgaggttgta ttaaataacc tcccaacatg tctgggtatt
     2281 ttgcaaagca tgtttttagt acaaatctgc ttctgtttaa ggctgttaaa atgtaggact
     2341 tactaagggg cttttagcac tttgttgtta cttagtatat acaggtgttc cataagtgct
     2401 acatattatt atagtatcca cttgcagagg cagtttggct tagattaatt tgatatctaa
     2461 aagcttcaag aatttcagaa ctacagcccc agcactgagc ttgagtttat ggtactaggg
     2521 cagggaacac agtgctacct agaacagtct tgttaaataa aacttgcatt gtactgtggg
     2581 aatatctgga aatccccctt ataaatctca ttgaactaat gaggggctct agtttggggg
     2641 cggcaggggg gttagaggga atagtagggc taagtgtggg ttttccggac tgccattgga
     2701 gctaaggatc acaagtgtct ttctggacag ccaaacttac agtaaatgta tcccagaaaa
     2761 agagcacact gatgtttttg ataactaggt ttcatttaga ccatttttgt gaggtagctt
     2821 ttcacttcca ctgtatggtt tcttgttacc tccaggatgc attaggagga aaaaccattg
     2881 ttgcctataa tgaatgtgct tgggcatcag gttagtttta aatgtaaaat aacagtttga
     2941 attagatttc caattgggca ttgatgagat actgttgttg aaattctaag tcacagttta
     3001 aatctaggtt ttcttagcta cacaataaag ggtagtgaat gccatgaact tgtgcatgtt
     3061 tacagatagg agtctgcaag cctcagaagc cctggatctc ctgaactgag ctttgtagat
     3121 tttgttaacc accatgtgaa gtttgaaagt caaacctgag tctttcaaga gcaacaagtt
     3181 ctcaacaagg tatagaatga gagaagagat cacacctgtg tcatgaacaa agcctgctgc
     3241 tcattctgta aatatgattt tcaggtcctt tgcttaccaa ggaggcccag ctcactctta
     3301 atgttttgag aactctttaa acattctcag gtccaacaaa actaataata aaaatgtaga
     3361 tgcagggcat gcaatgaata aaatactaca gttttaagta aaaaaaaaaa aaaaaa
//
