LOCUS       NM_199257               2547 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus transmembrane phosphatase with tensin homology (Tpte),
            mRNA.
ACCESSION   NM_199257 XM_001052108 XM_001052109 XM_001052115 XM_001052116
VERSION     NM_199257.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2547)
  AUTHORS   Kawai,T., Morioka,S., Miyata,H., Andriani,R.T., Akter,S., Toma,G.,
            Nakagawa,T., Oyama,Y., Iida-Norita,R., Sasaki,J., Watanabe,M.,
            Sakimura,K., Ikawa,M., Sasaki,T. and Okamura,Y.
  TITLE     The significance of electrical signals in maturing spermatozoa for
            phosphoinositide regulation through voltage-sensing phosphatase
  JOURNAL   Nat Commun 15 (1), 7289 (2024)
   PUBMED   39181879
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2547)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2547)
  AUTHORS   Kawai,T., Miyata,H., Nakanishi,H., Sakata,S., Morioka,S.,
            Sasaki,J., Watanabe,M., Sakimura,K., Fujimoto,T., Sasaki,T.,
            Ikawa,M. and Okamura,Y.
  TITLE     Polarized PtdIns(4,5)P2 distribution mediated by a voltage-sensing
            phosphatase (VSP) regulates sperm motility
  JOURNAL   Proc Natl Acad Sci U S A 116 (51), 26020-26028 (2019)
   PUBMED   31776261
REFERENCE   4  (bases 1 to 2547)
  AUTHORS   Lu,S., Ma,S., Wang,Y., Huang,T., Zhu,Z. and Zhao,G.
  TITLE     Mus musculus-microRNA-449a ameliorates neuropathic pain by
            decreasing the level of KCNMA1 and TRPA1, and increasing the level
            of TPTE
  JOURNAL   Mol Med Rep 16 (1), 353-360 (2017)
   PUBMED   28498403
  REMARK    GeneRIF: mmumiR449a may ameliorate neuropathic pain by decreasing
            the activity of the channel proteins TRPA1 and KCNMA1 and
            increasing the levels of TPTE.
REFERENCE   5  (bases 1 to 2547)
  AUTHORS   Mishra,R.R., Chaudhary,J.K., Bajaj,G.D. and Rath,P.C.
  TITLE     A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in
            human and mouse tissues, strongly inhibits cell growth in HeLa
            cells
  JOURNAL   PLoS One 6 (12), e28433 (2011)
   PUBMED   22164291
  REMARK    GeneRIF: the TPIP splice-variant (TPIP-C2) mRNA is expressed in
            human and mouse tissues and strongly inhibits cell growth in HeLa
            cells
REFERENCE   6  (bases 1 to 2547)
  AUTHORS   Tapparel,C., Reymond,A., Girardet,C., Guillou,L., Lyle,R.,
            Lamon,C., Hutter,P. and Antonarakis,S.E.
  TITLE     The TPTE gene family: cellular expression, subcellular localization
            and alternative splicing
  JOURNAL   Gene 323, 189-199 (2003)
   PUBMED   14659893
REFERENCE   7  (bases 1 to 2547)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   8  (bases 1 to 2547)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   9  (bases 1 to 2547)
  AUTHORS   Guipponi,M., Tapparel,C., Jousson,O., Scamuffa,N., Mas,C.,
            Rossier,C., Hutter,P., Meda,P., Lyle,R., Reymond,A. and
            Antonarakis,S.E.
  TITLE     The murine orthologue of the Golgi-localized TPTE protein provides
            clues to the evolutionary history of the human TPTE gene family
  JOURNAL   Hum Genet 109 (6), 569-575 (2001)
   PUBMED   11810268
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121933.3 and AC140326.3.
            
            On Mar 29, 2023 this sequence version replaced NM_199257.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ311311.1, BC107329.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AC121933.3         41356-41695         c
            341-436             AC121933.3         40162-40257         c
            437-490             AC121933.3         27917-27970         c
            491-547             AC121933.3         22278-22334         c
            548-592             AC121933.3         21123-21167         c
            593-649             AC121933.3         19242-19298         c
            650-700             AC121933.3         18150-18200         c
            701-748             AC121933.3         13809-13856         c
            749-802             AC121933.3         10032-10085         c
            803-853             AC121933.3         8807-8857           c
            854-904             AC121933.3         6759-6809           c
            905-970             AC121933.3         4215-4280           c
            971-1021            AC140326.3         202963-203013       c
            1022-1183           AC140326.3         200704-200865       c
            1184-1303           AC140326.3         195225-195344       c
            1304-1403           AC140326.3         193051-193150       c
            1404-1467           AC140326.3         192833-192896       c
            1468-1532           AC140326.3         191950-192014       c
            1533-1593           AC140326.3         183464-183524       c
            1594-1675           AC140326.3         182609-182690       c
            1676-1764           AC140326.3         182400-182488       c
            1765-1826           AC140326.3         179122-179183       c
            1827-1907           AC140326.3         176986-177066       c
            1908-2013           AC140326.3         172938-173043       c
            2014-2105           AC140326.3         169023-169114       c
            2106-2198           AC140326.3         162503-162595       c
            2199-2269           AC140326.3         158928-158998       c
            2270-2547           AC140326.3         157093-157370       c
FEATURES             Location/Qualifiers
     source          1..2547
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.2 cM"
     gene            1..2547
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /note="transmembrane phosphatase with tensin homology"
                     /db_xref="GeneID:234129"
                     /db_xref="MGI:MGI:2446460"
     exon            1..340
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            341..436
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             378..2372
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /EC_number="3.1.3.48"
                     /codon_start=1
                     /product="transmembrane phosphatase with tensin homology"
                     /protein_id="NP_954866.2"
                     /db_xref="CCDS:CCDS22173.1"
                     /db_xref="GeneID:234129"
                     /db_xref="MGI:MGI:2446460"
                     /translation="MYGEKKSHLYLWMEHYGYDMPANIYKMYSQPSRKTDDANKKVSV
                     SASRTIKLNGSTGYDTNEQITLITNGSSLSYPDEIKSASYADPISTKAYTNDSSVYDP
                     GGASSSTTLYELNSLSEVSKEIITQGESALLRDKEATSELKIPSTLQTQTSMSTNTLS
                     LSDLSSDYQEEQMNKCKLNQMSKLYDDDERTDIQKSYWNVVKKFVRILVSSVAFRIFG
                     IFLVILDVFLVVVDLNVSEKKIYIPLDYRSISLAIALFFLVDVLLRVSVEGRRRYFSD
                     VLNTLDAVVIGVTVVVAVIYALYDKHFLRDIPRLAVLLRPLRLLILIRILQLAHQKRQ
                     LERLTRKLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLD
                     TKHPNHYQVYNLCSERAYDPKHFHYRVRRIMIDDHNVPTLEEMLLFSKEVNNWMAQDP
                     ENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKESLYFFGERRTDKSNSSKFQGIETP
                     SQNRYVKYFEKLKINYQLTLPPKKVLVIKRLVVYSIHGVGKGDGSDLEVQIIMWQETV
                     FSFCNSRNCMIFHDPETDRAIINVFHCPALYDDVKVKFLSPNLPKYYDDCPFFFWFHT
                     SFIKNNRLYLPRNELDNTHKPKTWKIYGEKFAVEVDFGEN"
     exon            437..490
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            491..547
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            548..592
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            593..649
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            650..700
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            701..748
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            749..802
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            803..853
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            854..904
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            905..970
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1021
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1183
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1303
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1403
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1467
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1532
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1593
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1675
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1764
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1826
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1907
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2013
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2105
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2198
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..2269
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2547
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /note="hexamer: ATTAAA"
     polyA_site      2547
                     /gene="Tpte"
                     /gene_synonym="Pten2; Vsp"
                     /note="major polyA site"
ORIGIN      
        1 cgaccctgga catgggaact tttagatcag catatgtggg actacccttg tttctggcta
       61 tgaactgact gatttcgttg acttaccaag cttaatttgg gggaaaatta aaaagaaaag
      121 agaatgaaaa agaggaaaag ctgttattct gaagggcagc cggagaaaag actggcagca
      181 ggaactggag tggactcagc tcccccttcg ggtcgagggg tagctaagct gtaagactct
      241 aacttgtggg tccctctgtc cggccctgct gcagggtctt actggggctt tagcgacttc
      301 tgagcccaag cagcccagaa aaaaaaagca gtgccttcag attaattgta agttaagttg
      361 aatcacaaga caataccatg tatggagaaa agaagagcca tttgtatctc tggatggaac
      421 actatgggta tgacatgcct gcaaatattt acaagatgta ttctcagccc tccagaaaaa
      481 cggatgatgc aaataaaaag gtgtcagtga gtgcttcaag gaccattaaa ctaaatggca
      541 gcactggcta cgacacaaat gaacagataa cactaatcac taacgggagc agtttgtcat
      601 atccagatga aataaaatca gcaagttatg cggaccccat cagtacaaaa gcatatacaa
      661 atgattcgtc agtatacgac cctgggggag cttcgagcag cacaaccctg tatgaactga
      721 attccttgag tgaagtatcg aaagaaatca ttacccaggg agaatctgct ttactacgtg
      781 ataaagaagc taccagcgaa ctcaaaatcc caagtacact gcaaacgcag acgtccatgt
      841 ccaccaacac tctctcctta tctgatttat catcagatta ccaggaagag caaatgaaca
      901 aatgcaagtt aaaccagatg tccaagttgt acgacgatga tgaacgtact gatattcaaa
      961 agtcatactg gaatgtggtt aagaaatttg tgcgcatcct tgtgtcctcg gttgccttca
     1021 gaatatttgg aattttcctg gtcattctgg atgtatttct tgtggttgtc gatctaaatg
     1081 tctctgaaaa gaaaatttat attcctttgg actatcgttc catttcttta gcgattgctt
     1141 tatttttcct cgtggatgtt cttcttagag tgtctgtaga agggagacgg cgctatttct
     1201 ctgacgtact gaacacccta gacgctgtgg tcatcggtgt gactgtggtt gtggctgtca
     1261 tttatgcact ttatgacaaa cactttctca gagatatccc aagactggca gttttactgc
     1321 ggcctctacg actgctcatt ctgataagga ttctgcaact ggctcatcaa aagagacaac
     1381 tcgaaaggct gaccaggaag ctggtatcgg gtaacaagcg acgctacaag aaggatggct
     1441 ttgacctaga cctcacttac gtcactgagc gtattattgc catgtcattt ccatcgtctg
     1501 gaagggagtc cttctacaga aatccaatca aggaggttgt gcggttcctg gataccaagc
     1561 acccaaacca ctatcaagtc tacaatctat gcagtgagag agcttatgac cctaagcact
     1621 tccactacag ggtccgcaga atcatgattg atgatcataa tgtccccact cttgaggaaa
     1681 tgttgttgtt ctccaaggaa gtaaataatt ggatggctca agatcctgaa aatgttgtcg
     1741 cgattcactg taagggagga aaaggaagaa ctggaaccat ggtgtgtgcc tgcctcattg
     1801 ccagtgaaat agttttaaat gcaaaggaaa gtctgtactt ttttggagag cggcggacag
     1861 ataaaagcaa cagctcgaag ttccaaggaa tagagacccc ttctcagaat agatatgtga
     1921 aatattttga aaaactgaaa attaactacc aactaactct ccctcccaaa aaagtactcg
     1981 tgataaaaag attggtcgtt tattccattc atggcgttgg aaaaggcgac gggagtgacc
     2041 tggaagtaca aatcataatg tggcaggaga ctgttttttc cttttgtaat tccaggaatt
     2101 gtatgatatt tcatgaccct gaaacagaca gagcaataat caatgtgttc cattgcccgg
     2161 ctctatacga tgatgtgaaa gtgaaatttc tctctccgaa tcttcctaaa tactatgatg
     2221 actgcccctt tttcttttgg tttcatacat cttttattaa aaataacagg ctttatctac
     2281 caagaaacga attggataat acccataaac caaaaacatg gaaaatttat ggtgaaaagt
     2341 ttgcagtaga ggtggatttt ggtgagaact agctgttgag taagtgccgc tccccttctt
     2401 ggatagaatc atgttcttcc agatccatgc tacatagtta tgtcttctaa ccaatgtttt
     2461 tgatggtatg tctgtatttt atatatatgt gtgtgtatat gtatgtacat atgtttctgg
     2521 gaagtatatt aaatgtatac aggaaaa
//
