LOCUS       NP_033455                172 aa            linear   ROD 03-JUN-2025
DEFINITION  translationally-controlled tumor protein isoform 1 [Mus musculus].
ACCESSION   NP_033455
VERSION     NP_033455.1
DBSOURCE    REFSEQ: accession NM_009429.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 172)
  AUTHORS   Morimoto,Y., Tokumitsu,A., Sone,T., Hirota,Y., Tamura,R.,
            Sakamoto,A., Nakajima,K., Toda,M., Kawakami,Y., Okano,H. and
            Ohta,S.
  TITLE     TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and
            Brain Tumor Initiating Cells Regulated by Macrophage Migration
            Inhibitory Factor (MIF)
  JOURNAL   Neurochem Res 47 (9), 2741-2756 (2022)
   PUBMED   35622214
  REMARK    GeneRIF: TPT1 Supports Proliferation of Neural Stem/Progenitor
            Cells and Brain Tumor Initiating Cells Regulated by Macrophage
            Migration Inhibitory Factor (MIF).
REFERENCE   2  (residues 1 to 172)
  AUTHORS   Giri,J., Basu,M., Roy,S., Mishra,T., Jana,K., Chande,A. and Ukil,A.
  TITLE     Translationally Controlled Tumor Protein-Mediated Stabilization of
            Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of
            Infection by Intramacrophage Parasite Leishmania donovani
  JOURNAL   J Immunol 208 (11), 2540-2548 (2022)
   PUBMED   35562118
  REMARK    GeneRIF: Translationally Controlled Tumor Protein-Mediated
            Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for
            Establishment of Infection by Intramacrophage Parasite Leishmania
            donovani.
REFERENCE   3  (residues 1 to 172)
  AUTHORS   Jeon,H.J., Kang,M., Kim,J.S. and Oh,J.S.
  TITLE     TCTP overexpression reverses age-associated telomere attrition by
            upregulating telomerase activity in mouse oocytes
  JOURNAL   J Cell Physiol 237 (1), 833-845 (2022)
   PUBMED   34407217
  REMARK    GeneRIF: TCTP overexpression reverses age-associated telomere
            attrition by upregulating telomerase activity in mouse oocytes.
REFERENCE   4  (residues 1 to 172)
  AUTHORS   Chunhacha,P., Pinkaew,D., Sinthujaroen,P., Bowles,D.E. and
            Fujise,K.
  TITLE     Fortilin inhibits p53, halts cardiomyocyte apoptosis, and protects
            the heart against heart failure
  JOURNAL   Cell Death Discov 7 (1), 310 (2021)
   PUBMED   34689154
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 172)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 172)
  AUTHORS   Gachet,Y., Tournier,S., Lee,M., Lazaris-Karatzas,A., Poulton,T. and
            Bommer,U.A.
  TITLE     The growth-related, translationally controlled protein P23 has
            properties of a tubulin binding protein and associates transiently
            with microtubules during the cell cycle
  JOURNAL   J Cell Sci 112 (Pt 8), 1257-1271 (1999)
   PUBMED   10085260
REFERENCE   7  (residues 1 to 172)
  AUTHORS   Zoidl,G., Blanchard,A.D., Zoidl,C., Dong,Z., Brennan,A.,
            Parmantier,E., Mirsky,R. and Jessen,K.R.
  TITLE     Identification of transcriptionally regulated mRNAs from mouse
            Schwann cell precursors using modified RNA fingerprinting methods
  JOURNAL   J Neurosci Res 49 (1), 32-42 (1997)
   PUBMED   9211987
REFERENCE   8  (residues 1 to 172)
  AUTHORS   Lin,M.Y., Munshi,I.A. and Ouellette,A.J.
  TITLE     The defensin-related murine CRS1C gene: expression in Paneth cells
            and linkage to Defcr, the cryptdin locus
  JOURNAL   Genomics 14 (2), 363-368 (1992)
   PUBMED   1427853
REFERENCE   9  (residues 1 to 172)
  AUTHORS   Bohm,H., Benndorf,R., Gaestel,M., Gross,B., Nurnberg,P., Kraft,R.,
            Otto,A. and Bielka,H.
  TITLE     The growth-related protein P23 of the Ehrlich ascites tumor:
            translational control, cloning and primary structure
  JOURNAL   Biochem Int 19 (2), 277-286 (1989)
   PUBMED   2479380
REFERENCE   10 (residues 1 to 172)
  AUTHORS   Chitpatima,S.T., Makrides,S., Bandyopadhyay,R. and Brawerman,G.
  TITLE     Nucleotide sequence of a major messenger RNA for a 21 kilodalton
            polypeptide that is under translational control in mouse tumor
            cells
  JOURNAL   Nucleic Acids Res 16 (5), 2350 (1988)
   PUBMED   3357792
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140244.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152690.1, AK151894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..172
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 40.29 cM"
     Protein         1..172
                     /product="translationally-controlled tumor protein isoform
                     1"
                     /note="translationally regulated transcript (21 kDa);
                     translationally-controlled tumor protein; fortilin; 21 kDa
                     polypeptide under translational control"
                     /calculated_mol_wt=19331
     Region          1..167
                     /region_name="TCTP"
                     /note="Translationally controlled tumour protein;
                     pfam00838"
                     /db_xref="CDD:459957"
     Site            46
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P63028.1)"
     Site            53
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P13693; propagated from
                     UniProtKB/Swiss-Prot (P63028.1)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PLK1.
                     /evidence=ECO:0000250|UniProtKB:P13693; propagated from
                     UniProtKB/Swiss-Prot (P63028.1)"
     Region          70..172
                     /region_name="Required for reduction of TSC22D1 protein
                     stability. /evidence=ECO:0000250|UniProtKB:P13693"
                     /note="propagated from UniProtKB/Swiss-Prot (P63028.1)"
     CDS             1..172
                     /gene="Tpt1"
                     /gene_synonym="p21; p23; TCTP; Trt"
                     /coded_by="NM_009429.4:99..617"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS36980.1"
                     /db_xref="GeneID:22070"
                     /db_xref="MGI:MGI:104890"
ORIGIN      
        1 miiyrdlish delfsdiyki reiadglcle vegkmvsrte gaiddsligg nasaegpege
       61 gtestvvtgv divmnhhlqe tsftkeaykk yikdymkslk gkleeqkper vkpfmtgaae
      121 qikhilanfn nyqffigenm npdgmvalld yredgvtpfm iffkdgleme kc
//
