LOCUS       NM_009419               1776 bp    mRNA    linear   ROD 21-SEP-2024
DEFINITION  Mus musculus protein-tyrosine sulfotransferase 2 (Tpst2),
            transcript variant 1, mRNA.
ACCESSION   NM_009419
VERSION     NM_009419.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1776)
  AUTHORS   He,J., Yang,X., Yang,K., Xu,H., Chen,C., Wang,J. and Zeng,J.
  TITLE     TPST2-mediated receptor tyrosine sulfation enhances leukocidin
            cytotoxicity and S. aureus infection
  JOURNAL   Front Immunol 14, 1242330 (2023)
   PUBMED   37671153
  REMARK    GeneRIF: TPST2-mediated receptor tyrosine sulfation enhances
            leukocidin cytotoxicity and S. aureus infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1776)
  AUTHORS   Dai,D., Zhu,Z., Han,H., Xu,T., Feng,S., Zhang,W., Ding,F., Zhang,R.
            and Zhu,J.
  TITLE     Enhanced tyrosine sulfation is associated with chronic kidney
            disease-related atherosclerosis
  JOURNAL   BMC Biol 21 (1), 151 (2023)
   PUBMED   37424015
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1776)
  AUTHORS   Kobayashi,K., Yamamoto,K., Kikuyama,S., Tanaami,Y., Machida,T. and
            Kobayashi,T.
  TITLE     Delayed Postnatal Growth and Anterior Pituitary Development in
            Growth-Retarded (grt) Female Mice
  JOURNAL   Zoolog Sci 38 (3), 238-246 (2021)
   PUBMED   34057348
REFERENCE   4  (bases 1 to 1776)
  AUTHORS   Sawada,K., Saito,S., Sugasawa,A., Sato,C., Aoyama,J., Ohara,N.,
            Horiuchi-Hirose,M. and Kobayashi,T.
  TITLE     Regional hypoplasia of somatosensory cortex in growth-retarded mice
            (grt/grt)
  JOURNAL   Congenit Anom (Kyoto) 56 (4), 180-183 (2016)
   PUBMED   26915353
REFERENCE   5  (bases 1 to 1776)
  AUTHORS   Horiuchi-Hirose,M., Saito,S., Sato,C., Aoyama,J., Kobayashi,T. and
            Sawada,K.
  TITLE     Cerebral cortical hypoplasia with abnormal morphology of pyramidal
            neuron in growth-retarded mouse (grt/grt)
  JOURNAL   Acta Neurobiol Exp (Wars) 74 (3), 242-256 (2014)
   PUBMED   25231844
  REMARK    GeneRIF: cerebral abnormalities in grt/grt Tpst2 gene defect mice
            are characterized by cortical hypoplasia at the frontooccipital
            axis with immature pyramidal neurons and insufficient development
            of callosal fibers
REFERENCE   6  (bases 1 to 1776)
  AUTHORS   Ouyang,Y.B. and Moore,K.L.
  TITLE     Molecular cloning and expression of human and mouse tyrosylprotein
            sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue
            in Caenorhabditis elegans
  JOURNAL   J Biol Chem 273 (38), 24770-24774 (1998)
   PUBMED   9733778
REFERENCE   7  (bases 1 to 1776)
  AUTHORS   Tomita,K., Yoshida,T., Morita,J., Atsumi,S. and Totsuka,T.
  TITLE     In vivo responsiveness of thyroid glands to TSH in normal and novel
            'growth-retarded' mice: transient elevation in normal mice and
            impairment in 'growth-retarded' mice
  JOURNAL   J Endocrinol 144 (2), 209-214 (1995)
   PUBMED   7706974
REFERENCE   8  (bases 1 to 1776)
  AUTHORS   Yoshida,T., Yamanaka,K., Atsumi,S., Tsumura,H., Sasaki,R.,
            Tomita,K., Ishikawa,E., Ozawa,H., Watanabe,K. and Totsuka,T.
  TITLE     A novel hypothyroid 'growth-retarded' mouse derived from Snell's
            dwarf mouse
  JOURNAL   J Endocrinol 142 (3), 435-446 (1994)
   PUBMED   7964294
REFERENCE   9  (bases 1 to 1776)
  AUTHORS   Hibasami,H., Yoshida,T., Totsuka,T., Atsumi,S. and Nakashima,K.
  TITLE     Expression of high activity of ornithine decarboxylase and
            occurrence of unusual chromophobic cells in anterior pituitary
            gland of a novel growth-retarded strain of mice, grm/grm
  JOURNAL   Biochim Biophys Acta 1226 (1), 110-114 (1994)
   PUBMED   8155732
REFERENCE   10 (bases 1 to 1776)
  AUTHORS   Baeuerle,P.A. and Huttner,W.B.
  TITLE     Tyrosine sulfation is a trans-Golgi-specific protein modification
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2655-2664 (1987)
   PUBMED   3121635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123795.4 and AC123848.4.
            
            On Jun 12, 2019 this sequence version replaced NM_009419.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 4. Variants 1-4 all encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003721.1, AK149502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC123795.4         7327-7353           c
            28-99               AC123848.4         110800-110871       c
            100-1011            AC123848.4         106294-107205       c
            1012-1210           AC123848.4         104884-105082       c
            1211-1261           AC123848.4         103037-103087       c
            1262-1310           AC123848.4         101481-101529       c
            1311-1776           AC123848.4         99415-99880         c
FEATURES             Location/Qualifiers
     source          1..1776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 54.65 cM"
     gene            1..1776
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /note="protein-tyrosine sulfotransferase 2"
                     /db_xref="GeneID:22022"
                     /db_xref="MGI:MGI:1309516"
     exon            1..27
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /inference="alignment:Splign:2.1.0"
     exon            28..99
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /inference="alignment:Splign:2.1.0"
     exon            100..1011
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1303
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /EC_number="2.8.2.20"
                     /note="TPST-2; tyrosylprotein sulfotransferase 2"
                     /codon_start=1
                     /product="protein-tyrosine sulfotransferase 2"
                     /protein_id="NP_033445.3"
                     /db_xref="GeneID:22022"
                     /db_xref="MGI:MGI:1309516"
                     /translation="MRLSVRKVLLAAGCALALVLAVQLGQQVLECRAVLGGTRNPRRM
                     RPEQEELVMLGADHVEYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRII
                     PRVLAMRQAWTKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPF
                     TLKSSVYLARLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIE
                     VMYAQCMEVGRDKCLPVYYEQLVLHPRRSLKRILDFLGIAWSDTVLHHEDLIGKPGGV
                     SLSKIERSTDQVIKPVNLEALSKWTGHIPRDVVRDMAQIAPMLARLGYDPYANPPNYG
                     NPDPIVINNTHRVLKGDYKTPANLKGYFQVNQNSTSPHLGSS"
     exon            1012..1210
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1261
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1310
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1776
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /note="hexamer: AATAAA"
     polyA_site      1776
                     /gene="Tpst2"
                     /gene_synonym="D5Ucla3; grm; grt; Tango13b"
                     /note="major polyA site"
ORIGIN      
        1 gtctgcgcgg gcgccgattt gggcacggac tgtcagggca ggaagccgtg gtgaccaggc
       61 tcgaggactg gtgcttgaaa atgagggcgc ccaggggaga tgtataccag gtgggcctgc
      121 tgacccgtcc atgaggcggg ccccctggct gggcctgcga ccctggctgg gcatgcgcct
      181 gtcggtgcgt aaggtgctgc tggccgccgg ctgtgctctg gccctggtgc tcgctgtgca
      241 gcttgggcag caagtactgg agtgccgggc ggtgctcggg ggcacacgga acccacggag
      301 gatgcggccg gagcaggagg aactggtgat gctcggcgcc gaccacgtgg agtaccgcta
      361 tggcaaggcc atgccactca tctttgtggg cggcgtgcca cgcagtggca ccacgctcat
      421 gcgcgccatg ttggacgcac acccagaggt gcgctgtggg gaggagacgc gcatcatccc
      481 tcgtgtgctg gccatgcggc aggcctggac caagtctggc cgtgagaagc tgcggctgga
      541 cgaggcaggt gtgacggatg aggtgctgga cgcggccatg caggccttca ttctggaggt
      601 gatcgccaag cacggcgaac cagcccgcgt gctgtgtaac aaggacccct tcacactcaa
      661 gtcatccgtc tacctggcac gcctgttccc caactccaaa ttcctgctaa tggtgcgtga
      721 cggccgggcg tccgtgcact ccatgatcac gcgcaaggtc accatcgcgg gctttgacct
      781 cagcagctac cgagactgcc tcaccaagtg gaacaaggcc atcgaggtga tgtacgcaca
      841 gtgcatggag gtgggcaggg acaagtgcct gcccgtgtac tatgagcagt tggtgctgca
      901 cccccggcgc tcactcaaac gcatcctgga cttcctgggc atcgcctgga gtgacacagt
      961 cctgcaccac gaggacctca ttggcaagcc tgggggcgtc tccttgtcca agatcgagcg
     1021 gtccacggac caggtcatca aaccggtgaa cttggaagct ctctccaagt ggacgggcca
     1081 catccctaga gacgtggtga gggatatggc ccagattgcc cccatgctgg cccggcttgg
     1141 ctatgacccg tatgcgaatc cacccaacta tgggaacccc gaccccattg tcatcaacaa
     1201 cacacaccgg gtcttgaaag gagactataa aacgccagcc aatctgaaag gatattttca
     1261 ggtgaaccag aacagcacct ccccacacct aggaagttcg tgatttccag tccctgcagg
     1321 gctcagacgc ctcagtcctc gacctgcaca cggaagctgg actaacccaa gcacatggct
     1381 tgctctcagt cacgccgggc ggggcctgcc gggttggagc attcatacat ctcggccaaa
     1441 gcgggcttgg aacctccgct ccaggacaac actaaggagg gagagactac ttccgcttca
     1501 gaaacttgga gattttctaa tttttctctc cttgggaact ttttttttaa agaattgaat
     1561 ttgctatctt ccctaacgga cagacccctt ggtgacctca tctcctggga caagaccgga
     1621 gacccgtgcc tctccttgac tggacgttga actcaaagga tctatttaag agtttaatat
     1681 atgggctctc cttgctctag tcctactcag tttcacagag aaaagaaatt aattatttga
     1741 ataaagtaga caggctgctg tctgtgcctt acttca
//
