LOCUS       NM_001130476            2054 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus protein-tyrosine sulfotransferase 1 (Tpst1),
            transcript variant 1, mRNA.
ACCESSION   NM_001130476
VERSION     NM_001130476.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2054)
  AUTHORS   Dai,D., Zhu,Z., Han,H., Xu,T., Feng,S., Zhang,W., Ding,F., Zhang,R.
            and Zhu,J.
  TITLE     Enhanced tyrosine sulfation is associated with chronic kidney
            disease-related atherosclerosis
  JOURNAL   BMC Biol 21 (1), 151 (2023)
   PUBMED   37424015
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2054)
  AUTHORS   Westmuckett,A.D., Siefert,J.C., Tesiram,Y.A., Pinson,D.M. and
            Moore,K.L.
  TITLE     Salivary gland hypofunction in tyrosylprotein sulfotransferase-2
            knockout mice is due to primary hypothyroidism
  JOURNAL   PLoS One 8 (8), e71822 (2013)
   PUBMED   23951251
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2054)
  AUTHORS   Sherry,D.M., Kanan,Y., Hamilton,R., Hoffhines,A., Arbogast,K.L.,
            Fliesler,S.J., Naash,M.I., Moore,K.L. and Al-Ubaidi,M.R.
  TITLE     Differential developmental deficits in retinal function in the
            absence of either protein tyrosine sulfotransferase-1 or -2
  JOURNAL   PLoS One 7 (6), e39702 (2012)
   PUBMED   22745813
  REMARK    GeneRIF: Results demonstrate the importance of protein-tyrosine
            sulfation for proper development of the retina and suggest
            different phenotypes resulting from elimination of TPST-1 or -2 may
            reflect differential expression patterns or levels of the enzymes.
REFERENCE   4  (bases 1 to 2054)
  AUTHORS   Yang,I.V., Jiang,W., Rutledge,H.R., Lackford,B., Warg,L.A., De
            Arras,L., Alper,S., Schwartz,D.A. and Pisetsky,D.S.
  TITLE     Identification of novel innate immune genes by transcriptional
            profiling of macrophages stimulated with TLR ligands
  JOURNAL   Mol Immunol 48 (15-16), 1886-1895 (2011)
   PUBMED   21665277
  REMARK    GeneRIF: two genes identified in this analysis, PLEC1 and TPST1,
            reduced IL-6 production by macrophages
REFERENCE   5  (bases 1 to 2054)
  AUTHORS   Westmuckett,A.D., Thacker,K.M. and Moore,K.L.
  TITLE     Tyrosine sulfation of native mouse Psgl-1 is required for optimal
            leukocyte rolling on P-selectin in vivo
  JOURNAL   PLoS One 6 (5), e20406 (2011)
   PUBMED   21633705
  REMARK    GeneRIF: Data show that Tpst1/Tpst2 DKO leukocytes bound less
            P-selectin than wild type leukocytes despite equivalent surface
            expression of Psgl-1.
REFERENCE   6  (bases 1 to 2054)
  AUTHORS   Goettsch,S., Badea,R.A., Mueller,J.W., Wotzlaw,C., Schoelermann,B.,
            Schulz,L., Rabiller,M., Bayer,P. and Hartmann-Fatu,C.
  TITLE     Human TPST1 transmembrane domain triggers enzyme dimerisation and
            localisation to the Golgi compartment
  JOURNAL   J Mol Biol 361 (3), 436-449 (2006)
   PUBMED   16859706
REFERENCE   7  (bases 1 to 2054)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2054)
  AUTHORS   Ouyang,Y.B., Crawley,J.T., Aston,C.E. and Moore,K.L.
  TITLE     Reduced body weight and increased postimplantation fetal death in
            tyrosylprotein sulfotransferase-1-deficient mice
  JOURNAL   J Biol Chem 277 (26), 23781-23787 (2002)
   PUBMED   11964405
REFERENCE   9  (bases 1 to 2054)
  AUTHORS   Ouyang,Yb., Lane,W.S. and Moore,K.L.
  TITLE     Tyrosylprotein sulfotransferase: purification and molecular cloning
            of an enzyme that catalyzes tyrosine O-sulfation, a common
            posttranslational modification of eukaryotic proteins
  JOURNAL   Proc Natl Acad Sci U S A 95 (6), 2896-2901 (1998)
   PUBMED   9501187
REFERENCE   10 (bases 1 to 2054)
  AUTHORS   Baeuerle,P.A. and Huttner,W.B.
  TITLE     Tyrosine sulfation is a trans-Golgi-specific protein modification
  JOURNAL   J Cell Biol 105 (6 Pt 1), 2655-2664 (1987)
   PUBMED   3121635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ046784.1, AK150753.1 and AI183198.1.
            
            On Oct 2, 2013 this sequence version replaced NM_001130476.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150753.1, SRR1660815.216619.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               CJ046784.1         2-117
            117-2049            AK150753.1         2-1934
            2050-2054           AI183198.1         1-5                 c
FEATURES             Location/Qualifiers
     source          1..2054
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.53 cM"
     gene            1..2054
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /note="protein-tyrosine sulfotransferase 1"
                     /db_xref="GeneID:22021"
                     /db_xref="MGI:MGI:1298231"
     exon            1..292
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /inference="alignment:Splign:2.1.0"
     exon            293..1238
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1437
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1488
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1528
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..2054
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2028..2033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /note="hexamer: AATAAA"
     polyA_site      2050
                     /gene="Tpst1"
                     /gene_synonym="Tango13a"
                     /note="major polyA site"
ORIGIN      
        1 aaatcagaga ggcggacaca tcgcgcggcc cggctgcggg tagcctatgg cggcgtgcgt
       61 gagatcccgc ggccacgcgg cggcgggagg caggagctga ggcggcgacc gcggccagtc
      121 gctgctgagg cggccgcggg tgcgcttctc ggcggggccg ggcagggccg tcgcctggcg
      181 gtgaggacgc gctcccgggg cgggcgctat ggccaccaac tagggcggcc ggagaagcgg
      241 ccgaagccca agatgccgga gcgacggcac ggctgcgcct ccgccatcgt aggtgccgat
      301 ccccttgcca cagtcgagtc tccatggcct gaccgtgtct tgacaataat tttgagcaaa
      361 atctatgtct aataagaaga taaccacatc aagatggttg ggaagctgaa gcagaactta
      421 ctcttggcgt gtctggtgat tagttctgtg accgtgtttt acctgggcca gcatgccatg
      481 gagtgccatc accgaataga ggaacgtagc cagccagccc gactggagaa ccccaaggcg
      541 actgtgcgag ctggcctcga catcaaagcc aacaaaacat tcacctatca caaagatatg
      601 cctttaatat tcatcggggg tgtgcctcgg agcggcacca cactcatgag ggctatgctg
      661 gacgcacatc ctgacatccg ctgtggagag gaaaccaggg tcatccctcg aatcctggcc
      721 ctgaagcaga tgtggtcccg gtccagtaaa gagaagatcc gcttggatga ggcgggtgtc
      781 acagatgaag tgctagattc tgccatgcaa gccttccttc tggaggtcat tgttaaacat
      841 ggggagccgg caccttattt atgtaacaaa gatccgtttg ccctgaaatc cttgacttac
      901 cttgctaggt tatttcccaa tgccaaattt ctcctgatgg tccgagatgg ccgggcgtca
      961 gtacattcaa tgatttctcg gaaagttact atagctggct ttgacctgaa cagctaccgg
     1021 gactgtctga ccaagtggaa ccgggccata gaaaccatgt acaaccagtg tatggaagtt
     1081 ggttataaga aatgcatgtt ggttcactat gaacagctcg tcttacaccc tgaacggtgg
     1141 atgagaacgc tcttaaagtt cctccatatt ccatggaacc attccgtttt gcaccatgaa
     1201 gaaatgatcg ggaaagctgg gggagtttct ctgtcaaagg tggaaagatc aacagaccaa
     1261 gtcatcaaac ccgtcaacgt gggggcgcta tcgaagtggg ttgggaagat acccccggac
     1321 gtcttacaag acatggccgt gattgcaccc atgctcgcca agcttggata tgacccatac
     1381 gccaatcctc ctaactacgg aaaacctgac cccaagatcc ttgaaaacac caggagggtc
     1441 tataaaggag aatttcagct ccctgacttt ctgaaagaaa aaccccagac ggagcaagtg
     1501 gagtaactga gcccgtaact tcccacaggg acgactgctg ccttgtctac agaagggaaa
     1561 tctcgggaac ggctgtctgc tgcgacaagg agtgtctgtg cccatcgctc ctgttcacct
     1621 gccagcctcc tgtccccagg gggggtgtca cacacccggg cctccccaag tgatggctct
     1681 tgagcccagg aacatgcatg gccctcagga tgaggagccc agcagggaca cagttctgtc
     1741 acagctcctc ttgtccttgt ctttccttcc caggttccag tctttaattt caaggaaagg
     1801 agagtttgaa gttggcattc tgttaacaaa atcaggcagt ctcattccga ataggttcta
     1861 tgtacacgtt ccgatgtttt gtagaacact cgtgcctgtt gaaacgtatc gatgtggata
     1921 atagtaaata ccttaattat ttaaataatt cattgtattg tttcagagac gtttggaaat
     1981 tactgtatac atttacaacc taatgacttt tgtattttat ttttcaaaat aaaagcttaa
     2041 atgtgaagca ctca
//
