LOCUS       NM_012034               1183 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus tryptase gamma 1 (Tpsg1), transcript variant 1, mRNA.
ACCESSION   NM_012034
VERSION     NM_012034.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   2  (bases 1 to 1183)
  AUTHORS   Hansbro,P.M., Hamilton,M.J., Fricker,M., Gellatly,S.L.,
            Jarnicki,A.G., Zheng,D., Frei,S.M., Wong,G.W., Hamadi,S., Zhou,S.,
            Foster,P.S., Krilis,S.A. and Stevens,R.L.
  TITLE     Importance of mast cell Prss31/transmembrane
            tryptase/tryptase-gamma in lung function and experimental chronic
            obstructive pulmonary disease and colitis
  JOURNAL   J Biol Chem 289 (26), 18214-18227 (2014)
   PUBMED   24821729
  REMARK    GeneRIF: Prss31-null mice had increased airway reactivity to
            methacholine but markedly reduced experimental chronic obstructive
            pulmonary disease and colitis.
REFERENCE   3  (bases 1 to 1183)
  AUTHORS   Gregorieff,A., Stange,D.E., Kujala,P., Begthel,H., van den Born,M.,
            Korving,J., Peters,P.J. and Clevers,H.
  TITLE     The ets-domain transcription factor Spdef promotes maturation of
            goblet and paneth cells in the intestinal epithelium
  JOURNAL   Gastroenterology 137 (4), 1333-45 (2009)
   PUBMED   19549527
REFERENCE   4  (bases 1 to 1183)
  AUTHORS   Tang,L. and Rancourt,D.E.
  TITLE     Murine implantation serine proteinases 1 and 2: structure, function
            and evolution
  JOURNAL   Gene 364, 30-36 (2005)
   PUBMED   16257142
REFERENCE   5  (bases 1 to 1183)
  AUTHORS   Wong,G.W., Yasuda,S., Morokawa,N., Li,L. and Stevens,R.L.
  TITLE     Mouse chromosome 17A3.3 contains 13 genes that encode functional
            tryptic-like serine proteases with distinct tissue and cell
            expression patterns
  JOURNAL   J Biol Chem 279 (4), 2438-2452 (2004)
   PUBMED   14583634
REFERENCE   6  (bases 1 to 1183)
  AUTHORS   Caughey,G.H., Raymond,W.W., Blount,J.L., Hau,L.W., Pallaoro,M.,
            Wolters,P.J. and Verghese,G.M.
  TITLE     Characterization of human gamma-tryptases, novel members of the
            chromosome 16p mast cell tryptase and prostasin gene families
  JOURNAL   J Immunol 164 (12), 6566-6575 (2000)
   PUBMED   10843716
REFERENCE   7  (bases 1 to 1183)
  AUTHORS   Wong,G.W., Tang,Y., Feyfant,E., Sali,A., Li,L., Li,Y., Huang,C.,
            Friend,D.S., Krilis,S.A. and Stevens,R.L.
  TITLE     Identification of a new member of the tryptase family of mouse and
            human mast cell proteases which possesses a novel COOH-terminal
            hydrophobic extension
  JOURNAL   J Biol Chem 274 (43), 30784-30793 (1999)
   PUBMED   10521469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122454.4.
            
            On Aug 24, 2022 this sequence version replaced NM_012034.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052325.1, AF175523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC122454.4         157865-157978
            115-286             AC122454.4         159755-159926
            287-552             AC122454.4         160453-160718
            553-698             AC122454.4         161003-161148
            699-1183            AC122454.4         161236-161720
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1183
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /note="tryptase gamma 1"
                     /db_xref="GeneID:26945"
                     /db_xref="MGI:MGI:1349391"
     exon            1..114
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1001
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /EC_number="3.4.21.59"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane tryptase"
                     /codon_start=1
                     /product="tryptase gamma isoform 1 precursor"
                     /protein_id="NP_036164.2"
                     /db_xref="CCDS:CCDS28518.1"
                     /db_xref="GeneID:26945"
                     /db_xref="MGI:MGI:1349391"
                     /translation="MALGPYCGILLFLAVSGCGHPQVSNSGSRIVGGHAAPAGTWPWQ
                     ASLRLHKVHVCGGSLLSPEWVLTAAHCFSGSVNSSDYQVHLGELTVTLSPHFSTVKRI
                     IMYTGSPGPPGSSGDIALVQLSSPVALSSQVQPVCLPEASADFYPGMQCWVTGWGYTG
                     EGEPLKPPYNLQEAKVSVVDVKTCSQAYNSPNGSLIQPDMLCARGPGDACQDDSGGPL
                     VCQVAGTWQQAGVVSWGEGCGRPDRPGVYARVTAYVNWIHHHIPEAGGSGMQGLPWAP
                     LLAALFWPSLFLLLVSGVLMAKYWLSSPSHAASEL"
     exon            115..286
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /inference="alignment:Splign:2.1.0"
     exon            287..552
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /inference="alignment:Splign:2.1.0"
     exon            553..698
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1183
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1158..1163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /note="hexamer: CATAAA"
     polyA_site      1183
                     /gene="Tpsg1"
                     /gene_synonym="Prss31; Tmt"
                     /note="major polyA site"
ORIGIN      
        1 atactgatag gcctggggct gggcaggggc atggggtggt cctgactctg ctgtgggaag
       61 acaccatggc tctggggccc tactgtggca tcctactgtt tctggctgtt tctgggtgtg
      121 gccatcccca ggtttcaaac tcgggaagtc gaatcgtggg agggcatgct gccccagcag
      181 gcacatggcc gtggcaggct agcctccgtc tgcacaaggt gcacgtgtgt ggaggctccc
      241 tgctcagtcc agaatgggtg ctcacagcag cccactgctt ctctgggtct gtgaactcgt
      301 ctgattatca ggtgcacttg ggagagctta cggtcacact gtctccccac ttctccactg
      361 taaaacggat catcatgtac actggctctc caggaccacc ggggtccagt ggggacattg
      421 ccctggtgca gctgtcctcc ccggtggccc tttccagcca ggtccagcct gtgtgcctcc
      481 cagaggcctc agctgacttc taccctggga tgcagtgctg ggtgactggc tggggctata
      541 caggggaggg agagcctctg aagcccccat acaaccttca ggaggccaaa gtctctgtgg
      601 tggatgtaaa gacctgcagc caggcttaca atagtcccaa tggcagcctc atccagccag
      661 acatgctatg cgcccggggc cctggggatg cctgccagga tgactctgga gggccactag
      721 tctgccaggt ggctggaacc tggcagcagg ccggcgttgt cagctggggt gagggctgtg
      781 gccgccctga ccgccctggc gtctatgccc gggttactgc ctatgtaaac tggatccacc
      841 accacatccc agaagcaggg ggctcaggaa tgcaagggct tccctgggct cctctcctgg
      901 ctgccctctt ctggccaagc ctcttcctgc tgctggtctc tggagtcctg atggccaagt
      961 actggctgag ctctccctcc cacgcggcct cggaactctg aatgaggtgt agcaaccaac
     1021 ccaagtgtct ttcttaaata agttagtgtt tattcagctt tgctttgccc ctcccctccc
     1081 cttagctttg acttaggaag ccaagttttc tgcatcagat tattgcaaca tttaacctga
     1141 atttgtagaa cggatgacat aaagcaaatg gatgtcaaat gaa
//
