LOCUS       NM_010781               1088 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tryptase beta 2 (Tpsb2), mRNA.
ACCESSION   NM_010781
VERSION     NM_010781.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1088)
  AUTHORS   Nakazawa,M., Tochinai,R., Fujii,W., Komori,M., Yonezawa,T.,
            Momoi,Y. and Maeda,S.
  TITLE     Protective role of protease-activated receptor-2 in anaphylaxis
            model mice
  JOURNAL   PLoS One 19 (4), e0283915 (2024)
   PUBMED   38635782
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1088)
  AUTHORS   Li,Y., Di,C., Song,S., Zhang,Y., Lu,Y., Liao,J., Lei,B., Zhong,J.,
            Guo,K., Zhang,N. and Su,S.
  TITLE     Choroid plexus mast cells drive tumor-associated hydrocephalus
  JOURNAL   Cell 186 (26), 5719-5738 (2023)
   PUBMED   38056463
REFERENCE   3  (bases 1 to 1088)
  AUTHORS   Plum,T., Binzberger,R., Thiele,R., Shang,F., Postrach,D., Fung,C.,
            Fortea,M., Stakenborg,N., Wang,Z., Tappe-Theodor,A., Poth,T.,
            MacLaren,D.A.A., Boeckxstaens,G., Kuner,R., Pitzer,C., Monyer,H.,
            Xin,C., Bonventre,J.V., Tanaka,S., Voehringer,D., Vanden Berghe,P.,
            Strid,J., Feyerabend,T.B. and Rodewald,H.R.
  TITLE     Mast cells link immune sensing to antigen-avoidance behaviour
  JOURNAL   Nature 620 (7974), 634-642 (2023)
   PUBMED   37438525
REFERENCE   4  (bases 1 to 1088)
  AUTHORS   Rupani,D.N., Thege,F.I., Chandra,V., Rajaei,H., Cowan,R.W.,
            Wormann,S.M., Le Roux,O., Malaney,P., Manning,S.L., Hashem,J.,
            Bailey-Lundberg,J., Rhim,A.D. and McAllister,F.
  TITLE     Adar1 deletion causes degeneration of the exocrine pancreas via
            Mavs-dependent interferon signaling
  JOURNAL   Development 150 (2) (2023)
   PUBMED   36458554
REFERENCE   5  (bases 1 to 1088)
  AUTHORS   Song,J., He,Z., Yang,M., Yu,T., Wang,X., Liu,B. and Li,J.
  TITLE     HepaticIschemia/Reperfusion Injuryinvolves functional
            tryptase/PAR-2 signaling in liver sinusoidal endothelial cell
            population
  JOURNAL   Int Immunopharmacol 100, 108052 (2021)
   PUBMED   34454294
  REMARK    GeneRIF: HepaticIschemia/Reperfusion Injuryinvolves functional
            tryptase/PAR-2 signaling in liver sinusoidal endothelial cell
            population.
REFERENCE   6  (bases 1 to 1088)
  AUTHORS   Gurish,M.F., Johnson,K.R., Webster,M.J., Stevens,R.L. and
            Nadeau,J.H.
  TITLE     Location of the mouse mast cell protease 7 gene (Mcpt7) to
            chromosome 17
  JOURNAL   Mamm Genome 5 (10), 656-657 (1994)
   PUBMED   7849408
REFERENCE   7  (bases 1 to 1088)
  AUTHORS   Dosik,J.K., Barton,C.H., Holiday,D.L., Krall,M.M., Blackwell,J.M.
            and Mock,B.A.
  TITLE     An Nramp-related sequence maps to mouse chromosome 17
  JOURNAL   Mamm Genome 5 (7), 458-460 (1994)
   PUBMED   7919662
REFERENCE   8  (bases 1 to 1088)
  AUTHORS   Gurish,M.F., Ghildyal,N., McNeil,H.P., Austen,K.F., Gillis,S. and
            Stevens,R.L.
  TITLE     Differential expression of secretory granule proteases in mouse
            mast cells exposed to interleukin 3 and c-kit ligand
  JOURNAL   J Exp Med 175 (4), 1003-1012 (1992)
   PUBMED   1372640
REFERENCE   9  (bases 1 to 1088)
  AUTHORS   Reynolds,D.S., Gurley,D.S., Austen,K.F. and Serafin,W.E.
  TITLE     Cloning of the cDNA and gene of mouse mast cell protease-6.
            Transcription by progenitor mast cells and mast cells of the
            connective tissue subclass
  JOURNAL   J Biol Chem 266 (6), 3847-3853 (1991)
   PUBMED   1995638
REFERENCE   10 (bases 1 to 1088)
  AUTHORS   Reynolds,D.S., Stevens,R.L., Lane,W.S., Carr,M.H., Austen,K.F. and
            Serafin,W.E.
  TITLE     Different mouse mast cell populations express various combinations
            of at least six distinct mast cell serine proteases
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 3230-3234 (1990)
   PUBMED   2326280
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122454.4.
            
            On Mar 14, 2007 this sequence version replaced NM_010781.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024374.1, M57626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC122454.4         153611-153621
            12-81               AC122454.4         153830-153899
            82-247              AC122454.4         154038-154203
            248-513             AC122454.4         154324-154589
            514-677             AC122454.4         154723-154886
            678-1088            AC122454.4         154960-155370
FEATURES             Location/Qualifiers
     source          1..1088
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..1088
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /note="tryptase beta 2"
                     /db_xref="GeneID:17229"
                     /db_xref="MGI:MGI:96942"
     exon            1..11
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..842
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /EC_number="3.4.21.59"
                     /note="tryptase-2; mast cell protease 6"
                     /codon_start=1
                     /product="tryptase beta-2 precursor"
                     /protein_id="NP_034911.3"
                     /db_xref="CCDS:CCDS28517.1"
                     /db_xref="GeneID:17229"
                     /db_xref="MGI:MGI:96942"
                     /translation="MLKRLLLLLWALSLLASLVYSAPRPANQRVGIVGGHEASESKWP
                     WQVSLRFKLNYWIHFCGGSLIHPQWVLTAAHCVGPHIKSPQLFRVQLREQYLYYGDQL
                     LSLNRIVVHPHYYTAEGGADVALLELEVPVNVSTHLHPISLPPASETFPPGTSCWVTG
                     WGDIDNDEPLPPPYPLKQVKVPIVENSLCDRKYHTGLYTGDDFPIVHDGMLCAGNTRR
                     DSCQGDSGGPLVCKVKGTWLQAGVVSWGEGCAQPNKPGIYTRVTYYLDWIHRYVPEHS
                     "
     exon            12..81
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            82..247
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            248..513
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            514..677
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1088
                     /gene="Tpsb2"
                     /gene_synonym="Mcp-6; Mcp6; Mcpt6; MMCP-6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagctaa gatgctgaag cggctgctgc tgctgctgtg ggcactgtcc ctcctggcta
       61 gtctggtgta ctcggcccct cgcccagcca atcagcgagt gggcatcgtg ggaggacatg
      121 aggcttctga gagtaagtgg ccctggcagg tgagcctgag atttaaatta aactactgga
      181 tacatttctg cggaggttct ctcatccatc cacagtgggt gctcactgcg gcacactgtg
      241 tgggaccgca catcaaaagc ccacagctct tccgggtgca gcttcgtgag cagtatctat
      301 actatgggga ccagctcctc tctttgaaca ggatcgtggt gcacccccac tattacacgg
      361 ccgagggtgg ggcagacgtt gccctgctgg agcttgaggt ccctgtgaat gtctctaccc
      421 atctccaccc catatccctg ccccctgcct cggagacctt ccccccaggg acatcgtgct
      481 gggtgacagg ctggggcgac attgataatg acgagcctct cccacctcct tatcctctga
      541 agcaagtgaa ggttcccatt gtggaaaaca gcctgtgtga ccggaagtac cacactggcc
      601 tctacacggg agatgatttt cccattgtcc atgatggcat gctgtgtgct ggaaatacca
      661 ggagagactc ctgccagggc gattcagggg ggccactggt ctgcaaagtg aagggtacct
      721 ggctgcaggc aggagtggtc agctggggtg agggctgcgc acagcccaac aagcctggca
      781 tctacacccg ggtgacatac tacttagact ggatccaccg ctatgtccct gagcattcct
      841 gagacccatc cagggtcagg caagaaccag ggctgtgctg tctttaactc actgcttcct
      901 ggtcaggtgg aacccttgcc ttccttgtcc tctgtctccc ctgtctacta ggtgtccctc
      961 tgagcccccc acccccccag ttccgtcttg agtccctagc cattccggtt ccctcttgcc
     1021 tcccaccaca taatagttgc attgtgtggc tccctctctt ctgtggctca ttaaagtact
     1081 tgaaaaca
//
