LOCUS       NM_175286               2825 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus taperin (Tprn), mRNA.
ACCESSION   NM_175286
VERSION     NM_175286.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2825)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2825)
  AUTHORS   Qi,J., Tan,F., Zhang,L., Zhou,Y., Zhang,Z., Sun,Q., Li,N., Fang,Y.,
            Chen,X., Wu,Y., Zhong,G. and Chai,R.
  TITLE     Critical role of TPRN rings in the stereocilia for hearing
  JOURNAL   Mol Ther 32 (1), 204-217 (2024)
   PUBMED   37952086
  REMARK    GeneRIF: Critical role of TPRN rings in the stereocilia for
            hearing.
            Erratum:[Mol Ther. 2025 Jan 8;33(1):419-420. doi:
            10.1016/j.ymthe.2024.12.004.. PMID: 39672160]
REFERENCE   3  (bases 1 to 2825)
  AUTHORS   Liu,C., Luo,N. and Zhao,B.
  TITLE     Reducing Taperin Expression Restores Hearing in Grxcr2 Mutant Mice
  JOURNAL   Neuroscience 498, 85-92 (2022)
   PUBMED   35752427
  REMARK    GeneRIF: Reducing Taperin Expression Restores Hearing in Grxcr2
            Mutant Mice.
REFERENCE   4  (bases 1 to 2825)
  AUTHORS   Men,Y., Li,X., Tu,H., Zhang,A., Fu,X., Wang,Z., Jin,Y., Hou,C.,
            Zhang,T., Zhang,S., Zhou,Y., Li,B., Li,J., Sun,X., Wang,H. and
            Gao,J.
  TITLE     Tprn is essential for the integrity of stereociliary rootlet in
            cochlear hair cells in mice
  JOURNAL   Front Med 13 (6), 690-704 (2019)
   PUBMED   30159668
  REMARK    GeneRIF: Tprn is critical to the retention of the integrity of the
            stereociliary rootlet. Loss of Tprn in Tprn-null mice caused the
            disruption of the stereociliary rootlet, which resulted in damage
            to stereociliary bundles and hearing impairments.
REFERENCE   5  (bases 1 to 2825)
  AUTHORS   Liu,C., Luo,N., Tung,C.Y., Perrin,B.J. and Zhao,B.
  TITLE     GRXCR2 Regulates Taperin Localization Critical for Stereocilia
            Morphology and Hearing
  JOURNAL   Cell Rep 25 (5), 1268-1280 (2018)
   PUBMED   30380417
  REMARK    GeneRIF: Stereocilia lacking GRXCR2 are longer than normal and
            disorganized due to the mislocalization of taperin, which could
            modulate the actin cytoskeleton in stereocilia.
REFERENCE   6  (bases 1 to 2825)
  AUTHORS   Zhao,B., Wu,Z. and Muller,U.
  TITLE     Murine Fam65b forms ring-like structures at the base of stereocilia
            critical for mechanosensory hair cell function
  JOURNAL   Elife 5, e14222 (2016)
   PUBMED   27269051
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2825)
  AUTHORS   Salles,F.T., Andrade,L.R., Tanda,S., Grati,M., Plona,K.L.,
            Gagnon,L.H., Johnson,K.R., Kachar,B. and Berryman,M.A.
  TITLE     CLIC5 stabilizes membrane-actin filament linkages at the base of
            hair cell stereocilia in a molecular complex with radixin, taperin,
            and myosin VI
  JOURNAL   Cytoskeleton (Hoboken) 71 (1), 61-78 (2014)
   PUBMED   24285636
REFERENCE   8  (bases 1 to 2825)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   9  (bases 1 to 2825)
  AUTHORS   Rehman,A.U., Morell,R.J., Belyantseva,I.A., Khan,S.Y., Boger,E.T.,
            Shahzad,M., Ahmed,Z.M., Riazuddin,S., Khan,S.N., Riazuddin,S. and
            Friedman,T.B.
  TITLE     Targeted capture and next-generation sequencing identifies C9orf75,
            encoding taperin, as the mutated gene in nonsyndromic deafness
            DFNB79
  JOURNAL   Am J Hum Genet 86 (3), 378-388 (2010)
   PUBMED   20170899
REFERENCE   10 (bases 1 to 2825)
  AUTHORS   Li,Y., Pohl,E., Boulouiz,R., Schraders,M., Nurnberg,G., Charif,M.,
            Admiraal,R.J., von Ameln,S., Baessmann,I., Kandil,M., Veltman,J.A.,
            Nurnberg,P., Kubisch,C., Barakat,A., Kremer,H. and Wollnik,B.
  TITLE     Mutations in TPRN cause a progressive form of autosomal-recessive
            nonsyndromic hearing loss
  JOURNAL   Am J Hum Genet 86 (3), 479-484 (2010)
   PUBMED   20170898
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732309.9, AK082888.1 and AI842038.1.
            
            On Jun 11, 2008 this sequence version replaced NM_175286.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic and transcript sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089508.1, AK171799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               AL732309.9         155230-156046
            818-2750            AK082888.1         799-2731
            2751-2825           AI842038.1         1-75                c
FEATURES             Location/Qualifiers
     source          1..2825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.11 cM"
     gene            1..2825
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /note="taperin"
                     /db_xref="GeneID:97031"
                     /db_xref="MGI:MGI:2139535"
     exon            1..1956
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2340
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /codon_start=1
                     /product="taperin"
                     /protein_id="NP_780495.2"
                     /db_xref="CCDS:CCDS15759.2"
                     /db_xref="GeneID:97031"
                     /db_xref="MGI:MGI:2139535"
                     /translation="MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGQGSGAAPD
                     GPNERLVLAESLGPLSQNPFMRLESERRRGTRPAQQLLELYCRVPGVRTIRADNILII
                     ESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPAL
                     PQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDG
                     TAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPP
                     VPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSAN
                     DSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAGRQFEE
                     PKGEVGWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGACPRPAISDTDKCV
                     RWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVTFIDEVDSEEEAFQE
                     AKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQS
                     QQGAEEQDAESLSGPHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMK
                     ISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEGEEDGEEEEVGPDSEKPFTVFLPRAT
                     FVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQTPTDVELPPKEVMLTPASQNDLSD
                     FRSEPALYF"
     exon            1957..2170
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2277
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2808
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2787..2792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2807
                     /gene="Tprn"
                     /gene_synonym="C430004E15Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtggcacggc gcggtactga ggcaggtagc tgagagtctg taccgcgcgc ggtcgccgtg
       61 cagtcctatc ggcggccgcg cgtccgcagc atggccggcc tggggcggct cgacccgggg
      121 ccgcgaaccg tgatgcccgc ctggaaacgg gagatccttg agcggaggcg agctaaactg
      181 gccgccctga gcggaggcca gggatctgga gcggcgccgg atgggcctaa cgagcggctg
      241 gtgctggccg agagtctggg tccactaagc cagaacccgt tcatgcgact tgagtcggag
      301 cggcggcgcg ggacgcggcc cgctcagcag ctgctggagc tgtactgtcg cgtgcccggc
      361 gtgcggacca ttcgagcgga caacatcctc atcatcgagt cagcgccagg cttcccaccc
      421 gctgtgccgc ccgctgcggg catccgcgct gccgaggtag tagtgtacga ggcgccacag
      481 cccggccgtg tcagccgcct gctggaaaag ttcgactcgc ctgctgcgcc ctgccgccgc
      541 gggagcccag agcgcttccg ccctgcgctc ccgcagcttc ccgtggcgtc tgcatctgct
      601 gccacgcgca ctcctaccaa tcggtcgttg gctcctgcct caccggtgcg cctcagccag
      661 cccgcacccc ctatttcgcc tgtccccgtt gcccagcgcg cgggtcagcg ctctgcctgt
      721 tgcgagcccg cgcaccccga cggcactgcc ggccccgggg cccggcgcag cgacttttta
      781 cagaagaccg gcagcaactc tttcactgtt cacccccggg gcctgccccg cagtgcggtc
      841 aatcgctcgc tttctaatgg acccatgact caggaatccc ctaccggccc tgccaatggg
      901 ttgtcaggct ctccgcctgt accgggaaag tggaagccaa aggtggagtc aaaggaaccc
      961 tctctccacc cgcccccaag ccctgggact ccaagtgcca cttcagttgg gccccctgcc
     1021 ttcccagcgc ccagcccagc cagtgccact cccagtcagc gccagtgggt ctcctctgcc
     1081 accagcgcca atgattcctt tgaaataagg ccatcctcca agccagacat ggaaactatc
     1141 ccaatcgggg accttcaggc cagggccctg gccaacctcc gagtgaactc ccgcaactcc
     1201 ttcgtgttga tccccaagcg caaagcccct gggaactatc ctttggcggg gaggcaattt
     1261 gaggagccaa agggggaggt gggctgggcc tctcagagcc aggggctcgg atcccagctg
     1321 gtgtctacag tggatggtgc acctgcccta gagaagagtc ccttggctgc tgagatgcag
     1381 tgggcagtta ggaagggggc ctgccccagg ccagcaattt ctgacacaga caagtgtgtt
     1441 aggtggcaga gaccagcctc gccacctcca tttctaccag ccacagctga agctgagccg
     1501 gctgaaggct tgggggttcc tggcttggcc aagaatggcc aggagcctgt gaggccagga
     1561 cttccagtca ccttcattga tgaagtagac tcagaggagg aggcctttca agaagccaaa
     1621 ctgccctcct cagcagttgg tgtgccttcc cagtaccacc tgcaccctgc caggcctgga
     1681 cacacctcag aactcctgaa ccgaggtagc aacactttca cagtagtgcc caagagaaag
     1741 ccagggaccc ttcaggagcc acacttaagt cagaccaatg gtcagtccca gcaaggggca
     1801 gaggaacagg atgctgagag cctctcagga ccccatacta ccctggagaa caccctaaag
     1861 aaacgatacc ccactgtgca cgagattgag gtgattggtg gttacctggc cctgcagaag
     1921 tcctgcctca tcaaagctgg ctcctcgaga aaaaagatga agatctcctt caatgacaag
     1981 agcctgcata caacatttga gtacccttct gagagctctc tggcacagga agaggcggag
     2041 gaggaggagg aggaggaagg agaggaagat ggtgaagagg aggaagtggg gcctgactca
     2101 gagaaaccct tcacagtttt cttgccccgg gccacatttg taagcagtgt gggacctgag
     2161 agcagctcag gtctgtccag ctacactcca aagcattcca tggccttcag caagtggcag
     2221 gaacagacac tggtgcagac tccaactgat gtggagctcc caccgaagga ggtcatgctc
     2281 acacctgcca gtcagaacga cctctcggac ttccgcagcg agccagccct ctatttctga
     2341 cccctgcaac tgtcaggatg gccaagactt agccccaggt gtggtggtcc tggaagccag
     2401 tcaataccca ggagccctga ctgtattctg tgcccctcta cctggctctc cctgccttct
     2461 ctctctgtta cctccttttg cctttagggc cagatctgaa tctcacacca aggatgaaca
     2521 ggtgggaact gcctgtggga caggctgaca tctgtccata ctgtctcatc tgtgatgagg
     2581 tggaggcctg agcagatctt gtcccagagt gctgtcggaa atttcagctc ctaccttttg
     2641 aggagtggcc actgcgagga gtgagaggct accctagtta tttgttcttt gccgaaatcc
     2701 aagctcctgc cctcagcgaa ctcagctact tttcatgaaa gatggcaggg tgttttttct
     2761 tttttttctc ccctgatatt ggattcaata aacagcactg taacaaggaa aaaaaaaaaa
     2821 aaaaa
//
