LOCUS       NM_001362067            1188 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Tp53rk binding protein (Tprkb), transcript variant 6,
            mRNA.
ACCESSION   NM_001362067
VERSION     NM_001362067.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1188)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1188)
  AUTHORS   Iwata,S., Sasaki,T., Nagahara,M. and Iwamoto,T.
  TITLE     An efficient i-GONAD method for creating and maintaining lethal
            mutant mice using an inversion balancer identified from the
            C3H/HeJJcl strain
  JOURNAL   G3 (Bethesda) 11 (8) (2021)
   PUBMED   34849815
REFERENCE   3  (bases 1 to 1188)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   4  (bases 1 to 1188)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   5  (bases 1 to 1188)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   6  (bases 1 to 1188)
  AUTHORS   Miyoshi,A., Kito,K., Aramoto,T., Abe,Y., Kobayashi,N. and Ueda,N.
  TITLE     Identification of CGI-121, a novel PRPK (p53-related protein
            kinase)-binding protein
  JOURNAL   Biochem Biophys Res Commun 303 (2), 399-405 (2003)
   PUBMED   12659830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158679.8, CO424671.1 and BC027413.1.
            
            Transcript Variant: This variant (6) differs in the 5' UTR and in
            the 3' UTR and coding sequence compared to variant 3. The resulting
            isoform (b) has a shorter and distinct C-terminus compared to
            isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO424671.1, AI317221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC158679.8         123603-123637       c
            36-697              CO424671.1         18-679
            698-1188            BC027413.1         685-1175
FEATURES             Location/Qualifiers
     source          1..1188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.53 cM"
     gene            1..1188
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="Tp53rk binding protein"
                     /db_xref="GeneID:69786"
                     /db_xref="MGI:MGI:1917036"
     exon            1..72
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            73..161
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            162..324
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..660
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="isoform b is encoded by transcript variant 6;
                     TP53RK-binding protein; Prpk (p53-related protein
                     kinase)-binding protein; EKC/KEOPS complex subunit Tprkb;
                     PRPK-binding protein"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit Tprkb isoform b"
                     /protein_id="NP_001348996.1"
                     /db_xref="CCDS:CCDS90081.1"
                     /db_xref="GeneID:69786"
                     /db_xref="MGI:MGI:1917036"
                     /translation="MQLSQQLDLFPECRVTLLLFKDVKNAGDLRKKAMEGSIDGSLIN
                     PNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISETN
                     TSVLIVYIEDGSKQVPQEHLVSQVEGQQVPLESLPEITRLSEVKKVCPAHFEEFSR"
     exon            325..447
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..1160
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      696..701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="hexamer: TATAAA"
     polyA_site      735
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="major polyA site"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="hexamer: ATTAAA"
     polyA_site      1160
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="major polyA site"
ORIGIN      
        1 attaagcact tccggaagta gagagctaag tttcctaggg gacgatcttc tgatgcgggc
       61 gtaggatgca gggcattttc ccgactctac gggcccgtgc ttccaatctc ctgtaatcct
      121 aaacttctga ctctcctgac ctcccctgga ctggattctc ggagagtcct tcttgtctac
      181 gaaatgcagc tatcacagca gctggacttg tttcctgaat gcagggtgac ccttctgtta
      241 tttaaagatg taaaaaatgc aggagacttg agaaaaaagg ccatggaagg atctattgat
      301 ggttcattga taaaccccaa tgtgattgtc gatccatttc agatacttgt ggcagcaaac
      361 aaagccgttc atctccacag actgggaaaa atgaagacaa gaactctgtc tactgaaatt
      421 atcttcaacc tctccccaaa taataatatt tcagaggcct tgaagaaatt tggcatttca
      481 gaaactaaca cttcagttct gattgtttac attgaagatg gaagcaaaca agtaccacag
      541 gaacacctag tatctcaagt ggaaggccag caggtgcctt tggaaagtct tccagaaata
      601 acaaggctct cggaagtcaa gaaggtttgt cctgcacatt ttgaagagtt cagtagatga
      661 actctgctga cactgcttgc tcatcactgt ggttgtataa attttgaatg attaacattt
      721 tagttagcat acaaatactg ggactcatta catttataca aatcctgtta ctgctctttt
      781 tcatatctgc ctcctctctt attctcaata ccttttgaac ttttaagtac tagtgcaggg
      841 ctggaagatg actcatcagt tgagagcact tgctgtcctc cccaagtgcc gggcaggggc
      901 tgattcctgg caggctcata gccatctctg cctccacttc ccgggaatcc aatgtcttct
      961 tctggccgtc atgggaactg cacacatgta gtatacatac tacaggcaaa acacccatac
     1021 cagtaaaaat ttaaaaagct ttagaaatag taacatcatt ttacaaattc ttggaaagta
     1081 tttataaatg aaaactcaaa tgcataatga aaactaagaa aaaggatctc tttcaatatt
     1141 aaatgacttt atgaagttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
