LOCUS       NM_001362065            2198 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Tp53rk binding protein (Tprkb), transcript variant 4,
            mRNA.
ACCESSION   NM_001362065 XM_006506569
VERSION     NM_001362065.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2198)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2198)
  AUTHORS   Iwata,S., Sasaki,T., Nagahara,M. and Iwamoto,T.
  TITLE     An efficient i-GONAD method for creating and maintaining lethal
            mutant mice using an inversion balancer identified from the
            C3H/HeJJcl strain
  JOURNAL   G3 (Bethesda) 11 (8) (2021)
   PUBMED   34849815
REFERENCE   3  (bases 1 to 2198)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   4  (bases 1 to 2198)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   5  (bases 1 to 2198)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   6  (bases 1 to 2198)
  AUTHORS   Miyoshi,A., Kito,K., Aramoto,T., Abe,Y., Kobayashi,N. and Ueda,N.
  TITLE     Identification of CGI-121, a novel PRPK (p53-related protein
            kinase)-binding protein
  JOURNAL   Biochem Biophys Res Commun 303 (2), 399-405 (2003)
   PUBMED   12659830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158679.8.
            
            On Apr 6, 2018 this sequence version replaced XM_006506569.3.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 3. Variants 1-5 all encode the same isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.274588.1,
                                           SRR7345562.290963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC158679.8         123249-123385       c
            138-226             AC158679.8         117845-117933       c
            227-389             AC158679.8         114834-114996       c
            390-512             AC158679.8         111993-112115       c
            513-689             AC158679.8         111372-111548       c
            690-2198            AC158679.8         109072-110580       c
FEATURES             Location/Qualifiers
     source          1..2198
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.53 cM"
     gene            1..2198
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="Tp53rk binding protein"
                     /db_xref="GeneID:69786"
                     /db_xref="MGI:MGI:1917036"
     exon            1..137
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..226
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..389
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..776
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="isoform a is encoded by transcript variant 4;
                     TP53RK-binding protein; Prpk (p53-related protein
                     kinase)-binding protein; EKC/KEOPS complex subunit Tprkb;
                     PRPK-binding protein"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit Tprkb isoform a"
                     /protein_id="NP_001348994.1"
                     /db_xref="CCDS:CCDS20305.1"
                     /db_xref="GeneID:69786"
                     /db_xref="MGI:MGI:1917036"
                     /translation="MQLSQQLDLFPECRVTLLLFKDVKNAGDLRKKAMEGSIDGSLIN
                     PNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISETN
                     TSVLIVYIEDGSKQVPQEHLVSQVEGQQVPLESLPEITRLSEVKKIYKLSSQEERIGT
                     LLDAIICRMSTKDVL"
     exon            390..512
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            513..689
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..2198
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="hexamer: ATTAAA"
     polyA_site      2196
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="major polyA site"
ORIGIN      
        1 gaggctggag gagccgcgtg cggaccgcac agccacagcc aggcccagcg ctgggaggga
       61 ggcgcggcgg agagcggagt cgcctccacc ccaggcttta cccgggccag cgagcggcct
      121 tggcaggagg gacccaggca ttttcccgac tctacgggcc cgtgcttcca atctcctgta
      181 atcctaaact tctgactctc ctgacctccc ctggactgga ttctcggaga gtccttcttg
      241 tctacgaaat gcagctatca cagcagctgg acttgtttcc tgaatgcagg gtgacccttc
      301 tgttatttaa agatgtaaaa aatgcaggag acttgagaaa aaaggccatg gaaggatcta
      361 ttgatggttc attgataaac cccaatgtga ttgtcgatcc atttcagata cttgtggcag
      421 caaacaaagc cgttcatctc cacagactgg gaaaaatgaa gacaagaact ctgtctactg
      481 aaattatctt caacctctcc ccaaataata atatttcaga ggccttgaag aaatttggca
      541 tttcagaaac taacacttca gttctgattg tttacattga agatggaagc aaacaagtac
      601 cacaggaaca cctagtatct caagtggaag gccagcaggt gcctttggaa agtcttccag
      661 aaataacaag gctctcggaa gtcaagaaga tatataaact gtcatcacaa gaagagagga
      721 ttgggacgtt attggatgct atcatttgta gaatgtcaac gaaggatgtt ttataagatg
      781 tttaaaatgt caacagaaag ccgggcgtgg tgatgcatgc ctttaatccc agcacttggg
      841 aggcagaggc aggcggattt ctgagtttga ggccagcctg gtctacagag tgagttccag
      901 gacagccagg gctacacgga gaaaccctgt ctcgaaaaac caaaaaaaaa aaaaaattaa
      961 ctctaagcca ggtgtggtga ctcattacag tccactgctc aggaggctga ggcaggagaa
     1021 agctgcaagt ttgaggtcag cttgggatat gccacaaatt ccagatcagc ctaaagtact
     1081 atgtcaaatc ctatctcaat aaatagcaat tcatttaact ctcttagctg ctttttaggt
     1141 agatatgtct ttgtgcccac tttatacaag aggcagctaa aagagtatag cagtattaac
     1201 tgactagccc agggtcatgt aactagtata aaaccatgtt tgatggttcc ttttccccct
     1261 cactttatct tgtattggat tgtatccatc aagataggct tggtcaaggg ttagcaaagc
     1321 tctgtgaaga gccagataag tactttgctc ctcaaaggcc gcctcatctg gttcctgcta
     1381 caattactca atatgacctt tgcagtctga aagcagccac agaggacagg tacagagtga
     1441 gtggcctctg tccagtgagc cttgacttga acaagcagtg ggcagccctg gagttgagac
     1501 tgtagactcc agagttggct aggacatagt gacagtcaaa ccctaaagct cactggctta
     1561 gtacagcaga aggaaacatt ttgttatctt gaaggcagaa gggatcagag ggaaacccac
     1621 agcagggctt tagagccctc tgcgggggct tctcagcctg ggcttctagg ttactgtgca
     1681 gcttgtcaga agctctgggg agggcagaga aacctaaaag catccacatg gaagtggcag
     1741 gtattgctca cctcttttca ttcacacaag ttcaaaaatg gtgacccctt gttcttccca
     1801 caagcacagt cagttctgcc cctccagtcc cctctaaagc gccaagtctg caaagccagg
     1861 tgctctcata gtgcagttct ggggttgttc tctgggtacc ttatggtggt ttgaatatgt
     1921 ttggcccagg gagtggcact atttagagat gaggcctttt tggagttggt aagaccttgg
     1981 cagaaatgtg tcattgtggg catgggcttt aagagaccct ccctccttct agccgtgtgg
     2041 gagccagttt tctcttagcg gccttcagat gaagatgtag aactctcaga tcctcctgca
     2101 ccatgcctgc ctggacactg ccatgctcct gtcttgatga taacagactg aacctctgaa
     2161 cctgtaagcc agcccgatta aatgttgttc ttataaga
//
