LOCUS       NM_001362064            2488 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Tp53rk binding protein (Tprkb), transcript variant 3,
            mRNA.
ACCESSION   NM_001362064 XM_006506568
VERSION     NM_001362064.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2488)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2488)
  AUTHORS   Iwata,S., Sasaki,T., Nagahara,M. and Iwamoto,T.
  TITLE     An efficient i-GONAD method for creating and maintaining lethal
            mutant mice using an inversion balancer identified from the
            C3H/HeJJcl strain
  JOURNAL   G3 (Bethesda) 11 (8) (2021)
   PUBMED   34849815
REFERENCE   3  (bases 1 to 2488)
  AUTHORS   Braun,D.A., Rao,J., Mollet,G., Schapiro,D., Daugeron,M.C., Tan,W.,
            Gribouval,O., Boyer,O., Revy,P., Jobst-Schwan,T., Schmidt,J.M.,
            Lawson,J.A., Schanze,D., Ashraf,S., Ullmann,J.F.P.,
            Hoogstraten,C.A., Boddaert,N., Collinet,B., Martin,G., Liger,D.,
            Lovric,S., Furlano,M., Guerrera,I.C., Sanchez-Ferras,O., Hu,J.F.,
            Boschat,A.C., Sanquer,S., Menten,B., Vergult,S., De Rocker,N.,
            Airik,M., Hermle,T., Shril,S., Widmeier,E., Gee,H.Y., Choi,W.I.,
            Sadowski,C.E., Pabst,W.L., Warejko,J.K., Daga,A., Basta,T.,
            Matejas,V., Scharmann,K., Kienast,S.D., Behnam,B., Beeson,B.,
            Begtrup,A., Bruce,M., Ch'ng,G.S., Lin,S.P., Chang,J.H., Chen,C.H.,
            Cho,M.T., Gaffney,P.M., Gipson,P.E., Hsu,C.H., Kari,J.A., Ke,Y.Y.,
            Kiraly-Borri,C., Lai,W.M., Lemyre,E., Littlejohn,R.O., Masri,A.,
            Moghtaderi,M., Nakamura,K., Ozaltin,F., Praet,M., Prasad,C.,
            Prytula,A., Roeder,E.R., Rump,P., Schnur,R.E., Shiihara,T.,
            Sinha,M.D., Soliman,N.A., Soulami,K., Sweetser,D.A., Tsai,W.H.,
            Tsai,J.D., Topaloglu,R., Vester,U., Viskochil,D.H.,
            Vatanavicharn,N., Waxler,J.L., Wierenga,K.J., Wolf,M.T.F.,
            Wong,S.N., Leidel,S.A., Truglio,G., Dedon,P.C., Poduri,A., Mane,S.,
            Lifton,R.P., Bouchard,M., Kannu,P., Chitayat,D., Magen,D.,
            Callewaert,B., van Tilbeurgh,H., Zenker,M., Antignac,C. and
            Hildebrandt,F.
  TITLE     Mutations in KEOPS-complex genes cause nephrotic syndrome with
            primary microcephaly
  JOURNAL   Nat Genet 49 (10), 1529-1538 (2017)
   PUBMED   28805828
REFERENCE   4  (bases 1 to 2488)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   5  (bases 1 to 2488)
  AUTHORS   Daigo,Y., Takayama,I., Ward,S.M., Sanders,K.M. and Fujino,M.A.
  TITLE     Isolation of novel mouse genes that were differentially expressed
            in W/W(V) mouse fundus
  JOURNAL   J Gastroenterol 39 (3), 238-241 (2004)
   PUBMED   15065000
REFERENCE   6  (bases 1 to 2488)
  AUTHORS   Miyoshi,A., Kito,K., Aramoto,T., Abe,Y., Kobayashi,N. and Ueda,N.
  TITLE     Identification of CGI-121, a novel PRPK (p53-related protein
            kinase)-binding protein
  JOURNAL   Biochem Biophys Res Commun 303 (2), 399-405 (2003)
   PUBMED   12659830
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161888.5 and AC158679.8.
            
            On Apr 6, 2018 this sequence version replaced XM_006506568.3.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.188143.1,
                                           ERR3363660.1922170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC161888.5         189034-189099
            67-151              AC158679.8         125876-125960       c
            152-208             AC158679.8         124828-124884       c
            209-427             AC158679.8         123989-124207       c
            428-516             AC158679.8         117845-117933       c
            517-679             AC158679.8         114834-114996       c
            680-802             AC158679.8         111993-112115       c
            803-979             AC158679.8         111372-111548       c
            980-2488            AC158679.8         109072-110580       c
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.53 cM"
     gene            1..2488
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="Tp53rk binding protein"
                     /db_xref="GeneID:69786"
                     /db_xref="MGI:MGI:1917036"
     exon            1..66
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..151
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            152..208
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            209..427
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..516
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..679
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             539..1066
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="isoform a is encoded by transcript variant 3;
                     TP53RK-binding protein; Prpk (p53-related protein
                     kinase)-binding protein; EKC/KEOPS complex subunit Tprkb;
                     PRPK-binding protein"
                     /codon_start=1
                     /product="EKC/KEOPS complex subunit Tprkb isoform a"
                     /protein_id="NP_001348993.1"
                     /db_xref="CCDS:CCDS20305.1"
                     /db_xref="GeneID:69786"
                     /db_xref="MGI:MGI:1917036"
                     /translation="MQLSQQLDLFPECRVTLLLFKDVKNAGDLRKKAMEGSIDGSLIN
                     PNVIVDPFQILVAANKAVHLHRLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISETN
                     TSVLIVYIEDGSKQVPQEHLVSQVEGQQVPLESLPEITRLSEVKKIYKLSSQEERIGT
                     LLDAIICRMSTKDVL"
     exon            680..802
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..979
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..2488
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2467..2472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="hexamer: ATTAAA"
     polyA_site      2486
                     /gene="Tprkb"
                     /gene_synonym="0610033G21Rik; 1810034M08Rik; Cgi-121;
                     DRWMS1; mDRWMS1"
                     /note="major polyA site"
ORIGIN      
        1 tgtttcttaa cctgggggtc aatcaaccct cttacaggga ccacccaaga ccctccgaca
       61 taccagaatt ctcattacta tcgtgtgtgc catggcttga gtggaggtca gaaggcaagc
      121 tctcgcagtt ggttctcgcc ttcctcctca gaacaaagca tatttcagaa attctcactc
      181 caagacacag ctgctcctgc tacatatggt agcaaggact aaaatccgga ctcactatct
      241 tggtggccac ccttccccgt gagcagtacc ctggtcttgt ataattccct gaggcggatg
      301 gcttctgggg acttgatccc agcgtcgcgt cctctggtct gctcaagaaa tttgcctctt
      361 tcctctgtca cagctgtgaa agtccacttg tctctagatc tccaagcacc ggaagcgctc
      421 cttcaatgca ttttcccgac tctacgggcc cgtgcttcca atctcctgta atcctaaact
      481 tctgactctc ctgacctccc ctggactgga ttctcggaga gtccttcttg tctacgaaat
      541 gcagctatca cagcagctgg acttgtttcc tgaatgcagg gtgacccttc tgttatttaa
      601 agatgtaaaa aatgcaggag acttgagaaa aaaggccatg gaaggatcta ttgatggttc
      661 attgataaac cccaatgtga ttgtcgatcc atttcagata cttgtggcag caaacaaagc
      721 cgttcatctc cacagactgg gaaaaatgaa gacaagaact ctgtctactg aaattatctt
      781 caacctctcc ccaaataata atatttcaga ggccttgaag aaatttggca tttcagaaac
      841 taacacttca gttctgattg tttacattga agatggaagc aaacaagtac cacaggaaca
      901 cctagtatct caagtggaag gccagcaggt gcctttggaa agtcttccag aaataacaag
      961 gctctcggaa gtcaagaaga tatataaact gtcatcacaa gaagagagga ttgggacgtt
     1021 attggatgct atcatttgta gaatgtcaac gaaggatgtt ttataagatg tttaaaatgt
     1081 caacagaaag ccgggcgtgg tgatgcatgc ctttaatccc agcacttggg aggcagaggc
     1141 aggcggattt ctgagtttga ggccagcctg gtctacagag tgagttccag gacagccagg
     1201 gctacacgga gaaaccctgt ctcgaaaaac caaaaaaaaa aaaaaattaa ctctaagcca
     1261 ggtgtggtga ctcattacag tccactgctc aggaggctga ggcaggagaa agctgcaagt
     1321 ttgaggtcag cttgggatat gccacaaatt ccagatcagc ctaaagtact atgtcaaatc
     1381 ctatctcaat aaatagcaat tcatttaact ctcttagctg ctttttaggt agatatgtct
     1441 ttgtgcccac tttatacaag aggcagctaa aagagtatag cagtattaac tgactagccc
     1501 agggtcatgt aactagtata aaaccatgtt tgatggttcc ttttccccct cactttatct
     1561 tgtattggat tgtatccatc aagataggct tggtcaaggg ttagcaaagc tctgtgaaga
     1621 gccagataag tactttgctc ctcaaaggcc gcctcatctg gttcctgcta caattactca
     1681 atatgacctt tgcagtctga aagcagccac agaggacagg tacagagtga gtggcctctg
     1741 tccagtgagc cttgacttga acaagcagtg ggcagccctg gagttgagac tgtagactcc
     1801 agagttggct aggacatagt gacagtcaaa ccctaaagct cactggctta gtacagcaga
     1861 aggaaacatt ttgttatctt gaaggcagaa gggatcagag ggaaacccac agcagggctt
     1921 tagagccctc tgcgggggct tctcagcctg ggcttctagg ttactgtgca gcttgtcaga
     1981 agctctgggg agggcagaga aacctaaaag catccacatg gaagtggcag gtattgctca
     2041 cctcttttca ttcacacaag ttcaaaaatg gtgacccctt gttcttccca caagcacagt
     2101 cagttctgcc cctccagtcc cctctaaagc gccaagtctg caaagccagg tgctctcata
     2161 gtgcagttct ggggttgttc tctgggtacc ttatggtggt ttgaatatgt ttggcccagg
     2221 gagtggcact atttagagat gaggcctttt tggagttggt aagaccttgg cagaaatgtg
     2281 tcattgtggg catgggcttt aagagaccct ccctccttct agccgtgtgg gagccagttt
     2341 tctcttagcg gccttcagat gaagatgtag aactctcaga tcctcctgca ccatgcctgc
     2401 ctggacactg ccatgctcct gtcttgatga taacagactg aacctctgaa cctgtaagcc
     2461 agcccgatta aatgttgttc ttataaga
//
