LOCUS       NM_133780               7550 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus translocated promoter region, nuclear basket protein
            (Tpr), mRNA.
ACCESSION   NM_133780 XM_489807
VERSION     NM_133780.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7550)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7550)
  AUTHORS   Giacomini,C., Mahajani,S., Ruffilli,R., Marotta,R. and Gasparini,L.
  TITLE     Lamin B1 protein is required for dendrite development in primary
            mouse cortical neurons
  JOURNAL   Mol Biol Cell 27 (1), 35-47 (2016)
   PUBMED   26510501
REFERENCE   3  (bases 1 to 7550)
  AUTHORS   Jaberi,A., Hooker,E., Guillemette,J., Papillon,J., Kristof,A.S. and
            Cybulsky,A.V.
  TITLE     Identification of Tpr and alpha-actinin-4 as two novel
            SLK-interacting proteins
  JOURNAL   Biochim Biophys Acta 1853 (10 Pt A), 2539-2552 (2015)
   PUBMED   26094769
REFERENCE   4  (bases 1 to 7550)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 7550)
  AUTHORS   Schweizer,N., Ferras,C., Kern,D.M., Logarinho,E., Cheeseman,I.M.
            and Maiato,H.
  TITLE     Spindle assembly checkpoint robustness requires Tpr-mediated
            regulation of Mad1/Mad2 proteostasis
  JOURNAL   J Cell Biol 203 (6), 883-893 (2013)
   PUBMED   24344181
REFERENCE   6  (bases 1 to 7550)
  AUTHORS   Hughes,D.S., Keynes,R.J. and Tannahill,D.
  TITLE     Extensive molecular differences between anterior- and
            posterior-half-sclerotomes underlie somite polarity and spinal
            nerve segmentation
  JOURNAL   BMC Dev Biol 9, 30 (2009)
   PUBMED   19463158
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7550)
  AUTHORS   Lupu,F., Alves,A., Anderson,K., Doye,V. and Lacy,E.
  TITLE     Nuclear pore composition regulates neural stem/progenitor cell
            differentiation in the mouse embryo
  JOURNAL   Dev Cell 14 (6), 831-842 (2008)
   PUBMED   18539113
REFERENCE   8  (bases 1 to 7550)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   9  (bases 1 to 7550)
  AUTHORS   De Andrea,M., Zannetti,C., Noris,E., Gariglio,M., Azzimonti,B. and
            Landolfo,S.
  TITLE     The mouse interferon-inducible gene Ifi204 product interacts with
            the Tpr protein, a component of the nuclear pore complex
  JOURNAL   J Interferon Cytokine Res 22 (11), 1113-1121 (2002)
   PUBMED   12513910
REFERENCE   10 (bases 1 to 7550)
  AUTHORS   Kuznetsov,N.V., Sandblad,L., Hase,M.E., Hunziker,A., Hergt,M. and
            Cordes,V.C.
  TITLE     The evolutionarily conserved single-copy gene for murine Tpr
            encodes one prevalent isoform in somatic cells and lacks paralogs
            in higher eukaryotes
  JOURNAL   Chromosoma 111 (4), 236-255 (2002)
   PUBMED   12424524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161432.5.
            
            On Dec 8, 2009 this sequence version replaced NM_133780.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141406.1, SRR10223971.1032.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC161432.5         140533-140708       c
            177-479             AC161432.5         139888-140190       c
            480-584             AC161432.5         138243-138347       c
            585-658             AC161432.5         134873-134946       c
            659-755             AC161432.5         131195-131291       c
            756-859             AC161432.5         129845-129948       c
            860-1024            AC161432.5         129507-129671       c
            1025-1117           AC161432.5         126992-127084       c
            1118-1198           AC161432.5         126137-126217       c
            1199-1286           AC161432.5         125969-126056       c
            1287-1427           AC161432.5         124662-124802       c
            1428-1519           AC161432.5         124252-124343       c
            1520-1717           AC161432.5         123369-123566       c
            1718-1825           AC161432.5         121538-121645       c
            1826-2052           AC161432.5         120429-120655       c
            2053-2216           AC161432.5         119739-119902       c
            2217-2350           AC161432.5         118997-119130       c
            2351-2499           AC161432.5         118732-118880       c
            2500-2662           AC161432.5         117315-117477       c
            2663-2797           AC161432.5         116030-116164       c
            2798-2938           AC161432.5         115458-115598       c
            2939-3104           AC161432.5         113543-113708       c
            3105-3271           AC161432.5         111744-111910       c
            3272-3424           AC161432.5         110866-111018       c
            3425-3541           AC161432.5         110373-110489       c
            3542-3745           AC161432.5         109857-110060       c
            3746-3930           AC161432.5         109565-109749       c
            3931-4078           AC161432.5         108736-108883       c
            4079-4216           AC161432.5         107772-107909       c
            4217-4348           AC161432.5         106552-106683       c
            4349-4479           AC161432.5         105296-105426       c
            4480-4690           AC161432.5         104001-104211       c
            4691-4834           AC161432.5         102842-102985       c
            4835-5021           AC161432.5         102198-102384       c
            5022-5227           AC161432.5         100930-101135       c
            5228-5289           AC161432.5         100666-100727       c
            5290-5498           AC161432.5         99660-99868         c
            5499-5771           AC161432.5         97631-97903         c
            5772-5920           AC161432.5         96680-96828         c
            5921-6004           AC161432.5         96060-96143         c
            6005-6199           AC161432.5         94270-94464         c
            6200-6331           AC161432.5         93348-93479         c
            6332-6422           AC161432.5         93017-93107         c
            6423-6607           AC161432.5         91303-91487         c
            6608-6676           AC161432.5         90294-90362         c
            6677-6771           AC161432.5         90117-90211         c
            6772-6878           AC161432.5         89072-89178         c
            6879-6974           AC161432.5         87583-87678         c
            6975-7131           AC161432.5         87305-87461         c
            7132-7250           AC161432.5         85916-86034         c
            7251-7346           AC161432.5         84308-84403         c
            7347-7550           AC161432.5         83611-83814         c
FEATURES             Location/Qualifiers
     source          1..7550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 63.84 cM"
     gene            1..7550
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /note="translocated promoter region, nuclear basket
                     protein"
                     /db_xref="GeneID:108989"
                     /db_xref="MGI:MGI:1922066"
     exon            1..176
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..7402
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /note="NPC-associated intranuclear protein; translocated
                     promoter region and nuclear basket protein; nuclear pore
                     complex-associated protein Tpr"
                     /codon_start=1
                     /product="nucleoprotein TPR"
                     /protein_id="NP_598541.3"
                     /db_xref="CCDS:CCDS35734.2"
                     /db_xref="GeneID:108989"
                     /db_xref="MGI:MGI:1922066"
                     /translation="MTSGGSASRSGHRGVPMTSRGFDGSRRGSLRRAGARETASEAAD
                     GAAPAAGLRASPCSLASPSAAAAVAAIPADMAAVLQQVLERPELNKLPKSTQNKLEKF
                     LAEQQSEIDCLKGRHEKFKVESEQQYFEIEKRLSQSQERLVTETRECQNLRLELEKLN
                     NQVKVLTEKTKELETAQDRNLGIQSQFTRAKEELEAEKRDLIRTNERLSQEVEYLTED
                     VKRLNEKLKESNTTKGELQLKLDELQASDVAVKYREKRLEQEKELLHNQNSWLNTELK
                     TKTDELLALGREKGNEILELKCNLENKKEEVLRLEEQMNGLKTSNEHLQKHVEDLLTK
                     LKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVDELHKLLKEAG
                     EANKTIQDHLLQVEESKDQMEKEMLEKIGKLEKELENANDLLSATKRKGAILSEEELA
                     AMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKQENKRINKYLDEIVKEVEAKA
                     PILKRQREEYERAQKAVASLSAKLEQAMKEIQRLQEDTDKANKHSSVLERDNQRMEIQ
                     IKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQN
                     QRLLFALRELGETREREEQETTSSKIAELQHKLENSLAELEQLRESRQHQMQLVDSIV
                     RQRDMYRILLSQTTGMAIPLQASSLDDISLLSTPKRSSTSQTVSTPAPEPVIDSTEAI
                     EAKAALKQLQEIFENYKKEKIDSEKLQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR
                     YEMLQDNVEGYRREITSLQERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAE
                     NLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLNSQ
                     IEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTEINLHLNTKELLKNAQ
                     KDIATLKQHLNNMEAQLASQSTQRTGKGQPGDRDDVDDLKSQLRQAEEQVNDLKERLK
                     TSTSNVEQYRAMVTSLEDSLNKEKQVTEEVHKNIEVRLKESAEFQTQLEKKLMEVEKE
                     KQELQDDKRKAIESMEQQLSELKKTLSTVQNEVQEALQRASTALSNEQQARRDCQEQA
                     KIAVEAQNKYERELMLHAADVEALQAAKEQVSKMTSIRQHLEETTQKAESQLLECKAS
                     WEERERVLKDEVSKSVSRCEDLEKQNRLLHDQIEKLSDKVVTSMKDAVQAPLNVSLNE
                     EGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNVER
                     EKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQNLQQMQAKVRKLELDI
                     LPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQQLINQQKDPDTEEYRKLLSEKE
                     IHTKRIQQLNEEVGRLKAEIARSNASLTNNQNLIQSLREDLSKARTEKEGIQKDLDAK
                     IIDIQEKVKTITQVKKIGRRYKTQFEELKAQQNKAMETSTQSSGDHQEQHISVQEMQE
                     LKDTLSQSETKTKSLEGQVENLQKTLSEKETEARSLQEQTVQLQSELSRLRQDLQDKT
                     TEEQLRQQMNEKTWKTLALAKSKITHLSGVKDQLTKEIEELKQRNGALDQQKDELDVR
                     MTALKSQYEGRISRLERELREHQERHLEQRDEPQEPTNKAPEQQRQITLKTTPASGER
                     GIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPT
                     ATVMPTTQVESQEAMQSEGPVEHVPVFGNASGSVRSTSPNVQPSISQPILTVQQQTQA
                     TAFVQPTQQSHPQIEPTNQELSPNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKR
                     TREEEEDSTMEAGDQVSEDTVEMPLPKKLKMVTPVGTEEEVMAEESTDGEAETQAYNQ
                     DSQDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQQTTSSQDGQGKGDDVIVID
                     SDDEDDDEENDGEHEDYEEDEDDDDDEEDDTGMGDEGEDSNEGTGSADGNDGYEADDA
                     EGGDGTDPGTETEESMGGAESHQRAADSQNSGEGNTSAAESSFSQEVAREQQPTSASE
                     RQTPQAPQSPRRPPHPLPPRLTIHAPPQELGPPVQRIQMTRRQSVGRGLQLTPGIGGM
                     QQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDMPQTSSSHS
                     DLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHAS
                     QSVPMVTTSTGTLSTTNETAAGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASD
                     ESDLPSTSQDPPSSSSVDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGISHAMGGR
                     GGINRGNIN"
     exon            177..479
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            480..584
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            585..658
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            659..755
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            756..859
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1024
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1117
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1198
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1286
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1427
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1519
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1717
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1825
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..2052
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2216
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2350
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2499
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2662
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2797
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2938
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3104
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3271
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3424
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3541
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3745
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3930
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4078
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4079..4216
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4348
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..4479
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4480..4690
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4691..4834
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4835..5021
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..5227
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5228..5289
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5290..5498
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5499..5771
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5772..5920
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5921..6004
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6005..6199
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6200..6331
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6332..6422
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6423..6607
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6608..6676
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6677..6771
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6772..6878
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6879..6974
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6975..7131
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7132..7250
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7251..7346
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            7347..7550
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7522..7527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7547
                     /gene="Tpr"
                     /gene_synonym="2610029M07Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcagctcttc tacccaagcg agggaggcct gcaccccgcc cctctcgggg caccgttaag
       61 atcgtggcgg tagcccagag cctgtcgaga caccctgccg tgacccatga cctctggtgg
      121 ctcggcttct agaagtggcc acagaggagt acccatgaca tcccggggtt ttgacgggtc
      181 ccgccgcggg agtctcaggc gggcaggcgc gcgagagacc gcgagcgagg cggcggacgg
      241 ggcggctccg gcggctgggc tccgcgcttc tccttgctcc ttggcttctc cttcagccgc
      301 tgcggctgtt gccgcgatcc cggccgacat ggcggcggtg ttgcagcaag tgctggagcg
      361 cccggaactg aacaaactgc cgaagtcgac gcagaacaaa cttgagaagt tcctggccga
      421 gcagcagtcc gagatcgact gcctgaaggg gcggcacgag aaatttaagg tggagagtga
      481 acaacaatac tttgagatag agaagaggct ctcacagagt caggagaggc ttgtcactga
      541 aacccgggag tgtcagaact tgaggctgga gcttgagaag ctaaataacc aagtaaaagt
      601 gttaactgaa aaaaccaaag aactggaaac tgctcaagac cgtaatctgg gcattcagag
      661 ccagtttaca agagcaaagg aagagttaga agctgaaaaa agagatttaa tcagaaccaa
      721 tgagaggtta tctcaggaag ttgaatattt aacagaggat gttaaacgtc taaatgaaaa
      781 acttaaagaa agcaatacga cgaagggtga acttcagtta aagctggatg aacttcaagc
      841 ttctgatgtt gctgtgaagt atcgagaaaa acgcttagaa caagaaaagg aattgctaca
      901 caatcaaaat tcatggctga acacagagtt gaaaaccaaa actgatgagc tgttggctct
      961 aggaagagaa aaaggaaatg aaattctgga acttaagtgt aatcttgaaa acaaaaaaga
     1021 agaggttctg agactggaag aacagatgaa tggcttgaaa acatcaaatg aacatcttca
     1081 gaaacatgta gaggatttgt tgacaaaatt aaaagaggcc aaagaacagc aggccagtat
     1141 ggaagagaaa ttccacaatg agttaaatgc tcacataaag ctctctaatc tctacaagag
     1201 cgctgctgat gactcagagg caaagagtaa tgagctaacc cgggcagtgg acgagctgca
     1261 caaactgctc aaagaagcag gagaagccaa caaaacaata caagatcatc ttctacaagt
     1321 ggaagaatct aaagatcaga tggaaaaaga aatgcttgag aaaataggaa aattggagaa
     1381 ggaattagag aatgcaaatg acctgctttc tgctacaaaa cgtaaaggag ctatattgtc
     1441 tgaagaagag cttgcagcca tgtctcccac cgcagcagct gtagctaaaa ttgtaaagcc
     1501 tggcatgaaa ttaactgagc tatataatgc ttatgtggaa actcaggatc agttgctttt
     1561 ggaaaaacaa gaaaataaaa ggattaataa gtatctggat gagatagtaa aagaagtgga
     1621 agccaaagca ccgattttga aacgccagcg cgaagagtat gagcgtgcac agaaagctgt
     1681 ggccagtctt tctgcaaagc ttgagcaagc tatgaaggag attcagcgat tgcaggagga
     1741 cactgataaa gccaacaaac attcatcggt acttgaaagg gacaatcaga gaatggaaat
     1801 acaaataaaa gacctttcgc aacagataag agtgctcttg atggaacttg aagaagccag
     1861 gggtaaccat gtaattcggg atgaggaggt cagctctgct gacatcagta gttcgtctga
     1921 agtgatttcg cagcacctag tatcttacag gaacatcgaa gagcttcagc agcagaatca
     1981 gcgtctgcta ttcgctcttc gagaacttgg ggaaaccagg gaacgagaag agcaagagac
     2041 aacttcctct aagattgctg aacttcagca taaacttgag aactctctcg ctgaactgga
     2101 acagctccgt gagtcacgac aacatcagat gcagcttgtt gattccatag tgcgtcagcg
     2161 tgacatgtac cgaattttat tgtcacaaac aacaggaatg gccattccct tacaagcttc
     2221 aagtttagat gatatttctc ttctctcaac tccaaaacgt tcaagtacat cacagactgt
     2281 ttccactcct gctccggaac ccgtcattga ctccacagag gctatagaag caaaggctgc
     2341 ccttaaacag ttgcaggaaa tctttgagaa ctataaaaaa gaaaaaatag acagtgagaa
     2401 acttcaaaat gagcagctag agaaacttca agagcaagtc acagacctgc gctcacaaaa
     2461 caccaaaatt tctactcagc tagattttgc ttctaaacgt tatgaaatgc tgcaagataa
     2521 tgtagaagga tatcgtcgag aaataacatc tctacaagag agaaatcaga aactcactgc
     2581 aactactcag aagcaggaac agatcatcaa cacaatgacg caagacttga gaggagccaa
     2641 tgaaaagcta gcagttgcag aagtaagagc agaaaattta aagaaggaaa aagaaatgct
     2701 taaattgtct gaagtccgtc tttctcagca aagagagtct ttgttagctg aacagagggg
     2761 gcagaacttg ttgctgacta atctacagac aatccagggc atactagagc gatctgagac
     2821 tgaaaccaaa caaaggctga atagccagat agaaaaactg gagcatgaga tctctcactt
     2881 gaagaagaaa ttggaaaacg aggtggaaca aagacatacg cttacgagga atctagacgt
     2941 tcaactatta gataccaaga gacagctaga tacagaaata aatctccatc ttaacacaaa
     3001 agaactgtta aaaaatgctc agaaggacat tgctacactg aaacagcacc ttaataatat
     3061 ggaagcccag ctcgcttcac agtccacaca gagaaccggt aaaggtcagc ctggtgacag
     3121 agatgacgtt gatgatctta aaagtcagct aaggcaggct gaagaacagg tcaatgactt
     3181 gaaggagaga ctcaagacaa gtaccagtaa tgtggagcag tatcgagcca tggtgaccag
     3241 cttagaagat tccctgaaca aggagaaaca ggtgactgag gaggttcata agaacattga
     3301 agttcgcttg aaagaatcag cagagtttca gacacagttg gagaagaaat tgatggaagt
     3361 agagaaggaa aagcaagaac ttcaggatga taagaggaaa gccatcgaga gcatggaaca
     3421 gcaattaagt gaattgaaga aaacactgtc tactgttcag aatgaagtac aagaagctct
     3481 tcagagagca agcacagctt taagtaatga acagcaagcc aggcgtgact gtcaggaaca
     3541 agctaaaatc gctgtggaag cccagaataa gtatgagaga gaattgatgc tacatgctgc
     3601 tgatgtcgaa gctctgcaag ctgccaagga acaggtttca aaaatgacat caatccgtca
     3661 gcatttggaa gaaacaactc agaaagcaga atcccagttg ttggaatgta aagcatcttg
     3721 ggaagagaga gagagagtgt tgaaggatga agtttccaaa agtgtgtctc gctgtgaaga
     3781 tctagagaaa caaaaccgac tacttcatga tcaaatcgaa aaattaagtg acaaggtggt
     3841 cacctctatg aaggatgctg tgcaagcgcc attaaatgta tctctcaatg aagaagggaa
     3901 atctcaagaa caaattctag aaattcttag atttattcga cgagaaaaag aaattgctga
     3961 aactaggttt gaggtggctc aggttgagag tttgcggtat cgacaaagag ttgaacttct
     4021 agaacgggag ttgcaagaac tgcaggatag cctgaatgtg gaaagggaaa aggtgcaggt
     4081 aactgcaaaa acaatggcgc aacatgaaga gctgatgaag aaaactgaaa caatgaacgt
     4141 tgttatggag accaacaaga tgctacggga ggaaaaggaa aggctcgaac agaacctaca
     4201 acaaatgcaa gccaaggtga ggaaactgga gttagacatt ttacccttac aagaagccaa
     4261 tgctgagctg agtgagaaaa gcggtatgct ccaggcagaa aagaagctac tggaagagga
     4321 tgttaagcgt tggaaagcac ggaaccagca actaataaat caacagaaag atccagacac
     4381 agaagaatat cgaaagttgc tttctgaaaa ggaaattcac actaagagaa tccaacagct
     4441 aaatgaagaa gttggaaggc ttaaggctga aattgcaaga tcaaatgcat ccttgactaa
     4501 caaccagaat ttaatccaga gtctgcggga agacttaagt aaagcacgga ctgaaaagga
     4561 aggcattcag aaagatttag atgccaaaat aattgatata caggaaaagg tcaaaacaat
     4621 cactcaagtc aagaaaattg gacgcaggta caagactcag tttgaagaac tgaaagcgca
     4681 acaaaacaag gccatggaga cttccactca gtcttcagga gaccatcagg aacagcacat
     4741 ctctgtccag gaaatgcagg agctcaaaga taccctcagc caatccgaaa caaagacaaa
     4801 gtcacttgag ggtcaagtag agaatctgca gaagacatta tctgaaaaag agacagaagc
     4861 aagaagtctc caggagcaga cggtgcagct tcagtctgaa ctgtcacgcc ttcgtcagga
     4921 cctccaggat aaaaccacag aggagcagct ccgacagcaa atgaatgaaa agacttggaa
     4981 gacacttgca ctagccaaat caaaaattac acatctatct ggtgtgaaag atcagctgac
     5041 taaagaaatt gaagaactta aacaaaggaa cggagctcta gatcagcaga aagatgagct
     5101 tgatgtccga atgactgctc ttaagtccca gtatgaaggt cggattagtc gcttagagag
     5161 agagctcaga gagcatcaag agcgacacct tgagcagagg gatgagcctc aagaacccac
     5221 taataaggct ccagaacagc aaagacaaat cacactgaaa accactccag cttctggtga
     5281 aagaggaatt gccagcacat cagacccacc aacagccaat atcaagccaa ctcctgttgt
     5341 ttctactcca agtaaagtga cagctgcagc tatggctggg aataagtcga cacccagggc
     5401 aagtatccgc ccaatggtta cacctgcaac ggtcacaaat ccgaccacta ccccaacagc
     5461 aaccgtaatg cctactacac aggtggagtc acaggaagct atgcagtcag aagggcctgt
     5521 ggaacatgtt ccagtatttg gaaacgcaag tggatctgtt cgttctacta gtcctaatgt
     5581 tcagccctcc atttctcagc ccatcctaac tgtacagcag caaacacaag ctacagcttt
     5641 tgtacaaccc actcaacaga gccacccgca gattgagcct acaaatcaag aattgtcccc
     5701 aaacatagtt gaggtagtac aaagttcccc agtggagcgt ccatctactt ccacagcagt
     5761 atttggcact gtttcagcta ccccaagttc ctccttgcca aagcgcactc gggaggagga
     5821 agaggacagc accatggaag caggagacca agtctctgag gacacagtgg aaatgcctct
     5881 cccgaagaag ctgaagatgg tcacacccgt tggaaccgag gaagaagtta tggcagaaga
     5941 aagtactgat ggagaggcag aaactcaagc ctataatcag gactctcaag attccattgg
     6001 agaaggagtt acccagggag attatacacc aatggaagac agtgaagaaa catcacaatc
     6061 tctacaaatc gatcttggac cacttcagtc agatcaacag actacttcct ctcaagatgg
     6121 tcaaggcaaa ggagatgatg taattgtaat tgacagtgat gatgaagatg atgatgaaga
     6181 aaatgatggc gaacatgaag attatgaaga agacgaagat gatgatgatg atgaagaaga
     6241 tgacacgggg atgggagatg agggtgaaga tagtaatgaa ggaactggta gtgcagatgg
     6301 taatgatgga tatgaagctg atgatgctga gggtggtgat gggactgatc caggtacaga
     6361 aacagaagaa agtatgggtg gagctgaaag tcatcagaga gctgctgatt ctcaaaacag
     6421 tggtgaagga aatacaagtg cagcagagtc ttccttctct caggaggttg ccagggaaca
     6481 gcagcccacg tcagcgtctg agagacagac tccgcaagca ccgcagtcac caaggcgccc
     6541 tccacatcct ctccccccac gcctgaccat tcacgcccca cctcaggagc tgggaccacc
     6601 agttcagaga attcagatga cccggaggca gtctgtaggg cgtggtcttc agttgactcc
     6661 aggaataggt ggcatgcaac aacacttttt tgatgatgaa gacagaacag tcccgagtac
     6721 cccaactctt gtggtgccac atcgcactga tgggtttgct gaagctattc attccccaca
     6781 ggttgccggt gttcctagat tccggtttgg gccacctgaa gacatgccac agacaagttc
     6841 cagtcactct gatcttggcc aacttgcttc tcaaggaggt ttgggaatgt atgaaacacc
     6901 cctttttctg gctcatgaag aagagtctgg tggccgcagc gttcccacta cgcctctcca
     6961 agtagcagcc ccagtgactg tgttcactga gagtaccacc tctgatgctt cagaacatgc
     7021 ctctcagtcg gttcccatgg tgacaacgtc tacgggcact ttatccacga caaacgaaac
     7081 agcagcaggt gacgacggag atgaagtatt tgtagaggcg gagtctgaag gtattagttc
     7141 agaggcaggc ctagaaattg atagccagca ggaagaggag cctgtccaag catctgatga
     7201 atcagatctt ccctcaacca gccaagatcc cccttcgagc tcctccgtag ataccagtag
     7261 tagtcaaccg aagcctttca gacgagtaag acttcagaca accttgagac agggtgttcg
     7321 tggtcgtcag tttaaccgac aaagaggtat aagccatgca atgggaggaa gaggaggaat
     7381 aaatagaggg aatattaatt aagtgatctc taaactgtga cacatgtgaa taagattgac
     7441 gaatctgttt taatataatg attgtcaagt tgagaactgt tttgtattta aataggtatg
     7501 ctcatttcaa cattctttat taataaaatg tatttcaatg tcaaaaagta
//
