LOCUS       NM_026481               1040 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus tubulin polymerization-promoting protein family member
            3 (Tppp3), mRNA.
ACCESSION   NM_026481
VERSION     NM_026481.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1040)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1040)
  AUTHORS   Cherief,M., Xu,J., Li,Z., Tower,R.J., Ramesh,S., Qin,Q.,
            Gomez-Salazar,M., Yea,J.H., Lee,S., Negri,S., Xu,M., Price,T.,
            Kendal,A.R., Fan,C.M., Clemens,T.L., Levi,B. and James,A.W.
  TITLE     TrkA-mediated sensory innervation of injured mouse tendon supports
            tendon sheath progenitor cell expansion and tendon repair
  JOURNAL   Sci Transl Med 15 (727), eade4619 (2023)
   PUBMED   38117901
REFERENCE   3  (bases 1 to 1040)
  AUTHORS   Kuwahara,A., Lewis,A.E., Coombes,C., Leung,F.S., Percharde,M. and
            Bush,J.O.
  TITLE     Delineating the early transcriptional specification of the
            mammalian trachea and esophagus
  JOURNAL   Elife 9, e55526 (2020)
   PUBMED   32515350
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1040)
  AUTHORS   Harvey,T., Flamenco,S. and Fan,C.M.
  TITLE     A Tppp3+Pdgfra+ tendon stem cell population contributes to
            regeneration and reveals a shared role for PDGF signalling in
            regeneration and fibrosis
  JOURNAL   Nat Cell Biol 21 (12), 1490-1503 (2019)
   PUBMED   31768046
  REMARK    GeneRIF: These results support Tppp3(+)Pdgfra(+) cells as tendon
            stem cells.
REFERENCE   5  (bases 1 to 1040)
  AUTHORS   Komura,S., Ito,K., Ohta,S., Ukai,T., Kabata,M., Itakura,F.,
            Semi,K., Matsuda,Y., Hashimoto,K., Shibata,H., Sone,M., Jo,N.,
            Sekiguchi,K., Ohno,T., Akiyama,H., Shimizu,K., Woltjen,K.,
            Ozawa,M., Toguchida,J., Yamamoto,T. and Yamada,Y.
  TITLE     Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in
            clear cell sarcomas
  JOURNAL   Nat Commun 10 (1), 3999 (2019)
   PUBMED   31488818
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1040)
  AUTHORS   Liu,W., Watson,S.S., Lan,Y., Keene,D.R., Ovitt,C.E., Liu,H.,
            Schweitzer,R. and Jiang,R.
  TITLE     The atypical homeodomain transcription factor Mohawk controls
            tendon morphogenesis
  JOURNAL   Mol Cell Biol 30 (20), 4797-4807 (2010)
   PUBMED   20696843
REFERENCE   7  (bases 1 to 1040)
  AUTHORS   Zhou,W., Li,J., Wang,X. and Hu,R.
  TITLE     Stable knockdown of TPPP3 by RNA interference in Lewis lung
            carcinoma cell inhibits tumor growth and metastasis
  JOURNAL   Mol Cell Biochem 343 (1-2), 231-238 (2010)
   PUBMED   20571904
  REMARK    GeneRIF: findings suggested that the TPPP3 gene played an important
            role in tumorigenesis and metastasis, and it could potentially
            become a novel target for cancer therapy
REFERENCE   8  (bases 1 to 1040)
  AUTHORS   Staverosky,J.A., Pryce,B.A., Watson,S.S. and Schweitzer,R.
  TITLE     Tubulin polymerization-promoting protein family member 3, Tppp3, is
            a specific marker of the differentiating tendon sheath and synovial
            joints
  JOURNAL   Dev Dyn 238 (3), 685-692 (2009)
   PUBMED   19235716
  REMARK    GeneRIF: onset of Tppp3 expression in joints coincides with
            cavitation, representing a molecular marker that can be used to
            indicate this stage in joint transition in joint differentiation
REFERENCE   9  (bases 1 to 1040)
  AUTHORS   Amanai,M., Brahmajosyula,M. and Perry,A.C.
  TITLE     A restricted role for sperm-borne microRNAs in mammalian
            fertilization
  JOURNAL   Biol Reprod 75 (6), 877-884 (2006)
   PUBMED   16943360
REFERENCE   10 (bases 1 to 1040)
  AUTHORS   Keegan,C.E., Hutz,J.E., Else,T., Adamska,M., Shah,S.P., Kent,A.E.,
            Howes,J.M., Beamer,W.G. and Hammer,G.D.
  TITLE     Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd)
            mice is caused by a splicing mutation in a novel telomeric
            regulator
  JOURNAL   Hum Mol Genet 14 (1), 113-123 (2005)
   PUBMED   15537664
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF469439.1, AK160507.1 and AW494372.1.
            
            On Aug 15, 2009 this sequence version replaced NM_026481.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010788.1, AK155018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BF469439.1         1-30
            31-1020             AK160507.1         2-991
            1021-1040           AW494372.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..1040
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1040
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /note="tubulin polymerization-promoting protein family
                     member 3"
                     /db_xref="GeneID:67971"
                     /db_xref="MGI:MGI:1915221"
     exon            1..143
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /inference="alignment:Splign:2.1.0"
     exon            144..337
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..680
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /codon_start=1
                     /product="tubulin polymerization-promoting protein family
                     member 3"
                     /protein_id="NP_080757.1"
                     /db_xref="CCDS:CCDS22602.1"
                     /db_xref="GeneID:67971"
                     /db_xref="MGI:MGI:1915221"
                     /translation="MAASTDIAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKV
                     ADGKAVTGTDVDIVFSKVKAKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQL
                     IAGKEPANIGVTKAKTGGAVDRLTDTSKYTGSHKERFDESGKGKGIAGRQDILDDSGY
                     VSAYKNAGTYDAKVKK"
     exon            338..491
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /inference="alignment:Splign:2.1.0"
     exon            492..1024
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /note="hexamer: AATAAA"
     polyA_site      1024
                     /gene="Tppp3"
                     /gene_synonym="2700055K07Rik; Ceacam9; CGI-38; mmCGM8"
                     /note="major polyA site"
ORIGIN      
        1 gggataatac tacggagccg cccgggctgc agtcccgccc gggagccggc agggagcgga
       61 gctgtggagc ctcctggtct ccagcatcag ttcctgggtc ctgtccgaag gcacgctcag
      121 gagcagccaa gcggtagaag ccgggtggca tggcagcgag cacggacata gctgggctgg
      181 aggagagctt ccggaagttt gccatccatg gcgaccccaa ggccagcggg caagagatga
      241 atggcaagaa ctgggccaag ctgtgcaagg actgtaaggt ggccgacgga aaggccgtaa
      301 cgggcaccga cgtcgacatc gtcttctcca aagtcaaggc gaaatctgct agagtaatca
      361 actatgagga gttcaagaag gccctggaag agctggcaac taagcggttc aaggggaagt
      421 ccaaggagga ggcctttgat gccatctgcc agctgatagc gggcaaggaa ccggccaaca
      481 ttggcgtcac caaagctaaa acgggtggtg ctgtggaccg gctgacggac accagtaagt
      541 atacgggctc ccacaaagaa cgctttgatg agagcggcaa gggaaagggc atcgctggac
      601 ggcaggacat cctggacgac agtggctacg tgagtgccta caaaaacgca ggcacctatg
      661 acgccaaggt gaagaagtga cacctgccaa agcccccagg gaggctgtcc cactggaggc
      721 ccaggcctgg ggtccagggt cacatggagc aagaaagcct ggctccctcc ctgctggatc
      781 tgccaccaag agcttcctgc ccagtcccag ggccatccca tcaggcctct gacccagact
      841 gctgtgtccc ttcttcctgt ctccctgtca tctgtctggg agtcagtgcc tatatcctca
      901 ccgccccagc ctggtcccag gcatggctga ctcttgcctg cttttgcctc atatttaagc
      961 tgctgctctg gccaagtgcc taattcttac ccagacctca ataaagatac cttttgtacc
     1021 aggaaaaaaa aaaaaaaaaa
//
