LOCUS       NM_001128634             747 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tubulin polymerization-promoting protein family member
            2 (Tppp2), mRNA.
ACCESSION   NM_001128634 XM_001479332 XM_359331 XM_907853
VERSION     NM_001128634.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 747)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 747)
  AUTHORS   Zhu,F., Yan,P., Zhang,J., Cui,Y., Zheng,M., Cheng,Y., Guo,Y.,
            Yang,X., Guo,X. and Zhu,H.
  TITLE     Deficiency of TPPP2, a factor linked to oligoasthenozoospermia,
            causes subfertility in male mice
  JOURNAL   J Cell Mol Med 23 (4), 2583-2594 (2019)
   PUBMED   30680919
  REMARK    GeneRIF: Deficiency of TPPP2 might affect the translation of
            specific proteins, such as eEf1b, altering the structure and
            function of sperm mitochondria, and resulting in decreased sperm
            count, motility and fertility.
REFERENCE   3  (bases 1 to 747)
  AUTHORS   Yalcin,S., Zhang,X., Luciano,J.P., Mungamuri,S.K., Marinkovic,D.,
            Vercherat,C., Sarkar,A., Grisotto,M., Taneja,R. and Ghaffari,S.
  TITLE     Foxo3 is essential for the regulation of ataxia telangiectasia
            mutated and oxidative stress-mediated homeostasis of hematopoietic
            stem cells
  JOURNAL   J Biol Chem 283 (37), 25692-25705 (2008)
   PUBMED   18424439
  REMARK    GeneRIF: Foxo3 represses ROS in part via regulation of ATM and this
            repression is required for maintenance of the hematopoietic stem
            cell pool
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049709.1.
            
            On or before Jun 22, 2008 this sequence version replaced
            XM_907853.3, XM_359331.5, XM_001479332.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU936364.1, BC049709.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-747               BC049709.1         115-861
FEATURES             Location/Qualifiers
     source          1..747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.72 cM"
     gene            1..747
                     /gene="Tppp2"
                     /gene_synonym="Gm1790; Gm77"
                     /note="tubulin polymerization-promoting protein family
                     member 2"
                     /db_xref="GeneID:219038"
                     /db_xref="MGI:MGI:2684923"
     exon            1..200
                     /gene="Tppp2"
                     /gene_synonym="Gm1790; Gm77"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..540
                     /gene="Tppp2"
                     /gene_synonym="Gm1790; Gm77"
                     /note="p25 beta"
                     /codon_start=1
                     /product="tubulin polymerization-promoting protein family
                     member 2"
                     /protein_id="NP_001122106.1"
                     /db_xref="CCDS:CCDS49487.1"
                     /db_xref="GeneID:219038"
                     /db_xref="MGI:MGI:2684923"
                     /translation="MASEAERTFHRFAVFGESSSSSKEITNKNFSKLCKDCDIMDGKA
                     VTSTDVDIVFSKVKAKNARTINFQQFQEAMKELGQKRFKGKNPDEALQGVFKLMEGKD
                     PATTGVTKSTTVGGVDRLTDTSKYTGTHKERFDESGKGKGIEGREETTDNSGYVSGYK
                     GAGTYDKKNQ"
     exon            201..354
                     /gene="Tppp2"
                     /gene_synonym="Gm1790; Gm77"
                     /inference="alignment:Splign:2.1.0"
     exon            355..628
                     /gene="Tppp2"
                     /gene_synonym="Gm1790; Gm77"
                     /inference="alignment:Splign:2.1.0"
     regulatory      607..612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tppp2"
                     /gene_synonym="Gm1790; Gm77"
                     /note="hexamer: AATAAA"
     polyA_site      628
                     /gene="Tppp2"
                     /gene_synonym="Gm1790; Gm77"
                     /note="major polyA site"
ORIGIN      
        1 tcacccccac tcccccagca attgaccatg gcctcagaag cagaaagaac attccatcga
       61 ttcgctgtct ttggagaatc atccagcagc agcaaggaaa ttaccaacaa gaacttctcc
      121 aaactctgta aagactgtga tatcatggat ggcaaggcag tgacctccac agatgtggac
      181 attgtgttca gcaaagtgaa ggccaagaat gccagaacca tcaactttca acagtttcaa
      241 gaggcaatga aggagctggg ccaaaagcgc ttcaagggga agaacccaga tgaggctttg
      301 caaggtgttt ttaaactcat ggaaggcaaa gatcctgcca ccaccggtgt cactaaatca
      361 acgacggtgg gtggagtaga ccggttgaca gacaccagta agtacaccgg aactcacaag
      421 gagcgctttg atgagagtgg taagggaaaa ggtattgaag gtcgggaaga gaccactgac
      481 aactcaggct acgtgagtgg ctacaagggg gccggcacct atgacaagaa aaaccagtag
      541 agaggagcca tctttgcccg ctagtttcct gaccccgtgt ttttaacacc atgaaatcta
      601 ggaaataata aacgatgtgt gtgcagcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      661 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
      721 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
