LOCUS       NM_182839               5108 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tubulin polymerization promoting protein (Tppp), mRNA.
ACCESSION   NM_182839
VERSION     NM_182839.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5108)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5108)
  AUTHORS   Endres,T., Duesler,L., Corey,D.A. and Kelley,T.J.
  TITLE     In vivo impact of tubulin polymerization promoting protein (Tppp)
            knockout to the airway inflammatory response
  JOURNAL   Sci Rep 13 (1), 12272 (2023)
   PUBMED   37507487
  REMARK    GeneRIF: In vivo impact of tubulin polymerization promoting protein
            (Tppp) knockout to the airway inflammatory response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5108)
  AUTHORS   Ferreira,N., Gram,H., Sorrentino,Z.A., Gregersen,E., Schmidt,S.I.,
            Reimer,L., Betzer,C., Perez-Gozalbo,C., Beltoja,M., Nagaraj,M.,
            Wang,J., Nowak,J.S., Dong,M., Willen,K., Cholak,E.,
            Bjerregaard-Andersen,K., Mendez,N., Rabadia,P., Shahnawaz,M.,
            Soto,C., Otzen,D.E., Akbey,U., Meyer,M., Giasson,B.I.,
            Romero-Ramos,M. and Jensen,P.H.
  TITLE     Multiple system atrophy-associated oligodendroglial protein
            p25alpha stimulates formation of novel alpha-synuclein strain with
            enhanced neurodegenerative potential
  JOURNAL   Acta Neuropathol 142 (1), 87-115 (2021)
   PUBMED   33978813
  REMARK    GeneRIF: Multiple system atrophy-associated oligodendroglial
            protein p25alpha stimulates formation of novel alpha-synuclein
            strain with enhanced neurodegenerative potential.
REFERENCE   4  (bases 1 to 5108)
  AUTHORS   Nguyen,H., Meservey,L.M., Ishiko-Silveria,N., Zhou,M., Huang,T.T.
            and Fu,M.M.
  TITLE     Fear Deficits in Hypomyelinated Tppp Knock-Out Mice
  JOURNAL   eNeuro 7 (5) (2020)
   PUBMED   32878961
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5108)
  AUTHORS   Fu,M.M., McAlear,T.S., Nguyen,H., Oses-Prieto,J.A., Valenzuela,A.,
            Shi,R.D., Perrino,J.J., Huang,T.T., Burlingame,A.L., Bechstedt,S.
            and Barres,B.A.
  TITLE     The Golgi Outpost Protein TPPP Nucleates Microtubules and Is
            Critical for Myelination
  JOURNAL   Cell 179 (1), 132-146 (2019)
   PUBMED   31522887
  REMARK    GeneRIF: These results demonstrate that TPPP on Golgi outposts are
            important for local microtubule nucleation and myelin sheath
            elongation.
REFERENCE   6  (bases 1 to 5108)
  AUTHORS   Acevedo,K., Li,R., Soo,P., Suryadinata,R., Sarcevic,B.,
            Valova,V.A., Graham,M.E., Robinson,P.J. and Bernard,O.
  TITLE     The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its
            ability to assemble microtubules
  JOURNAL   Exp Cell Res 313 (20), 4091-4106 (2007)
   PUBMED   18028908
  REMARK    GeneRIF: LIMK1 phosphorylation of p25 blocks p25 activity, thus
            promoting microtubule disassembly.
REFERENCE   7  (bases 1 to 5108)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
REFERENCE   8  (bases 1 to 5108)
  AUTHORS   Vosseller,K., Trinidad,J.C., Chalkley,R.J., Specht,C.G.,
            Thalhammer,A., Lynn,A.J., Snedecor,J.O., Guan,S.,
            Medzihradszky,K.F., Maltby,D.A., Schoepfer,R. and Burlingame,A.L.
  TITLE     O-linked N-acetylglucosamine proteomics of postsynaptic density
            preparations using lectin weak affinity chromatography and mass
            spectrometry
  JOURNAL   Mol Cell Proteomics 5 (5), 923-934 (2006)
   PUBMED   16452088
REFERENCE   9  (bases 1 to 5108)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   10 (bases 1 to 5108)
  AUTHORS   Tirian,L., Hlavanda,E., Olah,J., Horvath,I., Orosz,F., Szabo,B.,
            Kovacs,J., Szabad,J. and Ovadi,J.
  TITLE     TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle
            formation
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 13976-13981 (2003)
   PUBMED   14623963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY124320.1, BC054803.1 and BM898784.1.
            
            On Oct 27, 2009 this sequence version replaced NM_182839.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054803.1, SRR1660819.184066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BY124320.1         1-59
            60-4723             BC054803.1         1-4664
            4724-5083           BM898784.1         25-384              c
            5084-5108           BC054803.1         5024-5048
FEATURES             Location/Qualifiers
     source          1..5108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.15 cM"
     gene            1..5108
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /note="tubulin polymerization promoting protein"
                     /db_xref="GeneID:72948"
                     /db_xref="MGI:MGI:1920198"
     exon            1..91
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
     exon            92..403
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..752
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /note="brain-specific protein p25 alpha; p25-alpha; 25 kDa
                     brain-specific protein"
                     /codon_start=1
                     /product="tubulin polymerization-promoting protein"
                     /protein_id="NP_878259.1"
                     /db_xref="CCDS:CCDS26638.1"
                     /db_xref="GeneID:72948"
                     /db_xref="MGI:MGI:1920198"
                     /translation="MADSKAKPAKAANKTPPKSPGDPARAAKRLSLESEGANEGATAA
                     PELSALEEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDGKNVTVTDVDIVFSKI
                     KGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGRAPVISGVTKAVSSP
                     TVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKHAGTYDQKVQGGK
                     "
     exon            404..557
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
     exon            558..5090
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5069..5074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /note="hexamer: AATAAA"
     polyA_site      5090
                     /gene="Tppp"
                     /gene_synonym="2900041A09Rik; TPPP/p25"
                     /note="major polyA site"
ORIGIN      
        1 ggagggcggg gcccggcgga cagctctgag agctcggcgc ccctgggcgc gcgtctagtc
       61 gctgaggcgc agcagtggac gcgttttgga gcaacatggc tgacagcaag gccaagcctg
      121 ccaaagctgc caacaagaca ccacccaagt ccccaggaga cccagccagg gctgctaaga
      181 ggttgtcact ggagtcagag ggtgccaatg agggtgcaac tgcagctcct gagctcagtg
      241 ccctggagga ggccttccgg cggtttgcag tacatgggga caccagggca acaggaaagg
      301 agatgcatgg caagaactgg tcaaaactgt gcaaggactg ccacgtgatc gatgggaaga
      361 atgtgaccgt cactgacgtg gacattgtct tcagcaagat caaaggaaag tcctgcagga
      421 ccatcacctt tgagcagttc caggaggcac tggaggagct ggccaagaag cggttcaagg
      481 ataagagcag cgaggaggct gtacgtgagg tgcacaggct cattgaggga cgagcaccag
      541 tcatctctgg cgtcacgaaa gctgtgtcct cacccacggt gtcacggctc acagacacaa
      601 gcaagttcac aggttcccac aaggagcgtt tcgaccaatc aggaaagggc aagggcaaag
      661 ctggccgtgt ggacctggtg gatgagtcag gctatgtgcc tggttacaag catgcaggca
      721 cctatgacca gaaggtgcag gggggcaagt agcctcatag gctgacgctc tggacactat
      781 aggtggcagg cacaggactt acacccattg cacttcatta cattcctatg tttaactggg
      841 cagaactcag aatgcacctc cactaggcga tggtgggggc aatgcccgat cctcctcctg
      901 ctgggtgctt tgacacttct ccctcagacc ccaggtttgg gccgtgattc actgtcctgt
      961 cctaacatac ctgccctgtc cacagctgga aagtggactg ctatttccaa ctgtctccca
     1021 ggatcatacc atactggcca cttgattttc aggtaaaagg gggtggtttg ggtaaggaga
     1081 agcagagcag atgccagaac tcacgctgac cttatctagg cacttctagg tcagcaggag
     1141 ctaagaaact aaccaactgc atagagtaat cctaaacagg ccctttcatc tttcttgacc
     1201 acagcacatg gctgaggcta cttggtgggt tagcacacat gtgtgtgaat acacatatgc
     1261 acacatgcat attaaccaac cgagtctgtg ctgtgagagg ccaagagaaa atggaagttc
     1321 cccagcgacc aggagagtga cttggagtat gaagctggaa gtttcttcag tgttgtttta
     1381 agaaatgaca agactatatg cttggtctca agagtgatcc agggagatcc agaacatcaa
     1441 gctgccatgt cccatcacca ggttgggacg cacatcatgc tgagacactt tgtccagacc
     1501 aggcctggac agttgttcca ccagtgtgag atggaagctt ttaccagggc aagttatact
     1561 gtgttttgct caaaattatg tgtcttcagc tctatggagc cttctctggg ttcagttttc
     1621 ttaacttttc tcacaagtct aagtgtaggg cactggaaac cagaactagg cccaagaaag
     1681 atttgcagca tctgctaagg tttctttttc tgccacagga gagaagtcag gactcagccc
     1741 atccatgtgt gaggatggca cttagctagg cccaaaggca tgcaccatcc tcataagagc
     1801 cccacagcaa ttgttccttt gcattaacac agccctagcc ttgcatgcaa cttggtggac
     1861 tgtgtggcct tgtttctaga aaacacacag tggcctcagg atatgcttcc tggagcagat
     1921 gggtgttgag ggtgggacat tttacatggc ttggacagca taggtagaca gcaaggctat
     1981 cttccccact gccatggcac atagtcacat tatccacctc tctggggttc agagagcatg
     2041 gcttcactgc agcaccagag aagactacct actagcctaa gagagaaaag atgggcctta
     2101 ataccagacc tcccagacag caggctctct gaaagttcaa agttaacaag ctcaaggaaa
     2161 atggggatgg ttggcttcct cccaaggttt tttgagtttg ctgtgcctgg caagtggtgg
     2221 agcctccttt ctggaatctt acctcactgg tctggggaaa caaaatgacc cttgcacttc
     2281 ttgcaccctc acccagaacc cctagtcccc atgtggctgg cagtctcctg ctctgaggat
     2341 gctcttttct actgccacca tcacagccaa gtaaaatgga acacacacac aaatccatca
     2401 ggaagtgact gcatgtgggc cagggcagag gggaaggcta gtaaggcatc agagggtccc
     2461 cacaacatgt agtgggtcag atgtttccct gacccccaaa atagtacgaa aaccctggac
     2521 aaagccttct gttcaaaggg ctaagatgcc agaatgatgt ccagatgaag attcaagcca
     2581 agtcaagggt taacagccta ggaacaccta ggaaacaaca taagtgtcca ccttcacgtg
     2641 accgcccagc gtcatgggga agcttcatta taaactggtc accttaccta tgtgctcagg
     2701 actgaacaga aaagctcaga gtggcaagcc cgcataggtc ctgggcagta gaggaccaga
     2761 actgccatca gagtgcccaa aggtatgatc ctcagcagga aagcattcca ggaaagcaac
     2821 tgagaaagca tttctaatgg ctcttacaca gcttggactt tgtaaatgaa aattgggtta
     2881 ctctgccttg ctggtcctta ctgtccaaga gcagaacctg agcacccttg ggtcctgagg
     2941 gatagtccta ggcctgccca tatagttccc cagcaacacc cagaactatg tcagacaagt
     3001 ggtcttcatt gtgttccccc tgccccccag agtttcctta cacagcacct ttctttagtc
     3061 agtgttaagt ttaactttga aaataaacgc tccctctaga ttatatgtca tctagcgagg
     3121 gaagggtagt aacaattaga tcacggagac ttggtgtctt tgtaccgtca gtttaaaatg
     3181 tctatggaat tcattgtgac atctgtgtac cctttcgaca tagaaactga tttgaatcaa
     3241 actttgctgc acaaaacaga tgtgtatttt cctcagtttg atttgaacac acaggtagag
     3301 tgtttgtctc tgctgcatgt tttatgcaat accaattagc tattactaat tatggataaa
     3361 tagaattcag tgtctgtgaa taaaaacaaa caaacaaaaa ctgcacagca tgcaaaccaa
     3421 gacccagggc catgtgctat taggtgacag gcacacgaga cagggatagg ttcccataga
     3481 gggtgacact caggaggtga cattttcatt tctagagggg acacccagga gacagagaca
     3541 tactttgttg tgagctgacc caggaaacaa aggatacatt ctatcagggg aagacactca
     3601 agagacagag acaggctttc tttgagttat gacagcaaag aataaggaca ggttctgtca
     3661 ggggcgacac tcagggacat ggattggagt gacagagtca tattttgttg cacgtgacac
     3721 tcgaagatat gttttgtcag agtgaaacct aggaacatgg tctgtagagg gtgacataca
     3781 ggaatacatt ctgttggagg tgacattcag gagaaaggga aaaattgcag ggaagagcca
     3841 tgcagatggt gtcttaagtg tcagggaacg atggtaggta ggttggaggc tgtctgcaaa
     3901 cactgactct agtagaaccc ctatttattt ctatttaatg taacgaacaa ctagttagtg
     3961 gaaatgcttt accaaaatca gagttcaaat tacgtattta aatattgttg aagatctata
     4021 tttatactgg agtattttta cacctttcag tatcctatct tatattgggg cataggggca
     4081 ttatgacaca tggagatagt tctgaactgg gctgcacaac agttctgcca cctccctgta
     4141 gtctgtccca gggagttgac aggtgcctgc cctgagccaa gacccactcg cagaggccct
     4201 gggctgcctc agctgcctgt tttaatgaat agttttactg gcacacagct gtacccatgt
     4261 gtttacatac tgttctgtag ctgctttggt attagaacta gctgggagga ttgagacaga
     4321 cgccatggca cagacacata tggtatttgc cacctgttct ttttcaggga acactgcctg
     4381 tctgtctgct tggttctctc tctgtagact tgtgtactac ctggctacaa catgggcaca
     4441 tgggggaagc cctgccaatt aagaatggca agagtgacaa tttagctgta ctgtgaagac
     4501 atcagtagac agaatatcct tccaacactg agccaaactg ctcttcttca ccaacatact
     4561 actgaccatt ttacagttca ggggtgtggc catcttggga cgcttaaatt atctcttcct
     4621 ttagatttaa ccaagccaaa aaacaaagga agcctgtaca acaacttaaa cttgaaagga
     4681 ataatatgct actactacta gtttgtacta agtttttttt ttttcaagaa agggagttaa
     4741 gtttatatat atgtgatata tatttttaca ctattttatt aatgttaggg atatggagtt
     4801 tatcacttta tcagtgtgat gggtaatgtt gatgtcatgg gtgttctgac tcagaaagac
     4861 acttatactg acatctaagc cacacttgct cagactgtct gtcaggtcag gatggccctg
     4921 ctgtccctcc tatagagcgc aaggcgtcta gtcacctagt tggacatatg gcctggctca
     4981 tattgcttta gtgaaacagc ttgtgtcttt tatttcgttt attgtgtttg ctgttattaa
     5041 cattgtgtgt caagttggta aagtgatgaa taaaggtttt aaaatatgga aaaaaaaaaa
     5101 aaaaaaaa
//
