LOCUS       NM_009417               3306 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus thyroid peroxidase (Tpo), mRNA.
ACCESSION   NM_009417 XM_975183
VERSION     NM_009417.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3306)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3306)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3306)
  AUTHORS   Didier-Mathon,H., Stoupa,A., Kariyawasam,D., Yde,S.,
            Cochant-Priollet,B., Groussin,L., Sebag,F., Cagnard,N.,
            Nitschke,P., Luton,D., Polak,M. and Carre,A.
  TITLE     Borealin/CDCA8 deficiency alters thyroid development and results in
            papillary tumor-like structures
  JOURNAL   Front Endocrinol (Lausanne) 14, 1286747 (2023)
   PUBMED   37964961
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3306)
  AUTHORS   Lee,Y., DiMaulo-Milk,E., Leslie,J. and Ding,L.
  TITLE     Hematopoietic stem cells temporally transition to thrombopoietin
            dependence in the fetal liver
  JOURNAL   Sci Adv 8 (11), eabm7688 (2022)
   PUBMED   35294228
REFERENCE   5  (bases 1 to 3306)
  AUTHORS   Johnson,K.R., Gagnon,L.H., Longo-Guess,C.M., Harris,B.S. and
            Chang,B.
  TITLE     Hearing impairment in hypothyroid dwarf mice caused by mutations of
            the thyroid peroxidase gene
  JOURNAL   J Assoc Res Otolaryngol 15 (1), 45-55 (2014)
   PUBMED   24297261
  REMARK    GeneRIF: Hearing impairment in hypothyroid dwarf mice caused by
            mutations of the thyroid peroxidase gene.
REFERENCE   6  (bases 1 to 3306)
  AUTHORS   Endo,Y., Onogi,S., Umeki,K., Yamamoto,I., Kotani,T., Ohtaki,S. and
            Fujita,T.
  TITLE     Regional localization of the gene for thyroid peroxidase to human
            chromosome 2p25 and mouse chromosome 12C
  JOURNAL   Genomics 25 (3), 760-761 (1995)
   PUBMED   7759120
REFERENCE   7  (bases 1 to 3306)
  AUTHORS   Kotani,T., Umeki,K., Yamamoto,I., Takeuchi,M., Takechi,S.,
            Nakayama,T. and Ohtaki,S.
  TITLE     Nucleotide sequence of the cDNA encoding mouse thyroid peroxidase
  JOURNAL   Gene 123 (2), 289-290 (1993)
   PUBMED   7916704
REFERENCE   8  (bases 1 to 3306)
  AUTHORS   Taylor,B.A., Reifsnyder,P.C. and DiLauro,R.
  TITLE     Linkage of the thyroid peroxidase locus (Tpo) to markers in the
            proximal part of chromosome 12 of the mouse
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 250-251 (1992)
   PUBMED   1354596
REFERENCE   9  (bases 1 to 3306)
  AUTHORS   Isozaki,O., Kohn,L.D., Kozak,C.A. and Kimura,S.
  TITLE     Thyroid peroxidase: rat cDNA sequence, chromosomal localization in
            mouse, and regulation of gene expression by comparison to
            thyroglobulin in rat FRTL-5 cells
  JOURNAL   Mol Endocrinol 3 (11), 1681-1692 (1989)
   PUBMED   2691880
REFERENCE   10 (bases 1 to 3306)
  AUTHORS   Burrow,G.N., Spaulding,S.W., Alexander,N.M. and Bower,B.F.
  TITLE     Normal peroxidase activity in Pendred's syndrome
  JOURNAL   J Clin Endocrinol Metab 36 (3), 522-530 (1973)
   PUBMED   4346605
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC157276.2 and X60703.1.
            
            On Sep 15, 2015 this sequence version replaced NM_009417.2.
            
            Summary: This gene encodes a membrane-bound glycoprotein. The
            encoded enzyme plays a central role in thyroid gland function. The
            enzyme functions in the iodination of tyrosine residues in
            thyroglobulin and phenoxy-ester formation between pairs of
            iodinated tyrosines to generate the thyroid hormones, thyroxine and
            triiodothyronine. Mice with homozygous missense mutations in this
            gene exhibit hypothyroid dwarfism and hearing impairment. [provided
            by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X60703.1, AK047843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC157276.2         56388-56402         c
            16-3306             X60703.1           1-3291
FEATURES             Location/Qualifiers
     source          1..3306
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     gene            1..3306
                     /gene="Tpo"
                     /note="thyroid peroxidase"
                     /db_xref="GeneID:22018"
                     /db_xref="MGI:MGI:98813"
     exon            1..81
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            82..182
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2833
                     /gene="Tpo"
                     /EC_number="1.11.1.8"
                     /codon_start=1
                     /product="thyroid peroxidase precursor"
                     /protein_id="NP_033443.1"
                     /db_xref="CCDS:CCDS25857.1"
                     /db_xref="GeneID:22018"
                     /db_xref="MGI:MGI:98813"
                     /translation="MRTLGAMAIMLVVMGTVIFLSFILRSRDILCGKTMKSHVISAVE
                     TSQLMVDHAVYNTMKRNLKKREVLSPAQLLSFFKLPESTSGAISRAAEIMETSIQVMK
                     REQSQFSTDALSADILGTIANLSGCLPFMLPPRCPDTCLANKYRPITGACNNRDHPRW
                     GASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPPVREVTRHLIQVSNEAVTEDD
                     QYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQNPCFPIQLPSNSSGTT
                     ACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRN
                     WSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTPCFLAGDGRASEVPALA
                     AVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDA
                     FRQYVGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELPRLQLR
                     DVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNVGTLDLASL
                     NLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWL
                     GGLAEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENTNVFTDAQRQELEKHSLPRV
                     ICDNTGLTRVPVDAFRIGKFPQDFESCEDIPSMDLELWRETFPQDDKCVFPEEVDNGN
                     FVHCEESGKLVLVYSCFHGYKLQGQEQVTCTQKGWDSEPPVCKDVNECADLTHPPCHP
                     SAQCKNTKGSFQCVCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLTWI
                     VICRWTHADKKATLPITERVTTQSGCRKSQGRGISPHKAAAQDTGQEPASGSRVLLCE
                     "
     exon            183..267
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            268..419
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            420..552
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            553..682
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            683..889
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1390
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1649
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1820
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2058
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2267
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2438
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2570
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2670
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2794
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..3297
                     /gene="Tpo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3275..3280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpo"
                     /note="hexamer: ATTAAA"
     polyA_site      3297
                     /gene="Tpo"
                     /note="major polyA site"
ORIGIN      
        1 ttcagaagtt aagaccacag agaacacacc cagcggtgca catcctgctt cttccgctgc
       61 tgagaaaagg aaaacgttca gctctagaat gagaacactt ggagctatgg caataatgct
      121 ggtggttatg ggaactgtaa ttttcctctc ttttatcctg agaagcagag acatcttgtg
      181 tgggaagacc atgaagtccc atgttatcag tgctgtggaa acgagccagc tcatggtgga
      241 ccatgcagtc tacaacacca tgaaaagaaa cctcaagaaa agggaagtcc tttctccagc
      301 ccagcttctc tctttcttta agctgcccga gtccaccagt ggggctattt cccgagcagc
      361 agagattatg gaaacatcaa tacaagtcat gaaacgtgaa cagtcacagt tctccacgga
      421 tgccttatca gcagacattc tgggcacaat tgccaacctg tcaggatgct tgcctttcat
      481 gctgccacca agatgtcctg acacctgcct ggcaaataag taccggccca tcacaggggc
      541 gtgcaacaat agagatcacc ccagatgggg agcctccaac acagccctag caagatggct
      601 gcctcctgtc tatgaagatg gcttcagtca gcccaaaggc tggaacccta atttcttata
      661 ccacggcttc ccactgcccc cggtacggga agtgacaagg cacctcattc aagtttccaa
      721 tgaggctgtg accgaagatg accagtactc tgattttctg ccggtgtggg gacagtacat
      781 cgatcatgac attgctctca caccacagag cactagcaca gcagccttct ggggaggtgt
      841 cgactgccag ctgacctgtg agaaccaaaa tccttgcttc cccatacagc ttccctcaaa
      901 ctcctcaggg accactgcat gcctgccttt ctaccgctcc tccgccgctt gtggcactgg
      961 ggaccaaggt gctctctttg gcaacctgtc tgcagccaat ccgaggcagc agatgaatgg
     1021 cttgacctcc ttccttgatg cttccactgt gtacggcagc tcccctggcg ttgagaagca
     1081 gctgcgcaac tggagcagct cggcaggact gctgcgtgtc aacactctcc acctagatgc
     1141 tggccgtgcc tacctgccct tcgcaacagc cgcctgcgct ccagagcctg gtaccccacg
     1201 caccaaccgc acgccctgct tcctggctgg agacggtcgc gccagtgagg tccctgccct
     1261 ggcagcggta cacaccttgt ggctgcgcga gcacaaccgc ctggcttcgg ccttcaaggc
     1321 cattaacaag cactggagcg ccaacactgc ctaccaggag gcgcgcaagg tggtaggggc
     1381 actgcaccag atcatcacca tgagggatta tatccccaaa atcctgggtc ctgatgcctt
     1441 caggcagtat gtgggcccct atgaaggcta caaccccact gtgaacccta ctgtgtccaa
     1501 catcttctcc actgctgcct ttcgctttgg ccatgccaca gtccatccac tggtgagacg
     1561 gctaaacact gacttccagg agcacacaga gctccccagg ttgcagctgc gtgatgtctt
     1621 cttcagaccc tggaggctta tccaggaagg tggtttggat ccgatagtga gaggcctcct
     1681 ggcgagagca gccaagctgc aagtccaagg gcagctgatg aatgaggagc tgaccgagag
     1741 gctcttcgtg ctgtctaacg tgggcacctt ggatctggca tcactgaact tgcagagggg
     1801 ccgggatcat ggcttaccag actacaatga atggagagag ttctgtggct tgtcacgcct
     1861 ggagacacca gctgagctga acaaggccat tgccaacaga agcatggtca acaagataat
     1921 ggacttatac aagcatgctg acaacattga cgtctggttg ggaggcttgg ctgaaaagtt
     1981 cttgccgggg gcccgcactg gtcctctgtt tgcatgtatc attgggaagc agatgaaggc
     2041 tctgagggat ggggacaggt tttggtggga gaacaccaat gtcttcacag acgctcagag
     2101 gcaggaacta gaaaagcatt cactacctcg ggtcatctgt gacaacactg gactcaccag
     2161 agtacctgtg gatgccttcc gtattggaaa gttcccccaa gactttgaat cctgtgagga
     2221 catcccgagc atggaccttg aactatggag ggagaccttc ccacaagatg acaagtgtgt
     2281 cttcccagag gaggtggaca atgggaactt tgtgcactgt gaagagtctg ggaagctggt
     2341 gcttgtatac tcctgtttcc atggatacaa gctgcagggc caggagcagg tcacatgtac
     2401 ccagaaggga tgggactccg aacctcctgt ctgtaaagat gttaatgagt gtgcagatct
     2461 gacacaccca ccttgccacc cctctgcaca gtgcaagaac accaagggaa gcttccagtg
     2521 tgtgtgcaca gacccctatg tgctaggtga ggatgagaag acctgcatag attctggcag
     2581 gctacctcgg gcatcctggg tctccattgc actgggtgca cttctcattg gtggtttggc
     2641 cagtctcacc tggatagtaa tttgcaggtg gacacatgct gataagaaag ccacattgcc
     2701 gatcacagag agagtgacca cccagtcagg atgcagaaag agtcagggga gggggatttc
     2761 accacacaag gccgcagctc aagacactgg acaggaacct gcaagtggat ccagggtcct
     2821 cctgtgcgaa tagaggtcct cactgctttg gagccagaca ttggcaaagg caagtctcaa
     2881 gctgcctggg caaagacatg acacgtgttg gagtcagaga cttgaggaca ccagatgctg
     2941 agtcttatca tcagcccaag gctgcagtag cttccatctc atgtgtttcc acaggagcag
     3001 tgcaggccag accgtgctaa tgcctctcct acgcactaag gctaatggat gcgtgggagg
     3061 aaggctatga gaatcacata agcctgaaag tcctgagaga cgctggcata gactccagat
     3121 ccttctagac aagttcatgt tcattcagaa tcagcaaggc tctttcaaat acactcagtt
     3181 ctctcgttac ggtccagtca ccacaaagca caggcgaaga aatgctatag cattttgctg
     3241 gtctggctca gatatcctcc tcctctaggc ttgcattaaa gacatattta catatgaaaa
     3301 aaaaaa
//
