LOCUS       XM_011244397            1643 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus thiopurine methyltransferase (Tpmt),
            transcript variant X2, mRNA.
ACCESSION   XM_011244397
VERSION     XM_011244397.3
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000079.7) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 21, 2020 this sequence version replaced XM_011244397.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1643
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="13"
     gene            1..1643
                     /gene="Tpmt"
                     /note="thiopurine methyltransferase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     ESTs, 111 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     17 samples with support for all annotated introns"
                     /db_xref="GeneID:22017"
                     /db_xref="MGI:MGI:98812"
     CDS             225..1373
                     /gene="Tpmt"
                     /codon_start=1
                     /product="thiopurine S-methyltransferase isoform X1"
                     /protein_id="XP_011242699.1"
                     /db_xref="GeneID:22017"
                     /db_xref="MGI:MGI:98812"
                     /translation="MSFHLGTGDTNLRDKNCLQPVDGTMSLDMKEHPDAEVQKNQVLT
                     LEDWKEKWVTRHISFHQEQGHQLLKKHLDTFLKGQSGLRVFFPLCGKAVEMKWFADRG
                     HTVVGVEISEIGIREFFAEQNLSYTEEPLAEIAGAKVFKSSSGSISLYCCSIFDLPRA
                     NIGKFDRIWDRGALVAINPGDHDRYADIILSLLRKEFQYLVAVLSYDPTKHAGPPFYV
                     PSAELKRLFEHTGLGPSIHMEVESAAVALPSRDSQTSASARVSRRDPERHQEKFSAVP
                     LSLKQRSEKTRDPQHCTASSISKTSSPPLTVHGVLLYSLQTARVLHEWVLPQHMCLSQ
                     LTSLCRSAQSPRKQQETTVHYHKSFGTFSLYGVLTNGGQPCNVREIHT"
ORIGIN      
        1 cctgggaggg gcctgcgcgc cctgggcgtg gtctgcacgc tgggcggagc ctgcgtgtcc
       61 tgggcagagt tctcacgccc cgggcagggc ctataggacc ggagcctgga taatcttttc
      121 cggggtggga tcagaccaca ttgggcgggg ccttcgcccc tggggcgggg cctgtgagtc
      181 cttgcacagc tcccggctta caaaggcggg ctagtgtctg agagatgtct ttccacttag
      241 gcactggaga caccaacctc agagacaaaa attgtctaca acccgtggat ggtaccatgt
      301 cccttgatat gaaagagcac cctgatgctg aggtacaaaa gaaccaagta ctaaccctgg
      361 aagactggaa agagaagtgg gtgacccgtc acatctcatt ccatcaggag caagggcatc
      421 agctgttgaa gaagcatttg gatacatttc ttaaaggcca gagtggactg cgagtgtttt
      481 tccccctctg tggaaaagcc gttgagatga aatggttcgc agatcggggc cacactgtag
      541 ttggtgtgga aatcagtgaa attgggattc gggaattttt tgcagaacag aatctttcct
      601 acacagaaga accgctcgcc gaaattgctg gagccaaagt atttaagagt tcttcaggga
      661 gcatttcctt atactgctgc agcatatttg atcttcctag agcaaacatt ggcaagtttg
      721 acaggatttg ggatagagga gcattagtgg ctatcaatcc aggcgatcat gatcgctatg
      781 cagatataat actgtcccta ctgagaaaag agtttcagta ccttgtggct gtcctttctt
      841 atgatccaac aaaacacgca ggcccaccat tttatgttcc atctgctgaa cttaaaaggt
      901 tatttgaaca cacaggtttg ggtcccagca ttcatatgga ggtggaatca gcagcggtgg
      961 cactacctag cagagacagc cagacctcag cctctgcaag agtcagcagg agggacccgg
     1021 agagacacca ggaaaagttc tcagctgtgc ctctctcatt gaagcaaaga tcagagaaga
     1081 ctcgagaccc acagcattgc acagctagct ctataagcaa gactagttca cctcccctca
     1141 ctgtccatgg agtcctttta tactccctcc aaacagcacg tgtcctccat gagtgggtct
     1201 tgcctcagca catgtgcctg tctcagctga catcactctg cagatcagcc cagagcccaa
     1261 ggaagcagca agaaactaca gtacactacc acaagtcttt tggtacattc tctctctatg
     1321 gagtcctgac aaatggaggt caaccatgca atgtaaggga gatccataca tgagtgttgt
     1381 tagtgaagaa tccttcatca agtgtccttt cacgtgctcg ctttagcaga atatcctctc
     1441 ttctgtgtct gcttcagtga aacgttcctt cacgagtctg ccttagcctt tcacctgcat
     1501 ccacttcagg aaaacactct gccaccatgt atgccccagc gaaacaccag ccaacacaaa
     1561 tgactctcca aagaaccctt aagtttccac tgtatatatg tatttttaaa atattaaatt
     1621 ctgaataaac tcctttaatg ctg
//
