LOCUS       NM_001357581            2335 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tropomyosin 3, gamma (Tpm3), transcript variant 7,
            mRNA.
ACCESSION   NM_001357581 XM_017319678
VERSION     NM_001357581.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2335)
  AUTHORS   Chaichim,C., Tomanic,T., Stefen,H., Paric,E., Gamaroff,L.,
            Suchowerska,A.K., Gunning,P.W., Ke,Y.D., Fath,T. and Power,J.
  TITLE     Overexpression of Tropomyosin Isoform Tpm3.1 Does Not Alter
            Synaptic Function in Hippocampal Neurons
  JOURNAL   Int J Mol Sci 22 (17), 9303 (2021)
   PUBMED   34502205
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2335)
  AUTHORS   Tomanic,T., Martin,C., Stefen,H., Paric,E., Gunning,P. and Fath,T.
  TITLE     Deletion of the Actin-Associated Tropomyosin Tpm3 Leads to Reduced
            Cell Complexity in Cultured Hippocampal Neurons-New Insights into
            the Role of the C-Terminal Region of Tpm3.1
  JOURNAL   Cells 10 (3), 715 (2021)
   PUBMED   33807093
  REMARK    GeneRIF: Deletion of the Actin-Associated Tropomyosin Tpm3 Leads to
            Reduced Cell Complexity in Cultured Hippocampal Neurons-New
            Insights into the Role of the C-Terminal Region of Tpm3.1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2335)
  AUTHORS   Parreno,J., Amadeo,M.B., Kwon,E.H. and Fowler,V.M.
  TITLE     Tropomyosin 3.1 Association With Actin Stress Fibers is Required
            for Lens Epithelial to Mesenchymal Transition
  JOURNAL   Invest Ophthalmol Vis Sci 61 (6), 2 (2020)
   PUBMED   32492110
REFERENCE   4  (bases 1 to 2335)
  AUTHORS   Cheng,C., Nowak,R.B., Amadeo,M.B., Biswas,S.K., Lo,W.K. and
            Fowler,V.M.
  TITLE     Tropomyosin 3.5 protects the F-actin networks required for tissue
            biomechanical properties
  JOURNAL   J Cell Sci 131 (23) (2018)
   PUBMED   30333143
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2335)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   6  (bases 1 to 2335)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2335)
  AUTHORS   Clayton,L. and Johnson,M.H.
  TITLE     Tropomyosin in preimplantation mouse development: identification,
            expression, and organization during cell division and polarization
  JOURNAL   Exp Cell Res 238 (2), 450-464 (1998)
   PUBMED   9473354
REFERENCE   8  (bases 1 to 2335)
  AUTHORS   Schevzov,G., Lloyd,C., Hailstones,D. and Gunning,P.
  TITLE     Differential regulation of tropomyosin isoform organization and
            gene expression in response to altered actin gene expression
  JOURNAL   J Cell Biol 121 (4), 811-821 (1993)
   PUBMED   8491774
REFERENCE   9  (bases 1 to 2335)
  AUTHORS   Takenaga,K., Nakamura,Y., Kageyama,H. and Sakiyama,S.
  TITLE     Nucleotide sequence of cDNA for nonmuscle tropomyosin 5 of mouse
            fibroblast
  JOURNAL   Biochim Biophys Acta 1087 (1), 101-103 (1990)
   PUBMED   2400784
REFERENCE   10 (bases 1 to 2335)
  AUTHORS   MacLeod,A.R. and Gooding,C.
  TITLE     Human hTM alpha gene: expression in muscle and nonmuscle tissue
  JOURNAL   Mol Cell Biol 8 (1), 433-440 (1988)
   PUBMED   3336363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163616.3 and AI842950.1.
            
            On Nov 4, 2017 this sequence version replaced XM_017319678.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.1893.1,
                                           SRR1660825.64229.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AC163616.3         187457-187799
            344-477             AC163616.3         194382-194515
            478-595             AC163616.3         195391-195508
            596-666             AC163616.3         195610-195680
            667-742             AC163616.3         196984-197059
            743-805             AC163616.3         197733-197795
            806-875             AC163616.3         197946-198015
            876-954             AC163616.3         198949-199027
            955-2328            AC163616.3         207464-208837
            2329-2335           AI842950.1         11-17               c
FEATURES             Location/Qualifiers
     source          1..2335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.2 cM"
     gene            1..2335
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /note="tropomyosin 3, gamma"
                     /db_xref="GeneID:59069"
                     /db_xref="MGI:MGI:1890149"
     exon            1..343
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..958
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /note="isoform Tpm3.3cy is encoded by transcript variant
                     7; tropomyosin alpha-3 chain; tropomyosin-3;
                     gamma-tropomyosin; tropomyosin 5; skalphaTM.2"
                     /codon_start=1
                     /product="tropomyosin alpha-3 chain isoform Tpm3.3cy"
                     /protein_id="NP_001344510.1"
                     /db_xref="CCDS:CCDS89659.1"
                     /db_xref="GeneID:59069"
                     /db_xref="MGI:MGI:1890149"
                     /translation="MAGTTTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQ
                     AEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDE
                     EKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEE
                     LKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTID
                     DLEDELYAQKLKYKAISDELDHALNDMTSI"
     exon            344..477
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     exon            478..595
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..666
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     exon            667..742
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     exon            743..805
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     exon            806..875
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     exon            876..954
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     exon            955..2329
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /note="hexamer: AATAAA"
     polyA_site      2329
                     /gene="Tpm3"
                     /gene_synonym="gamma-TM; hTM30nm; hTMnm; TM30nm; Tm5NM;
                     TMnm; Tpm-5; Tpm5; Trop-5"
                     /note="major polyA site"
ORIGIN      
        1 tccacccttc actttctgcg ggctgcccga gtggactgcg ttcccgcctg cttggcaggg
       61 ggaggacgcg cggtggcggc ggcgtcacat cccggcgtat gagtgagttc cggtatttca
      121 gggcggagca ggcggaagta gggtgaaaag cggctacaac gccgagcgga ggaggtagga
      181 acctgatttc cagaagcagc ttgtaggcac catggccggg accaccacca tcgaggcggt
      241 aaagcgcaag atccaggttc tgcagcagca agctgatgat gcggaggaaa gggccgagcg
      301 cctccagcgg gaagtggagg gagaaaggcg ggcccgggag caggctgaag ctgaggtggc
      361 ctccttgaac cgcaggatcc agctggttga agaggagctg gaccgtgcgc aggagcgcct
      421 tgccactgct ttgcagaagc tggaggaagc agagaaggct gctgatgaga gtgagagagg
      481 tatgaaggtg attgaaaatc gggctctaaa agatgaagaa aagatggaac tccaggaaat
      541 ccagctaaag gaagcaaagc acattgcaga agaggccgat aggaagtatg aagaggtggc
      601 tcgtaagttg gtgattattg aaggagactt ggaacgcacg gaggaacgtg ctgagctggc
      661 agagtctaag tgttctgagc tggaggagga gctgaagaat gtcaccaaca acctcaagtc
      721 tcttgaggct caggcggaga agtactctca aaaagaagac aagtatgaag aagaaataaa
      781 gattcttact gataaactca aggaggcaga gacccgtgct gagtttgctg aaagatcggt
      841 agccaagctg gagaagacca ttgatgacct ggaagacgag ctctatgccc agaaactgaa
      901 gtacaaggcc attagcgacg agctggacca cgccctcaat gacatgacct ctatataaac
      961 tgaagtgcac caaagaggag catctctgta cacaaaggat gctggaccag accctgctgg
     1021 acctgaacga gatgtagacc tccccatccc tgccccgcgg ccattcctcc ctctgacctt
     1081 gactccgcca gaggccagcc tccctgaagc tgaccttgaa actgagggct gatcttttta
     1141 actgaaggct gctttccctc ctgccacccc cttttactac ccctcttgtc tttttcacaa
     1201 aactgtgtca gccttttccc agagttccag ttggaggggc tgaacacctt tgggaacaat
     1261 atttaaggga atgtgagcac aacgcagtgt cttcaatgca gttgtgatac gcacattgtg
     1321 attactttct gtcttagcaa ccatttttaa cattccaagc acttctgccg cttggagcag
     1381 cacattttag cctaatggat actgtctcgc catggaggag aaacccagga ttgggcctgc
     1441 cttcctgaga gccagcagag cccaggcagg ctccactgtg ggagacctca gtgctctgca
     1501 ccaactctta gccaaacaac agggggattc taggaagtta gccaaaaaca aaaactgttc
     1561 tgggctgtga aggttttcag ctttggtgtc tttgaacaat tttacactta tttttatttt
     1621 ttactttttc catcagatgt gaccaaataa gacaatgaga cgtctgagac agccccacct
     1681 cccagggcct catgcatgtt agttaggcaa gcgtgctacc gttcagcccc agccctgagc
     1741 ccaaacttat cgcagctcta cccctttcct aactgctcaa agatggatca tgccgcccct
     1801 tagtgttgtg gagacctctt agaggtcacc tgcccccaag ggagacagag aaaggaaaat
     1861 tatgtttgtg ccactgattt agccacatga acatcatctc atcgccctct cctgaagctg
     1921 cggtctctaa agtgccatct cattgtgctt tgtatcagtc agtgctggag aaatcttgaa
     1981 tagcttatgt gtaaaaaaac aaaaaacaaa aaaaaaactt tttaaatttt atattatttt
     2041 gaagttttgt ttttgggggg ttgggttagc ttggccaagc cattgactgt gagaattctt
     2101 tgcagtctgt gagctagtgg tgtgctgatc tttcaagtgt ccccacccaa ttgccatgtt
     2161 caggtggttt cttctcggcc tgttaggtgg gcaccctgca gattcctggc ttgtttgtac
     2221 tctcctccga ccgaccgacc ggagaaagag aaccccgcag tgcaactgtt ttgatactga
     2281 atatcgataa gtgacatttt gaaataaaga accagtccct ccacgatcaa aaaaa
//
