LOCUS       NM_009416               3250 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus tropomyosin 2, beta (Tpm2), transcript variant Tpm2.2,
            mRNA.
ACCESSION   NM_009416
VERSION     NM_009416.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   Sun,A., Ge,J., Ding,K., Gao,Z. and Zhang,Y.
  TITLE     Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune
            Suppression, and Activation of the JNK Signaling Pathway in
            Colitis-Associated Cancer (CAC)
  JOURNAL   Discov Med 36 (183), 778-787 (2024)
   PUBMED   38665026
  REMARK    GeneRIF: Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune
            Suppression, and Activation of the JNK Signaling Pathway in
            Colitis-Associated Cancer (CAC).
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Duan,P., Cui,J., Li,H. and Yuan,L.
  TITLE     Tropomyosin 2 exerts anti-tumor effects in lung adenocarcinoma and
            is a novel prognostic biomarker
  JOURNAL   Histol Histopathol 38 (6), 669-680 (2023)
   PUBMED   36102257
  REMARK    GeneRIF: Tropomyosin 2 exerts anti-tumor effects in lung
            adenocarcinoma and is a novel prognostic biomarker.
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Perry,S.V.
  TITLE     Vertebrate tropomyosin: distribution, properties and function
  JOURNAL   J Muscle Res Cell Motil 22 (1), 5-49 (2001)
   PUBMED   11563548
  REMARK    Review article
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Gariboldi,M., Manenti,G., Dragani,T.A. and Pierotti,M.A.
  TITLE     Chromosome mapping of nine tropomyosin-related sequences in mice
  JOURNAL   Mamm Genome 6 (4), 273-277 (1995)
   PUBMED   7613033
REFERENCE   7  (bases 1 to 3250)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   8  (bases 1 to 3250)
  AUTHORS   Wang,Y.C. and Rubenstein,P.A.
  TITLE     Splicing of two alternative exon pairs in beta-tropomyosin pre-mRNA
            is independently controlled during myogenesis
  JOURNAL   J Biol Chem 267 (17), 12004-12010 (1992)
   PUBMED   1601870
REFERENCE   9  (bases 1 to 3250)
  AUTHORS   Wang,Y.C. and Rubenstein,P.A.
  TITLE     Choice of 3' cleavage/polyadenylation site in beta-tropomyosin RNA
            processing is differentiation-dependent in mouse BC3H1 muscle cells
  JOURNAL   J Biol Chem 267 (4), 2728-2736 (1992)
   PUBMED   1733968
REFERENCE   10 (bases 1 to 3250)
  AUTHORS   McInnes,C. and Leader,D.P.
  TITLE     The tropomyosin mRNAs of mouse striated muscles: molecular cloning
            of beta-tropomyosin
  JOURNAL   Biochim Biophys Acta 951 (1), 117-122 (1988)
   PUBMED   2461223
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY786644.1, AK003186.1 and
            AK132162.1.
            
            On Apr 25, 2013 this sequence version replaced NM_009416.3.
            
            Summary: This gene belongs to the tropomyosin family which encodes
            proteins that bind to actin filaments and stabilize them by
            regulating access to actin modifying proteins. The encoded protein
            is a high molecular weight tropomyosin expressed in slow skeletal
            muscle. In humans, mutations in this gene are associated with
            nemaline myopathy, cap disease and distal arthrogryposis syndromes.
            Alternative splicing of this gene results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Apr
            2013].
            
            Transcript Variant: This variant (Tpm2.2, also known as variant 1)
            represents the longest transcript and encodes isoform Tpm2.2st
            (also known as isoform 1), which is of the same size as isoforms
            Tpm2.1sm/cy and Tpm2.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M81086.1, AK003186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               BY786644.1         2-271
            271-1148            AK003186.1         182-1059
            1149-3250           AK132162.1         1062-3163
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..3250
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /note="tropomyosin 2, beta"
                     /db_xref="GeneID:22004"
                     /db_xref="MGI:MGI:98810"
     exon            1..314
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1055
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /note="isoform Tpm2.2st is encoded by transcript variant
                     Tpm2.2; tropomyosin beta chain"
                     /codon_start=1
                     /product="tropomyosin beta chain isoform Tpm2.2st"
                     /protein_id="NP_033442.2"
                     /db_xref="CCDS:CCDS18100.1"
                     /db_xref="GeneID:22004"
                     /db_xref="MGI:MGI:98810"
                     /translation="MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQ
                     ALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRA
                     QERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDR
                     KYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKE
                     DKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDN
                     ALNDITSL"
     exon            315..440
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     exon            441..574
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     exon            575..692
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..763
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..839
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     exon            840..902
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     exon            903..972
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     exon            973..3250
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2245..2250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /note="hexamer: AATAAA"
     polyA_site      2265
                     /gene="Tpm2"
                     /gene_synonym="Tpm-2; Trop-2"
                     /note="major polyA site"
ORIGIN      
        1 aaggtttggg ccttggtggg ggagggtcct ggtcccccgg ctccgcccgg ctcctccccg
       61 ccttttaggc gcccgcgctg ctgggacatc acagtccctc ttggtcctcc tgacctgtcc
      121 cctgtgcatc cagagctcgc gcctagccca gtctacctac tcttcaccgc tctcccgcca
      181 gcccactccc caccgcagcc atggacgcca tcaagaagaa gatgcagatg ctgaaactgg
      241 acaaggagaa tgccatcgac cgcgcggagc aggccgaagc cgacaaaaag caagctgaag
      301 accgatgcaa gcagctggag gaagagcagc aggccctcca gaagaagctg aaggggacag
      361 aggacgaggt ggaaaagtat tccgagtccg tgaaggatgc ccaggagaaa ctggagcagg
      421 ctgagaagaa ggccaccgac gctgaagcag atgtggcctc tctgaaccgc cgcattcagc
      481 tcgtagagga ggagttggat cgggcacagg agcgcctggc tacagccttg caaaagctgg
      541 aggaggctga gaaagccgcg gatgagagcg agagaggaat gaaggtcatt gaaaaccggg
      601 ccatgaagga tgaggaaaag atggagctgc aggagatgca gctgaaggaa gccaagcaca
      661 tcgctgagga ctcagaccgc aaatatgagg aggtggccag gaagctggtg atcctggaag
      721 gggagctgga gcgctcggaa gagagagccg aggtggctga gagtaaatgt ggggacctag
      781 aggaggagct gaaaattgtt accaacaact tgaaatccct ggaagcccaa gcggacaagt
      841 attccaccaa agaggacaaa tacgaagaag agatcaaact tctggaggag aagctgaaag
      901 aggctgagac ccgagcagag tttgctgaaa gatctgtggc aaagttggag aaaaccattg
      961 atgatctgga agatgaagtc tatgcacaga agatgaagta caaggccatc agcgaggagc
     1021 tggacaacgc actcaatgac atcacttccc tctgagtccc cactgtggcc atcgcaggcc
     1081 cctttctctc ctctctttac attctctctg aggggagggg gcagccagga ggagcaccag
     1141 ctagccacgt tgcacagcca gcctgagggc agcctgagga acacgtctgc cacccctgcc
     1201 acccactctg gcactggctt ttctcctgcc atctatctac catgcactga cctccacccc
     1261 tccactactt aataaactct gaacttggtc tccatgctct tctactccgg aagcccttct
     1321 ccctttcaaa gcactgattc actcctgagt ccctggcttt tactgccgtc ctccatctgt
     1381 gacgctcagc cctcctccct cagcacactg tggctcacac agaccctcct gcactgcact
     1441 cccagcctgg cactttctga taatcaatgc atgtggctat acacaccctt cctccccacc
     1501 tcggcagccc agtcactgac cttggcacac ttaactggga ttccaggatc tgagggcatt
     1561 gctgagaggg aaatggggtg ctggggtcag gggagggggc cagaaggtca ggaaaggtct
     1621 ggtgtgaagg tcgttaaagt cttggatctc tacaagaggg gcttttgcag catctgcagg
     1681 tctgttttct gtcccatgtc tgtctgacct tccctttcct ggctgaacct ttgtctttcc
     1741 ttttgtttcc atctttccta accttctaaa ggcttctaaa ggaaggcacc ccgtttacgt
     1801 tacaggcctc cccatcccag tgtcactacc ccagccaagg cctagagcaa gatttgcgtc
     1861 tagatagtcc acccacttac ccctaccata ggccccccgg tctcttaaca tgactcaggt
     1921 ctcctaacac atcccaggtc tcctaacatg tcccaggtct cctaacacgt cccaggtccc
     1981 ctaacaagtc ccaggtccat aaagtgtctc ctaacattcc taacatggtt tttgtctgtg
     2041 tcaccttccc ctgtccatgg ttcccttccc tcctgtttac cctcccctac ctcacctgct
     2101 gcttcccctc acagagactt tggccagtgc caaggaagag aacgtggaga tacaccagac
     2161 cttggaccag acccttctgg aactcaacaa cctgtaaggg ctggccctgc tgcctaccag
     2221 actacatagt tgcctcctcg ggccaataaa ctgatgttac tggcatgcca gggcccttta
     2281 agcctatttt gttgttgttg gcagtggagc gggaaggacc ctgactgagc aaagcctggc
     2341 tcccatccct gtagtgcagt cccactttca atgggagcta tgaggtatgg gtaccaggct
     2401 tagcaagcaa gttgtggtcc ccacagagca gaaccaccat ccatggcaca cctctgctcc
     2461 agcaggcact gggccagaca ttctaaaggc aaaactgcaa gaatggacag attttcctcc
     2521 atcagggtaa aagccagaaa gacttgctca gtgtgaattg aagtttagag gtgtggccaa
     2581 gctaacctcc taacacacac tgctaggtgt tcttgcccca aagaggttca tattctaatc
     2641 ctgagaaatg ccacattagc caggaagagg gactattcag atgagcaaag aatttgaagt
     2701 agaggaggtt atcctaggtt aacaggtcag gcttggaata atcacaaggt cctcaaaggt
     2761 taggagagcc gagcatgatg gtgcagacca gcactcccag cacttgggag actaaggctg
     2821 aaaggactgg gtcttgatcc agtctgagct acatatacag tgaggctgtc tagaaggcaa
     2881 aagaggggaa aaaaaaagag tgtgggggtg gggatgaggt cacaggcagg aggggaagat
     2941 gtgacaatga aagagaggag ttggacatag ggaaggagtc aggagcaagg aatactggga
     3001 agggccagga gcgaggaatg caggagtcat ctaaaatgaa gtgttccact tgagaaagcc
     3061 agggagaata cagcccatgc atacctggac tagccataac gttcatgcag acttccagct
     3121 ctgggactgt aaacgttata ggagcagaac aaccctaagc ttgtggaagt tgctttgttt
     3181 tcccggcaaa cataagaaat taatataata tccctttgat gtgaggaata aaggcaaata
     3241 cacgagtttt
//
