LOCUS       NM_001164254            1183 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus tropomyosin 1, alpha (Tpm1), transcript variant
            Tpm1.13, mRNA.
ACCESSION   NM_001164254
VERSION     NM_001164254.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Wilken,M.B., Fonar,G., Qiu,R., Bennett,L., Tober,J., Nations,C.,
            Pavani,G., Tsao,V., Garifallou,J., Petit,C., Maguire,J.A.,
            Gagne,A., Okoli,N., Gadue,P., Chou,S.T., French,D.L., Speck,N.A.
            and Thom,C.S.
  TITLE     Tropomyosin 1 deficiency facilitates cell state transitions and
            enhances hemogenic endothelial cell specification during
            hematopoiesis
  JOURNAL   Stem Cell Reports 19 (9), 1264-1276 (2024)
   PUBMED   39214082
  REMARK    GeneRIF: Tropomyosin 1 deficiency facilitates cell state
            transitions and enhances hemogenic endothelial cell specification
            during hematopoiesis.
REFERENCE   2  (bases 1 to 1183)
  AUTHORS   Wang,Z.X., Lin,X., Cao,J., Liu,Y.W., Luo,Z.W., Rao,S.S., Wang,Q.,
            Wang,Y.Y., Chen,C.Y., Zhu,G.Q., Li,F.X., Tan,Y.J., Hu,Y., Yin,H.,
            Li,Y.Y., He,Z.H., Liu,Z.Z., Yuan,L.Q., Zhou,Y., Wang,Z.G. and
            Xie,H.
  TITLE     Young osteocyte-derived extracellular vesicles facilitate
            osteogenesis by transferring tropomyosin-1
  JOURNAL   J Nanobiotechnology 22 (1), 208 (2024)
   PUBMED   38664789
  REMARK    GeneRIF: Young osteocyte-derived extracellular vesicles facilitate
            osteogenesis by transferring tropomyosin-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1183)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1183)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   5  (bases 1 to 1183)
  AUTHORS   Edwards,W., Bussey,O.K. and Conlon,F.L.
  TITLE     The Tbx20-TLE interaction is essential for the maintenance of the
            second heart field
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37756602
REFERENCE   6  (bases 1 to 1183)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   7  (bases 1 to 1183)
  AUTHORS   Schleef,M., Zuhlke,C., Schoffl,F. and Jockusch,H.
  TITLE     Subtractive cDNA cloning as a tool to analyse secondary effects of
            a muscle disease. Characterization of affected genes in the
            myotonic ADR mouse
  JOURNAL   Neuromuscul Disord 4 (3), 205-217 (1994)
   PUBMED   7522680
REFERENCE   8  (bases 1 to 1183)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   9  (bases 1 to 1183)
  AUTHORS   Ryseck,R.P., MacDonald-Bravo,H., Zerial,M. and Bravo,R.
  TITLE     Coordinate induction of fibronectin, fibronectin receptor,
            tropomyosin, and actin genes in serum-stimulated fibroblasts
  JOURNAL   Exp Cell Res 180 (2), 537-545 (1989)
   PUBMED   2521606
REFERENCE   10 (bases 1 to 1183)
  AUTHORS   Takenaga,K., Nakamura,Y., Tokunaga,K., Kageyama,H. and Sakiyama,S.
  TITLE     Isolation and characterization of a cDNA that encodes mouse
            fibroblast tropomyosin isoform 2
  JOURNAL   Mol Cell Biol 8 (12), 5561-5565 (1988)
   PUBMED   3244365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166370.3.
            
            Transcript Variant: This variant (Tpm1.13, also known as variant 8)
            differs in the 5' and 3' UTRs as well as the 5' and 3' coding
            sequences compared to variant Tpm1.6. The encoded isoform (Tpm1.13)
            has alternate N- and C- termini and is shorter, compared to isoform
            Tpm1.6cy.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX241654.1, SRR7652917.556609.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC166370.3         173859-173996       c
            139-294             AC166370.3         173703-173858       c
            295-428             AC166370.3         166120-166253       c
            429-546             AC166370.3         164001-164118       c
            547-617             AC166370.3         162919-162989       c
            618-693             AC166370.3         162076-162151       c
            694-756             AC166370.3         161577-161639       c
            757-826             AC166370.3         161154-161223       c
            827-905             AC166370.3         159789-159867       c
            906-1183            AC166370.3         158015-158292       c
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.27 cM"
     gene            1..1183
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="tropomyosin 1, alpha"
                     /db_xref="GeneID:22003"
                     /db_xref="MGI:MGI:98809"
     exon            1..294
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..909
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="isoform Tpm1.13 is encoded by transcript variant
                     Tpm1.13; tropomyosin alpha-1 chain; tropomyosin-1;
                     alpha-tropomyosin; tropomyosin 1 kappa"
                     /codon_start=1
                     /product="tropomyosin alpha-1 chain isoform Tpm1.13"
                     /protein_id="NP_001157726.1"
                     /db_xref="GeneID:22003"
                     /db_xref="MGI:MGI:98809"
                     /translation="MAGSSSLEAVRRKIRSLQEQADAAEERAGSLQRELDQERKLRET
                     AEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDE
                     EKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEE
                     LKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSID
                     DLEDELYAQKLKYKAISEELDHALNDMTSI"
     exon            295..428
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            429..546
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            547..617
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            618..693
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            694..756
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            757..826
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            827..905
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1183
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1082..1087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="hexamer: AATAAA"
     polyA_site      1099
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="major polyA site"
     regulatory      1155..1160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="hexamer: AATAAA"
     polyA_site      1181
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
ORIGIN      
        1 ggcccaggag ccgtgacttc cggcctgctt cttagccgca gggggcgccg gcgttacaaa
       61 gccggcctgg gcgggacgaa ccggacctgg gctcggtagc ggcagcagca gtagcagctg
      121 cagagcgcgg aggcagagca cagcctcagc caccgcctcg ccatggcggg tagcagctcg
      181 ctggaggcgg tgcggagaaa gatccggagc ctgcaggagc aggcggatgc cgcggaggag
      241 cgtgcgggca gcctgcagcg cgagctggac caggagcgga agctgcggga aaccgctgaa
      301 gctgacgtag cttctctgaa cagacgcatc cagctggttg aggaggagtt ggatcgtgct
      361 caggagcgtc tggccacagc tctgcagaag ctggaggagg ccgagaaggc tgcagatgag
      421 agtgagagag gcatgaaagt cattgaaagc cgagcccaaa aagatgaaga aaagatggag
      481 attcaggaga tccagctgaa agaggccaag cacattgctg aagatgctga ccggaagtat
      541 gaagaggtgg cccgtaagct ggtcatcatc gagagcgacc tggaacgtgc agaggagcgg
      601 gctgagctct cagaaggcaa atgtgccgag cttgaagaag aattgaaaac ggtgacgaac
      661 aacttgaagt cactggaggc tcaggctgag aagtactctc agaaggaaga caaatatgaa
      721 gaggagatca aggttctctc tgacaagctg aaggaggctg aaactcgggc tgagtttgca
      781 gagagatcag taaccaaatt ggagaaaagc attgatgact tagaagacga gctgtatgct
      841 cagaaactga agtacaaggc catcagcgag gagctggacc acgctctcaa cgatatgact
      901 tccatataag tttctttgct tcactcctcc caagactcct tcgtcaagct ggatgtccca
      961 cctctctgag ctctgcatct gtctgctctc cagctgaccc aggtttcttt ttagcgccca
     1021 cccaccttag ggccaggcac agactgcttt ctattgtaca gaagcaattc gcccagtgta
     1081 aaataaacac tgtacgctat tcctgtttgc tattctttta ctccttattt attgacattt
     1141 tcgtctcaac gctcaataaa actacacttc tgcttcgtgc atc
//
