LOCUS       NM_001164251            1210 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus tropomyosin 1, alpha (Tpm1), transcript variant
            Tpm1.5, mRNA.
ACCESSION   NM_001164251
VERSION     NM_001164251.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1210)
  AUTHORS   Wilken,M.B., Fonar,G., Qiu,R., Bennett,L., Tober,J., Nations,C.,
            Pavani,G., Tsao,V., Garifallou,J., Petit,C., Maguire,J.A.,
            Gagne,A., Okoli,N., Gadue,P., Chou,S.T., French,D.L., Speck,N.A.
            and Thom,C.S.
  TITLE     Tropomyosin 1 deficiency facilitates cell state transitions and
            enhances hemogenic endothelial cell specification during
            hematopoiesis
  JOURNAL   Stem Cell Reports 19 (9), 1264-1276 (2024)
   PUBMED   39214082
  REMARK    GeneRIF: Tropomyosin 1 deficiency facilitates cell state
            transitions and enhances hemogenic endothelial cell specification
            during hematopoiesis.
REFERENCE   2  (bases 1 to 1210)
  AUTHORS   Wang,Z.X., Lin,X., Cao,J., Liu,Y.W., Luo,Z.W., Rao,S.S., Wang,Q.,
            Wang,Y.Y., Chen,C.Y., Zhu,G.Q., Li,F.X., Tan,Y.J., Hu,Y., Yin,H.,
            Li,Y.Y., He,Z.H., Liu,Z.Z., Yuan,L.Q., Zhou,Y., Wang,Z.G. and
            Xie,H.
  TITLE     Young osteocyte-derived extracellular vesicles facilitate
            osteogenesis by transferring tropomyosin-1
  JOURNAL   J Nanobiotechnology 22 (1), 208 (2024)
   PUBMED   38664789
  REMARK    GeneRIF: Young osteocyte-derived extracellular vesicles facilitate
            osteogenesis by transferring tropomyosin-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1210)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1210)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   5  (bases 1 to 1210)
  AUTHORS   Edwards,W., Bussey,O.K. and Conlon,F.L.
  TITLE     The Tbx20-TLE interaction is essential for the maintenance of the
            second heart field
  JOURNAL   Development 150 (21) (2023)
   PUBMED   37756602
REFERENCE   6  (bases 1 to 1210)
  AUTHORS   Geeves,M.A., Hitchcock-DeGregori,S.E. and Gunning,P.W.
  TITLE     A systematic nomenclature for mammalian tropomyosin isoforms
  JOURNAL   J Muscle Res Cell Motil 36 (2), 147-153 (2015)
   PUBMED   25369766
  REMARK    Review article
REFERENCE   7  (bases 1 to 1210)
  AUTHORS   Schleef,M., Zuhlke,C., Schoffl,F. and Jockusch,H.
  TITLE     Subtractive cDNA cloning as a tool to analyse secondary effects of
            a muscle disease. Characterization of affected genes in the
            myotonic ADR mouse
  JOURNAL   Neuromuscul Disord 4 (3), 205-217 (1994)
   PUBMED   7522680
REFERENCE   8  (bases 1 to 1210)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   9  (bases 1 to 1210)
  AUTHORS   Ryseck,R.P., MacDonald-Bravo,H., Zerial,M. and Bravo,R.
  TITLE     Coordinate induction of fibronectin, fibronectin receptor,
            tropomyosin, and actin genes in serum-stimulated fibroblasts
  JOURNAL   Exp Cell Res 180 (2), 537-545 (1989)
   PUBMED   2521606
REFERENCE   10 (bases 1 to 1210)
  AUTHORS   Takenaga,K., Nakamura,Y., Tokunaga,K., Kageyama,H. and Sakiyama,S.
  TITLE     Isolation and characterization of a cDNA that encodes mouse
            fibroblast tropomyosin isoform 2
  JOURNAL   Mol Cell Biol 8 (12), 5561-5565 (1988)
   PUBMED   3244365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166370.3.
            
            Transcript Variant: This variant (Tpm1.5, also known as variant 5)
            differs in the 3' UTR and coding sequence, lacks internal exon, and
            contains another alternate internal exon compared to variant
            Tpm1.6. The encoded isoform (Tpm1.5cy) is the same length but has
            short regions of sequence differences, compared to isoform
            Tpm1.6cy.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077713.1, BU515546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AC166370.3         179144-179338       c
            196-321             AC166370.3         177911-178036       c
            322-455             AC166370.3         166120-166253       c
            456-573             AC166370.3         164001-164118       c
            574-644             AC166370.3         162919-162989       c
            645-720             AC166370.3         162591-162666       c
            721-783             AC166370.3         161577-161639       c
            784-853             AC166370.3         161154-161223       c
            854-932             AC166370.3         159789-159867       c
            933-1210            AC166370.3         158015-158292       c
FEATURES             Location/Qualifiers
     source          1..1210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 36.27 cM"
     gene            1..1210
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="tropomyosin 1, alpha"
                     /db_xref="GeneID:22003"
                     /db_xref="MGI:MGI:98809"
     exon            1..195
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..936
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="isoform Tpm1.5cy is encoded by transcript variant
                     Tpm1.5; tropomyosin alpha-1 chain; tropomyosin-1;
                     alpha-tropomyosin; tropomyosin 1 kappa"
                     /codon_start=1
                     /product="tropomyosin alpha-1 chain isoform Tpm1.5cy"
                     /protein_id="NP_001157723.1"
                     /db_xref="CCDS:CCDS52847.1"
                     /db_xref="GeneID:22003"
                     /db_xref="MGI:MGI:98809"
                     /translation="MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELV
                     SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRA
                     QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADR
                     KYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKE
                     DKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDH
                     ALNDMTSI"
     exon            196..321
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            322..455
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            456..573
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            574..644
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            645..720
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            721..783
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            784..853
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            854..932
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1210
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1109..1114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="hexamer: AATAAA"
     polyA_site      1126
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="major polyA site"
     regulatory      1182..1187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
                     /note="hexamer: AATAAA"
     polyA_site      1208
                     /gene="Tpm1"
                     /gene_synonym="alpha-TM; TM2; Tm3; Tmpa; Tpm-1; TPM1kappa"
ORIGIN      
        1 gctcgcactc cggctctgct accccaccgc gctcgcgtct cctctcgctc cgctgcctaa
       61 gggcccctcg ccaccgccac catggacgcc atcaagaaga agatgcagat gctgaagctc
      121 gacaaagaga acgccttgga tcgagctgag caagcggagg ctgataagaa ggcggcggaa
      181 gaccggagca agcagctgga agatgagctg gtgtcactgc aaaagaaact caagggcact
      241 gaagatgaac tggacaaata ctccgaggct ctcaaagatg cccaggagaa actggagctg
      301 gcggagaaaa aggccacaga tgctgaagct gacgtagctt ctctgaacag acgcatccag
      361 ctggttgagg aggagttgga tcgtgctcag gagcgtctgg ccacagctct gcagaagctg
      421 gaggaggccg agaaggctgc agatgagagt gagagaggca tgaaagtcat tgaaagccga
      481 gcccaaaaag atgaagaaaa gatggagatt caggagatcc agctgaaaga ggccaagcac
      541 attgctgaag atgctgaccg gaagtatgaa gaggtggccc gtaagctggt catcatcgag
      601 agcgacctgg aacgtgcaga ggagcgggct gagctctcag aaggccaagt tcgacagctg
      661 gaagaacagt taagaataat ggatcagacc ttgaaagcat taatggctgc agaggataag
      721 tactctcaga aggaagacaa atatgaagag gagatcaagg ttctctctga caagctgaag
      781 gaggctgaaa ctcgggctga gtttgcagag agatcagtaa ccaaattgga gaaaagcatt
      841 gatgacttag aagacgagct gtatgctcag aaactgaagt acaaggccat cagcgaggag
      901 ctggaccacg ctctcaacga tatgacttcc atataagttt ctttgcttca ctcctcccaa
      961 gactccttcg tcaagctgga tgtcccacct ctctgagctc tgcatctgtc tgctctccag
     1021 ctgacccagg tttcttttta gcgcccaccc accttagggc caggcacaga ctgctttcta
     1081 ttgtacagaa gcaattcgcc cagtgtaaaa taaacactgt acgctattcc tgtttgctat
     1141 tcttttactc cttatttatt gacattttcg tctcaacgct caataaaact acacttctgc
     1201 ttcgtgcatc
//
