LOCUS       NP_038889                243 aa            linear   ROD 19-SEP-2024
DEFINITION  thiamine pyrophosphokinase 1 isoform 1 [Mus musculus].
ACCESSION   NP_038889
VERSION     NP_038889.1
DBSOURCE    REFSEQ: accession NM_013861.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 243)
  AUTHORS   Sahu,U., Villa,E., Reczek,C.R., Zhao,Z., O'Hara,B.P., Torno,M.D.,
            Mishra,R., Shannon,W.D., Asara,J.M., Gao,P., Shilatifard,A.,
            Chandel,N.S. and Ben-Sahra,I.
  TITLE     Pyrimidines maintain mitochondrial pyruvate oxidation to support de
            novo lipogenesis
  JOURNAL   Science 383 (6690), 1484-1492 (2024)
   PUBMED   38547260
REFERENCE   2  (residues 1 to 243)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 243)
  AUTHORS   Liu,J.Y., Timm,D.E. and Hurley,T.D.
  TITLE     Pyrithiamine as a substrate for thiamine pyrophosphokinase
  JOURNAL   J Biol Chem 281 (10), 6601-6607 (2006)
   PUBMED   16365036
  REMARK    GeneRIF: Three-dimensional structure of thiamine pyrophosphokinase
            crystallized from an equilibrium substrate/product mixture shows
            clear electron density for pyrithiamine pyrophosphate bound in the
            enzyme active site.
REFERENCE   4  (residues 1 to 243)
  AUTHORS   Timm,D.E., Liu,J., Baker,L.J. and Harris,R.A.
  TITLE     Crystal structure of thiamin pyrophosphokinase
  JOURNAL   J Mol Biol 310 (1), 195-204 (2001)
   PUBMED   11419946
REFERENCE   5  (residues 1 to 243)
  AUTHORS   Zhao,R., Gao,F. and Goldman,I.D.
  TITLE     Molecular cloning of human thiamin pyrophosphokinase
  JOURNAL   Biochim Biophys Acta 1517 (2), 320-322 (2001)
   PUBMED   11342117
REFERENCE   6  (residues 1 to 243)
  AUTHORS   Nosaka,K., Onozuka,M., Kakazu,N., Hibi,S., Nishimura,H., Nishino,H.
            and Abe,T.
  TITLE     Isolation and characterization of a human thiamine
            pyrophosphokinase cDNA
  JOURNAL   Biochim Biophys Acta 1517 (2), 293-297 (2001)
   PUBMED   11342111
REFERENCE   7  (residues 1 to 243)
  AUTHORS   Nosaka,K., Onozuka,M., Nishino,H., Nishimura,H., Kawasaki,Y. and
            Ueyama,H.
  TITLE     Molecular cloning and expression of a mouse thiamin
            pyrophosphokinase cDNA
  JOURNAL   J Biol Chem 274 (48), 34129-34133 (1999)
   PUBMED   10567383
REFERENCE   8  (residues 1 to 243)
  AUTHORS   Bettendorff,L. and Wins,P.
  TITLE     Mechanism of thiamine transport in neuroblastoma cells. Inhibition
            of a high affinity carrier by sodium channel activators and
            dependence of thiamine uptake on membrane potential and
            intracellular ATP
  JOURNAL   J Biol Chem 269 (20), 14379-14385 (1994)
   PUBMED   8182042
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087844.1, AK052225.1, AK035044.1 and BE691023.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087844.1, BC015246.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..243
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 21.19 cM"
     Protein         1..243
                     /product="thiamine pyrophosphokinase 1 isoform 1"
                     /EC_number="2.7.6.2"
                     /note="thiamin pyrophosphokinase 1; mTPK1; thiamine
                     pyrophosphokinase 1"
                     /calculated_mol_wt=26937
     Region          21..241
                     /region_name="PLN02714"
                     /note="thiamin pyrophosphokinase"
                     /db_xref="CDD:178316"
     CDS             1..243
                     /gene="Tpk1"
                     /coded_by="NM_013861.4:159..890"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39474.1"
                     /db_xref="GeneID:29807"
                     /db_xref="MGI:MGI:1352500"
ORIGIN      
        1 mehaftplep llptgnlkyc lvvlnqplda rfrhlwkkal lracadggan hlydlteger
       61 esflpefvsg dfdsirpevk eyytkkgcdl istpdqdhtd ftkclqvlqr kieekelqvd
      121 vivtlgglgg rfdqimasvn tlfqathitp vpiiiiqkds liyllqpgkh rlhvdtgmeg
      181 swcglipvgq pcnqvtttgl kwnltndvlg fgtlvstsnt ydgsglvtve tdhpllwtma
      241 iks
//
