LOCUS       NM_009415               1469 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus triosephosphate isomerase 1 (Tpi1), mRNA.
ACCESSION   NM_009415
VERSION     NM_009415.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1469)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   2  (bases 1 to 1469)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1469)
  AUTHORS   Kawakami,H., Chen,K.Q., Zhang,R., Pappas,M.P., Bailey,A.,
            Reisz,J.A., Corcoran,D., Nishinakamura,R., D'Alessandro,A. and
            Kawakami,Y.
  TITLE     Sall4 restricts glycolytic metabolism in limb buds through
            transcriptional regulation of glycolytic enzyme genes
  JOURNAL   Dev Biol 501, 28-38 (2023)
   PUBMED   37301463
REFERENCE   4  (bases 1 to 1469)
  AUTHORS   Gehlen-Breitbach,S., Schmid,T., Frob,F., Rodrian,G., Weider,M.,
            Wegner,M. and Golz,L.
  TITLE     The Tip60/Ep400 chromatin remodeling complex impacts basic cellular
            functions in cranial neural crest-derived tissue during early
            orofacial development
  JOURNAL   Int J Oral Sci 15 (1), 16 (2023)
   PUBMED   37024457
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1469)
  AUTHORS   Stein,B.D., Ferrarone,J.R., Gardner,E.E., Chang,J.W., Wu,D.,
            Hollstein,P.E., Liang,R.J., Yuan,M., Chen,Q., Coukos,J.S.,
            Sindelar,M., Ngo,B., Gross,S.S., Shaw,R.J., Zhang,C., Asara,J.M.,
            Moellering,R.E., Varmus,H. and Cantley,L.C.
  TITLE     LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic
            Liability between Human and Mouse Lung Adenocarcinoma
  JOURNAL   Cancer Discov 13 (4), 1002-1025 (2023)
   PUBMED   36715544
  REMARK    GeneRIF: LKB1-Dependent Regulation of TPI1 Creates a Divergent
            Metabolic Liability between Human and Mouse Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 1469)
  AUTHORS   Siracusa,L.D., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification and applications of repetitive probes for gene
            mapping in the mouse
  JOURNAL   Genetics 127 (1), 169-179 (1991)
   PUBMED   1673105
REFERENCE   7  (bases 1 to 1469)
  AUTHORS   Minna,J.D., Bruns,G.A., Krinsky,A.H., Lalley,P.A., Francke,U. and
            Gerald,P.S.
  TITLE     Assignment of a Mus musculus gene for triosephosphate isomerase to
            chromosome 6 and for glyoxalase-I to chromosome 17 using somatic
            cell hybrids
  JOURNAL   Somatic Cell Genet 4 (2), 241-252 (1978)
   PUBMED   566476
REFERENCE   8  (bases 1 to 1469)
  AUTHORS   Leinwand,L.A., Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for triose phosphate isomerase to
            chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by
            somatic cell hybridization
  JOURNAL   Somatic Cell Genet 4 (2), 233-240 (1978)
   PUBMED   566475
REFERENCE   9  (bases 1 to 1469)
  AUTHORS   Kozak,C.A. and Ruddle,F.H.
  TITLE     Assignment of the genes for thymidine kinase and galactokinase to
            Mus musculus chromosome 11 and the preferential segregation of this
            chromosome in Chinese hamster/mouse somatic cell hybrids
  JOURNAL   Somatic Cell Genet 3 (2), 121-133 (1977)
   PUBMED   204065
REFERENCE   10 (bases 1 to 1469)
  AUTHORS   Bruns,G.A. and Gerald,P.S.
  TITLE     Human glyceraldehyde-3-phosphate dehydrogenase in man-rodent
            somatic cell hybrids
  JOURNAL   Science 192 (4234), 54-56 (1976)
   PUBMED   176725
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU945752.1, BC046761.1, AK008034.1, AK010808.1 and CD766215.1.
            
            On Jul 23, 2019 this sequence version replaced NM_009415.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript data. The 5'-most translation start codon, which appears
            to be mouse-specific, is used in the updated sequence. An
            alternative downstream start codon, which is well-conserved, is
            also present, and it would result in a protein that is 13 aa
            shorter at the N-terminus. The 5'-most start codon has a weak Kozak
            signal, so it is possible that ribosomal leaky scanning may
            sometimes allow the downstream start codon to be used. There is no
            experimental evidence indicating which start codon is
            preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1181931.1,
                                           SRR7652917.1215528.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BU945752.1         144-154
            12-1340             BC046761.1         1-1329
            1341-1428           AK008034.1         839-926
            1429-1463           AK010808.1         1437-1471
            1464-1469           CD766215.1         517-522
FEATURES             Location/Qualifiers
     source          1..1469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..1469
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /note="triosephosphate isomerase 1"
                     /db_xref="GeneID:21991"
                     /db_xref="MGI:MGI:98797"
     exon            1..151
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..786
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /EC_number="5.3.1.1"
                     /EC_number="4.2.3.3"
                     /note="triose-phosphate isomerase; methylglyoxal synthase"
                     /codon_start=1
                     /product="triosephosphate isomerase"
                     /protein_id="NP_033441.3"
                     /db_xref="CCDS:CCDS20530.2"
                     /db_xref="GeneID:21991"
                     /db_xref="MGI:MGI:98797"
                     /translation="MAPTRKFFVGGNWKMNGRKKCLGELICTLNAANVPAGTEVVCAP
                     PTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDLGATWVVLGHSERRHV
                     FGESDELIGQKVSHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSK
                     VVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVNDGVAQSTRIIYGGSVTGATC
                     KELASQPDVDGFLVGGASLKPEFVDIINAKQ"
     exon            152..275
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..360
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..493
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..579
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            580..667
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1469
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /note="hexamer: AATAAA"
     polyA_site      1340
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /note="major polyA site"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
                     /note="hexamer: AATACA"
     polyA_site      1469
                     /gene="Tpi1"
                     /gene_synonym="TIM; Tpi; Tpi-1"
ORIGIN      
        1 gtttgtactg accttcagag acttgagcct ggtacaatgg cgcctaccag gaagttcttc
       61 gttgggggca actggaagat gaacgggagg aagaagtgcc tgggagaact catctgcacc
      121 ctgaacgcag ccaacgtgcc ggcaggcacc gaggtggttt gtgcaccgcc caccgcttac
      181 atcgactttg ccagacagaa gctggatccc aaaattgctg tggccgcaca gaactgctac
      241 aaagtgacca atggggcctt cactggggaa atcagccctg gcatgatcaa agacttagga
      301 gccacctggg tcgtgctggg gcactcagaa agaagacatg tctttggaga atcagatgag
      361 ctgattggcc agaaagtgag ccacgcccta gcagagggac tcggggtgat cgcctgcatc
      421 ggggagaagc tagacgaaag ggaagccggc atcaccgaga aggtcgtgtt cgagcaaacc
      481 aaggtcatcg cagataatgt gaaagactgg agcaaggtgg tcctggccta tgaacctgtg
      541 tgggccattg ggactggcaa gacggcaacc cctcagcagg cacaggaagt acacgagaag
      601 ctccggggat ggctgaaatc caatgtcaat gatggggtgg ctcagagcac ccggatcatt
      661 tatggaggtt ctgtgactgg agcaacctgc aaagagctgg caagccagcc tgacgtggac
      721 ggcttccttg tgggtggcgc atctctcaag cctgaatttg tggacatcat caatgccaaa
      781 caatgagcac tgcccatccc tctacctgcc tgcatagcat ggactaggtt gcccagaagt
      841 ttagtaactg ctcccaccgg tcacatgctt ctgatgacat catctgcccc atcttgtggc
      901 ctaatccacg ctgtaccctc ctgagccgtt tccaccgccc tattatggtt gggaccaggc
      961 caatcccttt accacttaca gtgggtagaa tcaactgtca ccaaggtggc tcctagtgag
     1021 gggagggagt agaactgact gtccctttgg gccctgacaa gtgaaatcac cttccattgg
     1081 tttgggctgg aaactcatgg ttggagcaca ggaagtgggc ttcgtgtcac tttggcctgt
     1141 cacttagatg gccttggctc tagcttcact cccaagttct actggatgtc tgatgcagaa
     1201 attcagagct ttcgggtctg aattcggtat acatgagacc ctaagaggcc tgggatagtc
     1261 ccctccccca cggtgccaaa gcccctgtat tgtgtttgtg aaccatccta catgtaaggg
     1321 aaataaacac ctgggcctga gctttgtggg ttgtcataat tccttaagac agtgatgggg
     1381 ctctagcctg gggtggggga gtgtaaaaca aaacaaaaaa caataatgaa acaggttgtg
     1441 acaatacatc tcatttttta cttcaaaaa
//
