LOCUS       NM_173391               2626 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus tryptophan hydroxylase 2 (Tph2), mRNA.
ACCESSION   NM_173391
VERSION     NM_173391.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Warner,A.K., Iskander,L., Allen,K., Quatela,I., Borrelli,H. and
            Sachs,B.D.
  TITLE     The effects of brain serotonin deficiency on the behavioral and
            neurogenesis-promoting effects of voluntary exercise in tryptophan
            hydroxylase 2 (R439H) knock-in mice
  JOURNAL   Neuropharmacology 258, 110082 (2024)
   PUBMED   39009217
  REMARK    GeneRIF: The effects of brain serotonin deficiency on the
            behavioral and neurogenesis-promoting effects of voluntary exercise
            in tryptophan hydroxylase 2 (R439H) knock-in mice.
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Komleva,P.D., Alhalabi,G., Izyurov,A.E., Khotskin,N.V. and
            Kulikov,A.V.
  TITLE     Effects of the Combination of the C1473G Mutation in the Tph2 Gene
            and Lethal Yellow Mutations in the Raly-Agouti Locus on Behavior,
            Brain 5-HT and Melanocortin Systems in Mice
  JOURNAL   Biomolecules 13 (6), 963 (2023)
   PUBMED   37371543
  REMARK    GeneRIF: Effects of the Combination of the C1473G Mutation in the
            Tph2 Gene and Lethal Yellow Mutations in the Raly-Agouti Locus on
            Behavior, Brain 5-HT and Melanocortin Systems in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2626)
  AUTHORS   Sinenko,S.A., Kuzmin,A.A., Skvortsova,E.V., Ponomartsev,S.V.,
            Efimova,E.V., Bader,M., Alenina,N. and Tomilin,A.N.
  TITLE     Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses
            Cell Reprogramming into Pluripotent State
  JOURNAL   Int J Mol Sci 24 (5), 4862 (2023)
   PUBMED   36902295
  REMARK    GeneRIF: Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis
            Suppresses Cell Reprogramming into Pluripotent State.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2626)
  AUTHORS   Bazovkina,D.V., Fursenko,D.V., Naumenko,V.S. and Kulikov,A.V.
  TITLE     The Role of C1473G Polymorphism in Mouse Triptophan Hydroxylase 2
            Gene in the Acute Effects of Ethanol on the c-fos Gene Expression
            and Metabolism of Biogenic Amines in the Brain
  JOURNAL   Biochemistry (Mosc) 88 (3), 291-302 (2023)
   PUBMED   37076278
  REMARK    GeneRIF: The Role of C1473G Polymorphism in Mouse Triptophan
            Hydroxylase 2 Gene in the Acute Effects of Ethanol on the c-fos
            Gene Expression and Metabolism of Biogenic Amines in the Brain.
REFERENCE   6  (bases 1 to 2626)
  AUTHORS   Cote,F., Thevenot,E., Fligny,C., Fromes,Y., Darmon,M.,
            Ripoche,M.A., Bayard,E., Hanoun,N., Saurini,F., Lechat,P.,
            Dandolo,L., Hamon,M., Mallet,J. and Vodjdani,G.
  TITLE     Disruption of the nonneuronal tph1 gene demonstrates the importance
            of peripheral serotonin in cardiac function
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13525-13530 (2003)
   PUBMED   14597720
REFERENCE   7  (bases 1 to 2626)
  AUTHORS   Cheng,L., Chen,C.L., Luo,P., Tan,M., Qiu,M., Johnson,R. and Ma,Q.
  TITLE     Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic
            neurotransmitter phenotype
  JOURNAL   J Neurosci 23 (31), 9961-9967 (2003)
   PUBMED   14602809
REFERENCE   8  (bases 1 to 2626)
  AUTHORS   Walther,D.J. and Bader,M.
  TITLE     A unique central tryptophan hydroxylase isoform
  JOURNAL   Biochem Pharmacol 66 (9), 1673-1680 (2003)
   PUBMED   14563478
REFERENCE   9  (bases 1 to 2626)
  AUTHORS   Walther,D.J., Peter,J.U., Bashammakh,S., Hortnagl,H., Voits,M.,
            Fink,H. and Bader,M.
  TITLE     Synthesis of serotonin by a second tryptophan hydroxylase isoform
  JOURNAL   Science 299 (5603), 76 (2003)
   PUBMED   12511643
  REMARK    GeneRIF: a second tryptophan hydroxylase isoform detected in the
            brain
REFERENCE   10 (bases 1 to 2626)
  AUTHORS   Kirby,P.J., Waters,P.D., Delbridge,M., Svartman,M., Stewart,A.N.,
            Nagai,K. and Graves,J.A.
  TITLE     Cloning and mapping of platypus SOX2 and SOX14: insights into SOX
            group B evolution
  JOURNAL   Cytogenet Genome Res 98 (1), 96-100 (2002)
   PUBMED   12584449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153825.7.
            
            On Dec 12, 2009 this sequence version replaced NM_173391.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY090565.1, BC125430.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849381,
                                           SAMN00849382 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC153825.7         187143-187380       c
            239-382             AC153825.7         185114-185257       c
            383-566             AC153825.7         181881-182064       c
            567-667             AC153825.7         181680-181780       c
            668-735             AC153825.7         176410-176477       c
            736-932             AC153825.7         153443-153639       c
            933-1068            AC153825.7         148349-148484       c
            1069-1195           AC153825.7         122183-122309       c
            1196-1291           AC153825.7         93060-93155         c
            1292-1425           AC153825.7         82333-82466         c
            1426-2626           AC153825.7         80999-82199         c
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 63.51 cM"
     gene            1..2626
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /note="tryptophan hydroxylase 2"
                     /db_xref="GeneID:216343"
                     /db_xref="MGI:MGI:2651811"
     exon            1..238
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1600
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /EC_number="1.14.16.4"
                     /note="neuronal tryptophan hydroxylase; tryptophan
                     5-monooxygenase 2"
                     /codon_start=1
                     /product="tryptophan 5-hydroxylase 2"
                     /protein_id="NP_775567.2"
                     /db_xref="CCDS:CCDS36061.1"
                     /db_xref="GeneID:216343"
                     /db_xref="MGI:MGI:2651811"
                     /translation="MQPAMMMFSSKYWARRGLSLDSAVPEDHQLLGSLTQNKAIKSED
                     KKSGKEPGKGDTTESSKTAVVFSLKNEVGGLVKALRLFQEKHVNMLHIESRRSRRRSS
                     EVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPESIWTEEEDLEDVPWFPRKISELD
                     RCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTW
                     GVVFRELSKLYPTHACREYLKNLPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPV
                     AGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFS
                     QEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDK
                     ACVKSFDPKTTCLQECLITTFQDAYFVSDSFEEAKEKMRDFAKSITRPFSVYFNPYTQ
                     SIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI"
     exon            239..382
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            383..566
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            567..667
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            668..735
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            736..932
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1068
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1195
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1291
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1425
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..2626
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2604..2609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="Tph2"
                     /gene_synonym="Ntph"
                     /note="major polyA site"
ORIGIN      
        1 cactgctctt cagcaccagg gttctggaca gcgccccgag caggcagctg ccactgcagt
       61 tcctccttca tctctgccaa ggccgcccct ctggtccccc ctgctgctga gaaagaaaat
      121 tacatcggga gccatgcagc ccgcaatgat gatgttttcc agtaaatact gggccaggag
      181 agggttgtcc ttggattctg ctgtgccaga agatcatcag ctacttggca gcttaacaca
      241 aaataaggct atcaaaagcg aggacaagaa aagcggcaaa gagcccggca aaggcgacac
      301 cacagagagc agcaagacag cggtagtgtt ctccttgaag aatgaagttg gtgggctggt
      361 gaaagcactt agactattcc aggaaaaaca tgtcaacatg cttcatatcg aatccaggag
      421 gtcccgacga agaagttctg aagtcgaaat cttcgtggac tgcgaatgtg gcaaaacgga
      481 attcaatgag ctcatccagt tgctgaaatt tcagaccacc attgtgaccc tgaatccgcc
      541 tgagagcatt tggacggagg aagaagatct cgaggatgtg ccgtggttcc ctcggaagat
      601 ctctgagtta gacagatgct ctcaccgagt cctcatgtac ggcaccgagc ttgatgccga
      661 ccatccagga tttaaggaca atgtctatcg acagaggagg aagtattttg tggatgtggc
      721 catgggctat aaatatggtc agcccattcc cagggtcgag tacacagaag aagagactaa
      781 aacttggggt gttgtgttcc gggagctctc caaactctac ccgactcatg cttgccggga
      841 gtacctgaaa aacctccccc tgctgaccaa gtactgtggc tacagggaag acaacgtgcc
      901 gcaactggaa gacgtctcca tgtttctgaa agagcgatct ggcttcacag tgagaccagt
      961 ggctggctac ctgagcccaa gagacttcct ggcgggcctg gcctacagag tattccactg
     1021 cacccagtac gtgcggcatg gctccgaccc cctctacacc ccggaaccag atacatgcca
     1081 tgaactcttg ggacacgtgc cactgcttgc ggatcccaag tttgctcagt tttcccaaga
     1141 gataggctta gcgtctctgg gagcctcaga tgaggacgtt cagaaactag ccacgtgcta
     1201 tttcttcaca atcgagttcg gcctttgcaa gcaagagggt caactgcggg cgtatggagc
     1261 agggttactt tcgtccatcg gagaattgaa gcatgctctt tccgacaagg cgtgtgtgaa
     1321 atcctttgac ccaaagacga cctgcttgca ggaatgccta atcaccacct ttcaggacgc
     1381 ttactttgtt tcggacagtt ttgaagaagc caaagaaaag atgagggact ttgcaaagtc
     1441 aattacccgt cccttctcgg tatacttcaa cccctacacg cagagcattg aaattctgaa
     1501 agacaccaga agtattgaga atgtggtgca ggacctgcgc agtgatttga acacagtgtg
     1561 tgatgccttg aataaaatga accaatatct ggggatttga tgcctagaac cagagttatt
     1621 gtcagcatga gctcttgggg ggtgtagcaa caatgcagtc aatgttatcc aacatcaaca
     1681 actttctgtg tcatggttgg ctagtaagca tgcaattctg tatgtccata cctctgtgta
     1741 acttaataac acaaaaatgc tctaaagaac ccatgcagat aaccactcac catttgaaag
     1801 attgtgatcc tatttggaca tctcaagtag agttgacatt tctgattagc gaacaaactg
     1861 ttaacttaag caaactgtga ctttgaaatc tgtagcaaac attcctcgca caattccagt
     1921 cggtgagttg tggaactttt cttccttgga cctgagactt tcctctgtgt tcattagata
     1981 aaatgaaaat agttgggagg tggtttctat tttcaatagt atccgtgtta tttgagataa
     2041 actagagttg ctccacgctt tgcatcacag caacaaagga tttaatattc tacttcagaa
     2101 gctgttcaga aacacagcag ttgggatgga tgtagactga gtgttcagac aatgcaagca
     2161 aagaaaagtt ttgataaaca ggatatatag gttgtactga cctcgttgaa accaatttgt
     2221 ggcaagcttc ctgaagagct tctggaagga aacacttgaa caaagaatat tcgggaagct
     2281 taaacagaag ggatgaaaat cttggaactg tgaatgtatt gttaggatag agtgaattat
     2341 cactgcaggc ttttgactcc ttttgcttag actgagaacc tcaaatccca cagggatgta
     2401 aataccatct ctgattccaa agagttggag acggagtcgt agagaaacaa agggatttgc
     2461 ttcagttagg tctgatgaga tgtgccatgg tcataagcca ctgccctttt atgttggaca
     2521 tctgacaagt ctactgtagt gtacatgcat gtttatgtat tgacacagaa agaaaattat
     2581 tgcttataaa atgaatgctt ctcaataaac agaatcttgc ccccaa
//
