LOCUS       NM_009414               4581 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tryptophan hydroxylase 1 (Tph1), transcript variant 1,
            mRNA.
ACCESSION   NM_009414
VERSION     NM_009414.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4581)
  AUTHORS   Field,S.L., Galvan,E.A., Hernandez,L.L. and Laporta,J.
  TITLE     Exploring the contribution of mammary-derived serotonin on liver
            and pancreas metabolism during lactation
  JOURNAL   PLoS One 19 (6), e0304910 (2024)
   PUBMED   38837989
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4581)
  AUTHORS   Chan,J.C., Alenina,N., Cunningham,A.M., Ramakrishnan,A., Shen,L.,
            Bader,M. and Maze,I.
  TITLE     Serotonin Transporter-dependent Histone Serotonylation in Placenta
            Contributes to the Neurodevelopmental Transcriptome
  JOURNAL   J Mol Biol 436 (7), 168454 (2024)
   PUBMED   38266980
REFERENCE   3  (bases 1 to 4581)
  AUTHORS   De Giovanni,M., Vykunta,V.S., Biram,A., Chen,K.Y., Taglinao,H.,
            An,J., Sheppard,D., Paidassi,H. and Cyster,J.G.
  TITLE     Mast cells help organize the Peyer's patch niche for induction of
            IgA responses
  JOURNAL   Sci Immunol 9 (93), eadj7363 (2024)
   PUBMED   38427721
REFERENCE   4  (bases 1 to 4581)
  AUTHORS   Van,N.T., Zhang,K., Wigmore,R.M., Kennedy,A.I., DaSilva,C.R.,
            Huang,J., Ambelil,M., Villagomez,J.H., O'Connor,G.J., Longman,R.S.,
            Cao,M., Snook,A.E., Platten,M., Kasenty,G., Sigal,L.J.,
            Prendergast,G.C. and Kim,S.V.
  TITLE     Dietary L-Tryptophan consumption determines the number of colonic
            regulatory T cells and susceptibility to colitis via GPR15
  JOURNAL   Nat Commun 14 (1), 7363 (2023)
   PUBMED   37963876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4581)
  AUTHORS   Luo,J., Chen,Z., Castellano,D., Bao,B., Han,W., Li,J., Kim,G.,
            An,D., Lu,W. and Wu,C.
  TITLE     Lipids regulate peripheral serotonin release via gut CD1d
  JOURNAL   Immunity 56 (7), 1533-1547 (2023)
   PUBMED   37354904
REFERENCE   6  (bases 1 to 4581)
  AUTHORS   Reed,G.E., Kirchner,J.E. and Carr,L.G.
  TITLE     NF-Y activates mouse tryptophan hydroxylase transcription
  JOURNAL   Brain Res 682 (1-2), 1-12 (1995)
   PUBMED   7552299
REFERENCE   7  (bases 1 to 4581)
  AUTHORS   Stubbs,L., Rinchik,E.M., Goldberg,E., Rudy,B., Handel,M.A. and
            Johnson,D.
  TITLE     Clustering of six human 11p15 gene homologs within a 500-kb
            interval of proximal mouse chromosome 7
  JOURNAL   Genomics 24 (2), 324-332 (1994)
   PUBMED   7698755
REFERENCE   8  (bases 1 to 4581)
  AUTHORS   Sellar,G.C., Oghene,K., Boyle,S., Bickmore,W.A. and Whitehead,A.S.
  TITLE     Organization of the region encompassing the human serum amyloid A
            (SAA) gene family on chromosome 11p15.1
  JOURNAL   Genomics 23 (2), 492-495 (1994)
   PUBMED   7835903
REFERENCE   9  (bases 1 to 4581)
  AUTHORS   Stoll,J. and Goldman,D.
  TITLE     Isolation and structural characterization of the murine tryptophan
            hydroxylase gene
  JOURNAL   J Neurosci Res 28 (4), 457-465 (1991)
   PUBMED   1714508
REFERENCE   10 (bases 1 to 4581)
  AUTHORS   Stoll,J., Kozak,C.A. and Goldman,D.
  TITLE     Characterization and chromosomal mapping of a cDNA encoding
            tryptophan hydroxylase from a mouse mastocytoma cell line
  JOURNAL   Genomics 7 (1), 88-96 (1990)
   PUBMED   2110547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC072582.1, AC090122.26 and
            BM932391.1.
            
            On Feb 2, 2013 this sequence version replaced NM_009414.2.
            
            Summary: This gene encodes a member of the biopterin-dependent
            aromatic amino acid hydroxylase family. The encoded protein is one
            of two tryptophan hydroxylase enzymes that catalyze the first and
            rate limiting step in the biosynthesis of the hormone and
            neurotransmitter, serotonin. This gene is expressed in peripheral
            organs, while tryptophan hydroxylase 2 is expressed in neurons. The
            encoded protein is involved in the development of hypoxia-induced
            elevations in pulmonary pressures and pulmonary vascular
            remodeling, and has also been implicated as a regulator of immune
            tolerance. Disruption of this gene is associated with cardiac
            dysfunction. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072582.1, ERR3363658.5640776.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2027              BC072582.1         1-2027
            2028-4212           AC090122.26        151631-153815
            4213-4581           BM932391.1         23-391              c
FEATURES             Location/Qualifiers
     source          1..4581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.43 cM"
     gene            1..4581
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="tryptophan hydroxylase 1"
                     /db_xref="GeneID:21990"
                     /db_xref="MGI:MGI:98796"
     exon            1..426
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            427..559
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..1777
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /EC_number="1.14.16.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1"
                     /codon_start=1
                     /product="tryptophan 5-hydroxylase 1 isoform 1"
                     /protein_id="NP_033440.1"
                     /db_xref="CCDS:CCDS21280.1"
                     /db_xref="GeneID:21990"
                     /db_xref="MGI:MGI:98796"
                     /translation="MIEDNKENKENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQEN
                     HVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLKSHATVLSVDSPDQLTAKE
                     DVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKH
                     GDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNIPQLE
                     DVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHE
                     LLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFG
                     AGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREF
                     AKTVKRPFGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALARVTRWPSV"
     exon            560..743
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            744..844
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            845..912
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1109
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1245
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1372
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1468
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1602
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..4562
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2052..2057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="hexamer: ATTAAA"
     polyA_site      2073
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="major polyA site"
     regulatory      4181..4186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="hexamer: AATAAA"
     polyA_site      4200
                     /gene="Tph1"
                     /gene_synonym="Tph"
     regulatory      4540..4545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="hexamer: AATAAA"
     polyA_site      4562
                     /gene="Tph1"
                     /gene_synonym="Tph"
ORIGIN      
        1 gctacttgag agactaaagc agtcttgcct ggtcactcaa ggccagtctg agcaatatag
       61 tgaatcccaa attgctctgt gtgtgtttgt gcgtgcgtgc acgagtgcaa gccaaggttt
      121 caagagaggc cagaagaggg tgtcagattc tctggtgcat gagttacagc tggctgtgaa
      181 ctgcctgatg tcggggctgg aaactaaact caggcccaag aacagcaagt gctcttatct
      241 gatgagccat catcccagcc ccatgcccag cagacatggg ggctgttaac tgaaacatta
      301 gaagtatgtc cacgggcctc cccttttctg aagagaaagg ggagaggaat gcatggagga
      361 gagagaaggc gtggaggaag gactgagagg agaggaagga cgaaaaaccg cagtctggat
      421 gtaaaaattc accatgattg aagacaacaa ggagaacaaa gagaacaaag accattcctc
      481 cgaaagaggg agagtgactc tcatcttctc cttggagaat gaagtcggag gactcataaa
      541 agtgctgaaa atcttccagg agaatcatgt gagcctgtta cacatcgagt cccggaaatc
      601 aaagcaaaga aattcagaat ttgagatatt tgttgactgc gacatcagcc gagaacagtt
      661 gaatgacatc ttccccctgc tgaagtcgca cgccaccgtc ctctcggtgg actcgcccga
      721 tcagctcact gcgaaggaag acgttatgga gactgtccct tggtttccaa agaagatttc
      781 tgacctggac ttctgcgcca acagagtgct gttgtatgga tccgaacttg acgccgacca
      841 ccctggcttc aaagacaatg tctatcgtag aagacgaaag tattttgcag agttggctat
      901 gaactacaaa catggggacc ccattcccaa gattgaattc acggaagaag agattaagac
      961 ctgggggacc atcttccgag agctaaacaa actctacccg acccacgcct gcagggagta
     1021 cctcagaaac ctccctttgc tctcaaaata ctgtggctat cgggaagaca acatcccgca
     1081 actggaggat gtctccaact ttttaaaaga acgcactggg ttttccatcc gtcctgtggc
     1141 tggttacctc tcaccgagag attttctgtc ggggttagcc tttcgagtct ttcactgcac
     1201 tcagtatgtg agacacagtt cagatcccct ctacactcca gagccagaca cctgccatga
     1261 actcctaggc cacgttcctc tcttggctga acccagtttt gctcaattct cccaagaaat
     1321 tggcctggct tcccttggag cttcagagga gacagttcaa aaactggcaa cgtgctactt
     1381 tttcactgtg gagtttgggc tgtgcaaaca agatggacag ctgagagtct ttggggccgg
     1441 cttgctttct tccatcagtg aactcaaaca tgcactttct ggacatgcca aagtcaagcc
     1501 ctttgatccc aagattgcct gtaaacagga atgtctcatc acgagcttcc aggatgtcta
     1561 ctttgtatct gagagctttg aagatgcaaa ggagaagatg agagaatttg ccaagaccgt
     1621 gaagcgcccg tttggactga agtacaaccc gtacacacag agtgttcagg ttctcagaga
     1681 caccaagagc ataactagtg ccatgaatga gttgcggtat gaccttgatg tcatcagtga
     1741 tgccctcgct agggtcacca ggtggcccag tgtgtgatgg tttccagtgc atatccaaaa
     1801 agcctttgag catcagtcta gagccagggc tagttcttgc ttcccctgaa gacctgcttg
     1861 gggagggaca gcagctccca gcttagcaat gtctctcgcc tctctccata ttcaatcact
     1921 cactctctct gaaaatgcac acctggaact gcttatcttc tacttctgtt ttgtcttctg
     1981 gaacctgctg agggaaatat agttcacgtg ccacgtgatg cccaggacac acatttaaaa
     2041 tattttattt cattaaaatg taattgaatc attctctccc ttccctttct tccctccaac
     2101 ccctccctct caaattcatg gcctttctac caaatgcccg tctttgatgg gtgagttgtc
     2161 tgacactggc cagagctgga ctcatggtga tgccattttc cccagcccat cattagtgga
     2221 tggcctctct ggatgccacg atgaatgtgt ctgttaccta ttactgactg tgtgacagcc
     2281 caggcacagt cacacactag acttcaaggg gactcgctga aacagaagtg tggatgactt
     2341 tgcgctagag catggctagt aaagtgcaag ctggcttcaa gtgctgtgtc agacagggac
     2401 gtagaagcca ccaagactca gccagtgctt tctggcactt tgtttcaagg tgtaacccta
     2461 ggatatagtg agaaggtatg tgtgtgtgtg tggggtggtg cagagggtag gaaatgggga
     2521 tgggaatgga gaagggccaa agggagcagt ttgtatctga gactgtactt atgcgaggga
     2581 gagctgtgag gattggagca catgtggtgt ccgcataagc agttgtataa gcttttcact
     2641 actgtaacaa agtgtcaggg acaatcagct tatacagaga aaaggtttct cttggatgct
     2701 ttggtccatt agaagttgtt cccgtggttt aagccactgg tgaagcaagg catgatagga
     2761 gaatgtgaca gagcaaactt cataaagcta tacacgtcat aaaggatgga aagagaaaga
     2821 gtgaaggatt ttagagaagg aagaagggag agagggaaag agagagggag gaggacacac
     2881 acacacacac acacacacaa agggggtgag agagagagtc agagacagag acagagacag
     2941 aaagatccta cagttcagtt taagagttca ctaccagggt aagagagagg gctcagcagt
     3001 taagagtacc agctgttctt ccagaggacc ctggtttgct tcccagcatc cacactgtgg
     3061 cttagaacca tctgtaactc tagttccaga ggatccagtg ttttctggcc tccatagaga
     3121 gcaggcaggc atgcaagtgg tacacagata tgcatgcagc aaaaacaccc atacacatac
     3181 aataaaaagt agaagaccct acctctgctt ttcccattaa tagtgaaatt atataccatt
     3241 ggacaggctt catctcaagc ccactagata tattttcaca ctagattttt aaaaacacct
     3301 tttaaggatt cagaggaaac tattgaaagc tgcgcttcac cccatgctct acaaggaagt
     3361 gtaatccagc cgtctcagat ctttagaaac atacccactt taacagctgg tgagcacgca
     3421 tccgtccgca agtagatacg ttagctctga aatcacctga agtacaaacc agctagttta
     3481 cagcctgctt gattaccagg gaaagcacta taaagaaatc ctaccgacag caaacagaga
     3541 gtgccgtctg ctgtttctgg ttatttccac tagactctgg tggtgctgaa gaatcactta
     3601 ttggcttttt aattggttgt gctctgacta aagcacttta aactgtaaag ccacaacctt
     3661 accgtttgta acttcaggat agaaaaaata agcgaagggc ttgactttgt ctctgctctg
     3721 cttctgtgat atttggcaag tcagggttcc aagagccttg gagtcttcaa aacacctaag
     3781 aatcttttaa tagttattca aacaccaggc cagattcaaa caaaaagcaa ggcttgcaat
     3841 tctttcctgg agagccattc ctcgacagca gcagcgtgct tgactttttg aagaaaacac
     3901 aaatgctaat cgtcagagtg cctgcgttcc ttaatctcat gctttggcat ttggaattac
     3961 ataagtagca agatgcagca aaatgcacag aattattgct catttttaag ttggcttcta
     4021 aaccacagaa agaagaaagc caggacttct caaaagcact aaataactga gaccgtatgt
     4081 tcatttccag gaagtggata aaaagataac agtggtccat ttcactcttc atgttacagt
     4141 gccacataca cttataattt aagaatttgt tccactgggt aataaactta aagttcatga
     4201 tctcaagaag tatttttttt aaagcacatt taaaactttt attttatgtg tgtgggcccc
     4261 aggaatcaaa ctccagttgt caggcttggc cacaagcccc tttatttgct gagccagttt
     4321 ttgccacccc ctcccccaat tcttttaatc aaacacacat taaaaacagt ttcaatttta
     4381 tgttcacaat gttataagtt cagagaccct agcagtgatg atggttggta caaagaatca
     4441 gccttggggg ttagacaaag tatgaacatg cctcaatgga acccattact ttgtatacca
     4501 ctttaaaata tttttacaaa aagaaatcac aaaatataca ataaaaaata tacatcactc
     4561 taaaaaaaaa aaaaaaaaaa a
//
