LOCUS       NM_001276372             628 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tryptophan hydroxylase 1 (Tph1), transcript variant 3,
            mRNA.
ACCESSION   NM_001276372
VERSION     NM_001276372.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 628)
  AUTHORS   Field,S.L., Galvan,E.A., Hernandez,L.L. and Laporta,J.
  TITLE     Exploring the contribution of mammary-derived serotonin on liver
            and pancreas metabolism during lactation
  JOURNAL   PLoS One 19 (6), e0304910 (2024)
   PUBMED   38837989
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 628)
  AUTHORS   Chan,J.C., Alenina,N., Cunningham,A.M., Ramakrishnan,A., Shen,L.,
            Bader,M. and Maze,I.
  TITLE     Serotonin Transporter-dependent Histone Serotonylation in Placenta
            Contributes to the Neurodevelopmental Transcriptome
  JOURNAL   J Mol Biol 436 (7), 168454 (2024)
   PUBMED   38266980
REFERENCE   3  (bases 1 to 628)
  AUTHORS   De Giovanni,M., Vykunta,V.S., Biram,A., Chen,K.Y., Taglinao,H.,
            An,J., Sheppard,D., Paidassi,H. and Cyster,J.G.
  TITLE     Mast cells help organize the Peyer's patch niche for induction of
            IgA responses
  JOURNAL   Sci Immunol 9 (93), eadj7363 (2024)
   PUBMED   38427721
REFERENCE   4  (bases 1 to 628)
  AUTHORS   Van,N.T., Zhang,K., Wigmore,R.M., Kennedy,A.I., DaSilva,C.R.,
            Huang,J., Ambelil,M., Villagomez,J.H., O'Connor,G.J., Longman,R.S.,
            Cao,M., Snook,A.E., Platten,M., Kasenty,G., Sigal,L.J.,
            Prendergast,G.C. and Kim,S.V.
  TITLE     Dietary L-Tryptophan consumption determines the number of colonic
            regulatory T cells and susceptibility to colitis via GPR15
  JOURNAL   Nat Commun 14 (1), 7363 (2023)
   PUBMED   37963876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 628)
  AUTHORS   Luo,J., Chen,Z., Castellano,D., Bao,B., Han,W., Li,J., Kim,G.,
            An,D., Lu,W. and Wu,C.
  TITLE     Lipids regulate peripheral serotonin release via gut CD1d
  JOURNAL   Immunity 56 (7), 1533-1547 (2023)
   PUBMED   37354904
REFERENCE   6  (bases 1 to 628)
  AUTHORS   Reed,G.E., Kirchner,J.E. and Carr,L.G.
  TITLE     NF-Y activates mouse tryptophan hydroxylase transcription
  JOURNAL   Brain Res 682 (1-2), 1-12 (1995)
   PUBMED   7552299
REFERENCE   7  (bases 1 to 628)
  AUTHORS   Stubbs,L., Rinchik,E.M., Goldberg,E., Rudy,B., Handel,M.A. and
            Johnson,D.
  TITLE     Clustering of six human 11p15 gene homologs within a 500-kb
            interval of proximal mouse chromosome 7
  JOURNAL   Genomics 24 (2), 324-332 (1994)
   PUBMED   7698755
REFERENCE   8  (bases 1 to 628)
  AUTHORS   Sellar,G.C., Oghene,K., Boyle,S., Bickmore,W.A. and Whitehead,A.S.
  TITLE     Organization of the region encompassing the human serum amyloid A
            (SAA) gene family on chromosome 11p15.1
  JOURNAL   Genomics 23 (2), 492-495 (1994)
   PUBMED   7835903
REFERENCE   9  (bases 1 to 628)
  AUTHORS   Stoll,J. and Goldman,D.
  TITLE     Isolation and structural characterization of the murine tryptophan
            hydroxylase gene
  JOURNAL   J Neurosci Res 28 (4), 457-465 (1991)
   PUBMED   1714508
REFERENCE   10 (bases 1 to 628)
  AUTHORS   Stoll,J., Kozak,C.A. and Goldman,D.
  TITLE     Characterization and chromosomal mapping of a cDNA encoding
            tryptophan hydroxylase from a mouse mastocytoma cell line
  JOURNAL   Genomics 7 (1), 88-96 (1990)
   PUBMED   2110547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF273257.1, AK157858.1 and
            BC038864.1.
            
            Summary: This gene encodes a member of the biopterin-dependent
            aromatic amino acid hydroxylase family. The encoded protein is one
            of two tryptophan hydroxylase enzymes that catalyze the first and
            rate limiting step in the biosynthesis of the hormone and
            neurotransmitter, serotonin. This gene is expressed in peripheral
            organs, while tryptophan hydroxylase 2 is expressed in neurons. The
            encoded protein is involved in the development of hypoxia-induced
            elevations in pulmonary pressures and pulmonary vascular
            remodeling, and has also been implicated as a regulator of immune
            tolerance. Disruption of this gene is associated with cardiac
            dysfunction. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (3) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The resulting isoform (3)
            is shorter and has a distinct C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157858.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AF273257.1         2-35
            35-609              AK157858.1         1-575
            610-628             BC038864.1         502-520
FEATURES             Location/Qualifiers
     source          1..628
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.43 cM"
     gene            1..628
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="tryptophan hydroxylase 1"
                     /db_xref="GeneID:21990"
                     /db_xref="MGI:MGI:98796"
     exon            1..115
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            116..248
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..590
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /EC_number="1.14.16.4"
                     /note="isoform 2 is encoded by transcript variant 3;
                     tryptophan 5-hydroxylase 1; tryptophan 5-monooxygenase 1"
                     /codon_start=1
                     /product="tryptophan 5-hydroxylase 1 isoform 2"
                     /protein_id="NP_001263301.1"
                     /db_xref="CCDS:CCDS71970.1"
                     /db_xref="GeneID:21990"
                     /db_xref="MGI:MGI:98796"
                     /translation="MIEDNKENKENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQEN
                     HVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLKSHATVLSVDSPDQLTAKE
                     DVMETVPWFPKKISDLDFCANRVLLYGSELDADHPVNMFTKSRSANNLSQTED"
     exon            249..432
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            433..612
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      586..591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="hexamer: ATTAAA"
     polyA_site      612
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="major polyA site"
ORIGIN      
        1 gactctttaa actccagtgg ctctgaggtg agtgggtgag tgggatagcc cctccctggg
       61 acatcggatc agaagactcc cagcaaggac gggatcaact tctagtagga accagattca
      121 ccatgattga agacaacaag gagaacaaag agaacaaaga ccattcctcc gaaagaggga
      181 gagtgactct catcttctcc ttggagaatg aagtcggagg actcataaaa gtgctgaaaa
      241 tcttccagga gaatcatgtg agcctgttac acatcgagtc ccggaaatca aagcaaagaa
      301 attcagaatt tgagatattt gttgactgcg acatcagccg agaacagttg aatgacatct
      361 tccccctgct gaagtcgcac gccaccgtcc tctcggtgga ctcgcccgat cagctcactg
      421 cgaaggaaga cgttatggag actgtccctt ggtttccaaa gaagatttct gacctggact
      481 tctgcgccaa cagagtgctg ttgtatggat ccgaacttga cgccgaccac cctgtaaata
      541 tgtttacaaa gtcacgcagt gcgaataact taagtcaaac tgaagattaa aagttagagc
      601 ttttaaaaca gaaaaaaaaa aaaaaaaa
//
