LOCUS       NM_001136084            4270 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tryptophan hydroxylase 1 (Tph1), transcript variant 2,
            mRNA.
ACCESSION   NM_001136084
VERSION     NM_001136084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4270)
  AUTHORS   Field,S.L., Galvan,E.A., Hernandez,L.L. and Laporta,J.
  TITLE     Exploring the contribution of mammary-derived serotonin on liver
            and pancreas metabolism during lactation
  JOURNAL   PLoS One 19 (6), e0304910 (2024)
   PUBMED   38837989
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4270)
  AUTHORS   Chan,J.C., Alenina,N., Cunningham,A.M., Ramakrishnan,A., Shen,L.,
            Bader,M. and Maze,I.
  TITLE     Serotonin Transporter-dependent Histone Serotonylation in Placenta
            Contributes to the Neurodevelopmental Transcriptome
  JOURNAL   J Mol Biol 436 (7), 168454 (2024)
   PUBMED   38266980
REFERENCE   3  (bases 1 to 4270)
  AUTHORS   De Giovanni,M., Vykunta,V.S., Biram,A., Chen,K.Y., Taglinao,H.,
            An,J., Sheppard,D., Paidassi,H. and Cyster,J.G.
  TITLE     Mast cells help organize the Peyer's patch niche for induction of
            IgA responses
  JOURNAL   Sci Immunol 9 (93), eadj7363 (2024)
   PUBMED   38427721
REFERENCE   4  (bases 1 to 4270)
  AUTHORS   Van,N.T., Zhang,K., Wigmore,R.M., Kennedy,A.I., DaSilva,C.R.,
            Huang,J., Ambelil,M., Villagomez,J.H., O'Connor,G.J., Longman,R.S.,
            Cao,M., Snook,A.E., Platten,M., Kasenty,G., Sigal,L.J.,
            Prendergast,G.C. and Kim,S.V.
  TITLE     Dietary L-Tryptophan consumption determines the number of colonic
            regulatory T cells and susceptibility to colitis via GPR15
  JOURNAL   Nat Commun 14 (1), 7363 (2023)
   PUBMED   37963876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4270)
  AUTHORS   Luo,J., Chen,Z., Castellano,D., Bao,B., Han,W., Li,J., Kim,G.,
            An,D., Lu,W. and Wu,C.
  TITLE     Lipids regulate peripheral serotonin release via gut CD1d
  JOURNAL   Immunity 56 (7), 1533-1547 (2023)
   PUBMED   37354904
REFERENCE   6  (bases 1 to 4270)
  AUTHORS   Reed,G.E., Kirchner,J.E. and Carr,L.G.
  TITLE     NF-Y activates mouse tryptophan hydroxylase transcription
  JOURNAL   Brain Res 682 (1-2), 1-12 (1995)
   PUBMED   7552299
REFERENCE   7  (bases 1 to 4270)
  AUTHORS   Stubbs,L., Rinchik,E.M., Goldberg,E., Rudy,B., Handel,M.A. and
            Johnson,D.
  TITLE     Clustering of six human 11p15 gene homologs within a 500-kb
            interval of proximal mouse chromosome 7
  JOURNAL   Genomics 24 (2), 324-332 (1994)
   PUBMED   7698755
REFERENCE   8  (bases 1 to 4270)
  AUTHORS   Sellar,G.C., Oghene,K., Boyle,S., Bickmore,W.A. and Whitehead,A.S.
  TITLE     Organization of the region encompassing the human serum amyloid A
            (SAA) gene family on chromosome 11p15.1
  JOURNAL   Genomics 23 (2), 492-495 (1994)
   PUBMED   7835903
REFERENCE   9  (bases 1 to 4270)
  AUTHORS   Stoll,J. and Goldman,D.
  TITLE     Isolation and structural characterization of the murine tryptophan
            hydroxylase gene
  JOURNAL   J Neurosci Res 28 (4), 457-465 (1991)
   PUBMED   1714508
REFERENCE   10 (bases 1 to 4270)
  AUTHORS   Stoll,J., Kozak,C.A. and Goldman,D.
  TITLE     Characterization and chromosomal mapping of a cDNA encoding
            tryptophan hydroxylase from a mouse mastocytoma cell line
  JOURNAL   Genomics 7 (1), 88-96 (1990)
   PUBMED   2110547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF273257.1, BC072582.1,
            AC090122.26 and BM932391.1.
            
            On Feb 2, 2013 this sequence version replaced NM_001136084.1.
            
            Summary: This gene encodes a member of the biopterin-dependent
            aromatic amino acid hydroxylase family. The encoded protein is one
            of two tryptophan hydroxylase enzymes that catalyze the first and
            rate limiting step in the biosynthesis of the hormone and
            neurotransmitter, serotonin. This gene is expressed in peripheral
            organs, while tryptophan hydroxylase 2 is expressed in neurons. The
            encoded protein is involved in the development of hypoxia-induced
            elevations in pulmonary pressures and pulmonary vascular
            remodeling, and has also been implicated as a regulator of immune
            tolerance. Disruption of this gene is associated with cardiac
            dysfunction. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Feb 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146134.1, AK146171.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-610               AF273257.1         2-611
            611-1716            BC072582.1         922-2027
            1717-3901           AC090122.26        151631-153815
            3902-4270           BM932391.1         23-391              c
FEATURES             Location/Qualifiers
     source          1..4270
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 30.43 cM"
     gene            1..4270
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="tryptophan hydroxylase 1"
                     /db_xref="GeneID:21990"
                     /db_xref="MGI:MGI:98796"
     exon            1..115
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            116..248
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            249..432
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            433..533
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            534..601
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            602..798
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            799..934
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1061
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1157
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1291
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..4251
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1741..1746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="hexamer: ATTAAA"
     polyA_site      1762
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="major polyA site"
     regulatory      3870..3875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="hexamer: AATAAA"
     polyA_site      3889
                     /gene="Tph1"
                     /gene_synonym="Tph"
     regulatory      4229..4234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tph1"
                     /gene_synonym="Tph"
                     /note="hexamer: AATAAA"
     polyA_site      4251
                     /gene="Tph1"
                     /gene_synonym="Tph"
ORIGIN      
        1 gactctttaa actccagtgg ctctgaggtg agtgggtgag tgggatagcc cctccctggg
       61 acatcggatc agaagactcc cagcaaggac gggatcaact tctagtagga accagattca
      121 ccatgattga agacaacaag gagaacaaag agaacaaaga ccattcctcc gaaagaggga
      181 gagtgactct catcttctcc ttggagaatg aagtcggagg actcataaaa gtgctgaaaa
      241 tcttccagga gaatcatgtg agcctgttac acatcgagtc ccggaaatca aagcaaagaa
      301 attcagaatt tgagatattt gttgactgcg acatcagccg agaacagttg aatgacatct
      361 tccccctgct gaagtcgcac gccaccgtcc tctcggtgga ctcgcccgat cagctcactg
      421 cgaaggaaga cgttatggag actgtccctt ggtttccaaa gaagatttct gacctggact
      481 tctgcgccaa cagagtgctg ttgtatggat ccgaacttga cgccgaccac cctggcttca
      541 aagacaatgt ctatcgtaga agacgaaagt attttgcaga gttggctatg aactacaaac
      601 atggggaccc cattcccaag attgaattca cggaagaaga gattaagacc tgggggacca
      661 tcttccgaga gctaaacaaa ctctacccga cccacgcctg cagggagtac ctcagaaacc
      721 tccctttgct ctcaaaatac tgtggctatc gggaagacaa catcccgcaa ctggaggatg
      781 tctccaactt tttaaaagaa cgcactgggt tttccatccg tcctgtggct ggttacctct
      841 caccgagaga ttttctgtcg gggttagcct ttcgagtctt tcactgcact cagtatgtga
      901 gacacagttc agatcccctc tacactccag agccagacac ctgccatgaa ctcctaggcc
      961 acgttcctct cttggctgaa cccagttttg ctcaattctc ccaagaaatt ggcctggctt
     1021 cccttggagc ttcagaggag acagttcaaa aactggcaac gtgctacttt ttcactgtgg
     1081 agtttgggct gtgcaaacaa gatggacagc tgagagtctt tggggccggc ttgctttctt
     1141 ccatcagtga actcaaacat gcactttctg gacatgccaa agtcaagccc tttgatccca
     1201 agattgcctg taaacaggaa tgtctcatca cgagcttcca ggatgtctac tttgtatctg
     1261 agagctttga agatgcaaag gagaagatga gagaatttgc caagaccgtg aagcgcccgt
     1321 ttggactgaa gtacaacccg tacacacaga gtgttcaggt tctcagagac accaagagca
     1381 taactagtgc catgaatgag ttgcggtatg accttgatgt catcagtgat gccctcgcta
     1441 gggtcaccag gtggcccagt gtgtgatggt ttccagtgca tatccaaaaa gcctttgagc
     1501 atcagtctag agccagggct agttcttgct tcccctgaag acctgcttgg ggagggacag
     1561 cagctcccag cttagcaatg tctctcgcct ctctccatat tcaatcactc actctctctg
     1621 aaaatgcaca cctggaactg cttatcttct acttctgttt tgtcttctgg aacctgctga
     1681 gggaaatata gttcacgtgc cacgtgatgc ccaggacaca catttaaaat attttatttc
     1741 attaaaatgt aattgaatca ttctctccct tccctttctt ccctccaacc cctccctctc
     1801 aaattcatgg cctttctacc aaatgcccgt ctttgatggg tgagttgtct gacactggcc
     1861 agagctggac tcatggtgat gccattttcc ccagcccatc attagtggat ggcctctctg
     1921 gatgccacga tgaatgtgtc tgttacctat tactgactgt gtgacagccc aggcacagtc
     1981 acacactaga cttcaagggg actcgctgaa acagaagtgt ggatgacttt gcgctagagc
     2041 atggctagta aagtgcaagc tggcttcaag tgctgtgtca gacagggacg tagaagccac
     2101 caagactcag ccagtgcttt ctggcacttt gtttcaaggt gtaaccctag gatatagtga
     2161 gaaggtatgt gtgtgtgtgt ggggtggtgc agagggtagg aaatggggat gggaatggag
     2221 aagggccaaa gggagcagtt tgtatctgag actgtactta tgcgagggag agctgtgagg
     2281 attggagcac atgtggtgtc cgcataagca gttgtataag cttttcacta ctgtaacaaa
     2341 gtgtcaggga caatcagctt atacagagaa aaggtttctc ttggatgctt tggtccatta
     2401 gaagttgttc ccgtggttta agccactggt gaagcaaggc atgataggag aatgtgacag
     2461 agcaaacttc ataaagctat acacgtcata aaggatggaa agagaaagag tgaaggattt
     2521 tagagaagga agaagggaga gagggaaaga gagagggagg aggacacaca cacacacaca
     2581 cacacacaaa gggggtgaga gagagagtca gagacagaga cagagacaga aagatcctac
     2641 agttcagttt aagagttcac taccagggta agagagaggg ctcagcagtt aagagtacca
     2701 gctgttcttc cagaggaccc tggtttgctt cccagcatcc acactgtggc ttagaaccat
     2761 ctgtaactct agttccagag gatccagtgt tttctggcct ccatagagag caggcaggca
     2821 tgcaagtggt acacagatat gcatgcagca aaaacaccca tacacataca ataaaaagta
     2881 gaagacccta cctctgcttt tcccattaat agtgaaatta tataccattg gacaggcttc
     2941 atctcaagcc cactagatat attttcacac tagattttta aaaacacctt ttaaggattc
     3001 agaggaaact attgaaagct gcgcttcacc ccatgctcta caaggaagtg taatccagcc
     3061 gtctcagatc tttagaaaca tacccacttt aacagctggt gagcacgcat ccgtccgcaa
     3121 gtagatacgt tagctctgaa atcacctgaa gtacaaacca gctagtttac agcctgcttg
     3181 attaccaggg aaagcactat aaagaaatcc taccgacagc aaacagagag tgccgtctgc
     3241 tgtttctggt tatttccact agactctggt ggtgctgaag aatcacttat tggcttttta
     3301 attggttgtg ctctgactaa agcactttaa actgtaaagc cacaacctta ccgtttgtaa
     3361 cttcaggata gaaaaaataa gcgaagggct tgactttgtc tctgctctgc ttctgtgata
     3421 tttggcaagt cagggttcca agagccttgg agtcttcaaa acacctaaga atcttttaat
     3481 agttattcaa acaccaggcc agattcaaac aaaaagcaag gcttgcaatt ctttcctgga
     3541 gagccattcc tcgacagcag cagcgtgctt gactttttga agaaaacaca aatgctaatc
     3601 gtcagagtgc ctgcgttcct taatctcatg ctttggcatt tggaattaca taagtagcaa
     3661 gatgcagcaa aatgcacaga attattgctc atttttaagt tggcttctaa accacagaaa
     3721 gaagaaagcc aggacttctc aaaagcacta aataactgag accgtatgtt catttccagg
     3781 aagtggataa aaagataaca gtggtccatt tcactcttca tgttacagtg ccacatacac
     3841 ttataattta agaatttgtt ccactgggta ataaacttaa agttcatgat ctcaagaagt
     3901 atttttttta aagcacattt aaaactttta ttttatgtgt gtgggcccca ggaatcaaac
     3961 tccagttgtc aggcttggcc acaagcccct ttatttgctg agccagtttt tgccaccccc
     4021 tcccccaatt cttttaatca aacacacatt aaaaacagtt tcaattttat gttcacaatg
     4081 ttataagttc agagacccta gcagtgatga tggttggtac aaagaatcag ccttgggggt
     4141 tagacaaagt atgaacatgc ctcaatggaa cccattactt tgtataccac tttaaaatat
     4201 ttttacaaaa agaaatcaca aaatatacaa taaaaaatat acatcactct aaaaaaaaaa
     4261 aaaaaaaaaa
//
