LOCUS       NM_148934               1073 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus tubulin polyglutamylase complex subunit 1 (Tpgs1),
            mRNA.
ACCESSION   NM_148934
VERSION     NM_148934.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Valnegri,P., Huang,J., Yamada,T., Yang,Y., Mejia,L.A., Cho,H.Y.,
            Oldenborg,A. and Bonni,A.
  TITLE     RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the
            mammalian brain
  JOURNAL   Nat Commun 8 (1), 1271 (2017)
   PUBMED   29097665
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Ikegami,K., Heier,R.L., Taruishi,M., Takagi,H., Mukai,M.,
            Shimma,S., Taira,S., Hatanaka,K., Morone,N., Yao,I., Campbell,P.K.,
            Yuasa,S., Janke,C., Macgregor,G.R. and Setou,M.
  TITLE     Loss of alpha-tubulin polyglutamylation in ROSA22 mice is
            associated with abnormal targeting of KIF1A and modulated synaptic
            function
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3213-3218 (2007)
   PUBMED   17360631
  REMARK    GeneRIF: mutation results in a gross loss of alpha-tubulin
            polyglutamylation in brain, abnormal intracellular localization of
            a kinesin motor, KIF1A, and impaired synaptic transmission.
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
  REMARK    GeneRIF: constitutes a tubulin polyglutamylase complex.
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Regnard,C., Fesquet,D., Janke,C., Boucher,D., Desbruyeres,E.,
            Koulakoff,A., Insina,C., Travo,P. and Edde,B.
  TITLE     Characterisation of PGs1, a subunit of a protein complex
            co-purifying with tubulin polyglutamylase
  JOURNAL   J Cell Sci 116 (Pt 20), 4181-4190 (2003)
   PUBMED   12972506
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Campbell,P.K., Waymire,K.G., Heier,R.L., Sharer,C., Day,D.E.,
            Reimann,H., Jaje,J.M., Friedrich,G.A., Burmeister,M.,
            Bartness,T.J., Russell,L.D., Young,L.J., Zimmer,M., Jenne,D.E. and
            MacGregor,G.R.
  TITLE     Mutation of a novel gene results in abnormal development of
            spermatid flagella, loss of intermale aggression and reduced body
            fat in mice
  JOURNAL   Genetics 162 (1), 307-320 (2002)
   PUBMED   12242242
  REMARK    GeneRIF: mutation results in abnormal development of spermatid
            flagella, loss of intermale aggression and reduced body fat
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132265.4.
            
            On Jun 20, 2019 this sequence version replaced NM_148934.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: The coding region has been updated to start at a
            downstream in-frame start codon that is supported by conservation
            data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153467.1, BC138516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AC132265.4         171238-171582
            346-1073            AC132265.4         177199-177926
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1073
                     /gene="Tpgs1"
                     /gene_synonym="Gm16517; Gtrgeo22; PGs1"
                     /note="tubulin polyglutamylase complex subunit 1"
                     /db_xref="GeneID:110012"
                     /db_xref="MGI:MGI:106618"
     exon            1..345
                     /gene="Tpgs1"
                     /gene_synonym="Gm16517; Gtrgeo22; PGs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..883
                     /gene="Tpgs1"
                     /gene_synonym="Gm16517; Gtrgeo22; PGs1"
                     /note="PGs1 protein p32; gene trap ROSA b-geo 22"
                     /codon_start=1
                     /product="tubulin polyglutamylase complex subunit 1"
                     /protein_id="NP_683736.2"
                     /db_xref="CCDS:CCDS23982.1"
                     /db_xref="GeneID:110012"
                     /db_xref="MGI:MGI:106618"
                     /translation="MAAVEKRRPAVAPAANFPDSGRTSVSQAAAAAESEEDFLRQLGV
                     TEMLRAALLKVLEIRPEEPIAFLAHYFENMGLRSPTNGGAGEPPGQLLLQQQRLGRAL
                     WHLRLAHHSQRTAFNNNVSVAYECLSASGRKKKPGLDGRTYSELLKRVCRDGGAPEEV
                     VAPLLRKIQCRDHEAVPLGIFRTGMLSCFVLLEFVARAGALFQLLEDPGQAVADRRVG
                     QAVLDTLEGALSAGDMATAPTHYLEAGSRLGPDNLARALDRAASGRRPSVPMAREEFL
                     EKAAALFIAKVKPVG"
     exon            346..1073
                     /gene="Tpgs1"
                     /gene_synonym="Gm16517; Gtrgeo22; PGs1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpgs1"
                     /gene_synonym="Gm16517; Gtrgeo22; PGs1"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="Tpgs1"
                     /gene_synonym="Gm16517; Gtrgeo22; PGs1"
                     /note="major polyA site"
ORIGIN      
        1 aacaaagatg gcggcagtgg agaaacggcg gccggcagta gcaccagcgg ccaatttccc
       61 ggacagtggc cggacgtcgg tgtctcaggc ggcggcggcc gctgagagcg aggaggactt
      121 cctacggcag ctcggcgtga cggagatgct gcgcgcagcc ctcctaaagg tgctggagat
      181 ccggcccgag gagcccatcg ccttcttggc gcactacttc gagaacatgg gtctacgctc
      241 gccgaccaac ggaggcgccg gggagccccc gggccagctc ctcctgcagc aacagcgcct
      301 gggccgcgcg ctgtggcacc ttcgcctggc tcaccactcg cagaggaccg ccttcaacaa
      361 caacgtgagc gtggcctacg agtgtctgag tgccagcggc cgcaagaaga aaccggggct
      421 ggatgggcgc acgtacagcg agctgctgaa gcgtgtttgc agggacggcg gggcgcctga
      481 ggaggtggtg gcgccactgc ttcgcaagat ccagtgccgg gaccatgagg ctgtgcctct
      541 gggcatcttc agaaccggca tgctgtcctg ctttgtgctg ctggaattcg tggcacgcgc
      601 cggcgccctc ttccagctgc tggaggaccc tggtcaagcg gtggccgatc ggcgtgtggg
      661 ccaggccgtg ctggacacac tggagggtgc gctgagcgca ggagacatgg caacagcacc
      721 cacgcactac ctggaggccg gttcgcgctt gggccctgac aacctggcgc gtgccctgga
      781 cagggcagca agcgggcggc gacccagtgt gcccatggcc cgcgaggagt tcctggagaa
      841 ggctgcagcc ctcttcattg ccaaggtcaa gccagtgggc taagaccacg atgcacccac
      901 atcccgccac ctgcccagga cttgggacct gcaaactgat gtcccggcat tctgcacagg
      961 gtcatcaccc aggaaggggt acccgcttgg actttgcagg accagcacct gcagctcaat
     1021 cccctctgta ctggcctgcc taccccactc acagaaataa aatctaaaac gac
//
