LOCUS       NM_009411               1573 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus trophoblast specific protein alpha (Tpbpa), mRNA.
ACCESSION   NM_009411
VERSION     NM_009411.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1573)
  AUTHORS   Zietek,M.M., Jaszczyk,A., Stankiewicz,A.M. and Sampino,S.
  TITLE     Prenatal gene-environment interactions mediate the impact of
            advanced maternal age on mouse offspring behavior
  JOURNAL   Sci Rep 14 (1), 31733 (2024)
   PUBMED   39738558
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1573)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   3  (bases 1 to 1573)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   4  (bases 1 to 1573)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   5  (bases 1 to 1573)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1573)
  AUTHORS   Calzonetti,T., Stevenson,L. and Rossant,J.
  TITLE     A novel regulatory region is required for trophoblast-specific
            transcription in transgenic mice
  JOURNAL   Dev Biol 171 (2), 615-626 (1995)
   PUBMED   7556941
REFERENCE   7  (bases 1 to 1573)
  AUTHORS   Sibilia,M. and Wagner,E.F.
  TITLE     Strain-dependent epithelial defects in mice lacking the EGF
            receptor
  JOURNAL   Science 269 (5221), 234-238 (1995)
   PUBMED   7618085
  REMARK    Erratum:[Science 1995 Aug 18;269(5226):909]
REFERENCE   8  (bases 1 to 1573)
  AUTHORS   Guillemot,F., Caspary,T., Tilghman,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Anderson,D.J., Joyner,A.L., Rossant,J.
            and Nagy,A.
  TITLE     Genomic imprinting of Mash2, a mouse gene required for trophoblast
            development
  JOURNAL   Nat Genet 9 (3), 235-242 (1995)
   PUBMED   7773285
REFERENCE   9  (bases 1 to 1573)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   10 (bases 1 to 1573)
  AUTHORS   Lescisin,K.R., Varmuza,S. and Rossant,J.
  TITLE     Isolation and characterization of a novel trophoblast-specific cDNA
            in the mouse
  JOURNAL   Genes Dev 2 (12A), 1639-1646 (1988)
   PUBMED   3215514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005454.1 and AK028071.1.
            
            On Feb 8, 2019 this sequence version replaced NM_009411.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028071.1, AK005454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1052              AK005454.1         2-1053
            1053-1573           AK028071.1         1052-1572
FEATURES             Location/Qualifiers
     source          1..1573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 32.57 cM"
     gene            1..1573
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /note="trophoblast specific protein alpha"
                     /db_xref="GeneID:21984"
                     /db_xref="MGI:MGI:98795"
     exon            1..73
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /inference="alignment:Splign:2.1.0"
     exon            74..183
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..459
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /note="clone 4311; Mutant line 1247"
                     /codon_start=1
                     /product="trophoblast-specific protein alpha precursor"
                     /protein_id="NP_033437.2"
                     /db_xref="CCDS:CCDS36693.1"
                     /db_xref="GeneID:21984"
                     /db_xref="MGI:MGI:98795"
                     /translation="MTPTIFLVILCLGVASAAIVPEAQLDAELQEQKDKEVLIKAVWS
                     KFMKTNKLHSSENDQETEGSNIEMSASGQLTDEELMKIMTTVLHPMFEEEENKPQPVV
                     DDPEFEDYTESGDGFFVPNQPQ"
     exon            184..306
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /inference="alignment:Splign:2.1.0"
     exon            307..450
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /inference="alignment:Splign:2.1.0"
     exon            451..1573
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      695..700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /note="hexamer: AATAAA"
     polyA_site      715
                     /gene="Tpbpa"
                     /gene_synonym="b2b1247Clo; Tb-1; Tb1; Tpbp"
                     /note="major polyA site"
ORIGIN      
        1 tagattctgg atctccaagg acctctgaag agctgaacca ctggagtgcc cagcacagct
       61 ttggacatca caggtacttg agacatgact cctacaatct tcctagtcat cctatgcctg
      121 ggagtggcct cagctgctat agtccctgaa gcgcagttgg atgctgaact gcaagagcag
      181 aaggataaag aagttctcat aaaagcagtg tggagtaagt ttatgaagac taacaaactt
      241 cacagtagcg aaaatgacca ggagacggaa ggctccaaca tagaaatgag tgcctccggt
      301 cagctaactg atgaagaact catgaaaata atgactactg ttttacaccc aatgtttgaa
      361 gaggaggaaa acaaaccaca gccagttgtt gatgaccctg aatttgagga ttacacagag
      421 agtggcgatg ggttttttgt accaaatcag ccacagtaac atggacagca gtatgaagtt
      481 aggcaacgag cgaaacagcc actgtgccat tgtctaagaa atctctgccc caacatatga
      541 actgcctgat ggtgaaaaag aagatctgaa ctggggcaag ggcaagcaaa aacagcaggg
      601 acttccccaa ttcagtatcc cctgacaagt gggatcctgc actcaagtcc cttaaatata
      661 tactatgata tgaaatccaa aacatgttca cactaataaa accttaccat taccttaatc
      721 catgctctca actcatttat ataaatgacc ttcagaatca tttttaaatt taaaatttaa
      781 aaagaagatg caagtctata tctttaaaat aaaactattc aaaaggcagt gttctggttt
      841 ctttcaggtt ttgtgaaggc aaattgttag gtggataaga catagttctg tgtgaaggca
      901 taattaactg tgtgctggtg ttcagagaag agtgtgagtg gtcgtttcaa tatagaatca
      961 gtattccatc ctttattatg ttttgttcct caggttttaa gtgtactctc tcaacaattg
     1021 tctgaaagtc taattaaaaa tttcaggaat tcaatgatct taattcacat taatatgata
     1081 gattaaaatt gtttgcattc tctgtaaagt gatggctcct taatctgtta gacatctctg
     1141 cacctgtgca ggagaactct ttctacttca ttttatgaga ttcttttttt ctactttttt
     1201 ttttggtttt tcgaattcta tgagattcta attacatcat ttacccctct cctttcctcc
     1261 ccacaaactc tcccatatac ctcttctttc tctctcccaa attaactgcc tcctttttaa
     1321 attaattgtt gttttatgta ttccaaagta tgtaaaagca aggtgctaaa gtcagtataa
     1381 tggtaattgt gtgtatgttt tcagatctga gtttttgtta tcaaatagcc aatttttgag
     1441 ttcttttctg gggaaaaata tttttcttat agcattcctg agttgcctaa cttttactat
     1501 atattttaat aagtttacaa tcattaactt gagaataatg aatagtattt ataattaaat
     1561 tattatcaaa tat
//
