LOCUS       NM_001164792            3509 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus trophoblast glycoprotein (Tpbg), transcript variant 2,
            mRNA.
ACCESSION   NM_001164792
VERSION     NM_001164792.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Wakeham,C.M., Shi,Q., Ren,G., Haley,T.L., Duvoisin,R.M., von
            Gersdorff,H. and Morgans,C.W.
  TITLE     Trophoblast glycoprotein is required for efficient synaptic vesicle
            exocytosis from retinal rod bipolar cells
  JOURNAL   Front Cell Neurosci 17, 1306006 (2023)
   PUBMED   38099150
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Wakeham,C.M., Ren,G. and Morgans,C.W.
  TITLE     Expression and distribution of trophoblast glycoprotein in the
            mouse retina
  JOURNAL   J Comp Neurol 528 (10), 1660-1671 (2020)
   PUBMED   31891182
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Deryckere,A., Stappers,E., Dries,R., Peyre,E., van den Berghe,V.,
            Conidi,A., Zampeta,F.I., Francis,A., Bresseleers,M., Stryjewska,A.,
            Vanlaer,R., Maas,E., Smal,I.V., van IJcken,W.F.J., Grosveld,F.G.,
            Nguyen,L., Huylebroeck,D. and Seuntjens,E.
  TITLE     Multifaceted actions of Zeb2 in postnatal neurogenesis from the
            ventricular-subventricular zone to the olfactory bulb
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32253238
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   Takahashi,Y., Takahashi,H., Stern,P.L., Kirita,T. and Tsuboi,A.
  TITLE     Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae
  JOURNAL   Front Cell Neurosci 13, 343 (2019)
   PUBMED   31417363
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Imamura,F., Nagao,H., Naritsuka,H., Murata,Y., Taniguchi,H. and
            Mori,K.
  TITLE     A leucine-rich repeat membrane protein, 5T4, is expressed by a
            subtype of granule cells with dendritic arbors in specific strata
            of the mouse olfactory bulb
  JOURNAL   J Comp Neurol 495 (6), 754-768 (2006)
   PUBMED   16506198
  REMARK    GeneRIF: Because 5T4 is known to interact with actin cytoskeleton,
            these observations suggest that 5T4 is involved in the formation or
            maintenance of strata-specific dendritic ramification or synaptic
            connection of subsets of local interneurons.
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Barrow,K.M., Ward,C.M., Rutter,J., Ali,S. and Stern,P.L.
  TITLE     Embryonic expression of murine 5T4 oncofoetal antigen is associated
            with morphogenetic events at implantation and in developing
            epithelia
  JOURNAL   Dev Dyn 233 (4), 1535-1545 (2005)
   PUBMED   15977177
  REMARK    GeneRIF: A limited expression profile of 5T4 may contribute to the
            migration of actively cycling, undifferentiated epithelial
            progenitor cells during embryogenesis
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Ward,C.M., Barrow,K., Woods,A.M. and Stern,P.L.
  TITLE     The 5T4 oncofoetal antigen is an early differentiation marker of
            mouse ES cells and its absence is a useful means to assess
            pluripotency
  JOURNAL   J Cell Sci 116 (Pt 22), 4533-4542 (2003)
   PUBMED   14576347
  REMARK    GeneRIF: 5T4 glycoprotein expression is associated with early
            differentiative events of embryonic stem cells
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Shaw,D.M., Woods,A.M., Myers,K.A., Westwater,C., Rahi-Saund,V.,
            Davies,M.J., Renouf,D.V., Hounsell,E.F. and Stern,P.L.
  TITLE     Glycosylation and epitope mapping of the 5T4 glycoprotein
            oncofoetal antigen
  JOURNAL   Biochem J 363 (Pt 1), 137-145 (2002)
   PUBMED   11903056
  REMARK    GeneRIF: Glycosylation and epitope mapping of the 5T4 glycoprotein
            oncofoetal antigen
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   King,K.W., Sheppard,F.C., Westwater,C., Stern,P.L. and Myers,K.A.
  TITLE     Organisation of the mouse and human 5T4 oncofoetal leucine-rich
            glycoprotein genes and expression in foetal and adult murine
            tissues
  JOURNAL   Biochim Biophys Acta 1445 (3), 257-270 (1999)
   PUBMED   10366710
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158516.2 and AK143519.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_001164792.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143519.1, BC058198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC158516.2         111905-111966       c
            63-2053             AK143519.1         2-1992
            2054-3509           AC158516.2         107763-109218       c
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.4 cM"
     gene            1..3509
                     /gene="Tpbg"
                     /gene_synonym="5T4; WAIF1"
                     /note="trophoblast glycoprotein"
                     /db_xref="GeneID:21983"
                     /db_xref="MGI:MGI:1341264"
     exon            1..104
                     /gene="Tpbg"
                     /gene_synonym="5T4; WAIF1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..3509
                     /gene="Tpbg"
                     /gene_synonym="5T4; WAIF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             434..1714
                     /gene="Tpbg"
                     /gene_synonym="5T4; WAIF1"
                     /note="5T4 oncotrophoblast glycoprotein; 5T4 oncofetal
                     trophoblast glycoprotein; 5T4 oncofetal antigen;
                     wnt-activated inhibitory factor 1"
                     /codon_start=1
                     /product="trophoblast glycoprotein precursor"
                     /protein_id="NP_001158264.1"
                     /db_xref="CCDS:CCDS23380.1"
                     /db_xref="GeneID:21983"
                     /db_xref="MGI:MGI:1341264"
                     /translation="MPGAGSRGPSAGDGRLRLARLALVLLGWVSASAPSSSVPSSSTS
                     PAAFLASGSAQPPPAERCPAACECSEAARTVKCVNRNLLEVPADLPPYVRNLFLTGNQ
                     MTVLPAGAFARQPPLADLEALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPLTNLSAF
                     AFAGSNASVSAPSPLEELILNHIVPPEDQRQNGSFEGMVAFEGMVAAALRSGLALRGL
                     TRLELASNHFLFLPRDLLAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL
                     KVLHNSTLAEWHGLAHVKVFLDNNPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEK
                     MRNRGLLDLNSSDLDCDAVLPQSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMH
                     NIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tpbg"
                     /gene_synonym="5T4; WAIF1"
                     /note="hexamer: AATAAA"
     polyA_site      2445
                     /gene="Tpbg"
                     /gene_synonym="5T4; WAIF1"
                     /note="major polyA site"
ORIGIN      
        1 aggggctggg gttgagagga gagtcggcgc ccgcagcagg agctgggaag gcgcgtggac
       61 tcgggtggcc ctcggagttg gctttgcagg cgcggggtgc ggaggtcgct catccgatcc
      121 tgccctgaga gaggcgccaa caaaggagtt gaggaggtgc cacccacccc agctgcggcg
      181 ggaggaggag cgccaaggcc cgtgtcccga cccgccgtgc gtactcactg gagggaaggg
      241 cggggtgccg ctccgggagg gggacgcccg gtggctcggg gttagccaag ttccagcttt
      301 tggcgtcccc tcctctgctc ccacgcgagg aaagtttgcc gtcgacgctt gcggccggct
      361 cgcgcccgcc gggcccaggc ggtcgagtct tcggagcggg cgctgtccca gctccgggga
      421 accgcgagcc gcgatgcctg gggcgggctc ccggggcccc tccgccgggg acggacggct
      481 gaggttggca aggctggcgc tagtgctgct gggttgggtc tccgcgtcgg cccccagctc
      541 ttcggtaccc tcgtcttcca cctccccggc agccttcctg gcctcggggt ctgcgcagcc
      601 tccgccagcc gagagatgcc ccgcggcgtg cgagtgctcc gaggcggcgc gcacggttaa
      661 gtgcgtgaac cgcaacctgc tggaggtgcc ggcggatcta ccgccttacg tgcgcaacct
      721 tttccttacc ggcaaccaga tgaccgtgct cccggcgggc gccttcgccc gccagccgcc
      781 gctcgccgac ctggaggcgc tcaacctcag cggcaaccac ctgaaggaag tgtgtgcagg
      841 tgccttcgag catctgccgg gtctgcgccg gcttgacctc agccacaacc ctctcaccaa
      901 cctcagcgcc ttcgcctttg cgggcagcaa cgccagcgtc tcggccccca gccccctgga
      961 ggagctgatc ctgaatcaca tcgtgccccc tgaggatcag aggcagaacg ggagcttcga
     1021 gggtatggtg gccttcgaag gcatggtggc agcagctctg cgctcaggcc ttgcactccg
     1081 aggtcttaca cgcctggagc tagccagcaa tcactttctt ttcctgcctc gggacttact
     1141 agcccaactg ccgagtctca gatacctgga cctcaggaac aattccctgg tgagcctgac
     1201 ctacgcatcc ttccgcaacc tgacacacct cgaaagcctc cacttggagg acaatgccct
     1261 caaggtcctt cacaactcca ccttggctga gtggcacggc ctggctcatg tcaaggtgtt
     1321 cctggacaac aatccctggg tttgcgactg ctacatggct gacatggtgg cttggcttaa
     1381 agagacagag gtggtgccag ataaagccag gcttacctgc gcattcccgg agaaaatgag
     1441 gaatcgtggc ctcttagacc tcaacagctc tgacctggac tgtgacgctg tccttcccca
     1501 atccctgcag acttcctatg tcttcctagg tattgtttta gctctgatag gcgctatttt
     1561 cctcctcgtt ttgtatttga accgtaaagg cataaaaaag tggatgcata acatcagaga
     1621 tgcctgcagg gatcacatgg aagggtatca ttacagatac gaaatcaatg cggaccccag
     1681 attaacaaat cttagttcca actcggatgt ctgagaaacc ggacccgtca aggaggactc
     1741 tgcatgaggt gtagacttaa gggttttttt ttccccttta ctaggcttgc tccacttcca
     1801 cacttcaccg tagacactat tgactttgat ccttgttatg taaaatcccg gtgtgttctg
     1861 ttaatgtaag gacatgaaca actgcacatg tttattttcc ctattccttt cggtactcct
     1921 cgatgcctgc ggagggattg tttttttttt tttttcctct ctctcaagtc gcagcatgga
     1981 cttggattag ttcagttcaa ggtgtagcac agataacatt caacggaagc tgcctcagtt
     2041 tttttttttt tttgagaaaa gtactttatt cataaatatg agtttcatcc tcacctacct
     2101 aaatgatgga ggaaatattg catccccaaa ctgcctgcag accgtagcaa gctcttacat
     2161 agaactttgt agtgcataag agcacctgca tccaagagca tgcgtacatt ttactgttct
     2221 gcatattaaa aagaaaaagt tgcaacttca gataacttct ttgacaaact aaattacttt
     2281 ttgattgcag tttataggaa actgacctga gatttttcgg tgtttttttt tttttttttt
     2341 tgtttgtttt ggttttttgt tttgttttgt tttttaaata aactgcattg agatccaaca
     2401 aactggattg ttataaaaaa aatcaataaa agaatcttaa aagaagcatg ttgtgtttaa
     2461 ctttggtatt ttgaaaggag gattaagggc aatggtattg aatagtctgg attcaaataa
     2521 tactggagtt attagttagc agagctgaga atcagcctgg agcagtgcct tcatataaat
     2581 agactggaga gaattctgaa atgatggatt cttttagggc ttaagtggaa ttaaggttat
     2641 ttatagggtc atagtattag aggtccccaa gttaacggtg ttcattatgt gttatttaaa
     2701 agagcattgg gaggttggta atagtgaaga gtcctttatg gtaaacatgt cacagctgcc
     2761 actttgtcta gactaattta gttgctgaga cagaatcatt agccaaactg aatgaagttg
     2821 ctccatggaa tttgagagcc aagtgtgagt catgtggtgg caataaatgt gtgaaaataa
     2881 agtatcttaa aatattttga agtaaaaaaa atcttaaaag acaaattaag aacagtattt
     2941 tcagagatca taaattgtag ttcagagagc ctcgagaatc tgcttttaaa ttttcaaagt
     3001 ggaacattgt gtttcttgga gttattatga ttgtgtttaa ggaaataacc aaagatacat
     3061 ccttgtatct agagacaaat attataagta gttattagat tcttatgttc agtatttaag
     3121 aatttgaggg ctttttaaag aaggcccctc agctctgagc accatgtaag taaatgtata
     3181 tacctccata aggaataaat catacttagg tataaattaa agcaatttct cattaacatt
     3241 cttgtcatcc gatactcttg tctcgtctct atcccgccac ccctctgcca tcatgtgcca
     3301 cttacagtga acaggaagtg tcgttaacct gtctccaggc catcgattga aggaactgag
     3361 gttcaacttt tacttcagat aggaggtcac ttgcgtcaat aaatgttaag acccgttttc
     3421 atgctaagtg attcatgtct acatttgctt tacatgtgaa ataaaactta cgatttgctg
     3481 tttttataaa taaagtggct caggttatg
//
