LOCUS       NM_023434               4458 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TOX high mobility group box family member 4 (Tox4),
            mRNA.
ACCESSION   NM_023434
VERSION     NM_023434.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4458)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4458)
  AUTHORS   Huang,Y., Chen,T., Jiang,M., Xiong,C., Mei,C., Nie,J., Zhang,Q.,
            Zhu,Q., Huang,X., Zhang,X. and Li,Y.
  TITLE     E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury
            through inhibition of TOX4-mediated apoptosis
  JOURNAL   Cell Death Dis 15 (1), 29 (2024)
   PUBMED   38212319
  REMARK    GeneRIF: E3 ligase TRIM65 alleviates intestinal
            ischemia/reperfusion injury through inhibition of TOX4-mediated
            apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4458)
  AUTHORS   Wang,T., Zhao,R., Zhi,J., Liu,Z., Wu,A., Yang,Z., Wang,W., Ni,T.,
            Jing,L. and Yu,M.
  TITLE     Tox4 regulates transcriptional elongation and reinitiation during
            murine T cell development
  JOURNAL   Commun Biol 6 (1), 613 (2023)
   PUBMED   37286708
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4458)
  AUTHORS   Wang,L., Yu,J., Zhou,Q., Wang,X., Mukhanova,M., Du,W., Sun,L.,
            Pajvani,U.B. and Accili,D.
  TITLE     TOX4, an insulin receptor-independent regulator of hepatic glucose
            production, is activated in diabetic liver
  JOURNAL   Cell Metab 34 (1), 158-170 (2022)
   PUBMED   34914893
REFERENCE   5  (bases 1 to 4458)
  AUTHORS   Vanheer,L., Song,J., De Geest,N., Janiszewski,A., Talon,I.,
            Provenzano,C., Oh,T., Chappell,J. and Pasque,V.
  TITLE     Tox4 modulates cell fate reprogramming
  JOURNAL   J Cell Sci 132 (20) (2019)
   PUBMED   31519808
  REMARK    GeneRIF: study reveals Tox4 as a novel transcriptional modulator of
            cell fate that mediates reprogramming from the somatic state to the
            pluripotent and neuronal fate.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4458)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 4458)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 4458)
  AUTHORS   Zhou,Q., Law,A.C., Rajagopal,J., Anderson,W.J., Gray,P.A. and
            Melton,D.A.
  TITLE     A multipotent progenitor domain guides pancreatic organogenesis
  JOURNAL   Dev Cell 13 (1), 103-114 (2007)
   PUBMED   17609113
REFERENCE   9  (bases 1 to 4458)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4458)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY327085.1, AK173012.1, AK147023.1 and AK137050.1.
            
            On Feb 1, 2008 this sequence version replaced NM_023434.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK147023.1, SRR1660813.203537.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               BY327085.1         2-297
            297-3458            AK173012.1         1-3162
            3459-4346           AK147023.1         3165-4052
            4347-4458           AK137050.1         2572-2683
FEATURES             Location/Qualifiers
     source          1..4458
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.88 cM"
     gene            1..4458
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /note="TOX high mobility group box family member 4"
                     /db_xref="GeneID:268741"
                     /db_xref="MGI:MGI:1915389"
     exon            1..87
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..356
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2210
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /note="epidermal Langerhans cell protein LCP1"
                     /codon_start=1
                     /product="TOX high mobility group box family member 4"
                     /protein_id="NP_075923.2"
                     /db_xref="CCDS:CCDS36920.1"
                     /db_xref="GeneID:268741"
                     /db_xref="MGI:MGI:1915389"
                     /translation="MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISL
                     DSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSG
                     GLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGG
                     TILPPAQSPEDRLSTTPSPTNSLHEDGVDDFRRQLPAQKTVVVETGKKQKAPKKRKKK
                     DPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKT
                     EAAKKEYLKALAAYKDNQECQATVETVELDPVPQSQTPSPPPVTAADPASPAPASTES
                     PALPPCIIVNSTLSSYVANQASSGPGGQPNITKLIITKQMLPSSITMSQGGMVTVIPA
                     TVVTSRGLQVGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQMP
                     QPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQSKIVPPPTLKIQTTVVPP
                     TVESSPEQPMNSSPEAHTVEATSPETICEMIADVVPEVESPSQMDVELVSGSPVALSP
                     QPRCVRSGCENPPVVSKDWDNEYCSNECVVKHCRDVFLAWVASRNPNSVVFVK"
     exon            357..425
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..668
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..929
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1160
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1241
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1985
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2149
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..4458
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /note="hexamer: AGTAAA"
     polyA_site      3461
                     /gene="Tox4"
                     /gene_synonym="5730589K01Rik; A630040M18; LCP1"
                     /note="major polyA site"
ORIGIN      
        1 ggaggtagga tccccgcccc aactccgaag gcggtccgtc ggcgggttac ctgtgtctcc
       61 gatgatgatg tacttgaaga gataagcaaa tcttcgctgg atcggctgta ccggacgccg
      121 cctctagggc cacccagtgc tcttctacat gccattatcc caccaagctc cagggggcga
      181 cagcgaccct tcgggcagct gggatcgaga ctggttgcgt ccctgactcg gtccaatcat
      241 cggagagcga cgctttctcc ttgaggaagt gacgcgctcg gaacctagtg ggggcggtgg
      301 gagcgatgcg gacgcggaga cgctgagtcg ctggtagtgg tgctgtgaag atggagtttc
      361 ccggaggaaa tgacaattac ctgacgatca ctgggccctc gcaccctttc ctgtcaggag
      421 ccgagacatt ccatacacca agcttgggcg atgaggaatt tgaaattcca cctatctcct
      481 tggactctga tccctcactg gctgtctcag atgtggttgg ccactttgat gacctggcag
      541 acccctcctc ttcacaggat ggcagctttt cagctcaata cggggtccag acattggaca
      601 tgcctgtggg catgacccat ggcttgatgg agcagggcgg ggggctcctg agtgggggct
      661 tgactatgga cctggaccat tctataggaa ctcagtatag tgccaaccca cctgttacaa
      721 ttgatgtacc aatgacagac atgacatctg gcttaatggg acacagccag ttgaccacta
      781 ttgatcagtc agaactgagt tctcaacttg gtttgagttt aggaggtggc accatcttgc
      841 cacctgccca gtcacctgag gatcgtcttt caactactcc ttcacctacc aattcacttc
      901 atgaggatgg tgttgatgat ttccggaggc aacttcccgc ccagaagaca gtggtagtgg
      961 aaacagggaa aaagcaaaag gctcccaaga agagaaaaaa gaaagaccca aatgaacctc
     1021 agaagccagt ctctgcgtat gcattgttct ttcgagatac gcaggctgcc atcaagggac
     1081 aaaacccaaa cgcaaccttt ggggaggtat cgaagattgt ggcttccatg tgggacagtc
     1141 ttggagagga acagaagcag gtgtacaagc ggaagactga ggctgccaag aaagagtatc
     1201 tcaaggcact agctgcttat aaagacaacc aggaatgcca ggctactgtg gaaacagtgg
     1261 aattagatcc tgtgccacag tcacagactc cttccccacc tcctgtgact gctgctgacc
     1321 cagcatctcc agcaccagcc tcaacggagt ctcctgcttt gcccccttgc atcatagtga
     1381 attccacgct ttcatcttac gtggcaaacc aagcctcttc tgggcctgga ggtcagccca
     1441 atattaccaa gttgattatt accaaacaga tgttgccttc ttctatcacc atgtcccaag
     1501 gtggaatggt tactgttatc ccagccacag tggttacctc ccgtgggctc caggtaggcc
     1561 aaacaagtac agctactatt cagccaagcc agcaggccca gattgtcacc cggtcagtgt
     1621 tgcaggcagc tgcagctgct gctgcttcca tgcaactgcc tccaccccga ctacagcctc
     1681 ctccgttgca acagatgcct cagcccccaa ctcaacagca agtaaccatt ctacagcaac
     1741 cccctccact tcaggccatg cagcaacctc cacctcagaa agttagaatc aacttacagc
     1801 agcagccacc acctctgcag agcaagattg tgcctccacc cactctgaaa atacagacta
     1861 ctgtggtccc tccaactgta gaaagcagtc ctgagcagcc tatgaacagc agccccgagg
     1921 cccacacagt agaggcaacc tctcctgaga caatctgtga aatgatcgca gatgtagttc
     1981 ctgaggtgga gtctccttct cagatggatg ttgaattggt gagtggctcc cctgtggcac
     2041 tgtcacctca gcctcgatgt gtgaggtctg gttgtgagaa ccctcctgtt gtcagtaagg
     2101 actgggacaa cgagtactgc agcaatgagt gtgtggtgaa gcactgcagg gatgtattct
     2161 tggcctgggt ggcctctaga aatccaaact ctgtggtgtt tgtgaagtag ccttcgtctt
     2221 ctccaagcct tgaagattca tctgctgaac acgagtccaa aagcctgttt ttttgttttg
     2281 ttttgttggt tttccagaca gggtttctct atgtagccct ggctgtcctg gaactcattt
     2341 tgtagaccag gctggcctcg aactcagaaa tccacctgct ctgcctccca agtgctggga
     2401 ttaaaggcgt gcgccaccac cgcccggcca aaagcctgtt ttttaaacac aaactgggct
     2461 tctgtagtgc ctgaccttta cccatagtcc ttcatgcctc catctccctt ttctttcttc
     2521 agcagaggcc agactatgta gcagggccag caaattcact gtaatttaga attgcttttt
     2581 actctcaact gtaagcaaaa ttaccagctt actagcaagc acagggaaga gtgatgggag
     2641 caaatcatag gggtcattag aagaaacata ccagtaaaac ggtcagacaa cttgcctaga
     2701 atgtcattgg gcgagtgctt tgctttgttc tcggcagaaa aagctctggg agaagagaga
     2761 cttagggttt cagctcagtg gtaaagtgca ctgggtttaa atcccaagtg aaggaggaat
     2821 gaaaatactg atttaaaata aaatgtgtga tagcccttta aaagggaact attattgata
     2881 tacacagtgc tattaggagg aaggtttgaa ggcctggggt tatggcttag cactataaag
     2941 ctctgagttc agaccccagg ctggaagatc aggagttcaa ggtcatcctt ggcccactag
     3001 tgagtttgag aacagtctaa gatgcatgag gtaaaggttt tacagaacat ggtggcccgt
     3061 gcctttaatc ctaatacttt ggaagtagac aggaagattt ttgatctgaa cttaaatcag
     3121 actttgtctc aaaaaataga ccgggtgtgg tggcactccc ctttaatcct acaacttagg
     3181 aggcaagagg caggttggat ctctgagctt gaagttagcc aggattacct agtgagatcc
     3241 tatcttaagg tccccctccc tgctcctgac aaaaacacac aaattctgtt tgtctcagtc
     3301 ttagcacatt gggctagagg ggaaacgaca tcatccaaaa cgatcttttt ctgtacaagt
     3361 atttctttac ctgacttggt taccagtttt gcatgtaaga agcagaactc tataccccta
     3421 ataagaggtt ttacaaagta aagaatctgt gtttgatgaa acatctttta aatgtgcatt
     3481 catttacata atgcataggc caatttttta tattctaagc tctaatttta attgaaggta
     3541 ccttgttttt cttagaaatt agctacagac taataaacca gcaaacgtac atagaataag
     3601 caaaagttta gagtaccata tgcatggtaa aattcaaatt aatcctgttt atagcatatt
     3661 aattgctaag cactgtgaac ctgtgtagtc ttttctaaca cgctaggtag ctaacattct
     3721 tcttttactt ataatgaatc acgctaaata agagtagcac aaggacacac actaagtgga
     3781 aagccataat ttcacttcag aaattccaat tataatacaa acttttattt atttatatac
     3841 agggtagggg acactattgc gtaaacagtc ctcttaaggt gtggcctgta gcccatggct
     3901 ctgaacgctt agctttgtaa ggaagtgcgt ctataaattc ttaggtttag agatgatgcc
     3961 gtccggatac ctttgcttaa acctggcaac cacatctggg tctagtaggt gtatcccatc
     4021 cagttggttt ccaagagtaa tcctaaaaca agggggaaag aagaggcaaa ccaaaaatcc
     4081 tgtaagggct taatacttaa aatgttctac tttctggtga tacctatctc aggctgtcct
     4141 ggaactaact ctccatgtag accaggctaa ccttgaactc agagatctac ttgcctctgc
     4201 ctcccaagtg ctgaggctaa aggtgtgctc tactatgccc agtccacgtc aatttttttg
     4261 gtttggtttg gtttggtttt tgagacaggg tttctttgta tagccccggc tgacctggaa
     4321 ctcactttgt agaccaggct ggcttcagaa atccacctgc ctatgcctcc tgagtgctgg
     4381 gattaaaggc atgcgccacc acgcccggcc tacatcaact tttaaaaaga tcagagcaaa
     4441 taatatggca gtgtcaat
//
