LOCUS       NM_001372575            2747 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus TOX high mobility group box family member 2 (Tox2),
            transcript variant 4, mRNA.
ACCESSION   NM_001372575 XM_006499611
VERSION     NM_001372575.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2747)
  AUTHORS   Das,A., Martinez-Ruiz,G.U., Bouladoux,N., Stacy,A., Moraly,J.,
            Vega-Sendino,M., Zhao,Y., Lavaert,M., Ding,Y., Morales-Sanchez,A.,
            Harly,C., Seedhom,M.O., Chari,R., Awasthi,P., Ikeuchi,T., Wang,Y.,
            Zhu,J., Moutsopoulos,N.M., Chen,W., Yewdell,J.W., Shapiro,V.S.,
            Ruiz,S., Taylor,N., Belkaid,Y. and Bhandoola,A.
  TITLE     Transcription factor Tox2 is required for metabolic adaptation and
            tissue residency of ILC3 in the gut
  JOURNAL   Immunity 57 (5), 1019-1036 (2024)
   PUBMED   38677292
  REMARK    GeneRIF: Transcription factor Tox2 is required for metabolic
            adaptation and tissue residency of ILC3 in the gut.
REFERENCE   2  (bases 1 to 2747)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2747)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (bases 1 to 2747)
  AUTHORS   Xu,W., Zhao,X., Wang,X., Feng,H., Gou,M., Jin,W., Wang,X., Liu,X.
            and Dong,C.
  TITLE     The Transcription Factor Tox2 Drives T Follicular Helper Cell
            Development via Regulating Chromatin Accessibility
  JOURNAL   Immunity 51 (5), 826-839 (2019)
   PUBMED   31732165
  REMARK    GeneRIF: Tox2(-/-) mice exhibited defective Tfh differentiation,
            and inhibition of both Tox2 and the related transcription factor
            Tox abolished Tfh differentiation. Thus, a Tox2-Bcl6 axis
            establishes a transcriptional feed-forward loop that promotes the
            Tfh program.
REFERENCE   5  (bases 1 to 2747)
  AUTHORS   Seo,H., Chen,J., Gonzalez-Avalos,E., Samaniego-Castruita,D.,
            Das,A., Wang,Y.H., Lopez-Moyado,I.F., Georges,R.O., Zhang,W.,
            Onodera,A., Wu,C.J., Lu,L.F., Hogan,P.G., Bhandoola,A. and Rao,A.
  TITLE     TOX and TOX2 transcription factors cooperate with NR4A
            transcription factors to impose CD8+ T cell exhaustion
  JOURNAL   Proc Natl Acad Sci U S A 116 (25), 12410-12415 (2019)
   PUBMED   31152140
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19761. doi:
            10.1073/pnas.1914896116. PMID: 31527257]
REFERENCE   6  (bases 1 to 2747)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   7  (bases 1 to 2747)
  AUTHORS   Liang,S., Zhao,S., Mu,X., Thomas,T. and Klein,W.H.
  TITLE     Novel retinal genes discovered by mining the mouse embryonic
            RetinalExpress database
  JOURNAL   Mol Vis 10, 773-786 (2004)
   PUBMED   15496829
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2747)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2747)
  AUTHORS   Kajitani,T., Mizutani,T., Yamada,K., Yazawa,T., Sekiguchi,T.,
            Yoshino,M., Kawata,H. and Miyamoto,K.
  TITLE     Cloning and characterization of granulosa cell high-mobility group
            (HMG)-box protein-1, a novel HMG-box transcriptional regulator
            strongly expressed in rat ovarian granulosa cells
  JOURNAL   Endocrinology 145 (5), 2307-2318 (2004)
   PUBMED   14764631
  REMARK    GeneRIF: Identification and functional analysis of the rat Gcx1
            ortholog.
REFERENCE   10 (bases 1 to 2747)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589874.15 and AL589876.11.
            
            On Sep 4, 2019 this sequence version replaced XM_006499611.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.641254.1,
                                           SRR7652917.482690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL589874.15        61211-61346
            137-202             AL589876.11        34827-34892
            203-448             AL589876.11        63029-63274
            449-688             AL589876.11        101382-101621
            689-916             AL589876.11        102855-103082
            917-997             AL589876.11        106622-106702
            998-1390            AL589876.11        107358-107750
            1391-1518           AL589876.11        108481-108608
            1519-2747           AL589876.11        110004-111232
FEATURES             Location/Qualifiers
     source          1..2747
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.14 cM"
     gene            1..2747
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /note="TOX high mobility group box family member 2"
                     /db_xref="GeneID:269389"
                     /db_xref="MGI:MGI:3611233"
     exon            1..136
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..202
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            203..448
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..688
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..916
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..997
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1390
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1518
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..2747
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /note="hexamer: AATAAA"
     polyA_site      2747
                     /gene="Tox2"
                     /gene_synonym="Gcx1; RxHMG1"
                     /note="major polyA site"
ORIGIN      
        1 actgcccgcg ggagccgccg ccgccgccgc gcccgccatg gacgtccgcc tgtatccctc
       61 ggcgcccgcg gtaggtgcgc ggcccggggc cgagccggcc ggcctggcac acctggacta
      121 ctaccactgc ggcaagtttg atggtgacag tgcctacgtg gggatgagtg acggaaatcc
      181 agagctcctg tcaaccagcc agacctataa cagccagggc gagagtaacg aagactatga
      241 gattcctcct ataacgcctc ccaatctccc tgagccatcc ctcctgcacc tgggggatca
      301 cgaagccggc taccactcgc tgtgtcacgg ccttgcgccc aacggtctgc tccctgccta
      361 ctcgtaccaa gcaatggatc tccctgccat catggtgtcc aacatgctgg cccaggacgg
      421 ccatctgctg tcaggccagc tgcccacgat ccaggaaatg gtccactcgg aggtggcggc
      481 atatgactca ggccggccag ggcccctgct gggccgcccg gcgatgctgg ccagccacat
      541 gagtgccctc agccagtctc agctcatctc ccagatgggt atccggagtg gcattgctca
      601 cggctcccca tcacctccag ggagcaagtc agcgaccccc tctccatcca gttccacaca
      661 ggaggaggaa tcagatgccc atttcaagat ctcgggagag aagagaccct cagtggaccc
      721 aggcaaaaag gccaagaatc caaagaagaa gaagaagaag gaccccaatg agccacagaa
      781 gccagtgtcg gcctacgctc tcttcttcag agacactcag gctgccatca aggggcagaa
      841 tcccagtgcc acctttggag atgtgtccaa aatagtggcg tccatgtggg acagcctggg
      901 agaagagcag aaacaggcgt ataagaggaa gactgaagct gccaagaagg agtacctgaa
      961 agccttggcg gcctacagag ctagcctcgt gtccaagagc cccccggacc aaggtgaggc
     1021 caagaacact caggcaaacc caccagccaa aatgcttcca cccaagcagc ccatgtacgc
     1081 catgcccggc ctggcttcct tcctgacgcc ctccgacctg caggccttcc gcagtggagc
     1141 ctctcccgcc agccttgcca ggacgctggg ctccaaggcc ctgctgccgg gcctcagcac
     1201 atcgccgcca ccaccctcct tccctctcag cccctcactg caccagcagc tgccactgcc
     1261 cccccacgcg cagggcactc tcctcagccc gcctctcagc atgtccccag ccccgcagcc
     1321 tcctgtcctg cctgcctcca tggcactcca ggtgcagctg gcgatgagcc cctcacctcc
     1381 agggccacag gacttcccac acatctctga tttctccagt ggctctggct cccgctcacc
     1441 tggcccatcc aacccttcca gcagcggaga ctgggatggg agttacccca gtggggagcg
     1501 tggcctcggc acctgcagac tctgcagagg cagcccaccg cccaccacca gcccaaagaa
     1561 cctgcaggaa ccttctgccc gctgacctgc ttgctccagg gtagctgtgg accccgctcc
     1621 ttggcctgca cacagtcccc tgcgtctgga cttctggccc cagccccaac tcaccgggct
     1681 gcccccttcg aagttgctta gcaacagaca cccacccctg atgctgggcc agccacaggt
     1741 gtgctctcag tgtacacaaa gatgctgaaa ctcgttctgt gggttctgtg taagtagttc
     1801 actgttttag aactgtgctg aagacatctg taagattatt ttgtggggag aaagaaagtt
     1861 tcctttaagg ttaaaaaaat ttttataaga cctttggcac attttttttt aagttttatc
     1921 ttaagggaga catgtgcaca agcaactgtc aaggtgattc taatctgcac acagagaaaa
     1981 tgggaacttt taagccacac ccaggggcat tcttcttcct cttcttcctc ctcctcctct
     2041 tcttcttccc cctcttcctc ttctttttcc tcttcttcct cttcttcatc ctcttcttcc
     2101 tcttcctctt cttcatcttt tcctcttctt cctcttcttc cccttctttc tctttttcct
     2161 tttcctcttc ttcctattcc tcttcttccc cttcttcctc ttcttcttcc tcttcttccc
     2221 cttcttcttc ctcttcttcc ccttctttct cttcttcctt ttcctcttct tcctcttctt
     2281 ccccttcttt ctctttttac ttttcctctt cttcctattc ctcttcttcc tcttcttcct
     2341 cttcttcccc ttcttcttcc tcttcttccc cttctttctc tttttccttt tcctcttctt
     2401 cctattcctc ttcttcctct tcttcatctt cctcttcttc ttccccttct tcctcttcct
     2461 ctcctttcct tcttcttctg cctcttcgtc ctcttctttc tctttttttt gtttctgttt
     2521 tactcatata tcccccctat ttaaaattgc cggcaatgat tttggttatc tatttatgaa
     2581 gaaaaactga gaacagcatt gtggtttctc ctaacgtgtg tgtggtcggg gtttgggttt
     2641 ggttcttgtc gttcgcagct gtctcctggc ccctgcaatg tctgtcctgg tgccccagtg
     2701 cttcgctcag acctctttgt aataaaactg ctgaaaagtg gcaaaca
//
