LOCUS       NM_145711               3998 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus thymocyte selection-associated high mobility group box
            (Tox), transcript variant 1, mRNA.
ACCESSION   NM_145711 XM_905337 XM_919251 XM_919265 XM_919274 XM_919283
            XM_919293 XM_919306
VERSION     NM_145711.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3998)
  AUTHORS   Bao,K., Gu,X., Song,Y., Zhou,Y., Chen,Y., Yu,X., Yuan,W., Shi,L.,
            Zheng,J. and Hong,M.
  TITLE     TCF-1 and TOX regulate the memory formation of intestinal group 2
            innate lymphoid cells in asthma
  JOURNAL   Nat Commun 15 (1), 7850 (2024)
   PUBMED   39245681
  REMARK    GeneRIF: TCF-1 and TOX regulate the memory formation of intestinal
            group 2 innate lymphoid cells in asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3998)
  AUTHORS   Das,A., Martinez-Ruiz,G.U., Bouladoux,N., Stacy,A., Moraly,J.,
            Vega-Sendino,M., Zhao,Y., Lavaert,M., Ding,Y., Morales-Sanchez,A.,
            Harly,C., Seedhom,M.O., Chari,R., Awasthi,P., Ikeuchi,T., Wang,Y.,
            Zhu,J., Moutsopoulos,N.M., Chen,W., Yewdell,J.W., Shapiro,V.S.,
            Ruiz,S., Taylor,N., Belkaid,Y. and Bhandoola,A.
  TITLE     Transcription factor Tox2 is required for metabolic adaptation and
            tissue residency of ILC3 in the gut
  JOURNAL   Immunity 57 (5), 1019-1036 (2024)
   PUBMED   38677292
REFERENCE   3  (bases 1 to 3998)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3998)
  AUTHORS   Yeckes,A.R., Victor,A.R., Zhu,Z., Narayanan,M., Srinivasan,B.,
            Bruce,B. and Kaye,J.
  TITLE     The Tox Gene Encodes Two Proteins with Distinct and Shared Roles in
            Gene Regulation
  JOURNAL   J Immunol 210 (12), 1889-1898 (2023)
   PUBMED   37115203
  REMARK    GeneRIF: The Tox Gene Encodes Two Proteins with Distinct and Shared
            Roles in Gene Regulation.
REFERENCE   5  (bases 1 to 3998)
  AUTHORS   Luo,L., Feng,P., Yang,Q., Lv,W., Meng,W., Yin,Z., Li,Z., Sun,G.,
            Dong,Z. and Yang,M.
  TITLE     Transcription factor TOX maintains the expression of Mst1 in
            controlling the early mouse NK cell development
  JOURNAL   Theranostics 13 (7), 2072-2087 (2023)
   PUBMED   37153735
  REMARK    GeneRIF: Transcription factor TOX maintains the expression of Mst1
            in controlling the early mouse NK cell development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3998)
  AUTHORS   Muhlfriedel,S., Kirsch,F., Gruss,P., Chowdhury,K. and Stoykova,A.
  TITLE     Novel genes differentially expressed in cortical regions during
            late neurogenesis
  JOURNAL   Eur J Neurosci 26 (1), 33-50 (2007)
   PUBMED   17614941
REFERENCE   7  (bases 1 to 3998)
  AUTHORS   Laz,E.V., Holloway,M.G., Chen,C.S. and Waxman,D.J.
  TITLE     Characterization of three growth hormone-responsive transcription
            factors preferentially expressed in adult female liver
  JOURNAL   Endocrinology 148 (7), 3327-3337 (2007)
   PUBMED   17412818
REFERENCE   8  (bases 1 to 3998)
  AUTHORS   Aliahmad,P., O'Flaherty,E., Han,P., Goularte,O.D., Wilkinson,B.,
            Satake,M., Molkentin,J.D. and Kaye,J.
  TITLE     TOX provides a link between calcineurin activation and CD8 lineage
            commitment
  JOURNAL   J Exp Med 199 (8), 1089-1099 (2004)
   PUBMED   15078895
REFERENCE   9  (bases 1 to 3998)
  AUTHORS   O'Flaherty,E. and Kaye,J.
  TITLE     TOX defines a conserved subfamily of HMG-box proteins
  JOURNAL   BMC Genomics 4 (1), 13 (2003)
   PUBMED   12697058
REFERENCE   10 (bases 1 to 3998)
  AUTHORS   Wilkinson,B., Chen,J.Y., Han,P., Rufner,K.M., Goularte,O.D. and
            Kaye,J.
  TITLE     TOX: an HMG box protein implicated in the regulation of thymocyte
            selection
  JOURNAL   Nat Immunol 3 (3), 272-280 (2002)
   PUBMED   11850626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671871.4 and AL831740.9.
            
            On Dec 12, 2019 this sequence version replaced NM_145711.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All 3 variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080732.1, AK133397.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-447               AL671871.4         166836-167282       c
            448-513             AL671871.4         18807-18872         c
            514-756             AL831740.9         164316-164558       c
            757-1038            AL831740.9         82697-82978         c
            1039-1269           AL831740.9         63549-63779         c
            1270-1350           AL831740.9         52869-52949         c
            1351-1737           AL831740.9         38821-39207         c
            1738-1889           AL831740.9         30230-30381         c
            1890-3998           AL831740.9         27764-29872         c
FEATURES             Location/Qualifiers
     source          1..3998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 3.04 cM"
     gene            1..3998
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /note="thymocyte selection-associated high mobility group
                     box"
                     /db_xref="GeneID:252838"
                     /db_xref="MGI:MGI:2181659"
     exon            1..447
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            448..513
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            514..756
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1038
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1269
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1350
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1737
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1889
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..3998
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2875..2880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /note="hexamer: AATATA"
     polyA_site      2896
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /note="major polyA site"
     regulatory      3870..3875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3898
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
     regulatory      3976..3981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /note="hexamer: AATATA"
     polyA_site      3998
                     /gene="Tox"
                     /gene_synonym="1700007F02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaagttacct gcccggcggc ggcgggccga cagcgccggg gccgagcgga ccaggcaggc
       61 tgcgcgctcg gtgtggacgg gtgcgcgcca cggcttgggg gggagagttg agcgcttttc
      121 caccctctgt tttttttttc ctctctctct cttttctctc tctcttttct tcctcttctt
      181 aaacaaacca caaacggatg tgagggaagg aaggtgtttc ttttactcct gagcccagac
      241 gcctctctgt tccgtctgag cttttttttt tttttctgag cacttttttt tttttttttt
      301 ttttcaaaaa ggaaaagaaa aggagttgct tgatgtgaga gtgaaatgga cgtaagattt
      361 tatcctcctc cagcccagcc cgctgctgcg cccgccgctc cttgtctggg accttctccc
      421 tgcctggacc cctactattg caacaagttt gacggggaga acatgtatat gagcatgaca
      481 gagccgagcc aggactatgt gccagccagc cagtcctacc ctggaccaag tctggaaagt
      541 gaagatttta acatcccacc catcacgcct ccctccctcc ctgaccactc tctggtgcac
      601 ctgaatgagg tagaatccgg ttaccactct ctgtgtcacc ccatgaatca caatggcctg
      661 ctcccgttcc atccacaaac catggacctg ccagagatca cggtgtccaa catgctgggc
      721 caagatggcg cactgctctc caattccatc tctgtgatgc aagagattgg gaacgcagaa
      781 ggagctcagt acagctccca tcctcagatg gcagccatga ggccgagagg ccagcctaca
      841 gacatcagac agcaggcaag catgatgcag cccggccagc tgaccaccat caaccagtcg
      901 cagctgagcg cacagttggg cttgaacatg ggaggaacca atgtggccca caactcccct
      961 tctccacccg ggagcaagtc tgcaacccct tccccatcca gctcagtgca tgaggatgag
     1021 tgtgaggatg cctccaagat caatggagga gagaagcggc ctgcctctga tatggggaaa
     1081 aaacccaaaa ctcccaagaa gaagaagaag aaggatccta atgagcccca gaagcctgtg
     1141 tctgcctatg ctttgttctt tcgtgatacc caggctgcca ttaagggcca gaatccaaat
     1201 gctacttttg gtgaagtatc gaagattgtg gcatcaatgt gggatggcct aggagaagaa
     1261 cagaaacagg tctataagaa gaaaaccgag gctgcaaaga aggaatacct gaagcagcta
     1321 gcagcataca gagccagcct tgtatccaag agctacactg atcctgttga tgttaagaca
     1381 tctcagccac cccagctggt caactcaaag ccgtcagtat tccatgggcc cagccaggcc
     1441 cactcagctc tgtacctaag ttctcactat caccaacaac caggaatgac tcctcagctc
     1501 accgccatgc atccgagcct ccccagaaac atagcaccta agcccaataa ccaaatgcca
     1561 gtgactgtct ccatagccaa catggctgtg tccccaccac cgccccttca gatcagccca
     1621 cctcttcatc agcatctcag catgcagcag catcagtcgc ttgccatgca gcagcccctt
     1681 gggagtcagc tccccatgca ggtccagact gccttacact cgcccaccat gcagcaagga
     1741 tttactcttc aacccgacta tcagactatt atcaacccta catctacagc tgcacaagtt
     1801 gtcacccaag cgatggagta cgtgcgttct gggtgcagaa atccgccccc acagcccgtg
     1861 gactggagta ccgactactg cagtagtggg ggcatgcaga gggacaaagc gctgtatctc
     1921 acctgaaaat ctcgacacct cttctttcca ctgaggagtt cagggaaatc ttttcaccat
     1981 ggattgcttt gcgcactcaa agcagttctt catttgatta gaaaatacaa gttactaagc
     2041 acttaggacc atgtgagctt gtgggtcacc cacgctggaa gaaatagtca tgcttcttta
     2101 ttattttttt aatcttttat ggacattgtt cctcttccca gaaggaagtg tggaccattc
     2161 tgatttctgt tggttttgct gtgaagtgct gcggctctag taactgcctt agcaacggta
     2221 gatgtctggg gtaaacggtc ctgggttttc cattggtttt cataatgggt gtttatatga
     2281 aactactaaa gactttttaa atggcttgat gtagcagtca tagcaagttt gtaaatagca
     2341 tctatgttac actctcctag agtataaaat gtgaatgttt ttgtagctaa attgtaattt
     2401 gaaactggct caccccagtt tgttgatttc acagagggat taaaattggc aaacattcat
     2461 atttttactt catttttaaa aacaacttac taatagttct atattttcaa aatacttgaa
     2521 aaaatattcc caaatgattt taatttaaaa acaatttggc tttgtcttat tgatcagaca
     2581 aaaaagaagc tagtatggag ggaagcgcaa acacatttat tttgtattgc agaaaaaaaa
     2641 atcctttttt gtatcacttt tgtgtaatga ttagtaaatg tcatccaagt cctgttatgg
     2701 ataaagctgc caaatgctca ctggcatctt agctgcagaa acaggccgga acgcgctagc
     2761 taagtgctcc tctttatcta tggctctgtg ttactgtttc tccatactgt gtctgtattt
     2821 aatcgttttc ttcttttttt tatgaaactt gttgcgccta tttatgaaat aataaatata
     2881 ggtgtttgta agtaaatttg ttagtatttg aaagaggttt cattgatgtt ttaatttttg
     2941 ctggcaaaaa aaaaaaaaaa aatccatgct tggtgtgagt acttatttag tttttacagt
     3001 gacatgaata aaaccaaatc tgcttttcat ttagtagcaa actagaggaa cgaatctgta
     3061 tttttgcata tcttttgttg acataaatga aaaacaattc tacttagcaa tcttcttttc
     3121 ctgagcaaca caacagaaaa ctgctcctga ggtgccaccc ttgccaggcc taagcaaaca
     3181 ccagtgcatc ctcttcctaa agagataaaa agagctgttt ctcacttctc agttccaaaa
     3241 cagttgccac cccccacccc aacccccacc cccccaaccc caaccccccc ccccacacac
     3301 acacacaaat gctaagaacc aaattcaagt tgagtcaccc agaatcccaa aagtcacatg
     3361 cttctcatgg catgcagaaa acatttaaga attgaccaag ggttcaggaa gagatcaaag
     3421 gggatatggt gtctagaatc aatctagaaa tgaagggcta gtagtcagac cagctcaaga
     3481 aataggaaaa tcatgggaag tggacgcagt tgctagaaac tgagcaccct gctatccccc
     3541 gtctctgctc tcttcctttt ccacaaatcc tgggtcacca ctagcgatgt gccagtaggg
     3601 ctttgcatag ctctgatagc agaaggaagg ggtgaggaaa ggtccccttc cacagacttc
     3661 ggtcacataa attcatctgg ctagacatga agagaatggt ggttttgtgg aatgtatgaa
     3721 ataaccttag caatttaaat acatcatgta atccagtcaa aattgaaaag acaaaaggct
     3781 tgcttgcttt ggattgattt tcagacactg tacaacgttg aatcactcgg catgtaataa
     3841 ctaataaata atgcagatcc ggtgttatta ttaaaatgac gggggttgag agctcaaact
     3901 ttactgtctt gatactgtat aagaattcat gtgattaact tcccagttta ttgtttggct
     3961 gtttagtatt ttagaaatat accagcacta ctaattaa
//
