LOCUS       NM_146115               3428 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus torsin family 4, member A (Tor4a), mRNA.
ACCESSION   NM_146115
VERSION     NM_146115.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3428)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3428)
  AUTHORS   Diez-Roux,G., Banfi,S., Sultan,M., Geffers,L., Anand,S., Rozado,D.,
            Magen,A., Canidio,E., Pagani,M., Peluso,I., Lin-Marq,N., Koch,M.,
            Bilio,M., Cantiello,I., Verde,R., De Masi,C., Bianchi,S.A.,
            Cicchini,J., Perroud,E., Mehmeti,S., Dagand,E., Schrinner,S.,
            Nurnberger,A., Schmidt,K., Metz,K., Zwingmann,C., Brieske,N.,
            Springer,C., Hernandez,A.M., Herzog,S., Grabbe,F., Sieverding,C.,
            Fischer,B., Schrader,K., Brockmeyer,M., Dettmer,S., Helbig,C.,
            Alunni,V., Battaini,M.A., Mura,C., Henrichsen,C.N.,
            Garcia-Lopez,R., Echevarria,D., Puelles,E., Garcia-Calero,E.,
            Kruse,S., Uhr,M., Kauck,C., Feng,G., Milyaev,N., Ong,C.K.,
            Kumar,L., Lam,M., Semple,C.A., Gyenesei,A., Mundlos,S., Radelof,U.,
            Lehrach,H., Sarmientos,P., Reymond,A., Davidson,D.R., Dolle,P.,
            Antonarakis,S.E., Yaspo,M.L., Martinez,S., Baldock,R.A., Eichele,G.
            and Ballabio,A.
  TITLE     A high-resolution anatomical atlas of the transcriptome in the
            mouse embryo
  JOURNAL   PLoS Biol 9 (1), e1000582 (2011)
   PUBMED   21267068
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY199544.1 and AK043559.1.
            
            On Apr 23, 2010 this sequence version replaced NM_146115.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043559.1, AK155540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               BY199544.1         1-200
            201-3428            AK043559.1         2-3229
FEATURES             Location/Qualifiers
     source          1..3428
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 17.06 cM"
     gene            1..3428
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
                     /note="torsin family 4, member A"
                     /db_xref="GeneID:227612"
                     /db_xref="MGI:MGI:2442720"
     exon            1..222
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            223..3428
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1539
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
                     /note="torsin family protein C9orf167 homolog"
                     /codon_start=1
                     /product="torsin-4A"
                     /protein_id="NP_666227.2"
                     /db_xref="CCDS:CCDS15750.1"
                     /db_xref="GeneID:227612"
                     /db_xref="MGI:MGI:2442720"
                     /translation="MDRSHPSLEPQAKGPCVIAPVRAVLRLRRRVCVLRKRRLLQPGT
                     EPDSGTGTLGPTGSLGTLRADLDQPKFFTFDSLTELTSRTPRKRRRRSRVVLYPETSR
                     KCRPRTERQSRAQRCLLLLVAIVGFQVLNAIENLDDNAQRYDLDGLEKALQRSVFGQP
                     AAVGRIMALLRDYLATHVHSHPLLLALHGPSGVGKSHVGRLLARHFRAVLEDGALVLQ
                     YHARYHCPEPRPVQDCRKELAQRVADVVAQAEAEEKTPLLVLDEAELLPPALLDELHD
                     LLQPQRSHHFHNAIYVLLSGAGGIEITHFVLQNASRMLPPLRHSAGSTQTEESPAQEL
                     LTSLRELLAREHPLWHTAAIVPFLLLDKPDVVNCFREEMAGEGFFPEQALAEHLAEQL
                     SYYHVAGHEFAITGCKQVVAKVNLLQHKPAHAGH"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3182
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
                     /note="major polyA site"
     regulatory      3233..3238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3251
                     /gene="Tor4a"
                     /gene_synonym="A830007P12Rik"
ORIGIN      
        1 acttcctttg catctaagcg gaaacctccc cagagcttcc cctgttcctg tccctgggga
       61 cctgcagaag ttgttacccc ttcaagcctg agttgggcca gccagaccct ggcccaccca
      121 cctcaccgat tgggtggaag actagcattt cctgcttcct gagttgctgg ctcctggcct
      181 tggaagggag tggctgagct ggaggagcct gcgcagctgc agggagggga actacatgcc
      241 cagcataggt cctgaaccat ggaccgcagc catcctagcc tagagcccca ggccaaggga
      301 ccatgtgtga tagcgccagt gcgcgccgtg ctccgtctgc gccgccgagt ctgcgtcctg
      361 cgcaagaggc gcctcttgca gccaggcact gagccggact ctgggacagg gacacttggg
      421 cccaccggca gcttgggcac tctacgtgcc gacctagacc aacctaaatt cttcaccttc
      481 gacagcctga cagagctgac ttctaggaca ccccgcaaga ggcgcaggcg tagtcgggta
      541 gttctctacc cagaaacctc acggaagtgc cgaccccgca cagagcggca gagtcgtgca
      601 cagcgttgtc tgctgcttct tgtagccatt gtggggttcc aggttctcaa cgccattgag
      661 aatctagacg ataatgcaca acgttacgac ctcgacgggc tggagaaggc gctgcagcgt
      721 tctgtgtttg gacagccagc tgctgtgggc cgcatcatgg ccctgctgcg agactacctg
      781 gctacacatg tgcacagtca tcccttgctc ctggcactgc acgggcccag tggtgtaggc
      841 aagagtcacg tggggcgtct gttggcgcgc cactttcgcg cagtgctgga agatggtgct
      901 ttggttctgc agtaccatgc acgatatcac tgtccagagc cacgcccggt tcaggactgc
      961 cggaaggagc tggcacagcg agtggcagat gtggtggcac aggctgaggc cgaggagaag
     1021 acccctctct tggtcctgga tgaggctgaa ctcttgccac ctgcgctgct agatgagctc
     1081 cacgacctcc tgcagccaca gcgttcgcac catttccaca atgctatcta tgtactccta
     1141 agtggcgctg gtggtataga gatcacacac tttgtgctgc aaaatgcgtc acggatgttg
     1201 cccccactcc gccatagcgc aggcagtact cagactgagg aatctccagc ccaggagtta
     1261 ctcaccagtc ttcgagagct cctggcccga gaacaccctc tgtggcacac tgcagccatc
     1321 gtgcccttcc tgctactgga caagccggat gtggtcaact gcttcagaga ggagatggca
     1381 ggggagggct tttttcctga gcaggcactg gcagaacatc tggcagagca gctcagctac
     1441 taccatgttg ctggacatga atttgccatc accggctgca agcaggtagt agctaaggtc
     1501 aacctcttac agcacaagcc tgcacatgct ggacactagc cagtgggccc aggcaatcgg
     1561 aactgttgaa gaaaacagga aggatgtcag gtgacttgtc cccaagctgg ttcaccccag
     1621 gagctaggga ggctgatgca gtggcttagc tctgagctcc acgtccgtcc tcttcacccc
     1681 tgagccttga gattccctaa ggtcaccagg aaagtagcta ccttcccata tggagtcttc
     1741 cccatacccc cagctcccac tatgtccatc atatcccaga gacatgtgat agggcttccc
     1801 ataaccctag gaagtagcca gggttatggt agattatctc agagggtgtg aggctgcggt
     1861 aggattctgg tcctctggaa catgtggcag cctccatgcc tctcacaaac tcccaaccac
     1921 cccttgaatg cctccttagc ttagaggcca cgaggtgggg acagcttctc tgtctgtgca
     1981 cgtctctagg cctgcctcag aaggaagtta gatgtctgca agccagtgag tagatcatgg
     2041 aattcttcag atgctctggg gcatgaacct aagaggagac ccaccctcgt gagactggct
     2101 gcctgtttgc cccagagaca gacatgtaga atggcgttgg aatcagctac aaggttcagg
     2161 gtcctgctca ccagaagaga cccgagagga gagacctcta cctccaggga gatgatgtgt
     2221 cttcaccacc ctggggagac ctgggaaacc accaagctca ggtttcccaa gaaaggctca
     2281 ctggactcca gtctgtccta ctgctgagga actcactggc cccttccctt ccctggctct
     2341 ggagtgacag cggttgagtc catagcaaac tgggagcctt ggaagtgaac cctgctttga
     2401 ggctgactcg atgtaggaag caggaaacaa gcatgaggcc cagtggggtg gggtcagtct
     2461 gtgctgtgtg gttgccacag ttacacgtgg gtgaggttcc ctgtagcctt tggcagtcct
     2521 aggttcaacc tctccatttg cttggaattt gcaaggcaga aaggaggctt cttagtactc
     2581 tggccgtgtc tgtgctgcca tcttgtggct gcacccagac tttgcctgtg aatgctcatc
     2641 agtctgggtt agaaagcggt gcctcccaaa gtgtggcttg agggcacaca ggaagtggtg
     2701 acactagaag cgattagaga ggaggagccc ctcaatgggg gtgatatgtc cctgcccacg
     2761 cttgggggag aactgctgca aaactaccca gtcttaggtt tccctagaga ggattgctag
     2821 taggctccag tggaggtccc gtttgccgtg cgtggtctga ggatctggtg catgacctgc
     2881 tgagtttgga tgctgttcag ttcttgcagg attatgccaa gaaggcccct agggttgtca
     2941 cctgaaaacc tacctggaag tgtcccctac gcagccaagt gttgcttgta gtcattcact
     3001 taccatctac agagcgacta agtgagggta caaacccgag cagcatctcc tctttattta
     3061 tttataaaat cgtgcacttc taaaataatt tcatggaggc taatttcagg tctaaagagg
     3121 cctgtacact cagcactgag caggttgcat tgtgcccatg aataaaccgc agctcaaatc
     3181 tacccaccca ccttcttttc ttttctgact gtctatgaat tgagaaaggg gtattaaaac
     3241 ctgttaatgg ctgggctggt gagatggctc agtgggtaag agcaccggac tgctcttccg
     3301 aaggtcagga gttcaaatcc cagcaaccac atggtggctc acaaccatcc gtaacgagat
     3361 ctgactccct cttctggagt gtctgaggac agctacagtg tacttacaat aaataaataa
     3421 ataaatct
//
