LOCUS       NM_023141               3268 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus torsin family 3, member A (Tor3a), mRNA.
ACCESSION   NM_023141 XM_916735
VERSION     NM_023141.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Dron,M., Meritet,J.F., Dandoy-Dron,F., Meyniel,J.P., Maury,C. and
            Tovey,M.G.
  TITLE     Molecular cloning of ADIR, a novel interferon responsive gene
            encoding a protein related to the torsins
  JOURNAL   Genomics 79 (3), 315-325 (2002)
   PUBMED   11863361
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Ozelius,L.J., Page,C.E., Klein,C., Hewett,J.W., Mineta,M.,
            Leung,J., Shalish,C., Bressman,S.B., de Leon,D., Brin,M.F.,
            Fahn,S., Corey,D.P. and Breakefield,X.O.
  TITLE     The TOR1A (DYT1) gene family and its role in early onset torsion
            dystonia
  JOURNAL   Genomics 62 (3), 377-384 (1999)
   PUBMED   10644435
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Reese,D.E., Zavaljevski,M., Streiff,N.L. and Bader,D.
  TITLE     bves: A novel gene expressed during coronary blood vessel
            development
  JOURNAL   Dev Biol 209 (1), 159-171 (1999)
   PUBMED   10208750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009693.1 and AC145078.2.
            
            On Mar 11, 2009 this sequence version replaced NM_023141.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152484.1, AK152358.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1861              AK009693.1         19-1879
            1862-3268           AC145078.2         75287-76693         c
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.71 cM"
     gene            1..3268
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /note="torsin family 3, member A"
                     /db_xref="GeneID:30935"
                     /db_xref="MGI:MGI:1353652"
     exon            1..254
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1192
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /note="torsin-3A; ATP-dependent interferon-responsive
                     protein; ATP-dependant interferon responsive"
                     /codon_start=1
                     /product="torsin-3A precursor"
                     /protein_id="NP_075630.2"
                     /db_xref="CCDS:CCDS15394.1"
                     /db_xref="GeneID:30935"
                     /db_xref="MGI:MGI:1353652"
                     /translation="MFLGALWLLLLLPLRPPGAQGQEADEPTPWPSVKGLKEQLRKAG
                     ALSKRYWELFSCTLWPDHCEDQETPVPPLGWSLPLWGRRSLDVLTAWLCRFQDCCSGG
                     GDCRISNNLTGLESDLRVRLHGQHLASKLVLRAVKGYLEMPQVGKALALSFHGWSGTG
                     KNFLARILMDNLYRDGMRSDCVKMFISTFHFPHPKYVDTYKEELQRQMQETQWRCHQS
                     TFVFDEAEKLHPGLLELLEPYLEPRSPEARGVEAPRAIFLFLSNLGGSVINEVVLSLL
                     KAGWSREEITTQHLEVPLQAEIMEAADSSFGSSGLLKKHLIDHFIPFLPLEYCHVRLC
                     VRDAFLGQDLPYTEETLDEIAKMMTYVPEEERLFSSQGCKSISQRINLFLP"
     exon            255..371
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /inference="alignment:Splign:2.1.0"
     exon            372..637
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /inference="alignment:Splign:2.1.0"
     exon            638..816
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /inference="alignment:Splign:2.1.0"
     exon            817..941
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /inference="alignment:Splign:2.1.0"
     exon            942..3268
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1843..1848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /note="hexamer: ATTAAA"
     polyA_site      1864
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /note="major polyA site"
     regulatory      3247..3252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /note="hexamer: AATAAA"
     polyA_site      3268
                     /gene="Tor3a"
                     /gene_synonym="Adir"
                     /note="major polyA site"
ORIGIN      
        1 gggactcttg gaggcggaag cgctcgctcc ggtcatgttt cttggcgctc tctggttgct
       61 gctgctcctg ccgctgcgcc ccccgggagc gcagggccag gaggccgacg agcccacccc
      121 ttggccgagc gtcaaaggcc tgaaggagca gctgaggaag gccggtgccc tctccaaacg
      181 gtactgggag cttttcagct gcaccttgtg gcccgatcac tgtgaagacc aggagacccc
      241 cgtgccgcct ctgggctgga gccttcctct gtggggccgg cggtcgctgg atgtgctcac
      301 tgcatggctc tgtcgctttc aggactgctg cagcggcggc ggcgattgca ggatctccaa
      361 caacttgaca ggcttagaat cagacttgcg tgtacgactg cacggccagc atctcgctag
      421 caagctggtc ctaagagcag tgaagggcta cttagagatg ccccaagtag gcaaggccct
      481 ggctctgtca ttccacggct ggtctggcac aggcaagaac ttcttggcac ggatactgat
      541 ggacaacctg tatcgggacg gcatgaggag tgactgtgtc aagatgttta tttctacctt
      601 ccactttcca caccccaagt atgtggacac gtacaaggaa gagttgcaga ggcagatgca
      661 ggagacgcag tggcgctgcc accagagcac gttcgtcttt gacgaagcgg agaagctgca
      721 cccggggctg ctggagctgc ttgaacccta cctggaaccg aggagccctg aggcccgtgg
      781 agttgaggcg ccccgagcca tcttcctttt tctcagcaac ctcggaggca gtgtcatcaa
      841 tgaggtagtc ctgagtttgc ttaaggctgg atggtccagg gaggaaatta cgacgcagca
      901 cttggaggtg ccccttcagg ctgagatcat ggaggctgca gacagcagct ttggctccag
      961 cggtctcctg aagaaacacc ttattgacca ctttatcccc ttcctgccac tggagtactg
     1021 ccatgtgagg ctgtgcgtcc gagatgcctt cctgggccag gatctcccat acacagaaga
     1081 gaccctggat gaaatcgcca agatgatgac atatgtccct gaggaagagc ggcttttctc
     1141 ctctcagggc tgcaaatcca tttcccagag aatcaacctc ttcctgcctt gaaagtgact
     1201 cctgtgcacc ctaaacaatc ctcctccaca agagacagcc atctgccagg tgccctggcg
     1261 tccagcaatc actgctttca gctggtgtgc aagaggcagt tcctaacaga ggcagtttct
     1321 aaaaaccact tggtgcctta aaaacctaca ttctagacaa tctagactga gggtcaggaa
     1381 gccagtggaa cggaaggtcc aagtaccaaa ggatcctcag aacactccct acagtctcct
     1441 ggcaccgtag ctcttcctgg aaggcagctg gagttcatat gagcctgagg ctctaggatc
     1501 tttgggctac agaacaagga atatgtgtgg actagaggcg tgtggtccag gtctgcaggt
     1561 ctggctggct ttccttgctt tccggcaacg tgggggagag gggcagcttc tgcatgtgag
     1621 accagcaaag ggccttaggc taaaggacaa actgaagctt tcaaaacagg atgggtgtgg
     1681 cccagcactg tagtaggcta atatgggaga gagagctaaa gaaacctgag ctgcctcgtt
     1741 tgagcagcct gccaggcttg accaaaactc atgtgtatgg atagctaagg catgttctgt
     1801 tgtgcagact gaaaactttt taaagaggcc tcgtcatgtg taattaaatc ttgtattttt
     1861 ctaacatcct ttcttactga gacctggtcc ttgcactgcc ctggcaggct ggcacagcac
     1921 gtgctggtct caggctactt tagagcttct tactaaactc ctctgactca gccctcgaac
     1981 acacgtgttc tccgctccag ctcggacaag tggttcctga ggctgatgtg gcgaggcagg
     2041 tcagtaccac ctgtctttag aataccatgg gccattcttt tctggtccct tcacactttt
     2101 taaacataca ggtctttgtg ttttctcaga atttccccct cttattcaaa gtcctgctca
     2161 gcactctcac ctttagttct tgtaaaaatg gaccatttct gcaaccccca cttaccagta
     2221 catgtgtact cactcacctg ccttaaggct agggaccacc tagcccagcc atattcaaat
     2281 aactgaaata aaggagtgtg gtttggaagt gggatctcaa ttagcaaagg cagtcacaaa
     2341 gttcaaaagc ttaggagttc tgctgccaca aaccccaggg acagaaattt aacaattaag
     2401 gtttcttata aagcaagacc acatggtaat taataagcat aaaatgccca atgagactta
     2461 gattcttgtt caagccaggt gcttccatgc tgtccttgaa tattcaggag gacagagcgg
     2521 gatgggcaca aagtgagaac caagtgaact gtaacaggaa tactagtgaa tccctcccat
     2581 ccaagagcca gacacaccgt tctccctctc gacaggggat gctggagcgc tgagcaggtc
     2641 ttacctgatc taacagaact gaaatccgag aataccctgt ggtcacgagt attataggta
     2701 ggaaagcaga gcagggatta taagcagaaa cttacagttc cagaacaacc agcaggtcag
     2761 tggttagagt gaaatggaaa aatcttaatt ttgtgaggca aagcccatga ggaaaacagc
     2821 tctgagaaac tgcaacacac acacacatct cagacaggca ctgtgcccaa aggactagaa
     2881 aaacactaaa ctccaaatta gtataataac gagcactaca gtggtgaaaa agctccatga
     2941 ctcaagcact ccgaagactg aggcaggagg ctgtctagtg aatttgagac tggctaggga
     3001 tatacagcaa gactgtccct gtctttttga gacagtgtct cacacagcta aaaatggtct
     3061 tgaactcagt acgtaaccct gaagtgactt tgctttttca tctttcaagt gctataatta
     3121 caggcatgtg ccagtacacc tggctttatc tggtgctggg ctcagatcct gggcttcttg
     3181 ctaggcaagg actttactga tgcccagccc caagaccctg tttctaagaa tgacactgga
     3241 ctggacaata aaaacaaggt cagtgcaa
//
