LOCUS       NM_001369222            1496 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus torsin family 2, member A (Tor2a), transcript variant
            3, mRNA.
ACCESSION   NM_001369222 XM_006498122
VERSION     NM_001369222.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1496)
  AUTHORS   Bebee,T.W., Park,J.W., Sheridan,K.I., Warzecha,C.C., Cieply,B.W.,
            Rohacek,A.M., Xing,Y. and Carstens,R.P.
  TITLE     The splicing regulators Esrp1 and Esrp2 direct an epithelial
            splicing program essential for mammalian development
  JOURNAL   Elife 4, e08954 (2015)
   PUBMED   26371508
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1496)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   3  (bases 1 to 1496)
  AUTHORS   Jungwirth,M., Dear,M.L., Brown,P., Holbrook,K. and Goodchild,R.
  TITLE     Relative tissue expression of homologous torsinB correlates with
            the neuronal specific importance of DYT1 dystonia-associated
            torsinA
  JOURNAL   Hum Mol Genet 19 (5), 888-900 (2010)
   PUBMED   20015956
REFERENCE   4  (bases 1 to 1496)
  AUTHORS   Church,D.M., Goodstadt,L., Hillier,L.W., Zody,M.C., Goldstein,S.,
            She,X., Bult,C.J., Agarwala,R., Cherry,J.L., DiCuccio,M.,
            Hlavina,W., Kapustin,Y., Meric,P., Maglott,D., Birtle,Z.,
            Marques,A.C., Graves,T., Zhou,S., Teague,B., Potamousis,K.,
            Churas,C., Place,M., Herschleb,J., Runnheim,R., Forrest,D.,
            Amos-Landgraf,J., Schwartz,D.C., Cheng,Z., Lindblad-Toh,K.,
            Eichler,E.E. and Ponting,C.P.
  CONSRTM   Mouse Genome Sequencing Consortium
  TITLE     Lineage-specific biology revealed by a finished genome assembly of
            the mouse
  JOURNAL   PLoS Biol 7 (5), e1000112 (2009)
   PUBMED   19468303
REFERENCE   5  (bases 1 to 1496)
  AUTHORS   Wang,Z., Takahashi,T., Saito,Y., Nagasaki,H., Ly,N.K.,
            Nothacker,H.P., Reinscheid,R.K., Yang,J., Chang,J.K., Shichiri,M.
            and Civelli,O.
  TITLE     Salusin beta is a surrogate ligand of the mas-like G
            protein-coupled receptor MrgA1
  JOURNAL   Eur J Pharmacol 539 (3), 145-150 (2006)
   PUBMED   16697365
REFERENCE   6  (bases 1 to 1496)
  AUTHORS   Ozelius,L.J., Page,C.E., Klein,C., Hewett,J.W., Mineta,M.,
            Leung,J., Shalish,C., Bressman,S.B., de Leon,D., Brin,M.F.,
            Fahn,S., Corey,D.P. and Breakefield,X.O.
  TITLE     The TOR1A (DYT1) gene family and its role in early onset torsion
            dystonia
  JOURNAL   Genomics 62 (3), 377-384 (1999)
   PUBMED   10644435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772271.11.
            
            On Oct 4, 2022 this sequence version replaced NM_001369222.1.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422601.1414302.1,
                                           SRR13422592.519665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AL772271.11        172139-172401
            264-443             AL772271.11        173619-173798
            444-619             AL772271.11        174389-174564
            620-747             AL772271.11        175451-175578
            748-1496            AL772271.11        176358-177106
FEATURES             Location/Qualifiers
     source          1..1496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 22.09 cM"
     gene            1..1496
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /note="torsin family 2, member A"
                     /db_xref="GeneID:30933"
                     /db_xref="MGI:MGI:1353596"
     exon            1..263
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..992
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; torsin-2A"
                     /codon_start=1
                     /product="torsin-2A isoform 2 precursor"
                     /protein_id="NP_001356151.1"
                     /db_xref="GeneID:30933"
                     /db_xref="MGI:MGI:1353596"
                     /translation="MAVARHGYRPWGSILGLLGLALAAAAAWDVASLRCTFGSFCECD
                     FWPDLPGEGWEPVRTGGQPAVRRGSKHLPPRRPPAEDPAPSKPLVLSLHGWTGTGKSY
                     VSSLLAQHLFRDGLRSPHVHHFSPIIHFPHPSRTEQYKKELKSWVQGNLTACGRSLFL
                     FDEMDKLPPGLMEVLQPFLGPSWVVYGTNYRKAIFIFISNAGGEQINQVALEAWRSHR
                     DREEISLQEVEPVISRAVMDNPQHGFWRSGIMEEHLLDAVVPFLPLQRHHVRHCVLNE
                     LAQLGLEPSEEVVQAVLDSTTYFPEVEQLFSSNGCKTVASRLTFFL"
     exon            264..443
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /inference="alignment:Splign:2.1.0"
     exon            444..619
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /inference="alignment:Splign:2.1.0"
     exon            620..747
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1496
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="Tor2a"
                     /gene_synonym="Prosalusin"
                     /note="major polyA site"
ORIGIN      
        1 gaccgaaatc gggcctcaac cggatggcgg tggcgaggca cggctaccgg ccctggggct
       61 cgatcctcgg gctgctcggg ctggccttgg ctgccgccgc cgcctgggac gtggcttctc
      121 tgcgctgcac cttcggctcg ttctgcgaat gcgacttctg gcccgacttg ccgggtgagg
      181 ggtgggagcc ggtgcggacg ggcgggcagc cggcagttcg caggggctcg aaacatctgc
      241 cgccccgccg gccgccggcg gaggacccag cccccagcaa gccgttggtc ctttccctgc
      301 acggctggac aggcaccggg aagtcctacg ttagctccct gctggcacag catctcttcc
      361 gggatggcct tcgcagccct cacgtccatc acttctcccc tatcatccat ttcccacatc
      421 ccagccgcac tgagcagtac aagaaggagc tcaagagctg ggttcagggg aacctcactg
      481 cctgtggccg atcccttttc ctcttcgatg agatggacaa gctgcctcct ggcctgatgg
      541 aagtcctgca gcccttcctg ggcccttctt gggttgtgta tgggaccaac tatcgcaaag
      601 ccatcttcat ctttatcagc aatgctggtg gtgagcagat caaccaggtg gccttggagg
      661 cctggcgcag ccacagggac agggaagaaa tcagcctaca ggaggtggag ccagtaatct
      721 cccgagctgt gatggacaac cctcaacatg gcttctggcg gtctggcatc atggaggagc
      781 acctgctgga cgctgtggtg cccttcctcc cgctccagcg gcatcacgtg cgccactgcg
      841 tactcaatga gctggctcag ttgggcctgg agcccagcga ggaggtggtt caggcggtgc
      901 tggacagcac cacctacttc cctgaggtag aacagctctt ctcctccaat ggctgcaaga
      961 cagtggcctc ccgactcaca tttttcctct gagaagccca ggtggcatcg ctgcctcctc
     1021 tgcctggtca gagcaaacac gaaaggcctg ggtggctcct ggaagaaatc tttcctaagc
     1081 tggttggcaa gtgggaccca gagcacaatg ttaagatgaa gaaaggtgtt ggccaggcca
     1141 aggaagaaag gtctagaagc atctttgcta agaaactcct gggtaccccg caacctcaca
     1201 gccgtgccat tgccctgcag tctgagcctg agccttctca atgtgaacgg caactcaggg
     1261 acgaaggctc ctggctgctt ccagctgggg actcttactg gcatgccttg tctggctcct
     1321 ttcccagacc tcagcccaca gactgtggct ggacccagca atccagctag gccaggctag
     1381 cacctcacag gttccccaaa tggaaggact caagctacta catgggcctg aatttcaaag
     1441 tttttaattt tgtacaagag aacagagatt aaataaactt agccttggta ttagaa
//
