LOCUS       NM_133673               2997 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus torsin family 1, member B (Tor1b), mRNA.
ACCESSION   NM_133673
VERSION     NM_133673.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2997)
  AUTHORS   Li,J., Liang,C.C., Pappas,S.S. and Dauer,W.T.
  TITLE     TorsinB overexpression prevents abnormal twisting in DYT1 dystonia
            mouse models
  JOURNAL   Elife 9, e54285 (2020)
   PUBMED   32202496
  REMARK    GeneRIF: TorsinB overexpression prevents abnormal twisting in DYT1
            dystonia mouse models.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2997)
  AUTHORS   Tanabe,L.M., Liang,C.C. and Dauer,W.T.
  TITLE     Neuronal Nuclear Membrane Budding Occurs during a Developmental
            Window Modulated by Torsin Paralogs
  JOURNAL   Cell Rep 16 (12), 3322-3333 (2016)
   PUBMED   27653693
REFERENCE   3  (bases 1 to 2997)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   4  (bases 1 to 2997)
  AUTHORS   Jungwirth,M., Dear,M.L., Brown,P., Holbrook,K. and Goodchild,R.
  TITLE     Relative tissue expression of homologous torsinB correlates with
            the neuronal specific importance of DYT1 dystonia-associated
            torsinA
  JOURNAL   Hum Mol Genet 19 (5), 888-900 (2010)
   PUBMED   20015956
REFERENCE   5  (bases 1 to 2997)
  AUTHORS   Vasudevan,A., Breakefield,X.O. and Bhide,P.G.
  TITLE     Developmental patterns of torsinA and torsinB expression
  JOURNAL   Brain Res 1073-1074, 139-145 (2006)
   PUBMED   16458269
  REMARK    GeneRIF: torsinB expression was highest during late postnatal
            periods (from P14 onwards) and in the adult.
REFERENCE   6  (bases 1 to 2997)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2997)
  AUTHORS   Konakova,M. and Pulst,S.M.
  TITLE     Immunocytochemical characterization of torsin proteins in mouse
            brain
  JOURNAL   Brain Res 922 (1), 1-8 (2001)
   PUBMED   11730696
REFERENCE   8  (bases 1 to 2997)
  AUTHORS   Ozelius,L.J., Page,C.E., Klein,C., Hewett,J.W., Mineta,M.,
            Leung,J., Shalish,C., Bressman,S.B., de Leon,D., Brin,M.F.,
            Fahn,S., Corey,D.P. and Breakefield,X.O.
  TITLE     The TOR1A (DYT1) gene family and its role in early onset torsion
            dystonia
  JOURNAL   Genomics 62 (3), 377-384 (1999)
   PUBMED   10644435
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017290.1, AK159843.1, AK028859.1 and AV283130.1.
            
            On Jan 28, 2006 this sequence version replaced NM_133673.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054404.1, AK149754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AK017290.1         20-21
            3-1897              AK159843.1         2-1896
            1898-2994           AK028859.1         1712-2808
            2995-2997           AV283130.1         240-242
FEATURES             Location/Qualifiers
     source          1..2997
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 21.76 cM"
     gene            1..2997
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /note="torsin family 1, member B"
                     /db_xref="GeneID:30934"
                     /db_xref="MGI:MGI:1353605"
     exon            1..223
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /inference="alignment:Splign:2.1.0"
     exon            224..489
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /inference="alignment:Splign:2.1.0"
     exon            490..665
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /inference="alignment:Splign:2.1.0"
     exon            666..793
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /inference="alignment:Splign:2.1.0"
     exon            794..2997
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /note="hexamer: AATAAA"
     polyA_site      2997
                     /gene="Tor1b"
                     /gene_synonym="2610016F05Rik; DQ1; torsinB"
                     /note="major polyA site"
ORIGIN      
        1 ccgcacggtg cttccctgcg tgcgatgaga cgaatcggag cgtttggggg ctccacggcc
       61 ctgtgggcgc tgctggccgc ccacgtggcg ggggcgttcg agcccgtaag cgtgggcatc
      121 gccatcgggg ccgtgtcggc gctcaccggc tacctgtcct ataccgattt ctactgccgc
      181 ttcaccgagt gctgccatga ggaacggccc ctcaacacgt cggccctcaa gctggacttg
      241 gaagagaagc tgtttggaca gcaccttgcc accgaagtga ttctcaaggc attgactggc
      301 ttcaggaaca acaaaaattc caagaaacca ttgactctgt ccttgcacgg ctgggctggc
      361 acgggcaaga attttatcag ccagattgtg gctgaaaacc tttatccaaa aggcctgaag
      421 agtaactttg tccacctgtt cgtctctact ttgcacttcc ctcatgagca gaagataaag
      481 gtgtaccagg accagctcca gaagtggatc cgaggcaatg tgagtgcgtg tggcagctcc
      541 gtcttcatct ttgacgagat ggataagttg catcctggga tcattgatgc aatcaagccc
      601 ttcctggact actatgagca ggtggatggg atttcctacc gcagagccat cttcatcttc
      661 ctcagcaatg caggaggaga cctgatcact aagacggccc tggacttctg gcgggcagga
      721 agaaaaaggg aggagatcca gctgaaggac ctggagcctg tgctgtctgt gggcgtcttc
      781 aacaacaagc acagtggcct gtggcacagt gggctaatag acaaaaacct catcgactat
      841 tttatcccct tcctgccctt ggagtacaaa cacgtgaaga tgtgtgtgcg ggcagagatg
      901 agggcccgag gggctgccgt cgatgaggac gtcgtcacca gtgtggcaga tgaaatgacc
      961 ttcttcccca aggatgagaa gatctactca gacaagggct gcaagactgt gcagtcccgg
     1021 ctggatttcc actgagctct tcatccagtg gagtgggaag attcagggga acctcccacc
     1081 ccgttccagg ccttgtcatg gagcactttg aagagccccc ttggggcttt gcacatttgc
     1141 acctgtggac ttgggatgct gtcagtgcgg catctgaaga tgaactttaa gaatgctcac
     1201 actttactgt gaatcaagtg cctaaaaaaa aaaaaccaaa actgtctgaa cgcaggccaa
     1261 aagtcctgtg tggccaacag cacccatgcc tcagatgcca ctaatgggcc tgctgcaccc
     1321 tgctgtaccc tcagggaggc agggtttcct accactgggc tgtttttttc ttttctgcct
     1381 tgacctggta atcacaattt cggaagctgg tggcactgac agatgctcac tgctagaggg
     1441 gagcatgtgg gcttgacctt ggctggactg tcagtgtgag cagtgggggc tccctctgag
     1501 gcccctggag cacacaggga cacagagcct ttgagtttat gccttctgtt cgctactgct
     1561 cgcagccctg gctgtgggat gctctgtcca gtctcccact gtgtatgggt cacaacctgc
     1621 cttgtacctt gcctatcaat tgttagattc acccagcctc atccctgctt gcatcaggat
     1681 gagctgtcat ttttgaagga ggtctttgga ccctgtttgc ctgttacact tgctctgaag
     1741 gtcaagctcc gatttgcaga acatgcatag gaagagaagc tctaggctgg ggctgacctg
     1801 gccaaacccc atgggaagga gtgtgtctgc tgtacaccag agatgccgtt tttttttttt
     1861 ttaaaggaca tgcacatatt taaaatttat atttttactt ctaaagctta ggtaataaat
     1921 gtaagatgcc atgcatttta aaacctagga agtgccacaa gtgctggggc acacctttaa
     1981 tcccagcact cttgaggcaa aggcaggtag attctgggag tttgaaccca accttgtcta
     2041 cttagtgggt tccaggacag ccaagactac acagcccttt ttcaaaaaat aaagacctag
     2101 gaaggacata aaatagaatg aggcttattc tcaggttttt aacgttgctg gatatggggc
     2161 acaataccca tgatcccagc aggaagatca gggttcaggg ttcctcagct ggcttgagtt
     2221 taagaactgc ctgagttaca tgaaactcaa aagaaaaaaa aaaagggtct tattgttaat
     2281 tgtgtagaga gtagaactat actggcacaa ctcagcttgt gggttctggg tgtaatctca
     2341 ggatgacgcc ttgagtggca tctgggctgc tctgactgta gggagctgag cctgtgagcc
     2401 tatccttgtg aaccattctg tcctacagtt gctatgcagc tgcagacatg gaaactctgc
     2461 catgttttta tacaatgtgg tagaatggct atttttataa cacggaaatg ccttaaagag
     2521 aatcacagct tgtcacttag aaatgccacg ctgagctggg tgtggtggtg ctcaccttta
     2581 gtcccagaac ctgtgaggcc atggcaggac tgtctcaagt ttgaggcaag cctaggctac
     2641 acaagggaat gccaggccag tggtgtgcat gcctgcaatc ctagcacttc ggaagaggag
     2701 tttaaagtta gttgagctac gtacagagag accctgtctc aaagcaggaa gcaaaccaaa
     2761 acgtgccaag gtgagggtga ctttcaggcc atagtcttgg actggagccg agttactgtt
     2821 tgtgacctgt tgggctcccg gttttctgtt tacagtgatg taatacgtgg acacgtgttg
     2881 gccacctttg gactgctgtt actgatctcc aactttgaaa ggcctggtgt ggcctgcccc
     2941 agcctccctg tgagaacaga gatggacgca agataataaa agcattgcga gacgtaa
//
