LOCUS       NM_172843               5857 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus torsin A interacting protein 2 (Tor1aip2), transcript
            variant 5, mRNA.
ACCESSION   NM_172843
VERSION     NM_172843.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5857)
  AUTHORS   Hernandez-Ono,A., Zhao,Y.P., Murray,J.W., Ostlund,C., Lee,M.J.,
            Shi,A., Dauer,W.T., Worman,H.J., Ginsberg,H.N. and Shin,J.Y.
  TITLE     Dynamic regulation of hepatic lipid metabolism by torsinA and its
            activators
  JOURNAL   JCI Insight 9 (3), e175328 (2024)
   PUBMED   38194265
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5857)
  AUTHORS   Yang,Y., Wang,J., Zhao,C., Chen,X., Chen,L., Zhang,J., Huo,R.,
            Liu,C., Tong,H. and Ling,X.
  TITLE     The interferon alpha-responsive gene, Ifrg15, plays vital roles
            during mouse early embryonic development
  JOURNAL   Cell Mol Life Sci 73 (15), 2969-2984 (2016)
   PUBMED   26911731
  REMARK    GeneRIF: Preimplantation embryo development was arrested at the
            1-cell stage after knocking down Ifrg15 expression.
REFERENCE   3  (bases 1 to 5857)
  AUTHORS   Goodchild,R.E., Buchwalter,A.L., Naismith,T.V., Holbrook,K.,
            Billion,K., Dauer,W.T., Liang,C.C., Dear,M.L. and Hanson,P.I.
  TITLE     Access of torsinA to the inner nuclear membrane is activity
            dependent and regulated in the endoplasmic reticulum
  JOURNAL   J Cell Sci 128 (15), 2854-2865 (2015)
   PUBMED   26092934
  REMARK    GeneRIF: The data suggest that LULL1 oligomerizes to engage and
            transiently disassemble torsinA oligomers, and is thereby
            positioned to transduce cytoplasmic signals to the inner nuclear
            membrane through torsinA.
REFERENCE   4  (bases 1 to 5857)
  AUTHORS   Wu,F.R., Ding,B., Qi,B., Shang,M.B., Yang,X.X., Liu,Y. and Li,W.Y.
  TITLE     Sequence analysis, expression patterns and transcriptional
            regulation of mouse Ifrg15 during preimplantation embryonic
            development
  JOURNAL   Gene 507 (2), 119-124 (2012)
   PUBMED   22871540
  REMARK    GeneRIF: Ifrg15 transcription might be either potentially regulated
            or dependent on the post-transcriptional effects of IFN-alpha
            mediated by the three genes Oct4, c-Myc and Nanog indirectly
REFERENCE   5  (bases 1 to 5857)
  AUTHORS   Akhter,M., Kobayashi,I., Kiyoshima,T., Nagata,K., Wada,H.,
            Ookuma,Y., Fujiwara,H., Honda,J.Y. and Sakai,H.
  TITLE     In situ expression of 15 kDa interferon alpha responsive gene in
            the developing tooth germ of the mouse lower first molar
  JOURNAL   J Mol Histol 41 (4-5), 185-191 (2010)
   PUBMED   20623326
  REMARK    GeneRIF: These results suggest that Ifrg15 is closely related to
            odontogenesis, especially the differentiation of the ameloblasts
            and odontoblasts, and to the morphogenesis of the craniofacial
            organs.
REFERENCE   6  (bases 1 to 5857)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   7  (bases 1 to 5857)
  AUTHORS   Goodchild,R.E., Kim,C.E. and Dauer,W.T.
  TITLE     Loss of the dystonia-associated protein torsinA selectively
            disrupts the neuronal nuclear envelope
  JOURNAL   Neuron 48 (6), 923-932 (2005)
   PUBMED   16364897
REFERENCE   8  (bases 1 to 5857)
  AUTHORS   Goodchild,R.E. and Dauer,W.T.
  TITLE     The AAA+ protein torsinA interacts with a conserved domain present
            in LAP1 and a novel ER protein
  JOURNAL   J Cell Biol 168 (6), 855-862 (2005)
   PUBMED   15767459
  REMARK    GeneRIF: identifed a novel transmembrane protein, lumenal domain
            like LAP1 (LULL1), which appears to interact with torsinA; it
            resides in the main endoplasmic reticulum.
REFERENCE   9  (bases 1 to 5857)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 5857)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK038024.1 and AC159964.5.
            
            On Sep 25, 2009 this sequence version replaced NM_172843.3.
            
            Transcript Variant: This variant (5) represents the longest
            transcript and encodes the longer isoform b (torsin-1A-interacting
            protein 2), compared to isoform a. Variants 5, 6, and 7 encode the
            same isoform (b).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2634              AK038024.1         263-2896
            2635-5857           AC159964.5         150917-154139
FEATURES             Location/Qualifiers
     source          1..5857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 67.7 cM"
     gene            1..5857
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /note="torsin A interacting protein 2"
                     /db_xref="GeneID:240832"
                     /db_xref="MGI:MGI:3582695"
     exon            1..445
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..505
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..835
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1012
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /inference="alignment:Splign:2.1.0"
     CDS             946..2454
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /note="isoform b is encoded by transcript variant 5;
                     lumenal domain like LAP1; interferon alpha responsive
                     protein (15 kDa); torsin-1A-interacting protein 2;
                     interferon alpha responsive gene, 15 kDa; 15 kDa
                     interferon-responsive protein"
                     /codon_start=1
                     /product="torsin-1A-interacting protein 2 isoform b"
                     /protein_id="NP_766431.3"
                     /db_xref="CCDS:CCDS15389.1"
                     /db_xref="GeneID:240832"
                     /db_xref="MGI:MGI:3582695"
                     /translation="MSQSLKSQNTNMSDSGCRDPVGDSQNVLENDPSINSQTQDTRVT
                     PNNTAEAQPLQPTSDLKEDHHEIGARAQEHTDTGDRSESPEEPALEKPPLDKAELESS
                     PSSQDTELGHHPHSEHGGGDALDLDPNCSQSDLGGRADAHLESSSVASPEGAGDRGEA
                     DEHLESSSAAPTEGAGDRGEAGQELLAEDSTDGQSLGHSNTGPGNQDSLRRRLPVPEA
                     GSHEEETELVKEKQEVAQDTLRKTDKKSLWTYGSVFLGCLIVAVVLSSVNSYYSSPAQ
                     QVPQNPALEAFLAQFGQLKEKFPGQSSFLWQRGRKFLQKHLNASNPSEPATIIFTAAR
                     EGKETLKCLSYHVANAYTSSQKVTAVSIDGAERALQDSDTVKLLVDLELSDGFENGHK
                     AAVVHHFESLPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLEASVSPREIEEKV
                     RDLLWAKFTNSESPTSYSHMDSDKLSGLWSRISHLVLPVQPVRNIEERGCLL"
     exon            1013..1594
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1696
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..5857
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5790..5795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /note="hexamer: AATAAA"
     polyA_site      5814
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /note="major polyA site"
     regulatory      5839..5844
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
                     /note="hexamer: AATAAA"
     polyA_site      5857
                     /gene="Tor1aip2"
                     /gene_synonym="1110020D10Rik; 15kDa; A130072J07; Ifrg15;
                     Lull1"
ORIGIN      
        1 cggggccgga gcggggccgg cctccacggg ggcgcgcctg ccgccgcgtg cccgccgccg
       61 cgcgcgctcc cgagcccgca gccgagactg ttaccttcgc ggtcctcact ggaggacgga
      121 gagtcccgta accctcggcc gctcgtggcc ggagacagct gcggctgctg tgagtgctgc
      181 tcaaggcgag cagacctccg cgtcttcatc tcctcggctt cctgggctcg ccgctgcctc
      241 cgtggtcgag agcgaaggtt gtaagcgctt tctctcactt cctctcccgc agaagccggc
      301 cggaactttt ctggcggggt tcgtctcccc cccggagacc tttctttggc cgcccggggc
      361 tcgaagtcgc cgtacacttc tgccggctcc tctgaaaacc tcacttcccg tcgtccgcgg
      421 cgcgacgggt gagctccgta cgcaggtctt tgagaaagga tccctcccca cccccacctc
      481 ccctacggca caaacagaaa tcgaggtgtg tgacgcattc ccagaccatc ctgcaaactc
      541 aacaccagcg acttctctgt gactgggtcc agataaaggt cctttcaaga ctgacttcag
      601 tggatctact ccaccaggtc ttcccgacct tactacatca ctgccaagtg ctattggcga
      661 gactgcctgc accagcagaa gactcaccgg atccatcaga gcgtcggttt taccagagca
      721 aagcaagagc ctgtgtggtt ctgcctcccg ctaatactgg acaggaaaca gcaactggct
      781 tggactagag gcctggcttt cctttgaagg agctattctg tgatctgtgt tgctatcact
      841 gtctatatcc cttgcttctt gcttccatgg gaagcatgag tctattggaa cctgggacaa
      901 gaagaaacca aggtatctcc actacaaaac ccagacacta aaaagatgtc ccaaagtctg
      961 aagagccaga acacaaacat gagcgacagt ggctgcaggg atcctgtggg agactcacaa
     1021 aatgttttgg aaaatgatcc atcaataaac tctcaaacac aggacaccag agtcacaccg
     1081 aataacactg cagaagccca gcccctacag cccacatctg atcttaaaga agaccaccat
     1141 gaaatagggg ccagagctca ggagcataca gacacaggtg acaggtcaga aagtccagag
     1201 gaaccagcgt tagagaaacc tccactggat aaagcagagc tggagagcag cccgagttct
     1261 caggacacag agctcgggca tcacccccac tcagaacatg ggggcggaga cgccctagat
     1321 ctggatccta actgctctca aagcgacttg ggaggaagag cagatgcaca cctggagagc
     1381 agctctgtag cgtccccaga gggagcaggt gacaggggtg aagctgatga gcacctggag
     1441 agcagctctg cagcccccac agagggggca ggtgacaggg gtgaagctgg tcaggaactg
     1501 cttgctgaag actctaccga tggccagagt ctgggccatt ccaacacagg tccagggaac
     1561 caggattcac tgaggagacg actgcctgtg cccgaggctg gaagtcatga agaggagaca
     1621 gagttggtga aggaaaagca agaggttgca caggatacat tgagaaagac tgataaaaag
     1681 agtctctgga cctatggttc cgtgtttctc ggctgcctga tcgtggctgt tgtgctaagc
     1741 tccgtcaaca gctactattc ttccccagcc cagcaggtgc cccagaaccc ggctttggag
     1801 gccttcctgg ctcagtttgg ccaactgaag gagaaatttc caggtcagag ttccttcctg
     1861 tggcagcgag gacgtaagtt tctccagaag cacctcaatg cctcgaaccc cagtgagccg
     1921 gccaccatca tcttcacagc tgctcgagag ggcaaggaga ccctcaagtg cctgagctac
     1981 catgttgcca acgcctacac ctcttcccag aaggtgactg ccgtctccat agacggagcc
     2041 gaaagggccc tgcaggacag tgacacagtc aagctgctgg ttgacttgga gcttagcgat
     2101 gggtttgaga atggccacaa ggctgctgtg gtccaccact tcgaatccct tcctgccggc
     2161 tccaccctga tcttctacaa gtactgtgac catgagaacg ccgcctttaa agatgtggca
     2221 cttgtcctga cagtcctgct ggaggaggaa acgttagaag caagtgtaag ccccagggaa
     2281 atagaagaaa aggtgaggga tttactctgg gctaagttca ccaactctga gagccccacc
     2341 tcctacagcc acatggactc agacaaactg agtgggctct ggagccgcat ctcccacctg
     2401 gtgctgcccg tccagcccgt caggaacata gaagagcgag gctgcctttt gtgaagccag
     2461 tcacagaggt gacatggaag ggccatgtct cagggctctg tcccgctagg aggtgactgg
     2521 catgtgagag gaaacagctg ggaggccgtc actgtgttag aaaagaagct ttttttcttt
     2581 gacttttaaa aaatctttct agtctgaact ttgataaaac taacaattgg cctgatgttt
     2641 ttctttgttt tttaaagcca atcagggtta aaatacaaca tgatgtattg tttaagtgtc
     2701 cagcacatca gtagaataga attgttttgc acaggaagat ctgattctcc ggggaactgc
     2761 agccccactg ctgcctgcaa ggactctcac cagcctctag ggcagtgctt ggacctggac
     2821 gaggtgtcat gtaaatgatt ttagagaact cttctactac atattaagtg ctttttaata
     2881 ttcacttttt tttgttgttt ttttctgagg cagggtttct ctgtgtagct ctggctgtcc
     2941 tggaactcac tttgtagacc aggctggcct cgaactcaga aatctgcctg cctctgcctc
     3001 ctaagtgctg gggttaaagg cgtgcagcat cactgcctgg ccttaatact cactttaata
     3061 atacacttgt gggttgattg tgtcttacac agatttgcac tttgagtagg tgaaaacaga
     3121 aaactagaat tcaaccctcc aaacctacct aagagcctgg tgtgtgtgtg cttctgttcc
     3181 gttagtgagc tgaggccaga acagctgtgc tcaaaaaaga accttcccaa gcattggact
     3241 caatgacgaa attgttagta atcaccagaa atgaaaaaat cccccttggc catgtcactt
     3301 gtctttgcct acccagcagc ccctccttcc tgtgaatcat gcctgctctt ggctgctggg
     3361 tttggggttc tctgttagga tttcagtgga gctgagtttc acagagaagt ttgaaagcca
     3421 ttgatgaagt gaaagtgcat tctagagtag gaaggatagg aagacatgaa agggttaaag
     3481 ctgaggagta acaggaagtt ctgttgttca gggcgacaga gacctgcaga tgagctgcta
     3541 ctggagggtg tagggcaggg ccgtgagctt ttgtcccttt ctgtggatct ttcctgtcct
     3601 cccctgctgg aatctcactg ttgtctgtgt tctttcagaa aagacttgag gtcctcagct
     3661 agttagaaat gccgtcagga aaggaacttg ataaacacaa ggggaaggtc tcctgtaggg
     3721 aacagaaaga ggaatcatgg ccaatatccg ttgttaagct acatcccatg atttcagact
     3781 ggggccaata agctgttaat cagtacgtga actctgaaag taaaactcta gtaaaatgat
     3841 cttgacccac aaaaggtctg ttcctttaca tggatgggaa aagcccttgg aatcttgcac
     3901 tcagttttgg gtcatctgct gctaagagat catgtataca cttaagacat taagcaacct
     3961 gagtctaaag ggattttagg aaacactaag aagatgtcta ttggtagtta aatggatcac
     4021 agagacacgg gtgagaggtg atctgaaaat atttcccaca agatggcttt ggccacaacc
     4081 tttggtgtta agtaagttaa gtatgggggc acacatgaaa cagtatgtat ttgggatttt
     4141 gaaggaatcc tgatatagat ttcagaaaag accctacaca aagtttaagc atagtgaatg
     4201 gaatttttct gtcaactcat tgtaaaacac agggattgaa gaaaaatcca tttgccattt
     4261 ttgaattttt tttcttctgt atttctagac ttatttgttt tgaatgctag tggcttgtca
     4321 catagccatg tctggcctgg tgtttactct gtagcatagg ctgactttga acttagagta
     4381 atttctccta cctccgtgtg ctgagtgccg aggctacagg tgtgtgccat catatccaac
     4441 tttcatgtaa gctcttagcc actagcatta catcgcgtaa aaccacatca aatcgcgtca
     4501 aaaggtgcct tgcagactgt catgttggcc tttgacccat gctacctcag actctagagg
     4561 aatgtctaca gtatttgtgc acagtctatg tcagtggctc agatcacaag tggaaagcaa
     4621 tcgtttcctc attaaaacta tgtaaaacga cagccttaca tagtttcctg tcaacacaaa
     4681 tttaggatat aatacatttt agaaatttat tatttttcaa ttatttttgg tttttttact
     4741 acttaccttg taaaaataca cttttccttt tgtcataagt gcaatcagct gagtgagact
     4801 tgtcagttgt tgttgctttt tttttttcta tcctctgttt caaaactcag ggccttaaca
     4861 ttcaaggaaa gtgccctacc actaacctat atcccagacc tcttaaaagt cattttgaaa
     4921 agaagcagta tgttagtttg gggtcagaac aagtaatttt ctggttttga taccgagtct
     4981 ctacacagtc caaagtaatg attctcaagc ctcgggctct tacaggatgg gattacggta
     5041 gtgtgccgcc acaccagcct attatcccgt gtactgtctt ctagaccatt gcttttcata
     5101 ttcagttttc cagcctttta tgtgtgttgt aattctttgt gataatttgc ctgtgtgtgt
     5161 atgtttttta ttggtggtgg ggtttttttt gtttgttttt aactaggaat cccttcttga
     5221 gtaataccaa gtcttagaag caagcagggg aaatagaaac tgtctttaga cttgggtctt
     5281 tctttccctt tcaggtaaaa tttagggttc ttctgggcac cactcagaga ttgtcagaaa
     5341 agctctagag agttcttaac actgaactaa ttttagtaac ttttacctgg aagtccgcag
     5401 gcttaggggg agtagtgagg ctcagtaccc ttcccattgg cttatgtgcc ccacccccac
     5461 ccccaatcac tgtggctgat ggtacagctt tgtctcacag cctttggtcc acagtcttgt
     5521 taaagacagg agcactgtga gcacggatgt tggctatgac agacagatgc agcctgtgaa
     5581 cacgagagta gtgcagcaaa aatgattttc accaacactc ttactttctc taacaaagat
     5641 ttcttaaccc catagagttt tgcctttata tatttacaaa tgtaatggct tgtcaaactt
     5701 accaaatcac cataactgct ttttgcattc atttccatag tgatgatgtt gaatgtgcct
     5761 tattcaaatc aattgtctga ttactataca ataaatctct tcaatttttc ctgactgatt
     5821 ttttactaaa atttccaaaa taaagaattt atgaaaa
//
