LOCUS       NM_026652               2668 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus topoisomerase I binding, arginine/serine-rich like
            (Toporsl), transcript variant 1, mRNA.
ACCESSION   NM_026652
VERSION     NM_026652.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019748.1, AV041323.2, AV275899.1 and AL772233.6.
            
            On Sep 28, 2017 this sequence version replaced NM_026652.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019748.1, BY715651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2401              AK019748.1         2-2402
            2402-2549           AV041323.2         4-151
            2550-2667           AV275899.1         119-236
            2668-2668           AL772233.6         188769-188769       c
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 28.4 cM"
     gene            1..2668
                     /gene="Toporsl"
                     /gene_synonym="4930547C10Rik"
                     /note="topoisomerase I binding, arginine/serine-rich like"
                     /db_xref="GeneID:68274"
                     /db_xref="MGI:MGI:1915524"
     exon            1..63
                     /gene="Toporsl"
                     /gene_synonym="4930547C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            64..2668
                     /gene="Toporsl"
                     /gene_synonym="4930547C10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..2398
                     /gene="Toporsl"
                     /gene_synonym="4930547C10Rik"
                     /codon_start=1
                     /product="topoisomerase I binding, arginine/serine-rich
                     like"
                     /protein_id="NP_080928.1"
                     /db_xref="CCDS:CCDS18182.1"
                     /db_xref="GeneID:68274"
                     /db_xref="MGI:MGI:1915524"
                     /translation="MAIELSSKCECPSCAEGSPSESDWNYSSGKRGDGASYSRLTKKS
                     TISPIMQRFLSQCCSNELGSTNKEDFTFLASEEESSVDFSQTQNLSQTSKKTRSLREL
                     TIQELLSKFGDNERLPPHSVSLSHFRDHVVVKFRRALYYSGIWVKYVQGSGLKRFFSA
                     HYFKRNPSSLHRLIPWLKRELTAICGDYGYTVKNILTAILHHMTKFNLNSEAFTHLLE
                     PYLFQYTQHFLHEFISFVDSSYNMETYDRNAIYQCPVSKSSKKKSTVSAPAFSFPQEL
                     SFMKSQRGIKQSKKTWNKTGQSSDSGLKQFPKGHSSKNPQISTTHQKPANKRHVWTKD
                     EWGSDDFRGVVCTTNSLNWAYLRARRLDKEYYRNDNREKKSESTKLPPGHVQDLKSHE
                     TSPNIFRALVDSNQAPPKKYNIRETNVLDPGQQVHYQKKETERKKLEESSLKALQRLP
                     KERILIKSKSRESNHSCLCVSENSTSPTRNDKMLTSISKKMVRCSQSSQCVEVGSHHS
                     RRTQRQYSPRTPRSKSWCVRIRKQSMSRGQSNLSLRESHRSKHCALSKGSAHGCESTY
                     RVASLSPVHHDQVCLTAGKNCKCASMGEGESQTGGHCDSLSCLKTEKCHSPSKLGMKG
                     KHLVGRVTRIRTHRRKKPKYQCVGTQTTAEFRDDLGDLEDKSQKGFLNSHPECVTSCR
                     R"
     regulatory      2646..2651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Toporsl"
                     /gene_synonym="4930547C10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2668
                     /gene="Toporsl"
                     /gene_synonym="4930547C10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gattttttga aggttctaag agcagatcgg acttctcagt ggtcatagcc ataaaaatac
       61 aagcttgcct ttcagacctt gaaaaactac gttgaaaaag aaacaaccac aaaatgcctg
      121 tatcttcact gcctcgtatt cactgtgcgc cctgtgcacg ttaccaagaa tttgagaaat
      181 agtttgtctc ctcctaacgt cgttccagta ttaattccag agtgagcata ttataagcac
      241 atgcatggag tacttttaat agatcttttt catgcaagat gagaaactga tttggaactg
      301 tatttttttc tcaccttcga ctcatgaaat atgatctgtt aagccaatgg cgatcgagct
      361 ttcatccaag tgtgagtgcc ctagctgtgc ggaaggtagt ccgagtgagt ctgactggaa
      421 ttactcttcc ggaaagagag gggatggcgc ttcatactca aggttaacta agaaatccac
      481 aatctctccc atcatgcaac gcttcctttc tcagtgttgt tctaatgaac tggggagcac
      541 taacaaggaa gacttcacgt ttctcgcttc agaggaggaa agttctgtgg acttctctca
      601 aacacaaaac ctcagccaga catcaaagaa gaccagatca ttgagagaac tgactatcca
      661 agaactactg agcaagtttg gagacaatga gaggcttcca ccccactctg tgtccttgag
      721 ccattttaga gaccatgtgg ttgtgaagtt tagaagagct ctgtactatt ctgggatctg
      781 ggtaaaatat gtccagggct ctggactgaa aaggttcttt tcagctcatt attttaaaag
      841 aaatccaagt agcctgcacc gactgattcc ctggctgaaa cgagaactca cagctatctg
      901 tggagactat ggttacacag tgaagaatat cctaactgcc attctccatc acatgacgaa
      961 atttaacttg aacagtgaag ctttcactca cctactggag ccttatctct tccaatacac
     1021 ccagcacttt cttcatgagt ttatcagttt tgttgattca tcttacaaca tggagaccta
     1081 tgaccgcaat gccatctatc agtgtcctgt ttcaaagagt tcgaaaaaga agagcacggt
     1141 ttcagctcca gccttttctt tcccacagga gctctccttc atgaaatctc aacgaggcat
     1201 aaagcagtcc aagaagacct ggaataagac tgggcagagc tctgactctg gcttgaaaca
     1261 gtttcctaag ggtcattcct caaaaaatcc ccaaatctca acaacccatc agaaaccagc
     1321 aaataaacgc catgtttgga ccaaagatga gtggggatca gatgacttca gaggcgtggt
     1381 gtgtactact aattcactga attgggctta tctcagggca agaaggctag acaaagagta
     1441 ttatagaaat gataaccgag agaaaaagtc agaaagcaca aaactgcctc ctggccatgt
     1501 ccaggatcta aagagtcatg aaacaagtcc aaacatcttt agagcattgg tagattctaa
     1561 tcaggcaccc cccaaaaagt acaatataag ggaaacaaat gttttggatc ctggccaaca
     1621 ggtacattat cagaaaaaag aaacagaaag aaagaaactt gaagaatctt cactaaaggc
     1681 tcttcaaaga ttgcccaaag aaagaatctt gataaaaagc aaatccagag aaagtaatca
     1741 ttcttgtctt tgtgtctccg aaaatagcac ctctcctact agaaatgata agatgctgac
     1801 ttctattagt aaaaagatgg taaggtgcag ccagtcctcc caatgtgtag aagttggttc
     1861 acaccacagt agaagaaccc aaagacaata cagtcccagg acacccagat ccaaatcctg
     1921 gtgtgtcaga attagaaagc aatccatgag cagaggtcag agtaatctct ctctgaggga
     1981 aagtcacaga agcaagcact gtgcactgtc aaaaggaagt gctcatggct gtgaatcaac
     2041 ctacagggtg gcatctttga gcccagtcca ccatgaccag gtttgtttaa cagctggaaa
     2101 gaattgcaaa tgtgcatcca tgggtgaagg tgaatctcaa actggaggac attgtgacag
     2161 tctctcatgc ctaaagactg agaaatgtca ctctccaagt aagcttggta tgaaggggaa
     2221 gcacctagtt ggtagagtta cgagaatcag aacacatagg cgcaaaaaac ccaaatacca
     2281 gtgtgtgggt acacaaacca cagcagaatt cagggatgac ttgggggatc tcgaggataa
     2341 aagccaaaaa ggctttttga attctcatcc tgaatgtgtg acttcctgca gaaggtaaat
     2401 tagaaaaaga aaggaattca agacttcaga accttctagc caagaatgaa tctaaaatag
     2461 atatcatcag aagcataaag atctaagtgg ttttgaaagg caaattagtc tacttagcca
     2521 ccaaggctca ttgaaagtat ggatctaatc tgaaatatat gaaaatattt atcatagtac
     2581 tttgtaacta gaacaaaata tctgatgatt aaattcaaag ctttttttgg gcacaagtat
     2641 acattattaa attattcatt tatgtaaa
//
